The Oncosearch | Oncotarget

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Francesca Chiarini, Annalisa Lonetti, Gabriella Teti, Ester Orsini, Daniela Bressanin, Alessandra Cappellini, Francesca Ricci, Pier Luigi Tazzari, Andrea Ognibene, Mirella Falconi, Pasqualepaolo Pagliaro, Ilaria Iacobucci, Giovanni Martinelli, Sergio Amadori, James A McCubrey, Alberto M Martelli

Published Dec 18, 2012 · Vol. 3, No. 12 · pp. 1615-1628

Keywords: AML, PI3K/Akt/mTOR signaling, apoptosis, autophagy combination therapy, leukemia initiating cells

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Laura Lehtinen, Kirsi Ketola, Rami MÃ¤kelÃ¤, John-Patrick Mpindi, Miro Viitala, Olli Kallioniemi, Kristiina Iljin

Published Dec 17, 2012 · Vol. 4, No. 1 · pp. 48-63

Keywords: Breast cancer, vimentin, MTHFD2

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

Takayuki Yoshida, Junya Kakegawa, Takayuki Yamaguchi, Yoshiji Hantani, Nobuyuki Okajima, Toshiyuki Sakai, Yoshihiro Watanabe, Motonao Nakamura

Published Dec 1, 2012 · Vol. 3, No. 12 · pp. 1533-1545

Keywords: MEK inhibitor, JTP-74057/GSK1120212/trametinib, chemical probe-affinity chromatography, target identification, unphosphorylated MEK (u-MEK)

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Kyung H Yi, Jossette Axtmayer, John P Gustin, Anandita Rajpurohit, Josh Lauring

Published Nov 29, 2012 · Vol. 4, No. 1 · pp. 29-34

Keywords: AKT1, mutation, personalized, cancer, therapy

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) Research Paper

Harald Herrmann, Katharina Blatt, Junwei Shi, Karoline V. Gleixner, Sabine Cerny-Reiterer, Leonhard MÃ¼llauer, Christopher R. Vakoc, Wolfgang R. Sperr, Hans-Peter Horny, James E. Bradner, Johannes Zuber, Peter Valent

Published Nov 27, 2012 · Vol. 3, No. 12 · pp. 1588-1599

Keywords: AML, leukemic stem cells, BRD4, JQ1, targeted therapy

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

Swapna Asuthkar, Kiran Kumar Velpula, Chandramu Chetty, Bharathi Gorantla, Jasti S. Rao

Published Nov 16, 2012 · Vol. 3, No. 11 · pp. 1439-1454

Keywords: Matrix metalloproteinase-9 (MMP-9), microRNA-211 (miR-211), Cancer Stem Cells (CSC), Ionizing radiation (IR) and Temozolomide (Tem)

High-Throughput Chemical Screens Identify Disulfiram as an Inhibitor of Human Glioblastoma Stem Cells Research

Parvinder Hothi, Timothy J. Martins, LiPing Chen, Loic Deleyrolle, Jae-Geun Yoon, Brent Reynolds, Greg Foltz

Published Oct 23, 2012 · Vol. 3, No. 10 · pp. 1124-1136

Keywords: disulfiram, glioblastoma, high-throughput chemical screens, stem cells

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

William H Chappell, Stephen L. Abrams, Richard A Franklin, Giuseppe Montalto, Melchiorre Cervello, Alberto M Martelli, Saverio Candido, Massimo Libra, Jerry Polesel, Renato Talamini, Ralph Arlinghaus, Linda S Steelman, James A McCubrey

Published Oct 20, 2012 · Vol. 3, No. 10 · pp. 1236-1245

Keywords: NGAL, Lcn2, Doxorubicin, lipocalins, siderocalins, iron transport, MMP-9, drug resistance

Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glioblastoma and overrides resistance to temozolomide Research

Joanna Triscott, Cathy Lee, Kaiji Hu, Abbas Fotovati, Rachel Berns, Mary Pambid, Margaret Luk, Richard E Kast, Esther Kong, Eric Toyota, Stephen Yip, Brian Toyota, Sandra E Dunn

Published Oct 8, 2012 · Vol. 3, No. 10 · pp. 1112-1123

Keywords: glioblastoma, disulfiram, temozolomide, brain tumor, drug resistance

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

James Andrew McCubrey, Linda Steeman, William Chappell, Stephen Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria Mazzarino, Saverio Candido, Massimo Libra, Jorg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto Martelli

Published Sep 20, 2012 · Vol. 3, No. 9 · pp. 954-987

Keywords: targeted therapy, therapy resistance, mutations, Raf, Akt, PI3K, mTOR

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity Review

Gerald J Prud'homme, Yelena Glinka

Published Sep 3, 2012 · Vol. 3, No. 9 · pp. 921-939

Keywords: angiogenesis, cancer stem cell, growth factor, neuropilin, semaphorin, TGF-beta, VEGF

Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers Research Paper

Roberto Perez, Andrew V Schally, Irving Vidaurre, Ricardo Rincon, Norman L Block, Ferenc G Rick

