The Oncosearch | Oncotarget

Yin-and-Yang of mTORC1/C2 in Angelman syndrome mice Editorial

Xiaoning Bi, Jiandong Sun, Michel Baudry

Published May 27, 2015 · Vol. 6, No. 16 · pp. 13844-13845

Hypermaintenance and hypofunction of aged spermatogonia: insight from age-related increase of Plzf expression Research Paper

Ianina C. Ferder, Ning Wang

Published May 8, 2015 · Vol. 6, No. 18 · pp. 15891-15901

AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis Priority Research Paper

Wenting Mi, Qing Ye, Side Liu, Qing-Bai She

Published Apr 23, 2015 · Vol. 6, No. 16 · pp. 13962-13977

Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis Research Paper

Samira M. Sadowski, Myriem Boufraqech, Lisa Zhang, Amit Mehta, Payal Kapur, Yaqin Zhang, Zhuyin Li, Min Shen, Electron Kebebew

Published Apr 14, 2015 · Vol. 6, No. 20 · pp. 18038-18049

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts Priority Research Paper

Joffrey Pelletier, DaniÃ¨le Roux, Benoit Viollet, Nathalie M. Mazure, Jacques PouyssÃ©gur

Published Mar 30, 2015 · Vol. 6, No. 14 · pp. 11833-11847

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia Research Paper

Ayako Nogami, Gaku Oshikawa, Keigo Okada, Shusaku Fukutake, Yoshihiro Umezawa, Toshikage Nagao, Tetsuya Kurosu, Osamu Miura

Published Mar 16, 2015 · Vol. 6, No. 11 · pp. 9189-9205

GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth Research Paper

Junghui Koo, Xuerong Wang, Taofeek K. Owonikoko, Suresh S. Ramalingam, Fadlo R. Khuri, Shi-Yong Sun

Published Mar 12, 2015 · Vol. 6, No. 11 · pp. 8974-8987

Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver Research Paper

Xiaolei Li, Junyan Tao, Antonio Cigliano, Marcella Sini, Julien Calderaro, Daniel Azoulay, Chunmei Wang, Yan Liu, Lijie Jiang, Katja Evert, Maria I. Demartis, Silvia Ribback, Kirsten Utpatel, Frank Dombrowski, Matthias Evert, Diego F. Calvisi, Xin Chen

Published Mar 12, 2015 · Vol. 6, No. 12 · pp. 10102-10115

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Research Paper

Yan Luo, Lei Liu, Yang Wu, Karnika Singh, Bing Su, Nan Zhang, Xiaowei Liu, Yangmei Shen, Shile Huang

Published Jan 30, 2015 · Vol. 6, No. 6 · pp. 4286-4298

Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells Research Paper

Heather G. Hambright, Peng Meng, Addanki P. Kumar, Rita Ghosh

Published Jan 29, 2015 · Vol. 6, No. 9 · pp. 7195-7208

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion Research Paper

Long Chen, Baoshan Xu, Lei Liu, Chunxiao Liu, Yan Luo, Xin Chen, Mansoureh Barzegar, Jun Chung, Shile Huang

Published Jan 23, 2015 · Vol. 6, No. 9 · pp. 7136-7150

Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma Research Paper

Chi-Hao Chang, Po-Chao Chan, Jian-Ri Li, Chun-Jung Chen, Jeng-Jer Shieh, Yun-Ching Fu, Hong-Chen Chen, Ming-Ju Wu

Published Jan 20, 2015 · Vol. 6, No. 3 · pp. 1478-1489

Keywords: mTORCs, Gab1, EGF, urothelial carcinoma

DEPTOR has growth suppression activity against pancreatic cancer cells Research Paper

Hua Li, Grace Y. Sun, Yongchao Zhao, Dafydd Thomas, Joel K. Greenson, Mark M. Zalupski, Edgar Ben-Josef, Yi Sun

Published Dec 30, 2014 · Vol. 5, No. 24 · pp. 12811-12819

Keywords: DEPTOR, mTOR pathway, pancreatic cancer, growth suppression

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss Research Paper

Rafaela Andrade-Vieira, Donna Goguen, Heidi A. Bentley, Chris V. Bowen, Paola A. Marignani

