The Oncosearch | Oncotarget

AMPKÎ± phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation Research Paper

Min-Bin Chen, Yuan-Yuan Liu, Li-Bo Cheng, Jian-Wei Lu, Ping Zeng, Pei-Hua Lu

Published Mar 11, 2017 · Vol. 8, No. 19 · pp. 31288-31296

Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells Research Paper

Renan B. Ferreira, Mengxiong Wang, Mary E. Law, Bradley J. Davis, Ashton N. Bartley, Paul J. Higgins, Michael S. Kilberg, Katherine E. Santostefano, Naohiro Terada, Coy D. Heldermon, Ronald K. Castellano, Brian K. Law

Published Mar 7, 2017 · Vol. 8, No. 17 · pp. 28971-28989

The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agent Research Paper

Zuquan Xiong, Yiwen Zang, Shan Zhong, Lujia Zou, Yishuo Wu, Shenghua Liu, Zujun Fang, Zhoujun Shen, Qiang Ding, Shanwen Chen

Published Feb 22, 2017 · Vol. 8, No. 18 · pp. 30151-30161

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer Research Paper

Riley A. Hampsch, Kevin Shee, Darcy Bates, Lionel D. Lewis, Laurent DÃ©sirÃ©, Bertrand Leblond, Eugene Demidenko, Kurtis Stefan, Yina H. Huang, Todd W. Miller

Published Feb 21, 2017 · Vol. 8, No. 13 · pp. 21806-21817

Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model Research Paper

Kai Takegoshi, Masao Honda, Hikari Okada, Riuta Takabatake, Naoto Matsuzawa-Nagata, Jean S. Campbell, Masashi Nishikawa, Tetsuro Shimakami, Takayoshi Shirasaki, Yoshio Sakai, Taro Yamashita, Toshinari Takamura, Takuji Tanaka, Shuichi Kaneko

Published Feb 13, 2017 · Vol. 8, No. 11 · pp. 18191-18205

OIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways Research Paper

Hua Li, Jun Zhang, Mi-Jin Lee, Goung-Ran Yu, Xueji Han, Dae-Ghon Kim

Published Feb 8, 2017 · Vol. 8, No. 11 · pp. 18129-18144

Tumor suppressor role of miR-3622b-5p in ERBB2-positive cancer Research Paper

Mingjie Lu, Tongshan Wang, Mingfeng He, Wenfang Cheng, Ting Yan, Zebo Huang, Lan Zhang, Huo Zhang, Wei Zhu, Yichao Zhu, Ping Liu

Published Feb 1, 2017 · Vol. 8, No. 14 · pp. 23008-23019

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells Research Paper

Renate Wagner, Gerald StÃ¼biger, Daniel Veigel, Michael Wuczkowski, Peter Lanzerstorfer, Julian Weghuber, Emmanouil Karteris, Karin Nowikovsky, Nastasia Wilfinger-Lutz, Christian F. Singer, RamÃ³n Colomer, Bellinda BenhamÃº, MarÃa Luz LÃ³pez-RodrÃguez, Peter Valent, Thomas W. Grunt

Published Jan 10, 2017 · Vol. 8, No. 7 · pp. 11600-11613

Mcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells Research Paper

Yu Zhang, Xin Li, Shisheng Tan, Xinyu Liu, Xinyu Zhao, Zhu Yuan, Chunlai Nie

Published Dec 26, 2016 · Vol. 8, No. 7 · pp. 11042-11052

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells Review

James A. McCubrey, Timothy L. Fitzgerald, Li V. Yang, Kvin Lertpiriyapong, Linda S. Steelman, Stephen L. Abrams, Giuseppe Montalto, Melchiorre Cervello, Luca M. Neri, Lucio Cocco, Alberto M. Martelli, Piotr Laidler, Joanna DuliÅ„ska-Litewka, Dariusz Rakus, Agnieszka Gizak, Ferdinando Nicoletti, Luca Falzone, Saverio Candido, Massimo Libra

Published Dec 16, 2016 · Vol. 8, No. 8 · pp. 14221-14250

Potentiation of the anticancer effects of everolimus using a dual mTORC1/2 inhibitor in hepatocellular carcinoma cells Research Paper

Jong-Ok Kim, Kee-Hwan Kim, In Sang Song, Kwang-Sik Cheon, Ok-Hee Kim, Sang Chul Lee, Sang Kuon Lee, Say-June Kim

Published Dec 7, 2016 · Vol. 8, No. 2 · pp. 2936-2948

Preclinical study of cinobufagin as a promising anti-colorectal cancer agent Research Paper

Xing-sheng Lu, Yin-biao Qiao, Ya Li, Bo Yang, Min-bin Chen, Chun-gen Xing

Published Nov 23, 2016 · Vol. 8, No. 1 · pp. 988-998

TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress Research Paper

Govind M. Pai, Alexandra Zielinski, Dennis Koalick, Kristin Ludwig, Zhao-Qi Wang, Kerstin Borgmann, Helmut Pospiech, Ignacio Rubio

Published Nov 16, 2016 · Vol. 7, No. 51 · pp. 85365-85380

RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR Research Paper

Nneha Sakre, Gary Wildey, Mohadese Behtaj, Adam Kresak, Michael Yang, Pingfu Fu, Afshin Dowlati

