The Oncosearch | Oncotarget

Transcriptomics reveals in vivo efficacy of PARP inhibitor combinatorial synergy with platinum-based chemotherapy in human non-small cell lung carcinoma models Research Paper

Lindsay R. Stolzenburg, Barrett Ainsworth, Bridget Riley-Gillis, Tibor Pakozdi, Areej Ammar, Paul A. Ellis, Julie L. Wilsbacher, Cyril Y. Ramathal

Published Dec 17, 2021 · Vol. 13, No. 1 · pp. 1-12

Keywords: PARP inhibitor, veliparib, cisplatin, transcriptomics, NSCLC

Comparative transcriptome analysis between patient and endometrial cancer cell lines to determine common signaling pathways and markers linked to cancer progression Research Paper

Madelaine J. Cho-Clark, Gauthaman Sukumar, Newton Medeiros Vidal, Sorana Raiciulescu, Mario G. Oyola, Cara Olsen, Leonardo Mariño-Ramírez, Clifton L. Dalgard, T. John Wu

Published Dec 16, 2021 · Vol. 12, No. 26 · pp. 2500-2513

Keywords: endometrial cancer, cancer stage, comparative transcriptome analysis, signaling pathways, normalization

Using drug scheduling to manage adverse events associated with hedgehog pathway inhibitors for basal cell carcinoma Review

John T. Lear, Reinhard Dummer, Alexander Guminski

Published Dec 1, 2021 · Vol. 12, No. 26 · pp. 2531-2540

Keywords: adverse events, basal cell carcinoma, sonidegib, hedgehog inhibitor, drug scheduling

Optimization of tumor spheroid model in mesothelioma and lung cancers and anti-cancer drug testing in H2052/484 spheroids Research Paper

Dylan A.J. Gendre, Edis Ameti, Wolfram Karenovics, Nadja Perriraz-Mayer, Frédéric Triponez, Véronique Serre-Beinier

Published Nov 15, 2021 · Vol. 12, No. 24 · pp. 2375-2387

Keywords: cancer patient, lung tumor, pleura mesothelioma, tumor spheroid, chemosensitivity

Correction: Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Correction

Benny Zhitomirsky, Yehuda G. Assaraf

Published Oct 28, 2021 · Vol. 13, No. 1 · pp. 585-586

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy Review

Ana Chor, Maria Adriana Skeff, Christina Takiya, Raquel Gonçalves, Marcos Dias, Marcos Farina, Leonardo R. Andrade, Valeria de Mello Coelho

Published Oct 1, 2021 · Vol. 12, No. 22 · pp. 2283-2299

Keywords: oral mucositis, inflammation, regeneration, polymers, tissue engineering

A high-throughput customized cytokinome screen of colon cancer cell responses to small-molecule oncology drugs Research Paper

Kelsey E. Huntington, Anna Louie, Lanlan Zhou, Wafik S. El-Deiry

Published Sep 11, 2021 · Vol. 12, No. 20 · pp. 1980-1991

Keywords: cytokine profiling, inflammatory response, chemokine, growth factor, immune profiling

Luminescence complementation technology for the identification of MYC:TRRAP inhibitors Research Paper

Edmond J. Feris, John W. Hinds, Michael D. Cole

Published Sep 11, 2021 · Vol. 12, No. 21 · pp. 2147-2157

Keywords: cancer, drug discovery, targeted therapy, oncogene, transcription factor

Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells Research Paper

Lindsey Carlsen, Christoph Schorl, Kelsey Huntington, Liz Hernandez-Borrero, Aakash Jhaveri, Shengliang Zhang, Lanlan Zhou, Wafik S. El-Deiry

Published Sep 8, 2021 · Vol. 12, No. 20 · pp. 2006-2021

Keywords: chemotherapy mechanism, colon cancer, 5-fluorouracil, irinotecan, oxaliplatin

Tissue biodistribution and tumor targeting of near-infrared labelled anti-CD38 antibody-drug conjugate in preclinical multiple myeloma Research Paper

