The Oncosearch | Oncotarget

Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics Research Paper

Melanie Hussmann, Kirsten Janke, Philip Kranz, Fabian Neumann, Evgenija Mersch, Melanie Baumann, Kirsten Goepelt, Ulf Brockmeier, Eric Metzen

Published Oct 21, 2015 · Vol. 6, No. 36 · pp. 39247-39261

Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer Research Paper

Ulises D. Orlando, Ana F. Castillo, Melina A. Dattilo, Angela R. Solano, Paula M. Maloberti, Ernesto J. Podesta

Published Oct 19, 2015 · Vol. 6, No. 40 · pp. 42632-42650

A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway Research Paper

Azadeh Cheraghchi-Bashi, Christine A. Parker, Ed Curry, Jean-Frederic Salazar, Hatice Gungor, Azeem Saleem, Paula Cunnea, Nona Rama, Cristian Salinas, Gordon B. Mills, Shannon R. Morris, Rakesh Kumar, Hani Gabra, Euan A. Stronach

Published Oct 19, 2015 · Vol. 6, No. 39 · pp. 41736-41749

The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression Research Paper

Masako Harada, Juliana Benito, Shinichi Yamamoto, Surinder Kaur, Dirim Arslan, Santiago Ramirez, Rodrigo Jacamo, Leonidas Platanias, Hiromichi Matsushita, Tsutomu Fujimura, Saiko Kazuno, Kensuke Kojima, Yoko Tabe, Marina Konopleva

Published Oct 14, 2015 · Vol. 6, No. 35 · pp. 37930-37947

Amphiregulin activates regulatory T lymphocytes and suppresses CD8⁺ T cell-mediated anti-tumor response in hepatocellular carcinoma cells Research Paper

Chun-Hui Yuan, Xiao-Ming Sun, Cheng-Liang Zhu, Shao-Ping Liu, Long Wu, Hao Chen, Mao-Hui Feng, Ke Wu, Fu-Bing Wang

Published Oct 6, 2015 · Vol. 6, No. 31 · pp. 32138-32153

Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo Research Paper

Annarita Miluzio, Stefania Oliveto, Elisa Pesce, Luciano Mutti, Bruno Murer, Stefano Grosso, Sara Ricciardi, Daniela Brina, Stefano Biffo

Published Oct 6, 2015 · Vol. 6, No. 35 · pp. 37471-37485

Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection Research Paper

Hao Pan, Li-Hui Xu, Mei-Yun Huang, Qing-Bing Zha, Gao-Xiang Zhao, Xiao-Feng Hou, Zi-Jian Shi, Qiu-Ru Lin, Dong-Yun Ouyang, Xian-Hui He

Published Oct 2, 2015 · Vol. 6, No. 32 · pp. 32468-32483

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia Research Paper

Stefano Iacovelli, Maria Rosaria Ricciardi, Matteo Allegretti, Simone Mirabilii, Roberto Licchetta, Paola Bergamo, Cinzia Rinaldo, Ann Zeuner, Robin FoÃ, Michele Milella, James A. McCubrey, Alberto M. Martelli, Agostino Tafuri

Published Sep 16, 2015 · Vol. 6, No. 31 · pp. 32089-32103

Dual mTORC1/C2 inhibitors: gerosuppressors with potential anti-aging effect Research Perspective

Pedro Sousa-Victor, Laura GarcÃa-Prat, Pura MuÃ±oz-CÃ¡noves

Published Sep 10, 2015 · Vol. 6, No. 27 · pp. 23052-23054

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model Research Paper

Dudley W. Lamming, Nicole E. Cummings, Antonella L. Rastelli, Feng Gao, Edda Cava, Beatrice Bertozzi, Francesco Spelta, Roberto Pili, Luigi Fontana

Published Sep 3, 2015 · Vol. 6, No. 31 · pp. 31233-31240

Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis Research Paper

Chung-Ji Liu, Wan-Jung Chang, Chang-Yi Chen, Fang-Ju Sun, Hui-Wen Cheng, Tsai-Ying Chen, Shu-Chun Lin, Wan-Chun Li

Published Aug 21, 2015 · Vol. 6, No. 30 · pp. 29268-29284

Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A Priority Research Paper

Bi-Hong Xu, Xiao-Xing Li, Yang Yang, Mei-Yin Zhang, Hui-Lan Rao, Hui-Yun Wang, X.F. Steven Zheng

