The Oncosearch | Oncotarget

Preclinical evaluation of the anti-tumor activity of pralatrexate in high-risk neuroblastoma cells Research Paper

Rachael A. Clark, Sora Lee, Jingbo Qiao, Dai H. Chung

Published Jul 23, 2020 · Vol. 11, No. 32 · pp. 3069-3077

Keywords: neuroblastoma, pralatrexate, N-myc, folate metabolism

Losartan improves the therapeutic effect of metronomic cyclophosphamide in triple negative mammary cancer models Research Paper

Leandro E. Mainetti, María José Rico, Cintia Daniela Kaufman, Monica Carolina Grillo, Julian Guercetti, María Virginia Baglioni, Antonela Del Giúdice, Maria Celeste Capitani, Matias Fusini, Viviana Rosa Rozados, O. Graciela Scharovsky

Published Jul 22, 2020 · Vol. 11, No. 32 · pp. 3048-3060

Keywords: mammary cancer, metronomic chemotherapy, drug repurposing, cyclophosphamide, losartan

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

Justyna Magdalena Hermanowicz, Iwona Kwiatkowska, Dariusz Pawlak

Published Jul 21, 2020 · Vol. 11, No. 32 · pp. 3078-3101

Keywords: modulators of carcinogenesis, acetylcholine, peroxisome proliferator-activated receptors, aquaporins

Paradox breaker BRAF inhibitors have comparable potency and MAPK pathway reactivation to encorafenib in BRAF mutant colorectal cancer Research Paper

Oliver J. Pickles, Aneta Drozd, Louise Tee, Andrew D. Beggs, Gary W. Middleton

Published Jul 13, 2020 · Vol. 11, No. 34 · pp. 3188-3197

Keywords: colorectal cancer, BRAF, paradox breaker, encorafenib, PLX8394

Baicalin inhibits the TGF-β1/p-Smad3 pathway to suppress epithelial-mesenchymal transition-induced metastasis in breast cancer Research Paper

Ding-Kuo Liu, Hui-Feng Dong, Rui-Fen Liu, Xi-Long Xiao

Published Jul 4, 2020 · Vol. 11, No. 29 · pp. 2863-2872

Keywords: baicalin, TGF-β1, p-Smad3, epithelial-mesenchymal transition, breast cancer

Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma Research Paper

Rina Fujiwara-Tani, Takamitsu Sasaki, Kiyomu Fujii, Yi Luo, Takuya Mori, Shingo Kishi, Shiori Mori, Sayako Matsushima-Otsuka, Yukiko Nishiguchi, Kei Goto, Isao Kawahara, Masuo Kondoh, Masayuki Sho, Hiroki Kuniyasu

Published Jun 30, 2020 · Vol. 11, No. 31 · pp. 2982-2994

Keywords: diabetes, liver metastasis, colorectal cancer, biglycan, mesenchymal stem cell

cGAS-STING pathway in oncogenesis and cancer therapeutics Review

Brandon Yi Da Hoong, Yunn Hwen Gan, Haiyan Liu, Ee Sin Chen

Published Jun 30, 2020 · Vol. 11, No. 30 · pp. 2930-2955

Keywords: cyclic GMP-AMP synthase, stimulator of interferon, cGAS, STING, interferon

Can Denosumab be used in combination with Doxorubicin in Osteosarcoma? Research Paper

Francesca Punzo, Chiara Tortora, Maura Argenziano, Daniela Di Pinto, Elvira Pota, Martina Di Martino, Alessandra Di Paola, Francesca Rossi

Published Jun 27, 2020 · Vol. 11, No. 28 · pp. 2763-2773

Keywords: osteosarcoma, Denosumab, Doxorubicin, RANK-L, bone mass loss

TAF15 contributes to the radiation-inducible stress response in cancer Research Paper

Abhay Kumar Singh, Vaishali Kapoor, Dinesh Thotala, Dennis E. Hallahan

Published Jun 22, 2020 · Vol. 11, No. 27 · pp. 2647-2659

Keywords: TAF15, radiation inducible, lung cancer, antibody

Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients Research Paper

Mara W. Rosenberg, Kevin Watanabe-Smith, Jeffrey W. Tyner, Cristina E. Tognon, Brian J. Druker, Uma Borate

