The Oncosearch | Oncotarget

Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models Research Paper

Anne-Christine Wong Te Fong, Parames Thavasu, Sladjana Gagrica, Karen E. Swales, Martin O. Leach, Sabina C. Cosulich, Yuen-Li Chung, Udai Banerji

Published Dec 6, 2017 · Vol. 8, No. 69 · pp. 113874-113884

FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway Research Paper

Keigo Okada, Ayako Nogami, Shinya Ishida, Hiroki Akiyama, Cheng Chen, Yoshihiro Umezawa, Osamu Miura

Published Dec 4, 2017 · Vol. 9, No. 10 · pp. 8870-8886

A novel small-molecule arylsulfonamide causes energetic stress and suppresses breast and lung tumor growth and metastasis Priority Research Paper

Xin Dai, Stefan Kaluz, Ying Jiang, Lei Shi, DeAngelo Mckinley, Yingzhe Wang, Binghe Wang, Erwin G. Van Meir, Chalet Tan

Published Oct 29, 2017 · Vol. 8, No. 59 · pp. 99245-99260

VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim Research Paper

Nurulhuda Mustafa, Jeannie Xue Ting Lee, Huey Fang Adina Nee, Chonglei Bi, Tae-Hoon Chung, Stefan Hart, Wee Joo Chng

Published Oct 20, 2017 · Vol. 8, No. 60 · pp. 101847-101864

Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer Research Paper

Jian-Shu Lou, Wen-Chuan Bi, Gallant K.L. Chan, Jin Yan, Chau-Wing Wong, Zhong-Yu Zhou, Huai-You Wang, Ping Yao, Tina T.X. Dong, Karl W.K. Tsim

Published Oct 16, 2017 · Vol. 8, No. 54 · pp. 93131-93148

HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Research Paper

Laurence Booth, Jane L. Roberts, Andrew Poklepovic, Francesca Avogadri-Connors, Richard E. Cutler, Alshad S. Lalani, Paul Dent

Published Oct 9, 2017 · Vol. 8, No. 52 · pp. 90262-90277

Targeted inhibition of glutaminase as a potential new approach for the treatment of NF1 associated soft tissue malignancies Research Paper

Tahir N. Sheikh, Parag P. Patwardhan, Serge Cremers, Gary K. Schwartz

Published Oct 6, 2017 · Vol. 8, No. 55 · pp. 94054-94068

Sestrin2 and sestrin3 suppress NK-92 cell-mediated cytotoxic activity on ovarian cancer cells through AMPK and mTORC1 signaling Research Paper

Xuejin Wang, Weifeng Liu, Deyi Zhuang, Shaoxian Hong, Jingfang Chen

Published Oct 4, 2017 · Vol. 8, No. 52 · pp. 90132-90143

Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis Priority Research Paper

Antonio Cigliano, Maria G. Pilo, Lei Li, Gavinella Latte, Marta Szydlowska, Maria M. Simile, Panagiotis Paliogiannis, Li Che, Giovanni M. Pes, Giuseppe Palmieri, Maria C. Sini, Antonio Cossu, Alberto Porcu, Gianpaolo Vidili, Maria A. Seddaiu, Rosa M. Pascale, Silvia Ribback, Frank Dombrowski, Xin Chen, Diego F. Calvisi

Published Oct 3, 2017 · Vol. 8, No. 53 · pp. 90638-90650

Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7 Research Paper

Young Jin Jang, Hyo Jeong Son, Yong Min Choi, Jiyun Ahn, Chang Hwa Jung, Tae Youl Ha

Published Sep 16, 2017 · Vol. 8, No. 45 · pp. 78300-78311

Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development Priority Research Paper

Pin Liu, Diego F. Calvisi, Andras Kiss, Antonio Cigliano, Zsuzsa Schaff, Li Che, Silvia Ribback, Frank Dombrowski, Dongchi Zhao, Xin Chen

Published Sep 1, 2017 · Vol. 8, No. 43 · pp. 73433-73447

Hoxa5 increases mitochondrial apoptosis by inhibiting Akt/mTORC1/S6K1 pathway in mice white adipocytes Research Paper

Fei Feng, Qian Ren, Song Wu, Muhammad Saeed, Chao Sun

Published Aug 24, 2017 · Vol. 8, No. 56 · pp. 95332-95345

Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells Research Paper

Stephen L. Abrams, Peter P. Ruvolo, Vivian R. Ruvolo, Giovanni Ligresti, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Agostino Tafuri, Linda S. Steelman, Saverio Candido, Massimo Libra, James A. McCubrey

Published Aug 24, 2017 · Vol. 8, No. 44 · pp. 76525-76557

Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1α and hypoxia-mediated mitophagy Research Paper

NÃ©stor Prieto-DomÃnguez, Carolina MÃ©ndez-Blanco, Sara Carbajo-Pescador, Flavia Fondevila, AndrÃ©s GarcÃa-Palomo, Javier GonzÃ¡lez-Gallego, JosÃ© L. Mauriz

Published Aug 24, 2017 · Vol. 8, No. 53 · pp. 91402-91414

Uncoupling TORC2 from AGC kinases inhibits tumour growth Priority Research Paper

Angus J.M. Cameron, Selvaraju Veeriah, Jacqueline J.T. Marshall, Elizabeth R. Murray, BanafshÃ© Larijani, Peter J. Parker

