The Oncosearch | Oncotarget

Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer Research Paper

Jianchang Qian, Yaqing Chen, Tao Meng, Lanping Ma, Lanfang Meng, Xin Wang, Ting Yu, Arie Zask, Jingkang Shen, Ker Yu

Published Aug 22, 2016 · Vol. 7, No. 41 · pp. 67071-67086

Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447 Research Paper

Tara L. Peters, Lingxiao Li, Ana A. Tula-Sanchez, Praechompoo Pongtornpipat, Jonathan H. Schatz

Published Aug 20, 2016 · Vol. 7, No. 39 · pp. 63362-63373

Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer Research Paper

Nooshin Mirkheshti, Sulgi Park, Shoulei Jiang, Jodie Cropper, Sherry L. Werner, Chung S. Song, Bandana Chatterjee

Published Aug 19, 2016 · Vol. 7, No. 38 · pp. 62240-62254

TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2 Research Paper

Subramanian Venkatesan, Marlous Hoogstraat, Ester Caljouw, Tessa Pierson, Jochem K.H. Spoor, Lona Zeneyedpour, Hendrikus J. Dubbink, Lennard J. Dekker, MariÃ«lle van der Kaaij, Jenneke Kloezeman, Lotte M.E. Berghauser Pont, Nicolle J.M. Besselink, Theo M. Luider, Jos Joore, John W. Martens, Martine L.M. Lamfers, Stefan Sleijfer, Sieger Leenstra

Published Aug 11, 2016 · Vol. 7, No. 36 · pp. 58435-58444

Acquired savolitinib resistance in non-small cell lung cancer arises via multiple mechanisms that converge on MET-independent mTOR and MYC activation Research Paper

Ryan E. Henry, Evan R. Barry, Lillian Castriotta, Brendon Ladd, Aleksandra Markovets, Garry Beran, Yongxin Ren, Feng Zhou, Ammar Adam, Michael Zinda, Corinne Reimer, Weiguo Qing, Weiguo Su, Edwin Clark, Celina M. Dâ€™Cruz, Alwin G. Schuller

Published Jul 26, 2016 · Vol. 7, No. 36 · pp. 57651-57670

Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in Apc^Min/+ mice Research Paper

Aditi A. Narsale, Melissa J. Puppa, Justin P. Hardee, Brandon N. VanderVeen, Reilly T. Enos, E. Angela Murphy, James A. Carson

Published Jul 19, 2016 · Vol. 7, No. 37 · pp. 59482-59502

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells Research Paper

Mamatha Bhat, Akiko Yanagiya, Tyson Graber, Nataliya Razumilava, Steve Bronk, Domenick Zammit, Yunhao Zhao, Chadi Zakaria, Peter Metrakos, Michael Pollak, Nahum Sonenberg, Gregory Gores, Maritza Jaramillo, Masahiro Morita, Tommy Alain

Published Jul 18, 2016 · Vol. 8, No. 31 · pp. 50542-50556

VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation Research Paper

Nishant Mohan, Yi Shen, Milos Dokmanovic, Yukinori Endo, Dianne S. Hirsch, Wen Jin Wu

Published Jul 7, 2016 · Vol. 7, No. 32 · pp. 52239-52254

In-depth proteomic profiling of the uveal melanoma secretome Research Paper

Martina Angi, Helen Kalirai, Samuel Prendergast, Deborah Simpson, Dean E. Hammond, Michele C. Madigan, Robert J. Beynon, Sarah E. Coupland

Published Jul 6, 2016 · Vol. 7, No. 31 · pp. 49623-49635

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat Research Paper

Yajun He, Quan Mo, Biao Luo, Yan Qiao, Ruiguang Xu, Zhicai Zuo, Xiang Nong, Junliang Deng, Guangneng Peng, Wei He, Yahui Wei, Yanchun Hu

Published Jul 5, 2016 · Vol. 7, No. 34 · pp. 54537-54548

The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models Research Paper

Yun-Rong Zhu, Xiao-zhong Zhou, Lun-qing Zhu, Chen Yao, Jian-Feng Fang, Feng Zhou, Xiong-Wei Deng, Yun-Qing Zhang

Published Jul 2, 2016 · Vol. 7, No. 31 · pp. 49527-49538

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription Research Paper

Jian Kang, Eric P. Kusnadi, Allison J. Ogden, Rodney J. Hicks, Lukas Bammert, Ulrike Kutay, Sandy Hung, Elaine Sanij, Ross D. Hannan, Katherine M. Hannan, Richard B. Pearson

Published Jun 30, 2016 · Vol. 7, No. 31 · pp. 48887-48904

Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma Research Paper

Kosuke Watari, Ayumi Nishitani, Tomohiro Shibata, Masaki Noda, Akihiko Kawahara, Jun Akiba, Yuichi Murakami, Hirohisa Yano, Michihiko Kuwano, Mayumi Ono

Published Jun 18, 2016 · Vol. 7, No. 30 · pp. 47403-47417

Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings Research Paper

Pei-Hua Lu, Min-Bin Chen, Chao Ji, Wen-Ting Li, Mu-Xin Wei, Mian-Hua Wu

Published Jun 13, 2016 · Vol. 7, No. 29 · pp. 45889-45900

PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells Research Paper

Camila S. Matsumoto, Luciana O. Almeida, Douglas M. GuimarÃ£es, Manoela D. Martins, Petros Papagerakis, Silvana Papagerakis, Andreia M. Leopoldino, Rogerio M. Castilho, Cristiane H. Squarize

