The Oncosearch | Oncotarget

Real time ex vivo chemosensitivity assay for pancreatic adenocarcinoma Research Paper

Dae Won Kim, Francisca Beato, Youngchul Kim, Alexandra F. Tassielli, Ruifan Dai, Jason W. Denbo, Pamela J. Hodul, Mokenge P. Malafa, Jason B. Fleming

Published Sep 7, 2023 · Vol. 14, No. 1 · pp. 811-818

Keywords: pancreatic cancer, sensitivity assay, chemotherapy

Targeting Ras with protein engineering Review

Atilio Tomazini, Julia M. Shifman

Published Jun 21, 2023 · Vol. 14, No. 1 · pp. 672-687

Keywords: Ras oncogene, anti-Ras therapeutics, Ras targeting, protein engineering, protein design

Diphenyl ditelluride anticancer activity and DNA topoisomerase I poisoning in human colon cancer HCT116 cells Research Paper

André Luiz Mendes Juchem, Cristiano Trindade, Juliana Bondan da Silva, Miriana da Silva Machado, Temenouga Nikolova Guecheva, Jaqueline Cesar Rocha, Jenifer Saffi, Iuri Marques de Oliveira, João Antonio Pêgas Henriques, Alexandre Escargueil

Published Jun 16, 2023 · Vol. 14, No. 1 · pp. 637-649

Keywords: colorectal cancer, HCT116, diphenyl ditelluride, organotellurium, topoisomerase I

Potential repurposing of DPP4 inhibitors for target therapy resistance in renal cell carcinoma Editorial

Kuniko Horie, Satoshi Inoue

Published Jun 15, 2023 · Vol. 14, No. 1 · pp. 807-808

Keywords: renal cell carcinoma (RCC), tyrosine kinase inhibitor (TKI), Dipeptidyl peptidase IV (DPP4), drug resistance, drug repurposing

Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Research Paper

Devalingam Mahalingam, Salih Hanni, Anthony V. Serritella, Christos Fountzilas, Joel Michalek, Brian Hernandez, John Sarantopoulos, Paromitta Datta, Ofelia Romero, Sureshkumar Mulampurath Achutan Pillai, John Kuhn, Michael Pollak, Ian M. Thompson

Published Jun 8, 2023 · Vol. 14, No. 1 · pp. 622-636

Keywords: prostate cancer, metformin, metastatic, androgen deprivation therapy, clinical trial

The dark side of PLK1: Implications for cancer and genomic instability Editorial

Lilia Gheghiani, Zheng Fu

Published Jun 7, 2023 · Vol. 14, No. 1 · pp. 657-659

Keywords: polo-like kinase 1 (PLK1), oncogene, chromosomal instability, cell cycle checkpoints, tumorigenesis

Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment Research Paper

Valentin Feichtenschlager, Yixuan James Zheng, Wilson Ho, Linan Chen, Ciara Callanan, Christopher Chen, Albert Lee, Jose Ortiz, Klemens Rappersberger, Susana Ortiz-Urda

Published May 19, 2023 · Vol. 14, No. 1 · pp. 543-560

Keywords: MALAT1, MAPK-pathway, BRAF, melanoma, antisense oligonucleotides

Targeting the Src N-terminal regulatory element in cancer Research Perspective

Betlem Mezquita, Marjorie Reyes-Farias, Miquel Pons

Published May 12, 2023 · Vol. 14, No. 1 · pp. 503-513

Keywords: Src family kinases, intrinsically disordered proteins, SNRE, cell-type selective drugs, drug resistance

Targeting cellular respiration as a therapeutic strategy in glioblastoma Research Perspective

Enyuan Shang, Trang Thi Thu Nguyen, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin

Published May 2, 2023 · Vol. 14, No. 1 · pp. 419-425

Keywords: glioblastoma, metabolism, lactate, carbon tracing, central carbon metabolism

Using cancer proteomics data to identify gene candidates for therapeutic targeting Research Perspective

Diana Monsivais, Sydney E. Parks, Darshan S. Chandrashekar, Sooryanarayana Varambally, Chad J. Creighton

