Vol 7, No 11

Cis-acting elements in its 3′ UTR mediate post-transcriptional regulation of KRAS

p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression

Beneficial bacteria inhibit cachexia

Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

In normal aging ventricular system never attains pathological values of Evans’ index

Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice

The effect of D-serine administration on cognition and mood in older adults

Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1

Rationale and design of the allogeneiC human mesenchymal stem cells (hMSC) in patients with aging fRAilTy via intravenoUS delivery (CRATUS) study: A phase I/II, randomized, blinded and placebo controlled trial to evaluate the safety and potential efficacy of allogeneic human mesenchymal stem cell infusion in patients with aging frailty

Age-related alterations in blood and colonic dendritic cell properties

Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia

Anti-TNF-α treatment modulates SASP and SASP-related microRNAs in endothelial cells and in circulating angiogenic cells

Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome

Morphofunctional and signaling molecules overlap of the pineal gland and thymus: role and significance in aging

Ectopic mineralization of cartilage and collagen-rich tendons and ligaments in Enpp1^asj-2J mice

CD226 reduces endothelial cell glucose uptake under hyperglycemic conditions with inflammation in type 2 diabetes mellitus

CD274/PD-L1 gene amplification and PD-L1 protein expression are common events in squamous cell carcinoma of the oral cavity

REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially via LRP6-mediated Wnt-β-catenin signaling

Elevated expression of HIF-lα in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia

GDF11/BMP11 activates both smad1/5/8 and smad2/3 signals but shows no significant effect on proliferation and migration of human umbilical vein endothelial cells

Melatonin protects skin keratinocyte from hydrogen peroxide-mediated cell death via the SIRT1 pathway

Low-dose tacrolimus combined with donor-derived mesenchymal stem cells after renal transplantation: a prospective, non-randomized study

Biological outcome and mapping of total factor cascades in response to HIF induction during regenerative angiogenesis

Decellularized allogeneic intervertebral disc: natural biomaterials for regenerating disc degeneration

Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression

PGC-1α overexpression protects against aldosterone-induced podocyte depletion: role of mitochondria

A biodegradable killer microparticle to selectively deplete antigen-specific T cells in vitro and in vivo

Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice

The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells

The mitochondrial and death receptor pathways involved in the thymocytes apoptosis induced by aflatoxin B₁

A bovine herpesvirus 1 pUL51 deletion mutant shows impaired viral growth in vitro and reduced virulence in rabbits

CRISPR/Cas9 and cancer targets: future possibilities and present challenges

Stereotactic radiosurgery (SRS) in the modern management of patients with brain metastases

A fully human CXCR4 antibody demonstrates diagnostic utility and therapeutic efficacy in solid tumor xenografts

Clonal relationships in recurrent B-cell lymphomas

SOX2 boosts major tumor progression genes in prostate cancer and is a functional biomarker of lymph node metastasis

NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition

Angiomotin promotes renal epithelial and carcinoma cell proliferation by retaining the nuclear YAP

The mechanism of acquired resistance to irreversible EGFR tyrosine kinase inhibitor-afatinib in lung adenocarcinoma patients

Circulating miR-21, miR-378, and miR-940 increase in response to an acute exhaustive exercise in chronic heart failure patients

Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter

PP2A inhibition with LB100 enhances cisplatin cytotoxicity and overcomes cisplatin resistance in medulloblastoma cells

Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism

Therapeutic response and side effects of repeated radioligand therapy with ¹⁷⁷Lu-PSMA-DKFZ-617 of castrate-resistant metastatic prostate cancer

Intercellular transfer of small RNAs from astrocytes to lung tumor cells induces resistance to chemotherapy

Clinical and biological significance of HAX-1 overexpression in nasopharyngeal carcinoma

Naturally occurring basal core promoter A1762T/G1764A dual mutations increase the risk of HBV-related hepatocellular carcinoma: a meta-analysis

Rad18 is required for functional interactions between FANCD2, BRCA2, and Rad51 to repair DNA topoisomerase 1-poisons induced lesions and promote fork recovery

Mutant p53 protects ETS2 from non-canonical COP1/DET1 dependent degradation

Inverse agonist of estrogen-related receptor α suppresses the growth of triple negative breast cancer cells through ROS generation and interaction with multiple cell signaling pathways

Phospholipid profiling identifies acyl chain elongation as a ubiquitous trait and potential target for the treatment of lung squamous cell carcinoma