Published Aug 13, 2015 · Vol. 6, No. 25 · pp. 20813-20828

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy Research Paper

Nathalie Meo-Evoli, EugÃ¨nia Almacellas, Francesco Alessandro Massucci, Antonio Gentilella, Santiago Ambrosio, Sara C. Kozma, George Thomas, Albert Tauler

Published Aug 11, 2015 · Vol. 6, No. 29 · pp. 28057-28070

Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program) Research Paper

Olga V. Leontieva, Zoya N. Demidenko, Mikhail V. Blagosklonny

Published Jul 27, 2015 · Vol. 6, No. 27 · pp. 23238-23248

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma Priority Research Paper

Arindam P. Ghosh, Christopher B. Marshall, Tatjana Coric, Eun-hee Shim, Richard Kirkman, Mary E. Ballestas, Mitsuhiko Ikura, Mary-Ann Bjornsti, Sunil Sudarshan

Published Jul 22, 2015 · Vol. 6, No. 20 · pp. 17895-17910

OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo Research Paper

Xiao Zhi, Wei Chen, Fei Xue, Chao Liang, Bryan Wei Chen, Yue Zhou, Liang Wen, Liqiang Hu, Jian Shen, Xueli Bai, Tingbo Liang

Published Jul 21, 2015 · Vol. 6, No. 28 · pp. 26230-26241

A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas Priority Research Paper

Roberta L. Beauchamp, Marianne F. James, Patrick A. DeSouza, Vilas Wagh, Wen-Ning Zhao, Justin T. Jordan, Anat Stemmer-Rachamimov, Scott R. Plotkin, James F. Gusella, Stephen J. Haggarty, Vijaya Ramesh

Published Jul 15, 2015 · Vol. 6, No. 19 · pp. 16981-16997

p53 and rapamycin are additive Priority Research Paper

Barbara Christy, Marco Demaria, Judith Campisi, Jing Huang, Diane Jones, Sherry G. Dodds, Charnae Williams, Gene Hubbard, Carolina B. Livi, Xiaoli Gao, Susan Weintraub, Tyler Curiel, Z. Dave Sharp, Paul Hasty

Published Jun 23, 2015 · Vol. 6, No. 18 · pp. 15802-15813

mTORC1 sustains vision in retinitis pigmentosa Editorial

Lolita Petit, Claudio Punzo

Published Jun 14, 2015 · Vol. 6, No. 19 · pp. 16786-16787

Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism Research Paper

Guo-Qing Chen, Cheng-Fang Tang, Xiao-Ke Shi, Cheng-Yuan Lin, Sarwat Fatima, Xiao-Hua Pan, Da-Jian Yang, Ge Zhang, Ai-Ping Lu, Shu-Hai Lin, Zhao-Xiang Bian

Published Jun 8, 2015 · Vol. 6, No. 27 · pp. 24148-24162

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Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics Research Paper

Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer Research Paper

A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway Research Paper

The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression Research Paper

Amphiregulin activates regulatory T lymphocytes and suppresses CD8⁺ T cell-mediated anti-tumor response in hepatocellular carcinoma cells Research Paper

Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo Research Paper

Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection Research Paper

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia Research Paper

Dual mTORC1/C2 inhibitors: gerosuppressors with potential anti-aging effect Research Perspective

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model Research Paper

Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis Research Paper

Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A Priority Research Paper

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy Research Paper

Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program) Research Paper

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma Priority Research Paper

OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo Research Paper

A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas Priority Research Paper

p53 and rapamycin are additive Priority Research Paper

mTORC1 sustains vision in retinitis pigmentosa Editorial

Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics Research Paper

Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer Research Paper

A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway Research Paper

The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression Research Paper

Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells Research Paper

Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo Research Paper

Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection Research Paper

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia Research Paper

Dual mTORC1/C2 inhibitors: gerosuppressors with potential anti-aging effect Research Perspective

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model Research Paper

Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis Research Paper

Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A Priority Research Paper

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy Research Paper

Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program) Research Paper

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma Priority Research Paper

OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo Research Paper

A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas Priority Research Paper

p53 and rapamycin are additive Priority Research Paper

mTORC1 sustains vision in retinitis pigmentosa Editorial

Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism Research Paper

Amphiregulin activates regulatory T lymphocytes and suppresses CD8⁺ T cell-mediated anti-tumor response in hepatocellular carcinoma cells Research Paper