Nicholas Cho, Sooah Ko, Monica Shokeen

Published Sep 7, 2021 · Vol. 12, No. 20 · pp. 2039-2050

Keywords: near-infrared (NIR) fluorescence, multiple myeloma (MM), cluster of differentiation 38 (CD38), antibody-drug conjugate (ADC), small animal optical imaging

TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan Research Paper

Erling Håland, Ingrid Nyhus Moen, Elias Veidal, Hanne Hella, Kristine Misund, Tobias S. Slørdahl, Kristian K. Starheim

Published Sep 4, 2021 · Vol. 12, No. 21 · pp. 2158-2168

Keywords: multiple myeloma, TAK1, apoptosis, NF-κB, cancer treatment

Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells Research Paper

Jan A. Kaczmarczyk, Rhonda R. Roberts, Brian T. Luke, King C. Chan, Carly M. Van Wagoner, Robin A. Felder, Richard G. Saul, Colantonio Simona, Josip Blonder

Published Sep 3, 2021 · Vol. 12, No. 20 · pp. 2022-2038

Keywords: lung cancer, proteomics, 2D vs. 3D cultured cells, preclinical testing model, drug target discovery

Low tumour-infiltrating lymphocyte density in primary and recurrent glioblastoma Research Paper

Kelsey Maddison, Moira C. Graves, Nikola A. Bowden, Michael Fay, Ricardo E. Vilain, Sam Faulkner, Paul A. Tooney

Published Sep 1, 2021 · Vol. 12, No. 21 · pp. 2177-2187

Keywords: glioblastoma, tumour-infiltrating lymphocytes, programmed cell death 1, tumour recurrence, immune microenvironment

Exploratory comparisons between different anti-mitotics in clinically-used drug combination in triple negative breast cancer Research Paper

Bruna Cândido Guido, Douglas Cardoso Brandão, Ana Luisa Augusto Barbosa, Monique Jacob Xavier Vianna, Lucas Faro, Luciana Machado Ramos, Fabíola Nihi, Márcio Botelho de Castro, Brenno A.D. Neto, José Raimundo Corrêa, Sônia Nair Báo

Published Aug 27, 2021 · Vol. 12, No. 19 · pp. 1920-1936

Keywords: KIF11 inhibition, Kinesin Eg5, breast cancer, adjuvant treatment, cancer progression

Old drug, new trick: proton pump inhibitors find new purpose in cancer care News

Natalie A. Ridge, Mohit Shiv Agarwal, Mohamad Hassan Fakhreddine

Published Aug 18, 2021 · Vol. 12, No. 19 · pp. 1861-1862

Keywords: radiosensitizer, proton pump inhibitor, esomeprazole, radioresistance, radiotherapy

Anti-aging: senolytics or gerostatics (unconventional view) Review

Mikhail V. Blagosklonny

Published Aug 12, 2021 · Vol. 12, No. 18 · pp. 1821-1835

Keywords: geroscience, senolytics, hyperfunction theory, aging, sirolimus

Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status Research Paper

Hélène Marijon, Sigal Gery, Hua Chang, Yosef Landesman, Sharon Shacham, Dhong Hyun Lee, Aimery de Gramont, Harold Phillip Koeffler

Published Aug 10, 2021 · Vol. 12, No. 18 · pp. 1749-1762

Keywords: selinexor, XPO1, olaparib, triple negative breast cancer, BRCA1

Impact factor and citation metrics in phase III cancer trials Research Paper

Joseph Abi Jaoude, Ramez Kouzy, Michael Rooney, Petria Thompson, Roshal Patel, Maddie C. Turner, Marc Ghabach, C. David Fuller, Bruce D. Minsky, Cullen M. Taniguchi, Ethan B. Ludmir

