The Oncosearch | Oncotarget

Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine Research Paper

Balraj Singh, Vanessa N. Sarli, Anthony Lucci

Published Mar 12, 2021 · Vol. 12, No. 7 · pp. 626-637

Keywords: resistant TNBC, minimal residual disease, intratumor heterogeneity, breast cancer relapse, metastasis prevention

Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells Research Paper

Bhaskar Bhattacharya, Daniel Q. Huang, Sarah Hong Hui Low, Gim Hwa Tan, Min Ji Han, Sanamerjit Singh, Benny Tang, Sheng Chun Chang, Joey Sze Yun Lim, Mohd Feroz Mohd Omar, Yock Young Dan, Richie Soong

Published Mar 3, 2021 · Vol. 12, No. 7 · pp. 674-685

Keywords: drug development, microenvironment, glycolysis

Drug exposure: still relevant after all these years Editorial

David E. Gerber, William C. Putnam

Published Feb 10, 2021 · Vol. 12, No. 8 · pp. 721-722

Keywords: pharmacokinetics, pharmacodynamics, biomarkers, lung cancer

Extrahepatic cytochrome P450 epoxygenases: pathophysiology and clinical significance in human gastrointestinal cancers Review

Nataliya Pidkovka, Olena Rachkevych, Abbes Belkhiri

Published Feb 5, 2021 · Vol. 12, No. 4 · pp. 379-391

Keywords: cytochrome P450 epoxygenases, extrahepatic CYPs, gastrointestinal cancers, epoxyeicosatrienoic acids, arachidonic acid

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Thomas Perez, Raphaël Bergès, Hélène Maccario, Sarah Oddoux, Stéphane Honoré

Published Feb 5, 2021 · Vol. 12, No. 4 · pp. 304-315

Keywords: vorinostat, glioblastoma, EB1, microtubule, tubulin

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Naoko Takebe, Geraldine O'Sullivan Coyne, Shivaani Kummar, Jerry Collins, Joel M. Reid, Richard Piekarz, Nancy Moore, Lamin Juwara, Barry C. Johnson, Rachel Bishop, Frank I. Lin, Esther Mena, Peter L. Choyke, M. Liza Lindenberg, Larry V. Rubinstein, Cecilia Monge Bonilla, Matthew P. Goetz, Matthew M. Ames, Renee M. McGovern, Howard Streicher, Joseph M. Covey, James H. Doroshow, Alice P. Chen

Published Feb 1, 2021 · Vol. 12, No. 4 · pp. 268-277

Keywords: Z-endoxifen, phase 1, tamoxifen, pharmacokinetics

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Ali H. Zaidi, Ronan J. Kelly, Anastasia Gorbunova, Ashten N. Omstead, Madison S. Salvitti, Ping Zheng, Juliann E. Kosovec, Soyoung Lee, Shahin Ayazi, Laila Babar, Gene G. Finley, Ajay Goel, Blair A. Jobe

Published Feb 1, 2021 · Vol. 12, No. 4 · pp. 292-303

Keywords: esophageal adenocarcinoma, STING, PD-L1, CD8+ T-cells, IFNβ

Correction: Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers Correction

Ye Zhang, Xiujuan Qu, Yuee Teng, Zhi Li, Ling Xu, Jing Liu, Yanju Ma, Yibo Fan, Ce Li, Shizhou Liu, Zhenning Wang, Xuejun Hu, Jingdong Zhang, Yunpeng Liu

Published Jan 30, 2021 · Vol. 12, No. 16 · pp. 1634-1637

MicroRNA-214 enriched exosomes from human cerebral endothelial cells (hCEC) sensitize hepatocellular carcinoma to anti-cancer drugs Research Paper

Louie Semaan, Qingning Zeng, Yong Lu, Yi Zhang, Mehdi Mohamad Zreik, Mohamad Baqer Chamseddine, Michael Chopp, Zheng Gang Zhang, Dilip Moonka

