The Oncosearch | Oncotarget

Tuberin-deficiency downregulates N-cadherin and upregulates vimentin in kidney tumor of TSC patients Research Paper

Sitai Liang, Tiffanie Salas, Emre Gencaslan, Baojie Li, Samy L. Habib

Published Jul 13, 2014 · Vol. 5, No. 16 · pp. 6936-6946

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention Review

Nicole M. Davis, Melissa Sokolosky, Kristin Stadelman, Stephen L. Abrams, Massimo Libra, Saverio Candido, Ferdinando Nicoletti, Jerry Polesel, Roberta Maestro, Antonino Dâ€™Assoro, Lyudmyla Drobot, Dariusz Rakus, Agnieszka Gizak, Piotr Laidler, Joanna DuliÅ„ska-Litewka, Joerg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Giuseppe Montalto, Melchiorre Cervello, Timothy L. Fitzgerald, Zoya N. Demidenko, Alberto M. Martelli, Lucio Cocco, Linda S. Steelman, James A. McCubrey

Published Jul 12, 2014 · Vol. 5, No. 13 · pp. 4603-4650

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells Research Paper

Yue-Zhi Lee, Cheng-Wei Yang, Hsin-Yu Chang, Hsing-Yu Hsu, Ih-Shen Chen, Hsun-Shuo Chang, Chih-Hao Lee, Jinq-chyi Lee, Chidambaram Ramesh Kumar, Ya-Qi Qiu, Yu-Sheng Chao, Shiow-Ju Lee

Published Jul 8, 2014 · Vol. 5, No. 15 · pp. 6087-6101

The anti-tumor activator sMEK1 and paclitaxel additively decrease expression of HIF-1Î± and VEGF via mTORC1-S6K/4E-BP-dependent signaling pathways Research Paper

Boh-Ram Kim, Kyungsil Yoon, Hyun-Jung Byun, Seung Hee Seo, Seung-Hoon Lee, Seung Bae Rho

Published Jun 19, 2014 · Vol. 5, No. 15 · pp. 6540-6551

Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition Research Paper

Ilaria Passacantilli, Gabriele Capurso, Livia Archibugi, Sara Calabretta, Sara Caldarola, Fabrizio Loreni, Gianfranco Delle Fave, Claudio Sette

Published Jun 18, 2014 · Vol. 5, No. 14 · pp. 5381-5391

Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail Research Paper

Weijia Cai, Qing Ye, Qing-Bai She

Published Jun 16, 2014 · Vol. 5, No. 15 · pp. 6015-6027

Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma Research Paper

Scott A. Ezell, Michele Mayo, Teeru Bihani, Suprawee Tepsuporn, Suping Wang, Melissa Passino, Shaun E. Grosskurth, Mike Collins, Julie Parmentier, Corinne Reimer, Kate F. Byth

Published Jun 7, 2014 · Vol. 5, No. 13 · pp. 4990-5001

GSK-3 as potential target for therapeutic intervention in cancer Review

James A. McCubrey, Linda S. Steelman, Fred E. Bertrand, Nicole M. Davis, Melissa Sokolosky, Steve L. Abrams, Giuseppe Montalto, Antonino B. Dâ€™Assoro, Massimo Libra, Ferdinando Nicoletti, Roberta Maestro, Jorg Basecke, Dariusz Rakus, Agnieszka Gizak, Zoya Demidenko, Lucio Cocco, Alberto M. Martelli, Melchiorre Cervello

Published May 28, 2014 · Vol. 5, No. 10 · pp. 2881-2911

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Paul MÃ©sange, Virginie Poindessous, MichÃ¨le Sabbah, Alexandre E. Escargueil, Aimery de Gramont, Annette K. Larsen

Published Jan 20, 2014 · Vol. 5, No. 13 · pp. 4709-4721

Keywords: resistance, angiogenesis inhibition, vascular endothelial growth factor (VEGF)-signaling, hypoxia, bevacizumab, nintedanib

Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer Research Paper

Luigi Fontana, Remi M. Adelaiye, Antonella L. Rastelli, Kiersten Marie Miles, Eric Ciamporcero, Valter D. Longo, Holly Nguyen, Robert Vessella, Roberto Pili