Published Aug 3, 2021 · Vol. 12, No. 18 · pp. 1780-1786

Keywords: oncology, journal impact factor, clinical trials, FDA, industry

Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication Research Paper

Mario Scarpa, Shivani Kapoor, Eric S. Tvedte, Kshama A. Doshi, Ying S. Zou, Prerna Singh, Jonelle K. Lee, Aditi Chatterjee, Moaath K. Mustafa Ali, Robin E. Bromley, Julie C. Dunning Hotopp, Feyruz V. Rassool, Maria R. Baer

Published Aug 2, 2021 · Vol. 12, No. 18 · pp. 1763-1779

Keywords: FLT3 internal tandem duplication, Pim kinase, alternative non-homologous end-joining DNA repair, genomic instability, topoisomerase 2 inhibitors

Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Research Paper

Taylor J. Chen, Wa Du, Jacob J. Junco, Cory Seth Bridges, Ye Shen, Monica Puppi, Karen R. Rabin, H. Daniel Lacorazza

Published Jul 31, 2021 · Vol. 12, No. 18 · pp. 1787-1801

Keywords: T-ALL, MAP2K7, 5z-7-oxozeaenol

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Transcriptomics reveals in vivo efficacy of PARP inhibitor combinatorial synergy with platinum-based chemotherapy in human non-small cell lung carcinoma models Research Paper

Comparative transcriptome analysis between patient and endometrial cancer cell lines to determine common signaling pathways and markers linked to cancer progression Research Paper

Using drug scheduling to manage adverse events associated with hedgehog pathway inhibitors for basal cell carcinoma Review

Optimization of tumor spheroid model in mesothelioma and lung cancers and anti-cancer drug testing in H2052/484 spheroids Research Paper

Correction: Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Correction

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy Review

A high-throughput customized cytokinome screen of colon cancer cell responses to small-molecule oncology drugs Research Paper

Luminescence complementation technology for the identification of MYC:TRRAP inhibitors Research Paper

Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells Research Paper

Tissue biodistribution and tumor targeting of near-infrared labelled anti-CD38 antibody-drug conjugate in preclinical multiple myeloma Research Paper

TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan Research Paper

Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells Research Paper

Low tumour-infiltrating lymphocyte density in primary and recurrent glioblastoma Research Paper

Exploratory comparisons between different anti-mitotics in clinically-used drug combination in triple negative breast cancer Research Paper

Old drug, new trick: proton pump inhibitors find new purpose in cancer care News

Anti-aging: senolytics or gerostatics (unconventional view) Review

Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status Research Paper

Impact factor and citation metrics in phase III cancer trials Research Paper

Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication Research Paper

Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Transcriptomics reveals in vivo efficacy of PARP inhibitor combinatorial synergy with platinum-based chemotherapy in human non-small cell lung carcinoma models Research Paper

Comparative transcriptome analysis between patient and endometrial cancer cell lines to determine common signaling pathways and markers linked to cancer progression Research Paper

Using drug scheduling to manage adverse events associated with hedgehog pathway inhibitors for basal cell carcinoma Review

Optimization of tumor spheroid model in mesothelioma and lung cancers and anti-cancer drug testing in H2052/484 spheroids Research Paper

Correction: Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance Correction

Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy Review

A high-throughput customized cytokinome screen of colon cancer cell responses to small-molecule oncology drugs Research Paper

Luminescence complementation technology for the identification of MYC:TRRAP inhibitors Research Paper

Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells Research Paper

Tissue biodistribution and tumor targeting of near-infrared labelled anti-CD38 antibody-drug conjugate in preclinical multiple myeloma Research Paper

TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan Research Paper

Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells Research Paper

Low tumour-infiltrating lymphocyte density in primary and recurrent glioblastoma Research Paper

Exploratory comparisons between different anti-mitotics in clinically-used drug combination in triple negative breast cancer Research Paper

Old drug, new trick: proton pump inhibitors find new purpose in cancer care News

Anti-aging: senolytics or gerostatics (unconventional view) Review

Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status Research Paper

Impact factor and citation metrics in phase III cancer trials Research Paper

Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication Research Paper

Inhibition of the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia Research Paper