Published Jan 25, 2021 · Vol. 12, No. 3 · pp. 185-198

Keywords: hepatocellular carcinoma (HCC), human cerebral endothelial cells-derived exosomes, microRNA-214, therapeutic efficacy, anti-cancer drug

Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

Enric Carcereny, Alonso Fernández-Nistal, Araceli López, Carmen Montoto, Andrea Naves, Cristina Segú-Vergés, Mireia Coma, Guillem Jorba, Baldomero Oliva, Jose Manuel Mas

Published Jan 22, 2021 · Vol. 12, No. 4 · pp. 316-332

Keywords: ALK inhibitor, brigatinib, alectinib, mathematical model, systems biology

Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma Research Paper

Harish Potu, Malathi Kandarpa, Luke F. Peterson, Alison Durham, Nicholas J. Donato, Moshe Talpaz

Published Jan 12, 2021 · Vol. 12, No. 3 · pp. 160-172

Keywords: melanoma, deubiquitinase (DUB) enzyme, transcription factors, USP9X, DUB inhibitor

Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer Research Paper

Krastan B. Blagoev, Roumen Iordanov, Mengxi Zhou, Tito Fojo, Susan E. Bates

Published Dec 19, 2020 · Vol. 12, No. 1 · pp. 15-21

Keywords: drug resistance, metastatic prostate cancer, exponential growth, tumor kinetics, cancer stem cells

Amalgamation of PI3K and EZH2 blockade synergistically regulates invasion and angiogenesis: combination therapy for glioblastoma multiforme Research Paper

Vishnu S. Mishra, Naveen Kumar, Masoom Raza, Seema Sehrawat

Published Dec 2, 2020 · Vol. 11, No. 51 · pp. 4754-4769

Keywords: precision neuroOncology, combination therapy, glioblastoma multiforme, pharmacological intervention, cytokine based proteomics

Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites Research Paper

Judith E. den Ouden, Guido J.R. Zaman, Jelle Dylus, Antoon M. van Doornmalen, Winfried R. Mulder, Yvonne Grobben, Wilhelmina E. van Riel, Joanne A. de Hullu, Rogier C. Buijsman, Anne M. van Altena

Published Nov 20, 2020 · Vol. 11, No. 49 · pp. 4570-4581

Keywords: ovarian cancer, chemotherapy sensitivity, prediction, ascites, proliferation assays

Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism Research Paper

Abram Calderon, Samantha S. Soldan, Alessandra De Leo, Zhong Deng, Drew M. Frase, Emma M. Anderson, Yue Zhang, Olga Vladimirova, Fang Lu, Jessica C. Leung, Maureen E. Murphy, Paul M. Lieberman

Published Nov 7, 2020 · Vol. 11, No. 46 · pp. 4224-4242

Keywords: KSHV, LANA, high-throughput screen (HTS), primary effusion lymphoma, Mubritinib

2-methoxyestradiol sensitizes breast cancer cells to taxanes by targeting centrosomes Research Paper

Randa El-Zein, Jose Thaiparambil, Sherif Z. Abdel-Rahman

Published Nov 5, 2020 · Vol. 11, No. 48 · pp. 4479-4489

Keywords: breast cancer, 2-methoxyestradiol (2-ME), centrosome amplification, centrosome declustering

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Lanlan Zhou, Kelsey Huntington, Shengliang Zhang, Lindsey Carlsen, Eui-Young So, Cassandra Parker, Ilyas Sahin, Howard Safran, Suchitra Kamle, Chang-Min Lee, Chun Geun Lee, Jack A. Elias, Kerry S. Campbell, Mandar T. Naik, Walter J. Atwood, Emile Youssef, Jonathan A. Pachter, Arunasalam Navaraj, Attila A. Seyhan, Olin Liang, Wafik S. El-Deiry

