Reviews: Autophagy and Cell Death:
Autophagy: a decisive process for stemness
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Laura García-Prat1, Marta Martínez-Vicente2,* and Pura Muñoz-Cánoves1,3,*
1 Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain
2 Neurodegenerative Diseases Research Group, Vall d’Hebron Research Institute-CIBERNED, Barcelona, Spain
3 Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
* These authors have contributted equally to this work
Correspondence to:
Marta Martínez-Vicente, email:
Pura Muñoz-Cánoves, email:
Keywords: autophagy, stem cells, aging, muscle, senescence
Received: January 20, 2016 Accepted: February 16, 2016 Published: February 26, 2016
Abstract
Mature skeletal muscle is a stable tissue imposing low homeostatic demand on its stem cells, which remain in a quiescent state in their niche over time. We have shown that these long-lived resting stem cells attenuate proteotoxicity and avoid senescence through basal autophagy. This protective “clean-up” system is lost during aging, resulting in stem cell regenerative decline. Thus, autophagy is required for muscle stem cell homeostasis maintenance.