Vol 6, No 31

New tricks for KDEL receptors

Priming persistence of HCV

VDR and gemini ligands

Deconvoluting AMPK dynamics

Tension across adherens junctions: when less is more

PTX3 orchestrates tissue repair

Passive virus movements with organelle dynamics

Architecture of viral replication factories

Cutaneous bacteria induce immunosuppression

Disconnect between EMT and metastasis in pancreas cancer

Selective nuclear elimination in multinucleate cells

Warm up and cool down!

DOT1L: a new therapeutic target for aggressive breast cancer

High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant

Synergistic effects of p53 activation via MDM2 inhibition in combination with inhibition of Bcl-2 or Bcr-Abl in CD34⁺ proliferating and quiescent chronic myeloid leukemia blast crisis cells

Induction of KIAA1199/CEMIP is associated with colon cancer phenotype and poor patient survival

Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility

New insights into the impact of Lactobacillus population on host-bacteria metabolic interplay

Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny

Epigallocatechin gallate affects glucose metabolism and increases fitness and lifespan in Drosophila melanogaster

Rapid targeted somatic mutation analysis of solid tumors in routine clinical diagnostics

Effects of normobaric oxygen and melatonin on reperfusion injury: role of cerebral microcirculation

MCT4 surpasses the prognostic relevance of the ancillary protein CD147 in clear cell renal cell carcinoma

Low-dose ionizing radiation induces mitochondrial fusion and increases expression of mitochondrial complexes I and III in hippocampal neurons

Endothelial tyrosine kinase receptor B prevents VE-cadherin cleavage and protects against atherosclerotic lesion development in ApoE−/− mice

A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis

Ovarian clear cell carcinoma meets metabolism; HNF-1β confers survival benefits through the Warburg effect and ROS reduction

Approaches to isolation and molecular characterization of disseminated tumor cells

Discovery of Compound A – a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity

Cell context-dependent dual effects of EFEMP1 stabilizes subpopulation equilibrium in responding to changes of in vivo growth environment

Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer

Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy

XB130 promotes bronchioalveolar stem cell and Club cell proliferation in airway epithelial repair and regeneration

MiRNA-101 inhibits breast cancer growth and metastasis by targeting CX chemokine receptor 7

Dehydroandrographolide, an iNOS inhibitor, extracted from Andrographis paniculata (Burm.f.) Nees, induces autophagy in human oral cancer cells

Digital PCR analysis of plasma cell-free DNA for non-invasive detection of drug resistance mechanisms in EGFR mutant NSCLC: Correlation with paired tumor samples

Novel Axl-driven signaling pathway and molecular signature characterize high-grade ovarian cancer patients with poor clinical outcome

Dclk1+ small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal

URGCP/URG4 promotes apoptotic resistance in bladder cancer cells by activating NF-κB signaling

POL5551, a novel and potent CXCR4 antagonist, enhances sensitivity to chemotherapy in pediatric ALL

A novel far-red fluorescent xenograft model of ovarian carcinoma for preclinical evaluation of HER2-targeted immunotoxins

Low EGFR/MET ratio is associated with resistance to EGFR inhibitors in non-small cell lung cancer

B5, a thioredoxin reductase inhibitor, induces apoptosis in human cervical cancer cells by suppressing the thioredoxin system, disrupting mitochondrion-dependent pathways and triggering autophagy

PRMT6 increases cytoplasmic localization of p21^CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents

Comprehensive portrait of recurrent glioblastoma multiforme in molecular and clinical characteristics

Anxa2 binds to STAT3 and promotes epithelial to mesenchymal transition in breast cancer cells

Achaete scute-like 2 suppresses CDX2 expression and inhibits intestinal neoplastic epithelial cell differentiation

Aberrant mesenchymal differentiation of glioma stem-like cells: implications for therapeutic targeting

Targeted therapy for Epstein-Barr virus-associated gastric carcinoma using low-dose gemcitabine-induced lytic activation

Transcriptome analysis indicates TFEB1 and YEATS4 as regulatory transcription factors for drug resistance of ovarian cancer

Sub-apoptotic dosages of pro-oxidant vitamin cocktails sensitize human melanoma cells to NK cell lysis

Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma

CEBPD amplification and overexpression in urothelial carcinoma: a driver of tumor metastasis indicating adverse prognosis

Focal adhesion kinase overexpression and its impact on human osteosarcoma

A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer

Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer

HDAC inhibitor AR-42 decreases CD44 expression and sensitizes myeloma cells to lenalidomide

Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy

Human mesenchymal stem cells enhance the systemic effects of radiotherapy

Overexpression of CHD1L is positively associated with metastasis of lung adenocarcinoma and predicts patients poor survival

Suppression of CD300A inhibits the growth of diffuse large B-cell lymphoma

Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status

Apigenin blocks IKKα activation and suppresses prostate cancer progression

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

Upregulation of sex-determining region Y-box 9 (SOX9) promotes cell proliferation and tumorigenicity in esophageal squamous cell carcinoma

The association analysis of lncRNA HOTAIR genetic variants and gastric cancer risk in a Chinese population

Acceleration of atherogenesis in ApoE^−/− mice exposed to acute or low-dose-rate ionizing radiation

Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitors

Revealing very small FLT3 ITD mutated clones by ultra-deep sequencing analysis has important clinical implications in AML patients

A cytoplasmic C-terminal fragment of syndecan-1 is generated by sequential proteolysis and antagonizes syndecan-1 dependent lung tumor cell migration

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells

Application of a patient-derived xenograft model in cytolytic viral activation therapy for nasopharyngeal carcinoma

Tumor-targeting Salmonella typhimurium A1-R inhibits human prostate cancer experimental bone metastasis in mouse models

The generation and analyses of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic

Genetic variations in the TERT and CLPTM1L gene region and gastrointestinal stromal tumors risk

Therapeutic efficacy of tumor-targeting Salmonella typhimurium A1-R on human colorectal cancer liver metastasis in orthotopic nude-mouse models

Constitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression

CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity

Extracellular vesicle-mediated transfer of CLIC1 protein is a novel mechanism for the regulation of glioblastoma growth

Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemia therapeutic approaches

Integrated gene and miRNA expression analysis of prostate cancer associated fibroblasts supports a prominent role for interleukin-6 in fibroblast activation

Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells

Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy

Integrin α9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma

Cx25 contributes to leukemia cell communication and chemosensitivity

BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism

The significance of PIWI family expression in human lung embryogenesis and non-small cell lung cancer

Necdin is a breast cancer metastasis suppressor that regulates the transcription of c-Myc

Decoding c-Myc networks of cell cycle and apoptosis regulated genes in a transgenic mouse model of papillary lung adenocarcinomas

The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma

Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients

The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature

Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor

c-Met inhibitors attenuate tumor growth of small cell hypercalcemic ovarian carcinoma (SCCOHT) populations

Activin B induces human endometrial cancer cell adhesion, migration and invasion by up-regulating integrin β3 via SMAD2/3 signaling

CRC-113 gene expression signature for predicting prognosis in patients with colorectal cancer

A four gene signature predicts benefit from anthracyclines: evidence from the BR9601 and MA.5 clinical trials

KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27^kip1

Distinct breast cancer stem/progenitor cell populations require either HIF1α or loss of PHD3 to expand under hypoxic conditions

Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9

Expression of prokineticin-receptor2(PK-R2) is a new prognostic factor in human colorectal cancer

Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia

Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2

Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin

Mutation of cysteine 46 in IKK-beta increases inflammatory responses

Comparative genomic analysis reveals bilateral breast cancers are genetically independent

sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1α signaling pathways

Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age

Chaperone gp96 mediates ER-α36 cell membrane expression

EPHA4 is overexpressed but not functionally active in Sézary syndrome

Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice

Functional osteoclastogenesis: the baseline variability in blood donor precursors is not associated with age and gender

GSK-3β regulates tumor growth and angiogenesis in human glioma cells

Phosphorylation and inactivation of PTEN at residues Ser380/Thr382/383 induced by Helicobacter pylori promotes gastric epithelial cell survival through PI3K/Akt pathway

A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway

E2F7 overexpression leads to tamoxifen resistance in breast cancer cells by competing with E2F1 at miR-15a/16 promoter

miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer

The complex metabolic network gearing the G₁/S transition in leukemic stem cells: Hints to a rational use of antineoplastic agents

Differential regulation of metabolic pathways by androgen receptor (AR) and its constitutively active splice variant, AR-V7, in prostate cancer cells

Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment

Role of HER2 mutations in refractory metastatic breast cancers: targeted sequencing results in patients with refractory breast cancer

PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

Expression and function of the TL1A/DR3 axis in chronic lymphocytic leukemia

HER2-specific immunoligands engaging NKp30 or NKp80 trigger NK-cell-mediated lysis of tumor cells and enhance antibody-dependent cell-mediated cytotoxicity

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia

A constitutive active MAPK/ERK pathway due to BRAF^V600E positively regulates AHR pathway in PTC

miRNA expression patterns in normal breast tissue and invasive breast cancers of BRCA1 and BRCA2 germ-line mutation carriers

Amphiregulin activates regulatory T lymphocytes and suppresses CD8⁺ T cell-mediated anti-tumor response in hepatocellular carcinoma cells

Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer

Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma

GOLPH3 is a potential therapeutic target and a prognostic indicatior of poor survival in bladder cancer treated by cystectomy

XRCC2 as a predictive biomarker for radioresistance in locally advanced rectal cancer patients undergoing preoperative radiotherapy

A single nucleotide polymorphism in ADIPOQ predicts biochemical recurrence after radical prostatectomy in localized prostate cancer

Phase II study of docetaxel, cisplatin, and fluorouracil in patients with distantly metastatic penile cancer as first-line chemotherapy

Tolerance and dose-volume relationship of intrathoracic stomach irradiation after esophagectomy for patients with thoracic esophageal squamous cell carcinoma

A phase 1/2 study combining gemcitabine, Pegintron and p53 SLP vaccine in patients with platinum-resistant ovarian cancer

ABO blood type correlates with survival on prostate cancer vaccine therapy

Dynamic ¹H-MRS assessment of brain tumors: a novel approach for differential diagnosis of glioma

PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma