Search Oncotarget
3,506 results found
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The SCD1 inhibitor aramchol interacts with regorafenib and metformin to kill tumor cells Research Paper
Keywords: macroautophagy, ER stress, aramchol, regorafenib, BID
A personal perspective of patient-centred clinical trials Research Perspective
Keywords: precision oncology, patient-centric care, clinical trials, tumor agnostic, drug development
In vivo manipulation of the protein homeostasis network in rhabdomyosarcoma Research Paper
Keywords: protein homeostasis, rhabdomyosarcoma, unfolded protein response, preclinical therapeutics, p97
The SCD1 inhibitor aramchol interacts with regorafenib to kill GI tumor cells in vitro and in vivo Research Paper
Keywords: macroautophagy, flux, ER stress, aramchol, regorafenib
Clinical and analytical validation of MI Cancer Seek®, a companion diagnostic whole exome and whole transcriptome sequencing-based comprehensive molecular profiling assay Research Paper
Keywords: companion diagnostic, molecular profiling, solid tumors, precision oncology, next-generation sequencing
Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer Research Paper
Keywords: colorectal cancer, statins, SATB1, Wnt/β-catenin signaling, tumor-suppressive phenotype
Correction: Tissue biodistribution and tumor targeting of near-infrared labelled anti-CD38 antibody-drug conjugate in preclinical multiple myeloma Correction
Imipridones ONC201/ONC206 + RT/TMZ triple (IRT) therapy reduces intracranial tumor burden, prolongs survival in orthotopic IDH-WT GBM mouse model, and suppresses MGMT Research Paper
Keywords: glioblastoma multiforme, IDH, ONC201, ONC206, MGMT, temozolomide, radiotherapy
Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients Precision Oncology
Keywords: precision oncology, N-of-1 basket trials, AI algorithms, digital pathology, drug access
Evolving concepts in HER2-low breast cancer: Genomic insights, definitions, and treatment paradigms Review
Keywords: breast cancer, HER2-low, genomics
Gene regulatory network and signalling pathway rewiring: How blood cancer cells shift their shapes to evade drug treatment Editorial
Keywords: acute myeloid leukaemia, gene regulatory networks, aberrant growth factor signaling, transcription, RUNX1/AP-1 axis
B7-H4: A potential therapeutic target in adenoid cystic carcinoma Editorial
Keywords: salivary gland cancer, adenoid cystic carcinoma, rare cancer, b7-h4, antibody drug conjugate
Linking FOXM1 and PD-L1 to CDK4/6-MEK targeted therapy resistance in malignant peripheral nerve sheath tumors Mini-Review
Keywords: MPNST, FOXM1, PD-L1, CDK4/6-MEK targeting, therapy resistance
UBA1 dysfunction in VEXAS and cancer Research Perspective
Keywords: VEXAS, MDS, clonal cytopenia, ubiquitin, inflammation
A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice Research Paper
Keywords: vacuolar ATPase, breast cancer, invasion, tumor metastasis, tumor growth
Integrated stress response (ISR) activation and apoptosis through HRI kinase by PG3 and other p53 pathway-restoring cancer therapeutics Research Paper
Keywords: mutant p53, integrated stress response (ISR), ATF4, HRI, ClpP
Rapid but nondurable response of a BRAF exon 15 double-mutated spindle cell sarcoma to a combination of BRAF and MEK inhibitors Case Report
Keywords: undifferentiated sarcoma, BRAF V600E mutation, low grade spindle cell sarcoma, abdominal cocoon
Regorafenib synergizes with TAS102 against multiple gastrointestinal cancers and overcomes cancer stemness, trifluridine-induced angiogenesis, ERK1/2 and STAT3 signaling regardless of KRAS or BRAF mutational status Research Paper
Keywords: TAS102, regorafenib, ERK1/2, angiogenesis, microvessel density
Targeting ABC transporters in PDAC – past, present, or future? Editorial
Keywords: PDAC, chemoresistance, ABCB1