Characterization of long non-coding RNA-associated ceRNA network to reveal potential prognostic lncRNA biomarkers in human ovarian cancer

Exploiting machine learning for predicting skeletal-related events in cancer patients with bone metastases

Expression of the bitter receptor T2R38 in pancreatic cancer: localization in lipid droplets and activation by a bacteria-derived quorum-sensing molecule

Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis

Androgens downregulate miR-21 expression in breast cancer cells underlining the protective role of androgen receptor

Effectiveness of the Monte Carlo method in stereotactic radiation therapy applied to quasi-homogenous brain tumors

miR-21 expression and clinical outcome in locally advanced pancreatic cancer: exploratory analysis of the pancreatic cancer Erbitux, radiotherapy and UFT (PERU) trial

Arsenic trioxide inhibits glioma cell growth through induction of telomerase displacement and telomere dysfunction

MALAT1 long ncRNA promotes gastric cancer metastasis by suppressing PCDH10

The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway

Regression/Eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide

miR-451a is underexpressed and targets AKT/mTOR pathway in papillary thyroid carcinoma

Classification of large circulating tumor cells isolated with ultra-high throughput microfluidic Vortex technology

High Mobility Group A2 protects cancer cells against telomere dysfunction

Tumor-targeting Salmonella typhimurium A1-R in combination with doxorubicin eradicate soft tissue sarcoma in a patient-derived orthotopic xenograft (PDOX) model

Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo

Association of rituximab with graphene oxide confers direct cytotoxicity for CD20-positive lymphoma cells

G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells

Induction of cancer testis antigen expression in circulating acute myeloid leukemia blasts following hypomethylating agent monotherapy

Honokiol bis-dichloroacetate (Honokiol DCA) demonstrates activity in vemurafenib-resistant melanoma in vivo

SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer

Decision aid on breast cancer screening reduces attendance rate: results of a large-scale, randomized, controlled study by the DECIDEO group

MLN-8237: A dual inhibitor of aurora A and B in soft tissue sarcomas

Serum metabolomic profiling facilitates the non-invasive identification of metabolic biomarkers associated with the onset and progression of non-small cell lung cancer

A novel small molecule STAT3 inhibitor, LY5, inhibits cell viability, colony formation, and migration of colon and liver cancer cells

Targeting DNA repair by coDbait enhances melanoma targeted radionuclide therapy

MicroRNA-138 promotes acquired alkylator resistance in glioblastoma by targeting the Bcl-2-interacting mediator BIM

Targeting the p53-MDM2 interaction by the small-molecule MDM2 antagonist Nutlin-3a: a new challenged target therapy in adult Philadelphia positive acute lymphoblastic leukemia patients

Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes

Multi-kinase inhibitors can associate with heat shock proteins through their NH₂-termini by which they suppress chaperone function

Osteopontin promotes epithelial-mesenchymal transition of hepatocellular carcinoma through regulating vimentin

Prognostic relevance of HER2/neu in acute lymphoblastic leukemia and induction of NK cell reactivity against primary ALL blasts by trastuzumab

Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme

LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer

Tumor CTLA-4 overexpression predicts poor survival in patients with nasopharyngeal carcinoma

Validation of a preclinical model for assessment of drug efficacy in melanoma

Development of ⁸⁹Zr-Ontuxizumab for in vivo TEM-1/endosialin PET applications

The human 2B4 and NTB-A receptors bind the influenza viral hemagglutinin and co-stimulate NK cell cytotoxicity

The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression

AEG-1/MTDH-activated autophagy enhances human malignant glioma susceptibility to TGF-β1-triggered epithelial-mesenchymal transition

miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein

Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer

Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma

Ursolic acid inhibits the growth of human pancreatic cancer and enhances the antitumor potential of gemcitabine in an orthotopic mouse model through suppression of the inflammatory microenvironment

PARP activation promotes nuclear AID accumulation in lymphoma cells

Efficacy and toxicity of bevacizumab in recurrent ovarian disease: an update meta-analysis on phase III trials

Marital status independently predicts gastric cancer survival after surgical resection--an analysis of the SEER database

Ioncopy: a novel method for calling copy number alterations in amplicon sequencing data including significance assessment

Computed tomography texture analysis to facilitate therapeutic decision making in hepatocellular carcinoma

Acquired-resistance of bevacizumab treatment for radiation brain necrosis: a case report