The Oncosearch | Oncotarget

Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux Research Paper

Elena I. Ilina, Angela Armento, Leticia Garea Sanchez, Marina Reichlmeir, Yannick Braun, Cornelia Penski, David Capper, Felix Sahm, Lukas Jennewein, Patrick N. Harter, Sven Zukunft, Ingrid Fleming, Dorothea Schulte, Francois Le GuerrouÃ©, Christian Behrends, Michael W. Ronellenfitsch, Ulrike Naumann, Michel Mittelbronn

Published Jun 27, 2017 · Vol. 8, No. 40 · pp. 67567-67591

Silencing protein kinase C ζ by microRNA-25-5p activates AMPK signaling and inhibits colorectal cancer cell proliferation Research Paper

Shihu Zhang, Yiyang Zhang, Qing Cheng, Zhaoqun Ma, Guanwen Gong, Zhengming Deng, Kun Xu, Gaoyuan Wang, Yousong Wei, Xiaoping Zou

Published Jun 27, 2017 · Vol. 8, No. 39 · pp. 65329-65338

ERK inhibition sensitizes CZ415-induced anti-osteosarcoma activity in vitro and in vivo Research Paper

Gang Yin, Jin Fan, Wei Zhou, Qingfeng Ding, Jun Zhang, Xuan Wu, Pengyu Tang, Hao Zhou, Bowen Wan, Guoyong Yin

Published May 30, 2017 · Vol. 8, No. 47 · pp. 82027-82036

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition Priority Research Paper

Gongda Xue, Reto Kohler, Fengyuan Tang, Debby Hynx, Yuhua Wang, Francesca Orso, Vincent PrÃªtre, Reto Ritschard, Petra Hirschmann, Peter Cron, Tim Roloff, Reinhard Dummer, Mario MandalÃ, Sandrine Bichet, Christel Genoud, Alexandra G. Meyer, Manuele G. Muraro, Giulio C. Spagnoli, Daniela Taverna, Curzio RÃ¼egg, Taha Merghoub, Daniela Massi, Huifang Tang, Mitchell P. Levesque, Stephan Dirnhofer, Alfred Zippelius, Brian A. Hemmings, Andreas Wicki

Published May 25, 2017 · Vol. 8, No. 41 · pp. 69204-69218

Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/ CIP2A axis Research Paper

NiccolÃ² Bartalucci, Laura Calabresi, Manjola Balliu, Serena Martinelli, Maria Caterina Rossi, Jean Luc Villeval, Francesco Annunziato, Paola Guglielmelli, Alessandro M. Vannucchi

Published May 22, 2017 · Vol. 8, No. 57 · pp. 96710-96724

BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity Research Paper

Hexige Saiyin, Ning Na, Xu Han, Yuan Fang, Yanhua Wu, Wenhui Lou, Xianmei Yang

Published May 18, 2017 · Vol. 8, No. 27 · pp. 44669-44681

Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner Research Paper

Itziar M.D Posada, Benoit Lectez, Mukund Sharma, Christina Oetken-Lindholm, Laxman Yetukuri, Yong Zhou, Tero Aittokallio, Daniel Abankwa

Published May 11, 2017 · Vol. 8, No. 27 · pp. 44550-44566

While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts Research Paper

Olga V. Leontieva, Mikhail V. Blagosklonny

Published May 11, 2017 · Vol. 8, No. 65 · pp. 109848-109856

Preclinical study of CC223 as a potential anti-ovarian cancer agent Research Paper

Zhenzhen Jin, Huanfu Niu, Xuenan Wang, Lei Zhang, Qin Wang, Aijun Yang

Published May 10, 2017 · Vol. 8, No. 35 · pp. 58469-58479

Sestrin 2 suppresses cells proliferation through AMPK/mTORC1 pathway activation in colorectal cancer Research Paper

Jin-Lai Wei, Min Fang, Zhong-Xue Fu, Shouâ€“Ru Zhang, Jin-Bao Guo, Rong Wang, Zhen-Bing Lv, Yong-Fu Xiong

Published May 3, 2017 · Vol. 8, No. 30 · pp. 49318-49328

Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity Research Paper

Matthew McConnell, Shengmei Feng, Wei Chen, Guochun Zhu, Dejun Shen, Selvarangan Ponnazhagan, Lianfu Deng, Yi-Ping Li

Published May 2, 2017 · Vol. 8, No. 29 · pp. 47675-47690

Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R Priority Research Paper

Harilaos Filippakis, Nicola Alesi, Barbara Ogorek, Julie Nijmeh, Damir Khabibullin, Catherine Gutierrez, Alexander J. Valvezan, James Cunningham, Carmen Priolo, Elizabeth P. Henske

Published Apr 27, 2017 · Vol. 8, No. 24 · pp. 38099-38112

P53 suppresses ribonucleotide reductase via inhibiting mTORC1 Research Paper

Zhengfu He, Xing Hu, Weijin Liu, Adrienne Dorrance, Ramiro Garzon, Peter J. Houghton, Changxian Shen

Published Apr 26, 2017 · Vol. 8, No. 25 · pp. 41422-41431

Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells Research Paper

Eun-Hye Hong, Eun-Young Heo, Jae-Hyoung Song, Bo-Eun Kwon, Jae-Young Lee, Yaejeong Park, Jinwoong Kim, Sun-Young Chang, Young-Won Chin, Sang-Min Jeon, Hyun-Jeong Ko