Published Nov 25, 2014 · Vol. 5, No. 24 · pp. 12738-12752

DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1 Research Paper

Jogitha Selvarajah, Androulla Elia, Veronica A. Carroll, Abdeladim Moumen

Published Nov 15, 2014 · Vol. 6, No. 1 · pp. 427-440

The nuclear import of ribosomal proteins is regulated by mTOR Priority Research Paper

Dubek Kazyken, Yelimbek Kaz, Vladimir Kiyan, Assylbek A. Zhylkibayev, Chien-Hung Chen, Nitin K. Agarwal, Dos D. Sarbassov

Published Oct 3, 2014 · Vol. 5, No. 20 · pp. 9577-9593

Keywords: mTOR (mechanistic target of rapamycin), kinase, ribosomal proteins, nuclear import

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Carolina Simioni, Alice Cani, Alberto M. Martelli, Giorgio Zauli, Giovanna Tabellini, James McCubrey, Silvano Capitani, Luca M. Neri

Published Sep 16, 2014 · Vol. 5, No. 20 · pp. 10034-10047

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma Research Paper

Nathan F. Moore, Anna M. Azarova, Namrata Bhatnagar, Kenneth N. Ross, Lauren E. Drake, Stacey Frumm, Qinsong S. Liu, Amanda L. Christie, Takaomi Sanda, Louis Chesler, Andrew L. Kung, Nathanael S. Gray, Kimberly Stegmaier, Rani E. George

Published Aug 19, 2014 · Vol. 5, No. 18 · pp. 8737-8749

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors Research Paper

Burhan Hassan, Argun Akcakanat, Takafumi Sangai, Kurt W. Evans, Farrell Adkins, Agda Karina Eterovic, Hao Zhao, Ken Chen, Huiqin Chen, Kim-Anh Do, Shelly M. Xie, Ashley M. Holder, Aung Naing, Gordon B. Mills, Funda Meric-Bernstam

Published Aug 10, 2014 · Vol. 5, No. 18 · pp. 8544-8557

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells Research Paper

Frank Eckerdt, Elspeth Beauchamp, Jonathan Bell, Asneha Iqbal, Bing Su, Rikiro Fukunaga, Rishi R. Lulla, Stewart Goldman, Leonidas C. Platanias

Published Aug 6, 2014 · Vol. 5, No. 18 · pp. 8442-8451

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Yin-and-Yang of mTORC1/C2 in Angelman syndrome mice Editorial

Hypermaintenance and hypofunction of aged spermatogonia: insight from age-related increase of Plzf expression Research Paper

AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis Priority Research Paper

Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis Research Paper

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts Priority Research Paper

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia Research Paper

GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth Research Paper

Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver Research Paper

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Research Paper

Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells Research Paper

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion Research Paper

Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma Research Paper

DEPTOR has growth suppression activity against pancreatic cancer cells Research Paper

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss Research Paper

DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1 Research Paper

The nuclear import of ribosomal proteins is regulated by mTOR Priority Research Paper

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma Research Paper

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors Research Paper

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Yin-and-Yang of mTORC1/C2 in Angelman syndrome mice Editorial

Hypermaintenance and hypofunction of aged spermatogonia: insight from age-related increase of Plzf expression Research Paper

AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis Priority Research Paper

Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis Research Paper

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts Priority Research Paper

FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia Research Paper

GSK3 is required for rapalogs to induce degradation of some oncogenic proteins and to suppress cancer cell growth Research Paper

Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver Research Paper

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2 Research Paper

Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells Research Paper

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion Research Paper

Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma Research Paper

DEPTOR has growth suppression activity against pancreatic cancer cells Research Paper

Pre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss Research Paper

DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1 Research Paper

The nuclear import of ribosomal proteins is regulated by mTOR Priority Research Paper

Activity of the novel mTOR inhibitor Torin-2 in B-precursor acute lymphoblastic leukemia and its therapeutic potential to prevent Akt reactivation Research Paper

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma Research Paper

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors Research Paper

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells Research Paper