Clinical Research Papers:

Adjuvant radiation therapy in stage I seminoma: 20 years of oncologic results

Francesca De Felice _, Daniela Musio, Giovanni Luca Gravina, Francesco Marampon and Vincenzo Tombolini

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Oncotarget. 2016; 7:80077-80082. https://doi.org/10.18632/oncotarget.11374

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Francesca De Felice1, Daniela Musio1, Giovanni Luca Gravina2, Francesco Marampon2 and Vincenzo Tombolini1,3

1 Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy

2 Department of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L’Aquila, L’Aquila, Italy

3 Spencer-Lorillard Foundation, Viale Regina Elena, Rome, Italy

Correspondence to:

Francesca De Felice, email:

Keywords: radiotherapy; stage I seminoma; surveillance; chemotherapy; orchiectomy

Received: May 22, 2016 Accepted: August 13, 2016 Published: August 18, 2016


Aim: To report long term oncologic outcomes after adjuvant radiotherapy (RT) for stage I seminoma.

Method: We reviewed the complete data set for all patients treated at our institute between 1988 and 2005 for stage I seminoma with adjuvant RT after radical orchiectomy .

Results: A total of 85 patients were included. The median follow-up was 15 years. The 20-year overall survival (OS) and relapse free survival (RFS) were 92% and 96.3%, respectively. No severe acute and late complications were recorded. Overall 5.9% of patients had a second unrelated malignancy.

Conclusion: Adjuvant RT is an efficacious and safe treatment in stage I seminoma.

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