The Oncosearch | Oncotarget

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Lasse Dührsen, Sophie Hartfuß, Daniela Hirsch, Sabine Geiger, Cecile L. Maire, Jan Sedlacik, Christine Guenther, Manfred Westphal, Katrin Lamszus, Felix G. Hermann, Nils Ole Schmidt

Published Oct 22, 2019 · Vol. 10, No. 58 · pp. 6049-6061

Keywords: glioblastoma, brain tumor, stem cells, gene therapy, migration

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

Esmee Koedoot, Liesanne Wolters, Bob van de Water, Sylvia E. Le Dévédec

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 6021-6037

Keywords: hallmarks of cancer, breast cancer, alternative splicing, splice factors, RNA sequencing

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

Nikhil Gupta, Jung Eun Park, Wilford Tse, Jee Keem Low, Oi Lian Kon, Neil McCarthy, Siu Kwan Sze

Published Oct 15, 2019 · Vol. 10, No. 57 · pp. 5970-5982

Keywords: pancreatic cancer, hypoxia tumor, ERO1α, SILAC, proteomics

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Amanda M. Smith, Christine R.C. Zhang, Alexandre S. Cristino, John P. Grady, J. Lynn Fink, Andrew S. Moore

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5755-5767

Keywords: myeloid leukemia, therapy, drug resistance, hematological malignancies, gene mutation

Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery Research Paper

Jyotsna Kailashiya, Vineeta Gupta, Debabrata Dash

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5835-5846

Keywords: cancer targeting, drug-delivery vector, doxorubicin, leukemia, platelet-derived microparticles

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity Research Paper

Mark R. Woodford, Michael Hughes, Rebecca A. Sager, Sarah J. Backe, Alexander J. Baker-Williams, Michael S. Bratslavsky, Joseph M. Jacob, Oleg Shapiro, Michael Wong, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5824-5834

Keywords: tuberous sclerosis complex (TSC), Tsc1 (Hamartin), Tsc2 (Tuberin), heat shock protein (Hsp90), bladder cancer

GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways Research Paper

Aimee T. Farria, Lisa Maria Mustachio, Zeynep H. Coban Akdemir, Sharon Y.R. Dent

Published Oct 8, 2019 · Vol. 10, No. 56 · pp. 5847-5858

Keywords: GCN5, MYC, lymphoma, BCR

Ezrin, more than a metastatic detERMinant? Editorial

Victoria Hoskin, Abdi Ghaffari, Bruce E. Elliott

Published Sep 25, 2019 · Vol. 10, No. 63 · pp. 6755-6757

Keywords: ezrin, metastasis, breast cancer, therapeutic target

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

Kwang Woon Kim, Julia Y. Kim, Jingbo Qiao, Rachael A. Clark, Camille M. Powers, Hernan Correa, Dai H. Chung

Published Sep 24, 2019 · Vol. 10, No. 54 · pp. 5645-5659

Keywords: chemotherapy, radiotherapy, resistance, AKT2, MAPK

The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor Research Paper

Jamie M. Aye, Laura L. Stafman, Adele P. Williams, Evan F. Garner, Jerry E. Stewart, Joshua C. Anderson, Smitha Mruthyunjayappa, Mary G. Waldrop, Caroline D. Goolsby, Hooper R. Markert, Colin Quinn, Raoud Marayati, Elizabeth Mroczek-Musulman, Christopher D. Willey, Karina J. Yoon, Kimberly F. Whelan, Elizabeth A. Beierle

Published Sep 17, 2019 · Vol. 10, No. 53 · pp. 5534-5548

Keywords: kinase inhibition, Wilms tumor

One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer Research Paper

Fan Yang, Wenwu Xiao, Yanlei Liu, Ruiwu Liu, Randall Kramer, Xiaocen Li, Yousif Ajena, Christopher M. Baehr, Tatu Rojalin, Hongyong Zhang, Kit S. Lam

Published Sep 10, 2019 · Vol. 10, No. 52 · pp. 5468-5479

Keywords: oral squamous cancer, α3 integrin, optical imaging, cancer-targeting peptide, orthotopic xenograft model

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

Kwang Woon Kim, Julia Y. Kim, Jingbo Qiao, Rachael A. Clark, Camille M. Powers, Hernan Correa, Dai H. Chung

Published Sep 5, 2019

Keywords: chemotherapy, radiotherapy, resistance, AKT2, MAPK

SRC mediates cell cycle regulatory function of Pin1 and is a rational target in treating mucinous ovarian cancer Research Paper

Elisabeth Baron, Shubai Liu, Yuanyuan Hua, Junzheng Yang, Pui-Wah Choi, Wing-Chung Ng, Shu-Kay Ng, Jinyan Du, Charlene C. Ng, Xiao Zhen Zhou, Kun Ping Lu, William R. Welch, Christopher P. Crum, Ross S. Berkowitz, Shu-Wing Ng