Published Jun 17, 2020 · Vol. 11, No. 29 · pp. 2807-2818

Keywords: acute myeloid leukemia, drug sensitivity, midostaurin, drug resistance, FLT3

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

Ron C. Gaba, Lobna Elkhadragy, F. Edward Boas, Sulalita Chaki, Hanna H. Chen, Mohammed El-Kebir, Kelly D. Garcia, Eileena F. Giurini, Grace Guzman, Francesca V. LoBianco, Mario F. Neto, Jordan L. Newson, Aisha Qazi, Maureen Regan, Lauretta A. Rund, Regina M. Schwind, Matthew C. Stewart, Faith M. Thomas, Herbert E. Whiteley, Jiaqi Wu, Lawrence B. Schook, Kyle M. Schachtschneider

Published Jun 10, 2020 · Vol. 11, No. 28 · pp. 2686-2701

Keywords: liver cancer, transgenic pigs, large animal model, interventional radiology, personalized medicine

Potential use of lenvatinib for patients with unresectable hepatocellular carcinoma including after treatment with sorafenib: Real-world evidence and in vitro assessment via protein phosphorylation array Research Paper

Tetsu Tomonari, Yasushi Sato, Hironori Tanaka, Takahiro Tanaka, Yasuteru Fujino, Yasuhiro Mitsui, Akihiro Hirao, Tatsuya Taniguchi, Koichi Okamoto, Masahiro Sogabe, Hiroshi Miyamoto, Naoki Muguruma, Harumi Kagiwada, Masashi Kitazawa, Kazuhiko Fukui, Katsuhisa Horimoto, Tetsuji Takayama

Published Jun 8, 2020 · Vol. 11, No. 26 · pp. 2531-2542

Keywords: hepatocellular carcinoma, lenvatinib, sorafenib, hepatic reserve function, FGFR

Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway Research Paper

Ashley VanCleave, Mykayla Palmer, Fang Fang, Haydee Torres, Tania Rodezno, Qilin Li, Kirby Fuglsby, Claire Evans, Yohannes Afeworki, Alan Ross, Pulivarthi Rao, Patricia Leiferman, Siyuan Zheng, Peter Houghton, Jianning Tao

Published May 18, 2020 · Vol. 11, No. 27 · pp. 2597-2610

Keywords: osteosarcoma, COS-33, mTOR, osteogenic differentiation, TP53

Review: Organic nanoparticle based active targeting for photodynamic therapy treatment of breast cancer cells Review

Hanieh Montaseri, Cherie Ann Kruger, Heidi Abrahamse

Published May 4, 2020 · Vol. 11, No. 22 · pp. 2120-2136

Keywords: photodynamic therapy, photosensitizers, nanoparticle delivery, targeting agents, breast cancer treatment

Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice Priority Research Paper

Anusha Chaparala, Deepak Poudyal, Hossam Tashkandi, Erin E. Witalison, Alexander A. Chumanevich, Jenna L. Hofseth, Ivy Nguyen, Olivia Hardy, Douglas L. Pittman, Michael D. Wyatt, Anthony Windust, Elizabeth A. Murphy, Mitzi Nagarkatti, Prakash Nagarkatti, Lorne J. Hofseth

Published Apr 30, 2020 · Vol. 11, No. 22 · pp. 2026-2036

Keywords: inflammatory bowel diseases, ulcerative colitis, American ginseng, panaxynol, macrophages

Microbial metabolite mimicry: one step closer to drug discovery Editorial

Sridhar Mani

Published Apr 28, 2020 · Vol. 11, No. 19 · pp. 1680-1680

Keywords: microbial metabolites, inflammation, IBD, mimicry, drugs

PLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation Research Paper

Diana Barea Roldán, Matthias Grimmler, Christoph Hartmann, Stefanie Hubich-Rau, Tim Beißert, Claudia Paret, Giuseppe Cagna, Christoph Rohde, Stefan Wöll, Michael Koslowski, Özlem Türeci, Ugur Sahin

Published Apr 22, 2020 · Vol. 11, No. 20 · pp. 1862-1875

Keywords: PLAC1, tumorigenesis, extracellular matrix, fibroblast growth factor, AKT

Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2 Research Paper

Leanne Milton-Harris, Mark Jeeves, Sarah A. Walker, Simon E. Ward, Erika J. Mancini

Published Apr 22, 2020 · Vol. 11, No. 19 · pp. 1737-1748

Keywords: protein-protein interaction, leukaemia, T-ALL, drug discovery, LMO2

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

Al Hassan Kyakulaga, Farrukh Aqil, Radha Munagala, Ramesh C. Gupta

Published Apr 21, 2020 · Vol. 11, No. 16 · pp. 1399-1416

Keywords: non-small cell lung cancer, withaferin A, synergistic, combination index, paclitaxel

The cytotoxicity of gallium maltolate in glioblastoma cells is enhanced by metformin through combined action on mitochondrial complex 1 Research Paper

Hisham S. Alhajala, John L. Markley, Jin Hae Kim, Mona M. Al-Gizawiy, Kathleen M. Schmainda, John S. Kuo, Christopher R. Chitambar

Published Apr 15, 2020 · Vol. 11, No. 17 · pp. 1531-1544

Keywords: glioblastoma, iron, gallium, metformin, mitochondrial complex I

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Preclinical evaluation of the anti-tumor activity of pralatrexate in high-risk neuroblastoma cells Research Paper

Losartan improves the therapeutic effect of metronomic cyclophosphamide in triple negative mammary cancer models Research Paper

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

Paradox breaker BRAF inhibitors have comparable potency and MAPK pathway reactivation to encorafenib in BRAF mutant colorectal cancer Research Paper

Baicalin inhibits the TGF-β1/p-Smad3 pathway to suppress epithelial-mesenchymal transition-induced metastasis in breast cancer Research Paper

Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma Research Paper

cGAS-STING pathway in oncogenesis and cancer therapeutics Review

Can Denosumab be used in combination with Doxorubicin in Osteosarcoma? Research Paper

TAF15 contributes to the radiation-inducible stress response in cancer Research Paper

Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients Research Paper

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

Potential use of lenvatinib for patients with unresectable hepatocellular carcinoma including after treatment with sorafenib: Real-world evidence and in vitro assessment via protein phosphorylation array Research Paper

Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway Research Paper

Review: Organic nanoparticle based active targeting for photodynamic therapy treatment of breast cancer cells Review

Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice Priority Research Paper

Microbial metabolite mimicry: one step closer to drug discovery Editorial

PLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation Research Paper

Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2 Research Paper

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

The cytotoxicity of gallium maltolate in glioblastoma cells is enhanced by metformin through combined action on mitochondrial complex 1 Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Preclinical evaluation of the anti-tumor activity of pralatrexate in high-risk neuroblastoma cells Research Paper

Losartan improves the therapeutic effect of metronomic cyclophosphamide in triple negative mammary cancer models Research Paper

Important players in carcinogenesis as potential targets in cancer therapy: an update Review

Paradox breaker BRAF inhibitors have comparable potency and MAPK pathway reactivation to encorafenib in BRAF mutant colorectal cancer Research Paper

Baicalin inhibits the TGF-β1/p-Smad3 pathway to suppress epithelial-mesenchymal transition-induced metastasis in breast cancer Research Paper

Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma Research Paper

cGAS-STING pathway in oncogenesis and cancer therapeutics Review

Can Denosumab be used in combination with Doxorubicin in Osteosarcoma? Research Paper

TAF15 contributes to the radiation-inducible stress response in cancer Research Paper

Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients Research Paper

Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation Research Paper

Potential use of lenvatinib for patients with unresectable hepatocellular carcinoma including after treatment with sorafenib: Real-world evidence and in vitro assessment via protein phosphorylation array Research Paper

Development and characterization of the novel human osteosarcoma cell line COS-33 with sustained activation of the mTOR pathway Research Paper

Review: Organic nanoparticle based active targeting for photodynamic therapy treatment of breast cancer cells Review

Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice Priority Research Paper

Microbial metabolite mimicry: one step closer to drug discovery Editorial

PLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation Research Paper

Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2 Research Paper

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells Research Paper

The cytotoxicity of gallium maltolate in glioblastoma cells is enhanced by metformin through combined action on mitochondrial complex 1 Research Paper