Published Aug 9, 2017 · Vol. 8, No. 49 · pp. 84685-84696

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells Priority Research Paper

Hilaire C. Lam, Heng-Jia Liu, Christian V. Baglini, Harilaos Filippakis, Nicola Alesi, Julie Nijmeh, Heng Du, Alicia Llorente Lope, Katherine A. Cottrill, Adam Handen, John M. Asara, David J. Kwiatkowski, Issam Ben-Sahra, William M. Oldham, Stephen Y. Chan, Elizabeth P. Henske

Published Aug 4, 2017 · Vol. 8, No. 39 · pp. 64714-64727

Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species Research Paper

Jane L. Roberts, Andrew Poklepovic, Laurence Booth

Published Aug 2, 2017 · Vol. 8, No. 59 · pp. 99451-99469

Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1 Research Paper

Prasun Guha, Engin Kaptan, Padmaja Gade, Dhananjaya V. Kalvakolanu, Hafiz Ahmed

Published Jul 15, 2017 · Vol. 8, No. 40 · pp. 68191-68207

Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development Research Paper

Li Wang, Zhaofei Ni, Yujie Liu, Shuang Ji, Fuquan Jin, Keguo Jiang, Junfang Ma, Cuiping Ren, Hongbing Zhang, Zhongdong Hu, Xiaojun Zha

Published Jul 4, 2017 · Vol. 8, No. 33 · pp. 54858-54872

Longitudinal serum metabolomics evaluation of trastuzumab and everolimus combination as pre-operative treatment for HER-2 positive breast cancer patients Research Paper

Elodie Jobard, Olivier TrÃ©dan, Thomas Bachelot, Arnaud M. Vigneron, CÃ©line Mahier AÃ¯t-Oukhatar, Monica Arnedos, Maria Rios, Jacques Bonneterre, VÃ©ronique DiÃ©ras, Marta Jimenez, Jean-Louis Merlin, Mario Campone, BÃ©nÃ©dicte Elena-Herrmann

Published Jun 28, 2017 · Vol. 8, No. 48 · pp. 83570-83584

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Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models Research Paper

FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway Research Paper

A novel small-molecule arylsulfonamide causes energetic stress and suppresses breast and lung tumor growth and metastasis Priority Research Paper

VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim Research Paper

Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer Research Paper

HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Research Paper

Targeted inhibition of glutaminase as a potential new approach for the treatment of NF1 associated soft tissue malignancies Research Paper

Sestrin2 and sestrin3 suppress NK-92 cell-mediated cytotoxic activity on ovarian cancer cells through AMPK and mTORC1 signaling Research Paper

Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis Priority Research Paper

Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7 Research Paper

Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development Priority Research Paper

Hoxa5 increases mitochondrial apoptosis by inhibiting Akt/mTORC1/S6K1 pathway in mice white adipocytes Research Paper

Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells Research Paper

Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1α and hypoxia-mediated mitophagy Research Paper

Uncoupling TORC2 from AGC kinases inhibits tumour growth Priority Research Paper

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells Priority Research Paper

Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species Research Paper

Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1 Research Paper

Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development Research Paper

Longitudinal serum metabolomics evaluation of trastuzumab and everolimus combination as pre-operative treatment for HER-2 positive breast cancer patients Research Paper

Publication Alerts

European Cancer and Oncology Congress

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Post-Publication Promotion

Search Oncotarget

Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models Research Paper

FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway Research Paper

A novel small-molecule arylsulfonamide causes energetic stress and suppresses breast and lung tumor growth and metastasis Priority Research Paper

VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim Research Paper

Ginkgetin induces autophagic cell death through p62/SQSTM1-mediated autolysosome formation and redox setting in non-small cell lung cancer Research Paper

HDAC inhibitors enhance neratinib activity and when combined enhance the actions of an anti-PD-1 immunomodulatory antibody in vivo Research Paper

Targeted inhibition of glutaminase as a potential new approach for the treatment of NF1 associated soft tissue malignancies Research Paper

Sestrin2 and sestrin3 suppress NK-92 cell-mediated cytotoxic activity on ovarian cancer cells through AMPK and mTORC1 signaling Research Paper

Deregulated c-Myc requires a functional HSF1 for experimental and human hepatocarcinogenesis Priority Research Paper

Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7 Research Paper

Central role of mTORC1 downstream of YAP/TAZ in hepatoblastoma development Priority Research Paper

Hoxa5 increases mitochondrial apoptosis by inhibiting Akt/mTORC1/S6K1 pathway in mice white adipocytes Research Paper

Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells Research Paper

Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1α and hypoxia-mediated mitophagy Research Paper

Uncoupling TORC2 from AGC kinases inhibits tumour growth Priority Research Paper

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells Priority Research Paper

Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species Research Paper

Tunicamycin induced endoplasmic reticulum stress promotes apoptosis of prostate cancer cells by activating mTORC1 Research Paper

Hyperactivated mTORC1 downregulation of FOXO3a/PDGFRα/AKT cascade restrains tuberous sclerosis complex-associated tumor development Research Paper

Longitudinal serum metabolomics evaluation of trastuzumab and everolimus combination as pre-operative treatment for HER-2 positive breast cancer patients Research Paper