The Oncosearch | Oncotarget

Erratum: PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Errata

Amanda M. Smith, Christine R.C. Zhang, Alexandre S. Cristino, John P. Grady, J. Lynn Fink, Andrew S. Moore

Published Dec 18, 2019 · Vol. 11, No. 3 · pp. 305-305

CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma Research Paper

Adi Zheng, Nadja Chevalier, Margot Calderoni, Gilles Dubuis, Olivier Dormond, Panos G. Ziros, Gerasimos P. Sykiotis, Christian Widmann

Published Dec 17, 2019 · Vol. 10, No. 66 · pp. 7058-7070

Keywords: KEAP1, sorafenib, hepatocellular carcinoma, lenvatinib, Regorafenib

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. Mc Nulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Dec 16, 2019

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Tony Yeung, Oliver Fung, Mikhail Bashkurov, Arian Khandani, Omar Subedar, Alexandra Wudwud, Patricia Shaw, Blaise Clarke, John Bartlett, Robert Rottapel, Andras Kapus

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6691-6712

Keywords: hyperploid genome, apoptosis, platinum chemotherapy, cell cycle checkpoint, ovarian cancer

Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent Research Paper

Anne-Julie Cloux, Dominique Aubry, Mathieu Heulot, Christian Widmann, Oussama ElMokh, Francesco Piacente, Michele Cea, Alessio Nencioni, Axel Bellotti, Karima Bouzourène, Maxime Pellegrin, Lucia Mazzolai, Michel A. Duchosal, Aimable Nahimana

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6723-6738

Keywords: tumor cell death, parthanatos, non-apoptotic death, APO866/FK866, NAD

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

Sylvie Carmona, Jean-Michel Brunel, Rénaté Bonier, Véronique Sbarra, Stéphane Robert, Patrick Borentain, Dominique Lombardo, Eric Mas, René Gerolami

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6651-6667

Keywords: aminosterol, pancreas, liver, PTP1B, cancer

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

Sheila Dakhel, Tiziano Ongaro, Baptiste Gouyou, Mattia Matasci, Alessandra Villa, Dario Neri, Samuele Cazzamalli

Published Nov 19, 2019 · Vol. 10, No. 62 · pp. 6678-6690

Keywords: tumor targeting, antibody-cytokine fusions, targeted-tumor necrosis factor, EDB-fibronectin, intracellular RIPK1-inhibitors

Correction: FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells Correction

Ming Zhao, Ming-Lei Zhuo, Xiaofeng Zheng, Xiaoping Su, Funda Meric-Bernstam

Published Nov 16, 2019 · Vol. 10, No. 65 · pp. 7014-7015

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

Sarina A. Piha-Paul, Matthew H. Taylor, Daniel Spitz, Lee Schwartzberg, J. Thaddeus Beck, Todd M. Bauer, Funda Meric-Bernstam, Das Purkayastha, Linda Karpiak, Sebastian Szpakowski, Fadi Braiteh

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6526-6535

Keywords: phosphatidylinositol 3-kinase pathway, buparlisib, advanced malignancies, molecular selection, tissue agnostic

The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes Research Paper

Francesca Coperchini, Laura Croce, Marco Denegri, Oriana Awwad, Samuel Tata Ngnitejeu, Flavia Magri, Luca Chiovato, Mario Rotondi

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6432-6443

Keywords: phenformin, tumor-microenvironment, thyroid cancer, CXCL8

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

Dina Kats, Cora A. Ricker, Noah E. Berlow, Bénédicte Noblet, Delphine Nicolle, Katell Mevel, Sophie Branchereau, Jean-Gabriel Judde, Cody D. Stiverson, Christina L. Stiverson, Matthew N. Svalina, Teagan Settelmeyer, Kevin Matlock, Melvin Lathara, Charlotte Mussini, James I. Geller, Christopher Noakes, Ido Sloma, Narendra Bharathy, Stefano Cairo, Charles Keller