Published Nov 15, 2016 · Vol. 8, No. 4 · pp. 5992-6002

Arctigenin functions as a selective agonist of estrogen receptor Î² to restrict mTORC1 activation and consequent Th17 differentiation Research Paper

Xin Wu, Bei Tong, Yan Yang, Jinque Luo, Xusheng Yuan, Zhifeng Wei, Mengfan Yue, Yufeng Xia, Yue Dai

Published Nov 14, 2016 · Vol. 7, No. 51 · pp. 83893-83906

Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2 Research Paper

Beatrice Riva, Marco De Dominici, Ilaria Gnemmi, Samanta A. Mariani, Alberto Minassi, Valentina Minieri, Paolo Salomoni, Pier Luigi Canonico, Armando A. Genazzani, Bruno Calabretta, Fabrizio Condorelli

Published Nov 7, 2016 · Vol. 7, No. 49 · pp. 81555-81570

Elevation of n-3/n-6 PUFAs ratio suppresses mTORC1 and prevents colorectal carcinogenesis associated with APC mutation Research Paper

Miao Liu, Ling Zhou, Baiyu Zhang, Minhong He, Xiaoying Dong, Xiaojun Lin, Chunhong Jia, Xiaochun Bai, Yifan Dai, Yongchun Su, Zhipeng Zou, Hang Zheng

Published Oct 19, 2016 · Vol. 7, No. 47 · pp. 76944-76954

Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells Research Paper

Valeria Catena, Tiziana Bruno, Francesca De Nicola, Frauke Goeman, Matteo Pallocca, Simona Iezzi, Cristina Sorino, Giovanni Cigliana, Aristide Floridi, Giovanni Blandino, Maurizio Fanciulli

Published Sep 16, 2016 · Vol. 7, No. 43 · pp. 70546-70558

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2Î± phosphorylation in established cell lines and primary human leukemia cells Research Paper

Alison Yeomans, Elizabeth Lemm, Sarah Wilmore, Breeze E. Cavell, Beatriz Valle-Argos, Sergey Krysov, Marina Sanchez Hidalgo, Elodie Leonard, Anne E. Willis, Francesco Forconi, Freda K. Stevenson, Andrew J. Steele, Mark J. Coldwell, Graham Packham

Published Aug 27, 2016 · Vol. 7, No. 46 · pp. 74807-74819

Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinsonâ€™s disease model Research Paper

Jia Liu, Min Chen, Xue Wang, Yi Wang, Chunli Duan, Ge Gao, Lingling Lu, Xia Wu, Xiaomin Wang, Hui Yang

Published Aug 27, 2016 · Vol. 7, No. 38 · pp. 60823-60843

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AMPKÎ± phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation Research Paper

Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells Research Paper

The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agent Research Paper

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer Research Paper

Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model Research Paper

OIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways Research Paper

Tumor suppressor role of miR-3622b-5p in ERBB2-positive cancer Research Paper

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells Research Paper

Mcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells Research Paper

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells Review

Potentiation of the anticancer effects of everolimus using a dual mTORC1/2 inhibitor in hepatocellular carcinoma cells Research Paper

Preclinical study of cinobufagin as a promising anti-colorectal cancer agent Research Paper

TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress Research Paper

RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR Research Paper

Arctigenin functions as a selective agonist of estrogen receptor Î² to restrict mTORC1 activation and consequent Th17 differentiation Research Paper

Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2 Research Paper

Elevation of n-3/n-6 PUFAs ratio suppresses mTORC1 and prevents colorectal carcinogenesis associated with APC mutation Research Paper

Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells Research Paper

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2Î± phosphorylation in established cell lines and primary human leukemia cells Research Paper

Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinsonâ€™s disease model Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

AMPKÎ± phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation Research Paper

Disulfide bond disrupting agents activate the unfolded protein response in EGFR- and HER2-positive breast tumor cells Research Paper

The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agent Research Paper

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer Research Paper

Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model Research Paper

OIP5, a target of miR-15b-5p, regulates hepatocellular carcinoma growth and metastasis through the AKT/mTORC1 and β-catenin signaling pathways Research Paper

Tumor suppressor role of miR-3622b-5p in ERBB2-positive cancer Research Paper

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells Research Paper

Mcl-1 expression and JNK activation induces a threshold for apoptosis in Bcl-xL-overexpressing hematopoietic cells Research Paper

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells Review

Potentiation of the anticancer effects of everolimus using a dual mTORC1/2 inhibitor in hepatocellular carcinoma cells Research Paper

Preclinical study of cinobufagin as a promising anti-colorectal cancer agent Research Paper

TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress Research Paper

RICTOR amplification identifies a subgroup in small cell lung cancer and predicts response to drugs targeting mTOR Research Paper

Arctigenin functions as a selective agonist of estrogen receptor Î² to restrict mTORC1 activation and consequent Th17 differentiation Research Paper

Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2 Research Paper

Elevation of n-3/n-6 PUFAs ratio suppresses mTORC1 and prevents colorectal carcinogenesis associated with APC mutation Research Paper

Deptor transcriptionally regulates endoplasmic reticulum homeostasis in multiple myeloma cells Research Paper

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2Î± phosphorylation in established cell lines and primary human leukemia cells Research Paper

Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinsonâ€™s disease model Research Paper