The Oncosearch | Oncotarget

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Nikolai Petrov, Hee-Sheung Lee, Mikhail Liskovykh, Marie-Paule Teulade-Fichou, Hiroshi Masumoto, William C. Earnshaw, Yves Pommier, Vladimir Larionov, Natalay Kouprina

Published Jun 27, 2021 · Vol. 12, No. 15 · pp. 1444-1456

Keywords: chromosome instability, CIN, platinum-derived G4-quadruplexes, telomere dysfunction, human artificial chromosome

Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer Research Paper

Tara Williamson, Michelle Carvalho de Abreu, Dimitri G. Trembath, Cory Brayton, Byunghak Kang, Thais Biude Mendes, Paulo Pimentel de Assumpção, Janete M. Cerutti, Gregory J. Riggins

Published Jun 22, 2021 · Vol. 12, No. 14 · pp. 1326-1338

Keywords: mebendazole, pancreatic cancer, cancer prevention, metastasis, mouse models

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Reza Bayat Mokhtari, Bessi Qorri, Narges Baluch, Angelo Sparaneo, Federico Pio Fabrizio, Lucia Anna Muscarella, Albina Tyker, Sushil Kumar, Hai-Ling Margaret Cheng, Myron R. Szewczuk, Bikul Das, Herman Yeger

Published Jun 22, 2021 · Vol. 12, No. 15 · pp. 1470-1489

Keywords: sulforaphane, acetazolamide, bronchial carcinoid tumors, serotonin, carbonic anhydrase

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Kassidy A. Hebert, Sergio Jaramillo, Wangjie Yu, Min Wang, Ratna Veeramachaneni, Vlad C. Sandulache, Andrew G. Sikora, Mark D. Bonnen, Ananth V. Annapragada, David Corry, Farrah Kheradmand, Raj K. Pandita, Michelle S. Ludwig, Tej K. Pandita, Shixia Huang, Cristian Coarfa, Sandra L. Grimm, Dimuthu Perera, George Miles, Yohannes T. Ghebre

Published Jun 19, 2021 · Vol. 12, No. 14 · pp. 1339-1353

Keywords: esomeprazole, proton pump inhibitors, ionizing radiation, radiosensitization, tumor control

Clinicopathological utility of human epidermal growth factor receptor 2 (HER2)-heterogeneity for next-generation treatments of triple-negative breast cancer Editorial

Sasagu Kurozumi, Ayaka Katayama, Ken Shirabe, Jun Horiguchi, Emad A. Rakha

Published Jun 19, 2021 · Vol. 12, No. 22 · pp. 2302-2304

Keywords: breast cancer, HER2 low, triple negative, heterogeneity

Eltrombopag and its iron chelating properties in pediatric acute myeloid leukemia Research Paper

Maura Argenziano, Chiara Tortora, Alessandra Di Paola, Elvira Pota, Martina Di Martino, Daniela Di Pinto, Caterina Di Leva, Francesca Rossi

Published Jun 16, 2021 · Vol. 12, No. 14 · pp. 1377-1387

Keywords: acute monocytic leukemia, eltrombopag, deferasirox, iron chelation, cancer

Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells Research Paper

Andrew E. Greenstein, Hazel J. Hunt

Published Jun 9, 2021 · Vol. 12, No. 13 · pp. 1243-1255

Keywords: glucocorticoid, tumors, apoptosis, chemotherapy, drug resistance

Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target Research Paper

Natsumi Hayashi, Akitaka Yamasaki, Shiho Ueda, Shogo Okazaki, Yoshiya Ohno, Toshiyuki Tanaka, Yuichi Endo, Yoshihisa Tomioka, Kazue Masuko, Takashi Masuko, Reiko Sugiura

Published May 29, 2021 · Vol. 12, No. 13 · pp. 1256-1270

Keywords: CD98, LAT1, monoclonal antibody, NIH/3T3, oncogenicity

Mechanisms of resistance to mitochondria-targeted therapy in pancreatic cancer Editorial