Published Nov 5, 2019 · Vol. 10, No. 60 · pp. 6403-6417

Keywords: hepatoblastoma, PLK1, volasertib, liver, cell cycle

Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain metastases Research Paper

Gozde Uzunalli, Alexandra M. Dieterly, Chinyere M. Kemet, Hsin-Yi Weng, Arvin H. Soepriatna, Craig J. Goergen, Aparna B. Shinde, Michael K. Wendt, L. Tiffany Lyle

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6334-6348

Keywords: blood-brain barrier, blood-tumor barrier, non-small cell lung cancer, brain metastasis, aquaporin-4

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

Sean M. Flynn, Jacqueline Lesperance, Andrew Macias, Nikki Phanhthilath, Megan Rose Paul, Jong Wook Kim, Pablo Tamayo, Peter E. Zage

Published Oct 29, 2019 · Vol. 10, No. 59 · pp. 6323-6333

Keywords: neuroblastoma, RXDX-105, CEP-32496, RET, BRAF

Correction: A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy Correction

Tsung-I Hsu, Ying-Jung Chen, Chia-Yang Hung, Yi-Chang Wang, Sin-Jin Lin, Wu-Chou Su, Ming-Derg Lai, Sang-Yong Kim, Qiang Wang, Keduo Qian, Masuo Goto, Yu Zhao, Yoshiki Kashiwada, Kuo-Hsiung Lee, Wen-Chang Chang, Jan-Jong Hung

Published Oct 23, 2019 · Vol. 10, No. 60 · pp. 6536-6537

Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells Research Paper

Tatsuya Kawase, Taisuke Nakazawa, Tomohiro Eguchi, Hirofumi Tsuzuki, Yoko Ueno, Yasushi Amano, Tomoyuki Suzuki, Masamichi Mori, Taku Yoshida

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6111-6123

Keywords: FLT3, FL, FLT3 inhibitor, gilteritinib, antitumor activity

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer Research Paper

C. Andrew Boswell, Daniela Bumbaca Yadav, Eduardo E. Mundo, Shang-Fan Yu, Jennifer Arca Lacap, Aimee Fourie-O’Donohue, Katherine R. Kozak, Gregory Z. Ferl, Crystal Zhang, Jason Ho, Sheila Ulufatu, Leslie A. Khawli, Kedan Lin

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6234-6244

Keywords: antibody-drug conjugate, prostate cancer, pharmacokinetics, TENB2, imaging

Targeted photodynamic therapy treatment of in vitro A375 metastatic melanoma cells Research Paper

Channay Naidoo, Cherie Ann Kruger, Heidi Abrahamse

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6079-6095

Keywords: metastatic melanoma, nano active targeting, zinc phthalocyanine tetra-sulphonic acid, photodynamic therapy

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Erratum: PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Errata

CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent Research Paper

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

Correction: FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells Correction

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes Research Paper

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain metastases Research Paper

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

Correction: A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy Correction

Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells Research Paper

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer Research Paper

Targeted photodynamic therapy treatment of in vitro A375 metastatic melanoma cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Erratum: PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Errata

CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models Research Paper

Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent Research Paper

A squalamine derivative, NV669, as a novel PTP1B inhibitor: in vitro and in vivo effects on pancreatic and hepatic tumor growth Research Paper

Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade Research Paper

Correction: FGFR1β is a driver isoform of FGFR1 alternative splicing in breast cancer cells Correction

Efficacy and safety of buparlisib, a PI3K inhibitor, in patients with malignancies harboring a PI3K pathway activation: a phase 2, open-label, single-arm study Research Paper

The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes Research Paper

Volasertib preclinical activity in high-risk hepatoblastoma Research Paper

Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain metastases Research Paper

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo Research Paper

Correction: A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy Correction

Effect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells Research Paper

Biodistribution and efficacy of an anti-TENB2 antibody-drug conjugate in a patient-derived model of prostate cancer Research Paper

Targeted photodynamic therapy treatment of in vitro A375 metastatic melanoma cells Research Paper