Research Papers:

Tumor necrosis factor-alpha promoter polymorphism 308 G/A is not significantly associated with esophageal cancer risk: a meta-analysis

Ming Luo _, Yuan Yang, Dongmei Luo, Liang Liu, Yuening Zhang, Feifan Xiao, Jingcheng Yang, Chengdong Zhang, Shen Fu and Zhiguo Luo

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Oncotarget. 2016; 7:79901-79913. https://doi.org/10.18632/oncotarget.13093

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Ming Luo1,*, Yuan Yang2,*, Dongmei Luo3,*, Liang Liu4,*, Yuening Zhang5, Feifan Xiao5, Jingcheng Yang2, Chengdong Zhang1,2,6,7, Shen Fu6,7, Zhiguo Luo1

1Department of Clinical Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China

2School of Life Sciences, Fudan University, Shanghai, China

3School of Mathematics and Physics, Anhui University of technology, Maanshan, Anhui, China

4Department of Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China

5Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, China

6Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China

7Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

*These authors have contributed equally to this work and share first authorship

Correspondence to:

Shen Fu, email: shen_fu@hotmail.com

Zhiguo Luo, email: oncology_group@163.com

Keywords: esophageal cancer, TNF-α-308 G/A, meta-analysis, risk, association

Received: June 06, 2016     Accepted: October 21, 2016     Published: November 4, 2016


Many studies have investigated the association between Tumor necrosis factor-α-308 G>A (rs1800629) and the risk of esophageal cancer. However, their results are inconsistent. Therefore, we performed a meta-analysis of available data to investigate any possible association between this polymorphism and esophageal cancer risk. We searched PubMed, EMBASE, Web of Science, and the CNKI database for articles published up to 2016. Crude and adjusted odds ratio with 95% confidence intervals were calculated using fixed or random effects models. We used a dominant model (GA+AA vs GG), a recessive model (AA vs GG+GA), an over-dominant model (GG+AA vs GA), and allele frequency (G vs A) to identify any association. Eleven studies with 5617 participants were included in the meta-analysis. Our results suggest that TNF-α-308 G>A (rs1800629) is not significantly associated with a risk of esophageal squamous cell carcinoma and esophageal adenocarcinoma. For genetic association studies, negative results of meta-analysis have a high level of evidence, and these results are important in this era of high-throughput sequencing-based precision medicine.

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