Stepana Boukalova, Zuzana Ezrova, Jiri Neuzil

Published May 20, 2021 · Vol. 12, No. 16 · pp. 1627-1628

Keywords: complex I inhibitors, transforming growth factor β, SMAD4, pancreatic cancer, drug resistance

Dynamic cellular biomechanics in responses to chemotherapeutic drug in hypoxia probed by atomic force spectroscopy Research Paper

Lina Alhalhooly, Babak Mamnoon, Jiha Kim, Sanku Mallik, Yongki Choi

Published May 20, 2021 · Vol. 12, No. 12 · pp. 1165-1177

Keywords: cellular stiffness, roughness, adhesion, drug resistance, hypoxia

Developing next generation immunomodulatory drugs and their combinations in multiple myeloma Research Perspective

Anjan Thakurta, William E. Pierceall, Michael D. Amatangelo, Erin Flynt, Amit Agarwal

Published May 19, 2021 · Vol. 12, No. 15 · pp. 1555-1563

Keywords: multiple myeloma, combinations, immunomodulatory agents, apoptosis, protein degradation

Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma Research Paper

Rami Mäkelä, Ville Härmä, Nibal Badra Fajardo, Greg Wells, Zoi Lygerou, Olle Sangfelt, Juha Kononen, Juha K. Rantala

Published May 6, 2021 · Vol. 12, No. 11 · pp. 1100-1109

Keywords: cutaneous apocrine sweat gland carcinoma, ex vivo drug screening, DNA repair, PALB2, rare cancer

A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies Research Perspective

Elena Maria Tosca, Maurizio Rocchetti, Paolo Magni

Published May 6, 2021 · Vol. 12, No. 14 · pp. 1434-1441

Keywords: PK-PD modeling, tumor-growth-inhibition model, dynamic energy budget theory, cancer cachexia, xenograft model

Inhibitory effects of Tomivosertib in acute myeloid leukemia Research Paper

Milagros Suarez, Gavin T. Blyth, Alain A. Mina, Ewa M. Kosciuczuk, Blazej Dolniak, Shira Dinner, Jessica K. Altman, Elizabeth A. Eklund, Diana Saleiro, Elspeth M. Beauchamp, Leonidas C. Platanias

Published Apr 24, 2021 · Vol. 12, No. 10 · pp. 955-966

Keywords: MNK, Tomivosertib, acute myeloid leukemia, eIF4E

Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra^® Research Paper

Tracey White, Szabolcs Szelinger, Janine LoBello, Amy King, Jessica Aldrich, Nathan Garinger, Matthew Halbert, Ryan F. Richholt, Stephen D. Mastrian, Cody Babb, Audrey A. Ozols, Laurie J. Goodman, Gargi D. Basu, Thomas Royce

Published Apr 7, 2021 · Vol. 12, No. 8 · pp. 726-739

Keywords: comprehensive genomic profiling, whole exome sequencing, RNA sequencing, precision medicine, pan-cancer

Drug-development, dose-selection, rational combinations from bench-to-bedside: are there any lessons worth revisiting? Editorial

Alexander J. Bridges, Ranjit K. Mehta, Sushmita Shukla, Matthew J. Schipper, Theodore S. Lawrence, Mukesh K. Nyati

Published Mar 27, 2021 · Vol. 12, No. 11 · pp. 1032-1036

Keywords: dose selection, MTD, MED, drug development, AT13387

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Elodie Montaudon, Rania El Botty, Sophie Vacher, Olivier Déas, Adnan Naguez, Sophie Chateau-Joubert, Damien Treguer, Ludmilla de Plater, Leïla Zemoura, Fariba Némati, André Nicolas, Alain Chapelier, Alain Livartowski, Stefano Cairo, Catherine Daniel, Marie Brevet, Elisabetta Marangoni, Didier Meseure, Sergio Roman-Roman, Ivan Bieche, Nicolas Girard, Didier Decaudin