Published Oct 28, 2020 · Vol. 11, No. 46 · pp. 4201-4223

Keywords: ACE2, TMPRSS2, SARS-CoV-2, COVID-19, pseudovirus

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Lanlan Zhou, Kelsey Huntington, Shengliang Zhang, Lindsey Carlsen, Eui-Young So, Cassandra Parker, Ilyas Sahin, Howard Safran, Suchitra Kamle, Chang-Min Lee, Chun Geun Lee, Jack A. Elias, Kerry S. Campbell, Mandar T. Naik, Walter J. Atwood, Emile Youssef, Jonathan A. Pachter, Arunasalam Navaraj, Attila A. Seyhan, Olin Liang, Wafik S. El-Deiry

Published Oct 28, 2020

Keywords: ACE2, TMPRSS2, SARS-CoV-2, COVID-19, pseudovirus

Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer Research Paper

Chiara Nicolazzo, Flavia Loreni, Salvatore Caponnetto, Valentina Magri, Anna Rita Vestri, Rita Zamarchi, Angela Gradilone, Antonella Facchinetti, Elisabetta Rossi, Enrico Cortesi, Paola Gazzaniga

Published Oct 24, 2020 · Vol. 11, No. 45 · pp. 4115-4122

Keywords: cancer stem cells, CD44v6, circulating tumor cells, colorectal cancer, CellSearch^®

Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies Research Paper

Michael E. Clark, Helen Rizos, Michelle R. Pereira, Ashleigh C. McEvoy, Gabriela Marsavela, Leslie Calapre, Katie Meehan, Olivia Ruhen, Muhammad A. Khattak, Tarek M. Meniawy, Georgina V. Long, Matteo S. Carlino, Alexander M. Menzies, Michael Millward, Melanie Ziman, Elin S. Gray

Published Oct 22, 2020 · Vol. 11, No. 44 · pp. 4016-4027

Keywords: melanoma, targeted therapy, drug resistance, BRAF splicing, extracellular vesicles

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Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine Research Paper

Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells Research Paper

Drug exposure: still relevant after all these years Editorial

Extrahepatic cytochrome P450 epoxygenases: pathophysiology and clinical significance in human gastrointestinal cancers Review

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Correction: Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers Correction

MicroRNA-214 enriched exosomes from human cerebral endothelial cells (hCEC) sensitize hepatocellular carcinoma to anti-cancer drugs Research Paper

Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma Research Paper

Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer Research Paper

Amalgamation of PI3K and EZH2 blockade synergistically regulates invasion and angiogenesis: combination therapy for glioblastoma multiforme Research Paper

Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites Research Paper

Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism Research Paper

2-methoxyestradiol sensitizes breast cancer cells to taxanes by targeting centrosomes Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer Research Paper

Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Inhibition of resistant triple-negative breast cancer cells with low-dose 6-mercaptopurine and 5-azacitidine Research Paper

Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells Research Paper

Drug exposure: still relevant after all these years Editorial

Extrahepatic cytochrome P450 epoxygenases: pathophysiology and clinical significance in human gastrointestinal cancers Review

Low concentrations of vorinostat decrease EB1 expression in GBM cells and affect microtubule dynamics, cell survival and migration Research Paper

Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors Research Paper

Intratumoral immunotherapy with STING agonist, ADU-S100, induces CD8+ T-cell mediated anti-tumor immunity in an esophageal adenocarcinoma model Research Paper

Correction: Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers Correction

MicroRNA-214 enriched exosomes from human cerebral endothelial cells (hCEC) sensitize hepatocellular carcinoma to anti-cancer drugs Research Paper

Head to head evaluation of second generation ALK inhibitors brigatinib and alectinib as first-line treatment for ALK+ NSCLC using an in silico systems biology-based approach Research Paper

Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma Research Paper

Drug resistant cells with very large proliferative potential grow exponentially in metastatic prostate cancer Research Paper

Amalgamation of PI3K and EZH2 blockade synergistically regulates invasion and angiogenesis: combination therapy for glioblastoma multiforme Research Paper

Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites Research Paper

Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism Research Paper

2-methoxyestradiol sensitizes breast cancer cells to taxanes by targeting centrosomes Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection Priority Research Paper

Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer Research Paper

Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies Research Paper