The Oncosearch | Oncotarget

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

Benigno C. Valdez, Apostolia M. Tsimberidou, Bin Yuan, Yago Nieto, Mehmet A. Baysal, Abhijit Chakraborty, Clark R. Andersen, Borje S. Andersson

Published May 25, 2024 · Vol. 15, No. 1 · pp. 361-373

Keywords: decitabine, HDAC inhibitors, pancreatic cancer, PARP inhibitors, synergistic cytotoxicity

The importance of integrated therapies on cancer: Silibinin, an old and new molecule Review

Elisa Roca, Giuseppe Colloca, Fiorella Lombardo, Andrea Bellieni, Alessandra Cucinella, Giorgio Madonia, Licia Martinelli, Maria Elisa Damiani, Ilaria Zampieri, Antonio Santo

Published May 14, 2024 · Vol. 15, No. 1 · pp. 345-353

Keywords: silibinin, anti-inflammatory, inflammation, toxicity, integrated therapy

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

Laurence Booth, Jane L. Roberts, Ivan Spasojevic, Kaitlyn C. Baker, Andrew Poklepovic, Cameron West, John M. Kirkwood, Paul Dent

Published May 9, 2024 · Vol. 15, No. 1 · pp. 328-344

Keywords: autophagy, ER stress, GZ17-6.02, doxorubicin, afatinib, neratinib

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

Lulzim Shkreta, Johanne Toutant, Aurélie Delannoy, David Durantel, Anna Salvetti, Sophie Ehresmann, Martin Sauvageau, Julien A. Delbrouck, Alice Gravel-Trudeau, Christian Comeau, Caroline Huard, Jasmin Coulombe-Huntington, Mike Tyers, David Grierson, Pierre-Luc Boudreault, Benoit Chabot

Published May 9, 2024 · Vol. 15, No. 1 · pp. 313-325

Keywords: CLK kinases inhibitors, EMT, antiviral immune response, microtubules, metastasis

Novel therapeutic bispecific antibodies for B-cell lymphoma targeting IgM and other antigens on the B-cell surface Research Paper

Takahiro Ohashi, Sayuri Terada, Shinsuke Hiramoto, Yuko Nagata, Hirokazu Suzuki, Hitoshi Miyashita, Tetsuo Sasaki, Yasukatsu Tsukada, Keiko Fukushima

Published Mar 29, 2024 · Vol. 15, No. 1 · pp. 256-274

Keywords: bispecific antibody, Cys1m, IgM, lymphoma, cynomolgus monkey

ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells Research Paper

Benigno C. Valdez, Bin Yuan, David Murray, Jeremy L. Ramdial, Uday Popat, Yago Nieto, Borje S. Andersson

Published Feb 21, 2024 · Vol. 15, No. 1 · pp. 220-231

Keywords: acute myeloid leukemia, pre-transplant regimens, venetoclax, thiotepa, busulfan

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

Thomas M. Cardillo, Maria B. Zalath, Roberto Arrojo, Robert M. Sharkey, Serengulam V. Govindan, Chien-Hsing Chang, David M. Goldenberg

Published Jan 30, 2024 · Vol. 15, No. 1 · pp. 144-158

Keywords: sacituzumab govitecan, Trop-2, SN-38, carboplatin, cisplatin

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

Laurence Booth, Jane L. Roberts, Cameron West, Paul Dent

Published Jan 29, 2024 · Vol. 15, No. 1 · pp. 159-174

Keywords: autophagy, ER stress, GZ17-6.02, bortezomib, proteasome inhibitor

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

Michael R. Booth, Laurence Booth, Jane L. Roberts, Cameron West, Paul Dent

Published Jan 29, 2024 · Vol. 15, No. 1 · pp. 124-133

Keywords: autophagy, ER stress, GZ17-6.02, bexarotene, vorinostat

The fate of drug discovery in academia; dumping in the publication landfill? Editorial