Published Nov 23, 2013 · Vol. 4, No. 12 · pp. 2451-2461

Keywords: Protein diet restriction, prostate cancer, breast cancer

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper

Veronica Martinez-Marignac, Nader Toban, Miguel Bazile, Raquel Aloyz

Published Nov 7, 2013 · Vol. 4, No. 12 · pp. 2550-2566

Keywords: CLL, AMPK, Dasatinib, kinase inhibitor, metabolism, glycolysis, OXPHOS

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

Leigh Ellis, ShengYu Ku, Swathi Ramakrishnan, Elena Lasorsa, Gizzou Azabdaftari, Alejandro Godoy, Roberto Pili

Published Sep 27, 2013 · Vol. 4, No. 12 · pp. 2225-2236

Keywords: prostate cancer, BEZ235, panobinostat, DNA damage, ATM, therapy

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

Maria Giovanna Francipane, Eric Lagasse

Published Sep 19, 2013 · Vol. 4, No. 11 · pp. 1948-1962

Keywords: colorectal cancer, cancer stem cells, mTOR, apoptosis

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Francesca Chiarini, Annalisa Lonetti, Gabriella Teti, Ester Orsini, Daniela Bressanin, Alessandra Cappellini, Francesca Ricci, Pier Luigi Tazzari, Andrea Ognibene, Mirella Falconi, Pasqualepaolo Pagliaro, Ilaria Iacobucci, Giovanni Martinelli, Sergio Amadori, James A McCubrey, Alberto M Martelli

Published Dec 18, 2012 · Vol. 3, No. 12 · pp. 1615-1628

Keywords: AML, PI3K/Akt/mTOR signaling, apoptosis, autophagy combination therapy, leukemia initiating cells

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Daniela Bressanin, Camilla Evangelisti, Francesca Ricci, Giovanna Tabellini, Francesca Chiarini, Pier Luigi Tazzari, Fraia Melchionda, Francesca Buontempo, Pasqualepaolo Pagliaro, Andrea Pession, James A McCubrey, Alberto M. Martelli

Published Aug 9, 2012 · Vol. 3, No. 8 · pp. 811-823

Keywords: acute leukemia, targeted therapy, signal transduction modulators, PI3K/PDK1, vertical inhibition

Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence Research Perspective

Suzan K. Chao, Susan Band Horwitz, Hayley M. McDaid

Published Feb 22, 2011 · Vol. 2, No. 1-2 · pp. 89-98

Keywords: Senescence, 4E-BP1, mTORC1, p53, discodermolide

Targeting the PI3K/Akt/mTOR Pathway â€“ Beyond Rapalogs Review

Ben Markman, Rodrigo Dienstmann, Josep Tabernero

Published Oct 22, 2010 · Vol. 1, No. 7 · pp. 530-543

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Tuberin-deficiency downregulates N-cadherin and upregulates vimentin in kidney tumor of TSC patients Research Paper

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention Review

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells Research Paper

The anti-tumor activator sMEK1 and paclitaxel additively decrease expression of HIF-1Î± and VEGF via mTORC1-S6K/4E-BP-dependent signaling pathways Research Paper

Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition Research Paper

Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail Research Paper

Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma Research Paper

GSK-3 as potential target for therapeutic intervention in cancer Review

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer Research Paper

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence Research Perspective

Targeting the PI3K/Akt/mTOR Pathway â€“ Beyond Rapalogs Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Tuberin-deficiency downregulates N-cadherin and upregulates vimentin in kidney tumor of TSC patients Research Paper

Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention Review

Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells Research Paper

The anti-tumor activator sMEK1 and paclitaxel additively decrease expression of HIF-1Î± and VEGF via mTORC1-S6K/4E-BP-dependent signaling pathways Research Paper

Combined therapy with RAD001 e BEZ235 overcomes resistance of PET immortalized cell lines to mTOR inhibition Research Paper

Loss of 4E-BP1 function induces EMT and promotes cancer cell migration and invasion via cap-dependent translational activation of snail Research Paper

Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma Research Paper

GSK-3 as potential target for therapeutic intervention in cancer Review

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Dietary protein restriction inhibits tumor growth in human xenograft models of prostate and breast cancer Research Paper

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Harnessing the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia: Eliminating activity by targeting at different levels Research Paper

Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence Research Perspective

Targeting the PI3K/Akt/mTOR Pathway â€“ Beyond Rapalogs Review