Vol 6, No 8

Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target

Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety

Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma

Clinical and biological significance of de novo CD5⁺ diffuse large B-cell lymphoma in Western countries

Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis

Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling

Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinoma

Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer

2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma

Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells

NPM/ALK mutants resistant to ASP3026 display variable sensitivity to alternative ALK inhibitors but succumb to the novel compound PF-06463922

Preclinical antitumor activity of ST7612AA1: a new oral thiol-based histone deacetylase (HDAC) inhibitor

Myeloid differentiation primary response gene 88-leukotriene B4 receptor 2 cascade mediates lipopolysaccharide-potentiated invasiveness of breast cancer cells

Somatic microsatellite variability as a predictive marker for colorectal cancer and liver cancer progression

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells

EBNA3C regulates p53 through induction of Aurora kinase B

EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation

Afatinib increases sensitivity to radiation in non-small cell lung cancer cells with acquired EGFR T790M mutation

CD133⁺ ovarian cancer stem-like cells promote non-stem cancer cell metastasis via CCL5 induced epithelial-mesenchymal transition

ROS generation mediates the anti-cancer effects of WZ35 via activating JNK and ER stress apoptotic pathways in gastric cancer

DACH1 inhibits lung adenocarcinoma invasion and tumor growth by repressing CXCL5 signaling

CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid

Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer

New insights into the genetics of glioblastoma multiforme by familial exome sequencing

MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN

Discrete functions of GSK3α and GSK3β isoforms in prostate tumor growth and micrometastasis

Transforming growth factor-β pathway activity in glioblastoma

Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen

The over-expression of survivin enhances the chemotherapeutic efficacy of YM155 in human hepatocellular carcinoma

Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway

miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells

Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer

Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model

The anti-tumor effect is enhanced by simultaneously targeting VEGF and PROK1 in colorectal cancer

miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo

HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients

miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression

Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy

Up-regulation of C1GALT1 promotes breast cancer cell growth through MUC1-C signaling pathway

Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in mice

Gene expression profile predictive of response to chemotherapy in metastatic colorectal cancer

Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFκB signaling

Late-phase miRNA-controlled oncolytic adenovirus for selective killing of cancer cells

Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma

Autophagy protects against dasatinib-induced hepatotoxicity via p38 signaling

Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation

Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer

ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells

Coexpression analysis of CD133 and CD44 identifies Proneural and Mesenchymal subtypes of glioblastoma multiforme

Function of phosphorylation of NF-kB p65 ser536 in prostate cancer oncogenesis

Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin

FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells

Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells

Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs

MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation

Fatty acid binding protein 5 promotes metastatic potential of triple negative breast cancer cells through enhancing epidermal growth factor receptor stability

Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP

Drug metabolism and clearance system in tumor cells of patients with multiple myeloma

Efficacy and safety of decitabine in combination with G-CSF, low-dose cytarabine and aclarubicin in newly diagnosed elderly patients with acute myeloid leukemia

Antibody response to BK polyomavirus as a prognostic biomarker and potential therapeutic target in prostate cancer