Uzma Saqib, Isaac S. Demaree, Alexander G. Obukhov, Mirza S. Baig, Amiram Ariel, Krishnan Hajela

Published Jan 6, 2024 · Vol. 15, No. 1 · pp. 31-34

Keywords: drug discovery and development, clinical trials, academia-industry collaboration, translational research, drug database

ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines Research Paper

Mathew Lozinski, Nikola A. Bowden, Moira C. Graves, Michael Fay, Bryan W. Day, Brett W. Stringer, Paul A. Tooney

Published Jan 5, 2024 · Vol. 15, No. 1 · pp. 1-18

Keywords: glioblastoma, DNA damage response, ataxia-telangiectasia and rad3-related protein, radiation therapy, temozolomide

Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation Research Perspective

Mark Lee, Luc GT Morris

Published Dec 15, 2023 · Vol. 15, No. 1 · pp. 36-48

Keywords: thyroid cancer, drug resistance, anaplastic transformation, BRAF inhibitors, PIK3CA

The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies Research Paper

Fusheng Zhou, Lili Tang, Siyuan Le, Mei Ge, Dragan Cicic, Fubo Xie, Jinmin Ren, Jiong Lan, Qiang Lu

Published Dec 9, 2023 · Vol. 14, No. 1 · pp. 997-1008

Keywords: GFH009, CDK9, cancer, leukemia, cell cycle

Current perspectives on the management of refractory or relapsed classic hodgkin lymphoma in Brazil: Balancing efficacy, safety, and tolerability Review

Flávia Dias Xavier, Danielle Leão Cordeiro de Farias, Abrahão Elias Hallack Neto, Glaciano Nogueira Ribeiro, Marco Aurelio Salvino de Araujo, Thiago Xavier Carneiro, Otavio Cesar Carvalho Guimarães Baiocchi

Published Dec 5, 2023 · Vol. 14, No. 1 · pp. 977-994

Keywords: brentuximab vedotin, drug therapy, hodgkin lymphoma, nivolumab, pembrolizumab

Osteopontin induces mitochondrial biogenesis in deadherent cancer cells Research Paper

Gulimirerouzi Fnu, Georg F. Weber

Published Nov 24, 2023 · Vol. 14, No. 1 · pp. 957-969

Keywords: metastasis, metabolism, anchorage independence, mitochondrial mass, peroxide

Plasma levels of BCMA-positive extracellular vesicles correlate to response and side effects in myeloma patients treated with belantamab-mafodotin Research Paper

Carsten Springer, Jürgen Krauter, Arne Trummer

Published Nov 23, 2023 · Vol. 14, No. 1 · pp. 949-956

Keywords: myeloma, b cell maturation antigen, extracellular vesicles, belantamab-mafodotin, eryptosis

Melatonin and carcinogenesis in mice: the 50th anniversary of relationships Research Perspective

Vladimir N. Anisimov, Alexey G. Golubev

Published Nov 22, 2023 · Vol. 14, No. 1 · pp. 972-976

Keywords: cancer, melatonin, mice

FAAH inhibition ameliorates breast cancer in a murine model Research Paper

Mallika Tripathy, Amy Bui, Jared Henderson, Jeffrey Sun, Christian Rutan Woods, Soumya Somani, Thao Doan, Anto Sam Crosslee Louis Sam Titus, Chandra Mohan

Published Oct 26, 2023 · Vol. 14, No. 1 · pp. 910-918

Keywords: FAAH, breast cancer, cancer therapy, apoptosis

Inhibiting BRAF/EGFR/MEK suppresses cancer stemness and drug resistance of primary colorectal cancer cells Research Paper

Astha Lamichhane, Gary D. Luker, Seema Agarwal, Hossein Tavana

Published Sep 25, 2023 · Vol. 14, No. 1 · pp. 879-889

Keywords: drug resistance, cancer stem cells, patient-derived tumor model, colorectal cancer, combination treatment