Published Aug 30, 2012 · Vol. 3, No. 9 · pp. 988-997

Keywords: neuropeptide analog, tumor gene expression, receptor silencing, targeted therapy, inflammation

Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells Research Paper

Baolin Zhang, Jun-Jie Chen, Jennifer H.-C. Shen, Leslie Rivera Rosado, Yaqin Zhang, Xu Di

Published Aug 19, 2012 · Vol. 3, No. 8 · pp. 833-842

Keywords: death receptors, cellular localization, breast cancer, targeted cancer therapy, drug resistance

Meta-analysis of clinical data using human meiotic genes identifies a novel cohort of highly restricted cancer-specific marker genes. Research Paper

Julia Feichtinger, Ibrahim Aldeailej, Rebecca Anderson, Mikhlid Almatrafi, Naif Alsiwiehri, keith Griffiths, Nicholas Stuart, Jane A Wakeman, Lee Larcombe, Ramsay James McFarlane

Published Aug 13, 2012 · Vol. 3, No. 8 · pp. 843-853

Keywords: cancer biomarkers, cancer testes antigens, oncogenes, meiosis, PRDM9, cohesins drug targets

A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing Research Paper

Kalpesh Patel, Sashidhar R. Yerram, Nilofer A. Azad, Scott E. Kern

Published Jul 22, 2012 · Vol. 3, No. 7 · pp. 678-685

Keywords: ternary complex, thymidylate synthase, drug adduct, drug adduct-specific antibody, ternary complex-specific antibody, FTS

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells Research Perspective

Mikhail V. Blagosklonny

Published Jul 12, 2012 · Vol. 3, No. 6 · pp. 601-607

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper

Efrat Mashiach Farkash, Roni Rak, Galit Elad-Sfadia, Roni Haklai, Shmuel Carmeli, Yoel Kloog, Haim Wolfson

Published Jul 7, 2012 · Vol. 3, No. 6 · pp. 629-639

Keywords: Cofilin, Ras, Rac, Rho, LIMK

Targeting of Rac GTPases blocks the spread of intact human breast cancer Research Paper

Elad Katz, Andrew H. Sims, Duncan Sproul, Helen Caldwell, J. Michael Dixon, Richard R. Meehan, David J. Harrison

Published Jun 9, 2012 · Vol. 3, No. 6 · pp. 608-619

Keywords: breast cancer, gtpases, rac1, stat3, invasion

Clinical utility of gene-expression profiling for tumor-site origin in patients with metastatic or poorly differentiated cancer: impact on diagnosis, treatment, and survival Research Paper

J Scott Nystrom, John C. Hornberger, Gauri R. Varadhachary, Richard J. Hornberger, Hialy R. Gutierrez, W. David Henner, Shawn H. Becker, Mahul B. Amin, Michael G. Walker

Published Jun 9, 2012 · Vol. 3, No. 6 · pp. 620-628

Keywords: cancer of unknown primary, diagnosis, genomics, clinical utility, tissue of origin

Cell-based high-throughput screens for the discovery of chemotherapeutic agents Research Perspective

Jennifer T Fox, Kyungiae Myung

Published May 29, 2012 · Vol. 3, No. 5 · pp. 581-585

Keywords: ATAD5-luciferase, genotoxins, DNA repair mutants, cancer, drug discovery

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A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) Research Paper

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

High-Throughput Chemical Screens Identify Disulfiram as an Inhibitor of Human Glioblastoma Stem Cells Research

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glioblastoma and overrides resistance to temozolomide Research

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity Review

Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers Research Paper

Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells Research Paper

Meta-analysis of clinical data using human meiotic genes identifies a novel cohort of highly restricted cancer-specific marker genes. Research Paper

A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing Research Paper

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells Research Perspective

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper

Targeting of Rac GTPases blocks the spread of intact human breast cancer Research Paper

Clinical utility of gene-expression profiling for tumor-site origin in patients with metastatic or poorly differentiated cancer: impact on diagnosis, treatment, and survival Research Paper

Cell-based high-throughput screens for the discovery of chemotherapeutic agents Research Perspective

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) Research Paper

Epigenetic Regulation of miRNA-211 by MMP-9 Governs Glioma Cell Apoptosis, Chemosensitivity and Radiosensitivity Research Paper

High-Throughput Chemical Screens Identify Disulfiram as an Inhibitor of Human Glioblastoma Stem Cells Research

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glioblastoma and overrides resistance to temozolomide Research

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity Review

Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers Research Paper

Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells Research Paper

Meta-analysis of clinical data using human meiotic genes identifies a novel cohort of highly restricted cancer-specific marker genes. Research Paper

A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing Research Paper

Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells Research Perspective

Computer-Based Identification of a Novel LIMK1/2 Inhibitor that Synergizes with Salirasib to Destabilize the Actin Cytoskeleton Research Paper

Targeting of Rac GTPases blocks the spread of intact human breast cancer Research Paper

Clinical utility of gene-expression profiling for tumor-site origin in patients with metastatic or poorly differentiated cancer: impact on diagnosis, treatment, and survival Research Paper

Cell-based high-throughput screens for the discovery of chemotherapeutic agents Research Perspective