Published Mar 26, 2021 · Vol. 12, No. 8 · pp. 859-872

Keywords: NSCLC, Pi3K signalling pathway, mTORC1, RAD001 (everolimus), PLK1

Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas Research Paper

Chandni Desai, Jon Thomason, Jordan L. Kohlmeyer, Anna C. Reisetter, Parmanand Ahirwar, Khadijeh Jahanseir, Mariah Leidinger, Georgina Ofori-Amanfo, Karen Fritchie, Sadanandan E. Velu, Patrick Breheny, Dawn E. Quelle, Munir R. Tanas

Published Mar 21, 2021 · Vol. 12, No. 8 · pp. 740-755

Keywords: sarcoma, YAP, TAZ, p53-MDM2, RABL6A

Advances in innovative exosome-technology for real time monitoring of viable drugs in clinical translation, prognosis and treatment response Editorial

Mujib Ullah, Nicole Pek Min Qian, Gustavo Yannarelli

Published Mar 19, 2021 · Vol. 12, No. 11 · pp. 1029-1031

Keywords: exosomes, artificial intelligence, drug delivery, extracellular vesicles, cancer

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Christelle Morris, Sébastien Durand, Pierre Jalinot

Published Mar 13, 2021 · Vol. 12, No. 7 · pp. 649-664

Keywords: breast cancer, senescence-associated secretory phenotype, eIF3, PARP1, mTORC1

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Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer Research Paper

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Clinicopathological utility of human epidermal growth factor receptor 2 (HER2)-heterogeneity for next-generation treatments of triple-negative breast cancer Editorial

Eltrombopag and its iron chelating properties in pediatric acute myeloid leukemia Research Paper

Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells Research Paper

Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target Research Paper

Mechanisms of resistance to mitochondria-targeted therapy in pancreatic cancer Editorial

Dynamic cellular biomechanics in responses to chemotherapeutic drug in hypoxia probed by atomic force spectroscopy Research Paper

Developing next generation immunomodulatory drugs and their combinations in multiple myeloma Research Perspective

Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma Research Paper

A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies Research Perspective

Inhibitory effects of Tomivosertib in acute myeloid leukemia Research Paper

Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra^® Research Paper

Drug-development, dose-selection, rational combinations from bench-to-bedside: are there any lessons worth revisiting? Editorial

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas Research Paper

Advances in innovative exosome-technology for real time monitoring of viable drugs in clinical translation, prognosis and treatment response Editorial

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer Research Paper

Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis Research Paper

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Clinicopathological utility of human epidermal growth factor receptor 2 (HER2)-heterogeneity for next-generation treatments of triple-negative breast cancer Editorial

Eltrombopag and its iron chelating properties in pediatric acute myeloid leukemia Research Paper

Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells Research Paper

Oncogenic transformation of NIH/3T3 cells by the overexpression of L-type amino acid transporter 1, a promising anti-cancer target Research Paper

Mechanisms of resistance to mitochondria-targeted therapy in pancreatic cancer Editorial

Dynamic cellular biomechanics in responses to chemotherapeutic drug in hypoxia probed by atomic force spectroscopy Research Paper

Developing next generation immunomodulatory drugs and their combinations in multiple myeloma Research Perspective

Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma Research Paper

A Dynamic Energy Budget (DEB) based modeling framework to describe tumor-in-host growth inhibition and cachexia onset during anticancer treatment in in vivo xenograft studies Research Perspective

Inhibitory effects of Tomivosertib in acute myeloid leukemia Research Paper

Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra® Research Paper

Drug-development, dose-selection, rational combinations from bench-to-bedside: are there any lessons worth revisiting? Editorial

High in vitro and in vivo synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC Research Paper

Prognostic and therapeutic value of the Hippo pathway, RABL6A, and p53-MDM2 axes in sarcomas Research Paper

Advances in innovative exosome-technology for real time monitoring of viable drugs in clinical translation, prognosis and treatment response Editorial

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra^® Research Paper