Published Apr 24, 2017 · Vol. 8, No. 25 · pp. 41401-41411

PRAS40 signaling in tumor Review

Dan Lv, Lianying Guo, Ting Zhang, Lin Huang

Published Apr 20, 2017 · Vol. 8, No. 40 · pp. 69076-69085

The dual PI3K/mTOR inhibitor GSK2126458 is effective for treating solid renal tumours in Tsc2^+/- mice through suppression of cell proliferation and induction of apoptosis Research Paper

Kalin Narov, Jian Yang, Paulina Samsel, Ashley Jones, Julian R. Sampson, Ming Hong Shen

Published Apr 19, 2017 · Vol. 8, No. 35 · pp. 58504-58512

PDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242 Research Paper

Chunmei Yang, Xianbo Huang, Hui Liu, Feng Xiao, Jueying Wei, Liangshun You, Wenbin Qian

Published Mar 29, 2017 · Vol. 8, No. 24 · pp. 39185-39197

Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1 Research Paper

Kazumasa Sekihara, Kaori Saitoh, Lina Han, Stefan Ciurea, Shinichi Yamamoto, Mika Kikkawa, Saiko Kazuno, Hikari Taka, Naoko Kaga, Hajime Arai, Takashi Miida, Michael Andreeff, Marina Konopleva, Yoko Tabe

Published Mar 27, 2017 · Vol. 8, No. 21 · pp. 34552-34564

Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1Î± axis inhibition Research Paper

AurÃ©lia Nguyen, FranÃ§ois Marie Moussalieh, Alan Mackay, A. Ercument Cicek, Andres Coca, Marie Pierre Chenard, Noelle Weingertner, Benoit Lhermitte, Eric LetouzÃ©, Eric GuÃ©rin, Erwan Pencreach, Sarah Jannier, Dominique Guenot, Izzie Jacques Namer, Chris Jones, Natacha Entz-WerlÃ©

Published Mar 23, 2017 · Vol. 8, No. 42 · pp. 71597-71617

Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells Research Paper

Elaine A. Dunlop, Charlotte E. Johnson, Marie Wiltshire, Rachel J. Errington, Andrew R. Tee

Published Mar 15, 2017 · Vol. 8, No. 30 · pp. 48711-48724

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Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux Research Paper

Silencing protein kinase C ζ by microRNA-25-5p activates AMPK signaling and inhibits colorectal cancer cell proliferation Research Paper

ERK inhibition sensitizes CZ415-induced anti-osteosarcoma activity in vitro and in vivo Research Paper

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition Priority Research Paper

Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/ CIP2A axis Research Paper

BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity Research Paper

Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner Research Paper

While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts Research Paper

Preclinical study of CC223 as a potential anti-ovarian cancer agent Research Paper

Sestrin 2 suppresses cells proliferation through AMPK/mTORC1 pathway activation in colorectal cancer Research Paper

Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity Research Paper

Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R Priority Research Paper

P53 suppresses ribonucleotide reductase via inhibiting mTORC1 Research Paper

Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells Research Paper

PRAS40 signaling in tumor Review

The dual PI3K/mTOR inhibitor GSK2126458 is effective for treating solid renal tumours in Tsc2^+/- mice through suppression of cell proliferation and induction of apoptosis Research Paper

PDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242 Research Paper

Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1 Research Paper

Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1Î± axis inhibition Research Paper

Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux Research Paper

Silencing protein kinase C ζ by microRNA-25-5p activates AMPK signaling and inhibits colorectal cancer cell proliferation Research Paper

ERK inhibition sensitizes CZ415-induced anti-osteosarcoma activity in vitro and in vivo Research Paper

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition Priority Research Paper

Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/ CIP2A axis Research Paper

BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity Research Paper

Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner Research Paper

While reinforcing cell cycle arrest, rapamycin and Torins suppress senescence in UVA-irradiated fibroblasts Research Paper

Preclinical study of CC223 as a potential anti-ovarian cancer agent Research Paper

Sestrin 2 suppresses cells proliferation through AMPK/mTORC1 pathway activation in colorectal cancer Research Paper

Osteoclast proton pump regulator Atp6v1c1 enhances breast cancer growth by activating the mTORC1 pathway and bone metastasis by increasing V-ATPase activity Research Paper

Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R Priority Research Paper

P53 suppresses ribonucleotide reductase via inhibiting mTORC1 Research Paper

Trans-scirpusin A showed antitumor effects via autophagy activation and apoptosis induction of colorectal cancer cells Research Paper

PRAS40 signaling in tumor Review

The dual PI3K/mTOR inhibitor GSK2126458 is effective for treating solid renal tumours in Tsc2+/- mice through suppression of cell proliferation and induction of apoptosis Research Paper

PDK1 inhibitor GSK2334470 exerts antitumor activity in multiple myeloma and forms a novel multitargeted combination with dual mTORC1/C2 inhibitor PP242 Research Paper

Targeting mantle cell lymphoma metabolism and survival through simultaneous blockade of mTOR and nuclear transporter exportin-1 Research Paper

Characterization of the transcriptional and metabolic responses of pediatric high grade gliomas to mTOR-HIF-1Î± axis inhibition Research Paper

Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells Research Paper

The dual PI3K/mTOR inhibitor GSK2126458 is effective for treating solid renal tumours in Tsc2^+/- mice through suppression of cell proliferation and induction of apoptosis Research Paper