Genetic and therapeutic landscapes in cohort of pancreatic adenocarcinomas: next-generation sequencing and machine learning for full tumor exome analysis Research Paper

P.A. Shatalov, N.A. Falaleeva, E.A. Bykova, D.O. Korostin, V.A. Belova, A.A. Zabolotneva, A.P. Shinkarkina, A. Yu Gorbachev, M.B. Potievskiy, V.S. Surkova, Zh V. Khailova, N.A. Kulemin, Denis Baranovskii, A.A. Kostin, A.D. Kaprin, P.V. Shegai

Published Sep 13, 2023 · Vol. 15, No. 1 · pp. 91-103

Keywords: pancreatic cancer, tumor mutation burden, somatic mutations, artificial intelligence, machine learning

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Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

The importance of integrated therapies on cancer: Silibinin, an old and new molecule Review

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

Novel therapeutic bispecific antibodies for B-cell lymphoma targeting IgM and other antigens on the B-cell surface Research Paper

ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells Research Paper

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

The fate of drug discovery in academia; dumping in the publication landfill? Editorial

ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines Research Paper

Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation Research Perspective

The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies Research Paper

Current perspectives on the management of refractory or relapsed classic hodgkin lymphoma in Brazil: Balancing efficacy, safety, and tolerability Review

Osteopontin induces mitochondrial biogenesis in deadherent cancer cells Research Paper

Plasma levels of BCMA-positive extracellular vesicles correlate to response and side effects in myeloma patients treated with belantamab-mafodotin Research Paper

Melatonin and carcinogenesis in mice: the 50th anniversary of relationships Research Perspective

FAAH inhibition ameliorates breast cancer in a murine model Research Paper

Inhibiting BRAF/EGFR/MEK suppresses cancer stemness and drug resistance of primary colorectal cancer cells Research Paper

Genetic and therapeutic landscapes in cohort of pancreatic adenocarcinomas: next-generation sequencing and machine learning for full tumor exome analysis Research Paper

Publication Alerts

European Cancer and Oncology Congress

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Post-Publication Promotion

Search Oncotarget

Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy Research Paper

The importance of integrated therapies on cancer: Silibinin, an old and new molecule Review

GZ17-6.02 kills PDX isolates of uveal melanoma Research Paper

The anticancer potential of the CLK kinases inhibitors 1C8 and GPS167 revealed by their impact on the epithelial-mesenchymal transition and the antiviral immune response Research Paper

Novel therapeutic bispecific antibodies for B-cell lymphoma targeting IgM and other antigens on the B-cell surface Research Paper

ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells Research Paper

Sacituzumab govitecan plus platinum-based chemotherapy mediates significant antitumor effects in triple-negative breast, urinary bladder, and small-cell lung carcinomas Research Paper

GZ17-6.02 interacts with proteasome inhibitors to kill multiple myeloma cells Research Paper

GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells Research Paper

The fate of drug discovery in academia; dumping in the publication landfill? Editorial

ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines Research Paper

Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation Research Perspective

The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies Research Paper

Current perspectives on the management of refractory or relapsed classic hodgkin lymphoma in Brazil: Balancing efficacy, safety, and tolerability Review

Osteopontin induces mitochondrial biogenesis in deadherent cancer cells Research Paper

Plasma levels of BCMA-positive extracellular vesicles correlate to response and side effects in myeloma patients treated with belantamab-mafodotin Research Paper

Melatonin and carcinogenesis in mice: the 50th anniversary of relationships Research Perspective

FAAH inhibition ameliorates breast cancer in a murine model Research Paper

Inhibiting BRAF/EGFR/MEK suppresses cancer stemness and drug resistance of primary colorectal cancer cells Research Paper

Genetic and therapeutic landscapes in cohort of pancreatic adenocarcinomas: next-generation sequencing and machine learning for full tumor exome analysis Research Paper