Published Jun 7, 2016 · Vol. 7, No. 27 · pp. 42393-42407

Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma Priority Research Paper

Guillaume Carita, Estelle Frisch-Dit-Leitz, Ahmed Dahmani, ChloÃ© Raymondie, Nathalie Cassoux, Sophie Piperno-Neumann, Fariba NÃ©mati, CÃ©cile Laurent, Leanne De Koning, Ensar Halilovic, Sebastien Jeay, Andrew Wylie, Caroline Emery, Sergio Roman-Roman, Marie Schoumacher, Didier Decaudin

Published May 22, 2016 · Vol. 7, No. 23 · pp. 33542-33556

Morphoproteomics and biomedical analytics confirm the mTORC2/Akt pathway as a resistance signature and activated ERK and STAT3 as concomitant prosurvival/antiapoptotic pathways in metastatic renal cell carcinoma (RCC) progressing on rapalogs: Pathogenesis and therapeutic options Research Paper

Robert E. Brown, Jamie Buryanek, Varaha S. Tammisetti, Mary F. McGuire, Keri Csencsits-Smith

Published May 20, 2016 · Vol. 7, No. 27 · pp. 41612-41621

Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors Research Paper

Seraina Faes, Anne Planche, Emilie Uldry, Tania Santoro, Catherine Pythoud, Jean-Christophe Stehle, Janine Horlbeck, Igor Letovanec, Nicolo Riggi, Dipak Datta, Nicolas Demartines, Olivier Dormond

Published May 2, 2016 · Vol. 7, No. 24 · pp. 36666-36680

Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes Research Paper

Junjie Gao, Tak Sum Cheng, An Qin, Nathan J. Pavlos, Tao Wang, Kai Song, Yan Wang, Lianzhi Chen, Lin Zhou, Qing Jiang, Hiroshi Takayanagi, Sheng Yan, Minghao Zheng

Published Apr 27, 2016 · Vol. 7, No. 19 · pp. 26966-26978

Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas Research Paper

DarÃo GarcÃa-Carracedo, Maria Ãngeles Villaronga, SaÃºl Ãlvarez-Teijeiro, Francisco Hermida-Prado, IÃ±igo SantamarÃa, Eva Allonca, Laura SuÃ¡rez-FernÃ¡ndez, Maria Victoria Gonzalez, Milagros BalbÃn, Aurora Astudillo, Pablo MartÃnez-Camblor, Gloria H. Su, Juan Pablo Rodrigo, Juana MarÃa GarcÃa-Pedrero

Published Apr 23, 2016 · Vol. 7, No. 20 · pp. 29780-29793

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Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer Research Paper

Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447 Research Paper

Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer Research Paper

TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2 Research Paper

Acquired savolitinib resistance in non-small cell lung cancer arises via multiple mechanisms that converge on MET-independent mTOR and MYC activation Research Paper

Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in Apc^Min/+ mice Research Paper

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells Research Paper

VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation Research Paper

In-depth proteomic profiling of the uveal melanoma secretome Research Paper

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat Research Paper

The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models Research Paper

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription Research Paper

Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma Research Paper

Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings Research Paper

PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells Research Paper

Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma Priority Research Paper

Morphoproteomics and biomedical analytics confirm the mTORC2/Akt pathway as a resistance signature and activated ERK and STAT3 as concomitant prosurvival/antiapoptotic pathways in metastatic renal cell carcinoma (RCC) progressing on rapalogs: Pathogenesis and therapeutic options Research Paper

Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors Research Paper

Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes Research Paper

Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer Research Paper

Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447 Research Paper

Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer Research Paper

TP53 mutated glioblastoma stem-like cell cultures are sensitive to dual mTORC1/2 inhibition while resistance in TP53 wild type cultures can be overcome by combined inhibition of mTORC1/2 and Bcl-2 Research Paper

Acquired savolitinib resistance in non-small cell lung cancer arises via multiple mechanisms that converge on MET-independent mTOR and MYC activation Research Paper

Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in ApcMin/+ mice Research Paper

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells Research Paper

VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation Research Paper

In-depth proteomic profiling of the uveal melanoma secretome Research Paper

Induction of apoptosis and autophagy via mitochondria- and PI3K/Akt/mTOR-mediated pathways by E. adenophorum in hepatocytes of saanen goat Research Paper

The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models Research Paper

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription Research Paper

Phosphorylation of mTOR Ser2481 is a key target limiting the efficacy of rapalogs for treating hepatocellular carcinoma Research Paper

Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings Research Paper

PI3K-PTEN dysregulation leads to mTOR-driven upregulation of the core clock gene BMAL1 in normal and malignant epithelial cells Research Paper

Dual inhibition of protein kinase C and p53-MDM2 or PKC and mTORC1 are novel efficient therapeutic approaches for uveal melanoma Priority Research Paper

Morphoproteomics and biomedical analytics confirm the mTORC2/Akt pathway as a resistance signature and activated ERK and STAT3 as concomitant prosurvival/antiapoptotic pathways in metastatic renal cell carcinoma (RCC) progressing on rapalogs: Pathogenesis and therapeutic options Research Paper

Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors Research Paper

Glucocorticoid impairs cell-cell communication by autophagy-mediated degradation of connexin 43 in osteocytes Research Paper

Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas Research Paper

Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in Apc^Min/+ mice Research Paper