Published Apr 28, 2023 · Vol. 14, No. 1 · pp. 399-412

Keywords: proteomics, proteogenomics, multi-omics, cancer, TTK protein kinase

The molecular dialogue between the tumor cells and fibroblasts Editorial

Ramesh Butti, Gopal C. Kundu

Published Apr 4, 2023 · Vol. 14, No. 1 · pp. 462-463

Keywords: CAFs, heterogeneity, myofibroblasts, drug resistance, osteopontin

A phase I trial of riluzole and sorafenib in patients with advanced solid tumors: CTEP #8850 Research Paper

Kristen R. Spencer, Daniella E. Portal, Joseph Aisner, Mark N. Stein, Jyoti Malhotra, Weichung Shih, Nancy Chan, Ann W. Silk, Shridar Ganesan, Susan Goodin, Murugesan Gounder, Hongxia Lin, Jiadong Li, Robert Cerchio, Christina Marinaro, Suzie Chen, Janice M. Mehnert

Published Apr 3, 2023 · Vol. 14, No. 1 · pp. 302-315

Keywords: GRM1, riluzole, sorafenib, phase I, clinical trial

Selective protection of normal cells from chemotherapy, while killing drug-resistant cancer cells Review

Mikhail V. Blagosklonny

Published Mar 3, 2023 · Vol. 14, No. 1 · pp. 193-206

Keywords: oncology, resistance, cyclotherapy, trilaciclib, rapamycin

Spleen tyrosine kinase/FMS-like tyrosine kinase-3 inhibition in relapsed/refractory B-cell lymphoma, including diffuse large B-cell lymphoma: updated data with mivavotinib (TAK-659/CB-659) Research Paper

Leo I. Gordon, Reem Karmali, Jason B. Kaplan, Rakesh Popat, Howard A. Burris III, Silvia Ferrari, Sumit Madan, Manish R. Patel, Giuseppe Gritti, Dima El-Sharkawi, F. Ian Chau, John Radford, Jaime Pérez de Oteyza, Pier Luigi Zinzani, Swaminathan P. Iyer, William Townsend, Harry Miao, Igor Proscurshim, Shining Wang, Shilpi Katyayan, Ying Yuan, Jiaxi Zhu, Kate Stumpo, Yaping Shou, Cecilia Carpio, Francesc Bosch

Published Jan 20, 2023 · Vol. 14, No. 1 · pp. 57-70

Keywords: Non-Hodgkin’s lymphoma, DLBCL, relapsed/refractory, SYK inhibitor, TAK-659

Candidate drugs associated with sensitivity of cancer cell lines with DLST amplification or high mRNA levels Research Paper

Christina Kuhn, Myriam Boeschen, Manuel Philip, Torsten Schöneberg, Doreen Thor, Susanne Horn

Published Dec 27, 2022 · Vol. 14, No. 1 · pp. 14-20

Keywords: neuroblastoma, drug sensitivity, drug resistance, drug repurposing, DLST

Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001 Research Paper

Xiaofan Li, Cristina Abrahams, Abigail Yu, Millicent Embry, Robert Henningsen, Venita DeAlmeida, Shannon Matheny, Toni Kline, Alice Yam, Ryan Stafford, Trevor Hallam, Mark Lupher, Arturo Molina

Published Dec 27, 2022 · Vol. 14, No. 1 · pp. 1-13

Keywords: CD74, antibody-drug conjugate, non-Hodgkin lymphoma, xenograft models, STRO-001

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

Hirofumi Tsuzuki, Tatsuya Kawase, Taisuke Nakazawa, Masamichi Mori, Taku Yoshida

Published Dec 13, 2022 · Vol. 13, No. 1 · pp. 1359-1368

Keywords: acute myeloid leukemia (AML), ASP1235, antibody drug conjugate (ADC), venetoclax, azacitidine

Resistance of MMTV-NeuT/ATTAC mice to anti-PD-1 immune checkpoint therapy is associated with macrophage infiltration and Wnt pathway expression Research Paper

Hongyan Yuan, Lu Jin, Handan Xiang, Anannya Bhattacharya, Philip E. Brandish, Gretchen Baltus, Alexander Tong, Changyan Zhou, Robert I. Glazer

