Oncotarget

Research Papers:

Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation

Huiru Wang, Qing Sun, Yanhong Wu, Lin Wang, Chunxia Zhou, Wenbo Ma, Youhui Zhang, Shengdian Wang and Shuren Zhang _

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Oncotarget. 2015; 6:5818-5831. https://doi.org/10.18632/oncotarget.3461

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Abstract

Huiru Wang1, Qing Sun2, Yanhong Wu1, Lin Wang3, Chunxia Zhou1, Wenbo Ma1, Youhui Zhang1, Shengdian Wang4 and Shuren Zhang1

1 Department of Immunology, Cancer Hospital & Cancer Institute, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

2 Department of Parasitology, Capital Medical University, Beijing, China

3 Department of Pathology, Cancer Hospital & Cancer Institute, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

4 Center of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

Correspondence to:

Shuren Zhang, email:

Keywords: cancer, granzyme M, chemoresistance, metastasis, epithelial-mesenchymal transition

Received: September 28, 2014 Accepted: January 22, 2015 Published: February 28, 2015

Abstract

Granzyme M is a serine protease known to be often expressed by natural killer cells and induce target cells apoptosis in combination with perforin. However, we detected granzyme M expression in murine and human cancer cell lines and human tumor samples in our study. Granzyme M increased chemoresistance, colony-formation, cytokine secretion and invasiveness in vitro. Most importantly, granzyme M facilitated tumor growth and metastasis in vivo. Granzyme M induced the epithelial-mesenchymal transition (EMT) in cancer cells associated with STAT3 activation. Our study revealed the role of granzyme M expressed by tumor in chemoresistance, invasion, metastasis and EMT.


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