Published Sep 3, 2019 · pp. 5724-5736

Keywords: cell cycle regulation, drug sensitivity, ovarian cancer, signal transduction, combination treatment

Targeted drug combination therapy design based on driver genes Research Paper

Lilian Zsákai, Anna Sipos, Judit Dobos, Dániel Erős, Csaba Szántai-Kis, Péter Bánhegyi, János Pató, László Őrfi, Zsolt Matula, Gábor Mikala, György Kéri, István Peták, István Vályi-Nagy

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5255-5266

Keywords: combination therapy, cancer driver gene, primary culture, small molecule compound, multiple myeloma

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer Research Paper

Maud-Emmanuelle Gilles, Liangliang Hao, Kaelyn Brown, Jihoon Lim, Sangeeta N. Bhatia, Frank J. Slack

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5349-5358

Keywords: miRNAs, KRAS, RNA-based-therapy, PDAC, tumor-penetrating nanocomplexes

A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation Research Paper

Henning Karlsson, Wojciech Senkowski, Mårten Fryknäs, Sharmineh Mansoori, Stig Linder, Joachim Gullbo, Rolf Larsson, Peter Nygren

Published Sep 3, 2019 · Vol. 10, No. 51 · pp. 5372-5382

Keywords: spheroid, tumor model, high-throughput, radiosensitizer, hypoxia

Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma Research Paper

Jennifer Bryant, Nikolaos Batis, Anna Clara Franke, Gabriella Clancey, Margaret Hartley, Gordon Ryan, Jill Brooks, Andrew D. Southam, Nicholas Barnes, Joanna Parish, Sally Roberts, Farhat Khanim, Rachel Spruce, Hisham Mehanna

Published Aug 27, 2019 · Vol. 10, No. 50 · pp. 5229-5244

Keywords: head and neck cancer, drug repurposing, drug repositioning, quinacrine, mepacrine

Detection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A Research Paper

Jennifer Bourn, Sony Pandey, Jashim Uddin, Lawrence Marnett, Maria Cekanova

Published Aug 27, 2019 · Vol. 10, No. 50 · pp. 5168-5180

Keywords: bladder cancer, TKIs, RTKIs, COX-2, targeted therapies

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model Research Paper

Takeshi Jimbo, Mana Hatanaka, Takahiro Komatsu, Tomoe Taira, Kentaro Kumazawa, Naoyuki Maeda, Takashi Suzuki, Masahiro Ota, Noriyasu Haginoya, Takeshi Isoyama, Kosaku Fujiwara

Published Aug 27, 2019 · Vol. 10, No. 50 · pp. 5152-5167

Keywords: AXL, DS-1205, EGFR-TKI resistance, erlotinib, osimertinib

Correction: HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Correction

Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Francesca Avogadri-Connors, Richard E. Cutler, Alshad S. Lalani, Paul Dent

Published Aug 16, 2019 · Vol. 10, No. 49 · pp. 5120-5122

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Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery Research Paper

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity Research Paper

GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways Research Paper

Ezrin, more than a metastatic detERMinant? Editorial

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor Research Paper

One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer Research Paper

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

SRC mediates cell cycle regulatory function of Pin1 and is a rational target in treating mucinous ovarian cancer Research Paper

Targeted drug combination therapy design based on driver genes Research Paper

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer Research Paper

A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation Research Paper

Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma Research Paper

Detection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A Research Paper

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model Research Paper

Correction: HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Correction

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma Research Paper

Splicing regulatory factors in breast cancer hallmarks and disease progression Review

ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer Research Paper

PTEN deletion drives acute myeloid leukemia resistance to MEK inhibitors Research Paper

Engineered human platelet-derived microparticles as natural vectors for targeted drug delivery Research Paper

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity Research Paper

GCN5 HAT inhibition reduces human Burkitt lymphoma cell survival through reduction of MYC target gene expression and impeding BCR signaling pathways Research Paper

Ezrin, more than a metastatic detERMinant? Editorial

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor Research Paper

One-bead one-compound combinatorial library derived targeting ligands for detection and treatment of oral squamous cancer Research Paper

Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma Research Paper

SRC mediates cell cycle regulatory function of Pin1 and is a rational target in treating mucinous ovarian cancer Research Paper

Targeted drug combination therapy design based on driver genes Research Paper

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer Research Paper

A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation Research Paper

Repurposed quinacrine synergizes with cisplatin, reducing the effective dose required for treatment of head and neck squamous cell carcinoma Research Paper

Detection of tyrosine kinase inhibitors-induced COX-2 expression in bladder cancer by fluorocoxib A Research Paper

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model Research Paper

Correction: HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Correction