Published Dec 10, 2022 · Vol. 13, No. 1 · pp. 1350-1358

Keywords: PD-1, NeuT, Wnt, macrophages, mammary tumorigenesis

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway Research Paper

Jen-Chieh Lee, Shu Liu, Yucheng Wang, You Liang, David M. Jablons

Published Oct 26, 2022 · Vol. 13, No. 1 · pp. 1217-1236

Keywords: AML, CDK8, kinase inhibitor, STAT pathway, xenograft

Nectin-4 is widely expressed in head and neck squamous cell carcinoma Research Paper

Christine Sanders, Jan-Frederic Lau, Dimo Dietrich, Sebastian Strieth, Peter Brossart, Glen Kristiansen

Published Oct 14, 2022 · Vol. 13, No. 1 · pp. 1166-1173

Keywords: Nectin-4, enfortumab-vedotin, HNSCC, p16

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Real time ex vivo chemosensitivity assay for pancreatic adenocarcinoma Research Paper

Targeting Ras with protein engineering Review

Diphenyl ditelluride anticancer activity and DNA topoisomerase I poisoning in human colon cancer HCT116 cells Research Paper

Potential repurposing of DPP4 inhibitors for target therapy resistance in renal cell carcinoma Editorial

Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Research Paper

The dark side of PLK1: Implications for cancer and genomic instability Editorial

Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment Research Paper

Targeting the Src N-terminal regulatory element in cancer Research Perspective

Targeting cellular respiration as a therapeutic strategy in glioblastoma Research Perspective

Using cancer proteomics data to identify gene candidates for therapeutic targeting Research Perspective

The molecular dialogue between the tumor cells and fibroblasts Editorial

A phase I trial of riluzole and sorafenib in patients with advanced solid tumors: CTEP #8850 Research Paper

Selective protection of normal cells from chemotherapy, while killing drug-resistant cancer cells Review

Spleen tyrosine kinase/FMS-like tyrosine kinase-3 inhibition in relapsed/refractory B-cell lymphoma, including diffuse large B-cell lymphoma: updated data with mivavotinib (TAK-659/CB-659) Research Paper

Candidate drugs associated with sensitivity of cancer cell lines with DLST amplification or high mRNA levels Research Paper

Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001 Research Paper

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

Resistance of MMTV-NeuT/ATTAC mice to anti-PD-1 immune checkpoint therapy is associated with macrophage infiltration and Wnt pathway expression Research Paper

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway Research Paper

Nectin-4 is widely expressed in head and neck squamous cell carcinoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Real time ex vivo chemosensitivity assay for pancreatic adenocarcinoma Research Paper

Targeting Ras with protein engineering Review

Diphenyl ditelluride anticancer activity and DNA topoisomerase I poisoning in human colon cancer HCT116 cells Research Paper

Potential repurposing of DPP4 inhibitors for target therapy resistance in renal cell carcinoma Editorial

Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer Research Paper

The dark side of PLK1: Implications for cancer and genomic instability Editorial

Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment Research Paper

Targeting the Src N-terminal regulatory element in cancer Research Perspective

Targeting cellular respiration as a therapeutic strategy in glioblastoma Research Perspective

Using cancer proteomics data to identify gene candidates for therapeutic targeting Research Perspective

The molecular dialogue between the tumor cells and fibroblasts Editorial

A phase I trial of riluzole and sorafenib in patients with advanced solid tumors: CTEP #8850 Research Paper

Selective protection of normal cells from chemotherapy, while killing drug-resistant cancer cells Review

Spleen tyrosine kinase/FMS-like tyrosine kinase-3 inhibition in relapsed/refractory B-cell lymphoma, including diffuse large B-cell lymphoma: updated data with mivavotinib (TAK-659/CB-659) Research Paper

Candidate drugs associated with sensitivity of cancer cell lines with DLST amplification or high mRNA levels Research Paper

Targeting CD74 in B-cell non-Hodgkin lymphoma with the antibody-drug conjugate STRO-001 Research Paper

Anti-tumor effect of antibody drug conjugate ASP1235 targeting Fms-like tyrosine kinase 3 with venetoclax plus azacitidine in an acute myeloid leukemia xenograft mouse model Research Paper

Resistance of MMTV-NeuT/ATTAC mice to anti-PD-1 immune checkpoint therapy is associated with macrophage infiltration and Wnt pathway expression Research Paper

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway Research Paper

Nectin-4 is widely expressed in head and neck squamous cell carcinoma Research Paper