The Oncosearch | Oncotarget

A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma. Research Paper

Francesco Sottile, Ilaria Gnemmi, Sandra Cantilena, Walter C. D'Acunto, Arturo Sala

Published May 19, 2012 · Vol. 3, No. 5 · pp. 535-545

Keywords: Neuroblastoma, chemotherapeutic drug, oncogene, transcription

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper

Elisabeth J. Walsby, Laurence Pearce, Alan K. Burnett, Chris Fegan, Chris Pepper

Published May 19, 2012 · Vol. 3, No. 5 · pp. 525-534

Keywords: Hsp90, CLL, apoptosis, synergy, NF-ÎºB

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment Review

Alberto M. Martelli, Francesca Chiarini, Camilla Evangelisti, Alessandra Cappellini, Francesca Buontempo, Daniela Bressanin, Milena Fini, James A. McCubrey

Published May 4, 2012 · Vol. 3, No. 4 · pp. 371-394

Keywords: apoptosis, leukemia initiating cells, mRNA translation, PI3K/Akt/mTOR, targeted therapy

Drug-Targeted Inhibition of Peroxisome Proliferator-Activated Receptorγ Enhances the Chemopreventive Effect of Anti-Estrogen Research Paper

Hongyan Yuan, Levy Kopelovich, Yuzhi Yin, Jin Lu, Robert I Glazer

Published Apr 13, 2012 · Vol. 3, No. 3 · pp. 345-358

Keywords: PPAR-gamma, GW9662, mammary tumorigenesis, gene expression profile

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Changping Li, Michael A. Thompson, Archito T. Tamayo, Zhuang Zuo, John Lee, Francisco Vega, Richard J. Ford, Lan V. Pham

Published Mar 23, 2012 · Vol. 3, No. 3 · pp. 314-326

Keywords: Trx-1, chemoresistance, DLBCL, cellular redox

Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice Brief Reports

Carolina Vicente-DueÃ±as, Marcos Barajas-Diego, Isabel Romero-Camarero, Ines Gonzalez-Herrero, Teresa Flores, Isidro Sanchez-Garcia

Published Mar 8, 2012 · Vol. 3, No. 3 · pp. 261-266

Keywords: cancer, cancer stem cells (CSC), stem cells, mouse models, Telomerase inhibitors, drug discovery

Targeting Mnks for Cancer Therapy Review

Jinqiang Hou, Frankie Kam, Christopher G Proud, Shudong Wang

Published Mar 3, 2012 · Vol. 3, No. 2 · pp. 118-131

Keywords: eIF4E, Mnk, Ras, Raf, MAPK, Akt, PI3K, mTOR, Targeted Cancer Therapy, Structure based drug design, Mnk Inhibitors

Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes Research Paper

Elizabeta Aizman, Adi Mor, Ayelet Levy, Jacob George, Yoel Kloog

Published Feb 7, 2012 · Vol. 3, No. 2 · pp. 144-157

Keywords: Ras, Glioblastoma, CTL, FTS, Salirasib

Curtailing side effects in chemotherapy: a tale of PKCÎ´ in cisplatin treatment Research Perspective

Navjotsingh Pabla, Zheng Dong

Published Jan 31, 2012 · Vol. 3, No. 1 · pp. 107-111

Keywords: cisplatin, chemotherapy, side effect, protein kinase C Î´

Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in cancer Research Perspective

Helen M. Coley, Eleftheria Hatzmichael, Sarah P. Blagden, Iain A. McNeish, Alastair Thompson, Tim Crook, Nelofer Syed

Published Jan 28, 2012 · Vol. 3, No. 1 · pp. 78-83

Keywords: PLK2, drug resistance, ovarian cancer

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer Research Paper

Roland H. Stauber, Shirley K. Knauer, Negusse Habtemichael, Carolin Bier, Britta Unruhe, Simona Weisheit, Stephanie Spange, Frank Nonnenmacher, Verena Fetz, Torsten Ginter, Sigrid Reichardt, Claus Liebmann, GÃ¼nter Schneider, Oliver H. KrÃ¤mer

Published Jan 28, 2012 · Vol. 3, No. 1 · pp. 31-43

Keywords: apoptosis, BH3-only protein, chemotherapy, hydroxyurea, oral cancer, therapy resistance, tumor xenograft, valproic acid

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target Review

Mourad Sanhaji, Claire T Friel, Linda Wordeman, Frank Louwen, Juping Yuan

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 935-947

Keywords: MCAK, mitotic kinases, chromosome instability, drug resistance, invasiveness

Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1 Research Paper

Yan Hu, Mary L. Spengler, Karen K. Kuropatwinski, Maria Comas, Marilyn Jackson, Mikhail V. Chernov, Anatoly S. Gleiberman, Natalia Fedtsova, Youcef M. Rustum, Andrei V. Gudkov, Marina Antoch

Published Dec 31, 2011 · Vol. 2, No. 12 · pp. 1279-1290

Keywords: L-Methyl-selenocysteine, TIEG1, circadian rhythms, cyclophosphamide, anticancer treatment, liver, transcription

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review

Sharmin Esmailzadeh, Xiaoyan Jiang

Published Dec 30, 2011 · Vol. 2, No. 12 · pp. 918-934

Keywords: AHI-1, oncogene, CML, CTCL, AHI-1-BCR-ABL-JAK2 interaction complex, tyrosine kinase inhibitors, leukemic stem cells, TKI resistance

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1) Research Paper

Nancy Liu-Sullivan, Jianping Zhang, Amy Bakleh, John Marchica, Jinyu Li, Despina Siolas, Sylvie Laquerre, Yan Y. Degenhardt, Richard Wooster, Kenneth Chang, Gregory J. Hannon, Scott Powers

Published Dec 30, 2011 · Vol. 2, No. 12 · pp. 1254-1264

Keywords: Polo-like kinase 1, shRNA library screening, retinoids, combination therapy strategies

Metformin: Multi-faceted protection against cancer Review

Sonia Del Barco, Alejandro Vazquez-Martin, SÃlvia CufÃ, Cristina Oliveras-Ferraros, Joaquim Bosch-Barrera, Jorge Joven, BegoÃ±a Martin-Castillo, Javier A Menendez

Published Dec 24, 2011 · Vol. 2, No. 12 · pp. 896-917

Keywords: Diabetes, cancer, metformin, cancer stem cells, senescence

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation Research Paper

Michal Sheffer, Amos J. Simon, Jasmine Jacob-Hirsch, Gideon Rechavi, Eytan Domany, David Givol, Gabriella D'Orazi

Published Dec 24, 2011 · Vol. 2, No. 12 · pp. 1191-1202

Keywords: hypoxia, cobalt, pathway analysis, Principal Component Analysis (PCA), cDNA microarray, colon cancer

Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins Research Paper

Paula Vainio, Laura Lehtinen, Tuomas Mirtti, Mika Hilvo, Tuulikki SeppÃ¤nen-Laakso, Johannes Virtanen, Anna Sankila, Stig Nordling, Johan Lundin, Antti Rannikko, Matej OreÅ¡iÄ, Olli Kallioniemi, Kristiina Iljin

Published Dec 22, 2011 · Vol. 2, No. 12 · pp. 1176-1190

Keywords: Prostate cancer, PLA2G7, drug target, biomarker, statins

TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death Research Paper

Naveen Muppani, Ulrika Nyman, Bertrand Joseph

Published Dec 22, 2011 · Vol. 2, No. 12 · pp. 1145-1154

Keywords: p73, caspase-2, cancer, apoptosis

Finding cancerâ€™s weakest link Research Perspective

Nicole Michel Sodir, Gerard I. Evan

Published Dec 22, 2011 · Vol. 2, No. 12 · pp. 1307-1313

Keywords: Myc inhibition, tumor, microenvironment, cancer therapeutics

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma. Research Paper

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment Review

Drug-Targeted Inhibition of Peroxisome Proliferator-Activated Receptorγ Enhances the Chemopreventive Effect of Anti-Estrogen Research Paper

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice Brief Reports

Targeting Mnks for Cancer Therapy Review

Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes Research Paper

Curtailing side effects in chemotherapy: a tale of PKCÎ´ in cisplatin treatment Research Perspective

Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in cancer Research Perspective

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer Research Paper

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target Review

Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1 Research Paper

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1) Research Paper

Metformin: Multi-faceted protection against cancer Review

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation Research Paper

Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins Research Paper

TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death Research Paper

Finding cancerâ€™s weakest link Research Perspective

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma. Research Paper

The Hsp90 inhibitor NVP-AUY922-AG inhibits NF-ÎºB signaling, overcomes microenvironmental cytoprotection and is highly synergistic with fludarabine in primary CLL cells Research Paper

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment Review

Drug-Targeted Inhibition of Peroxisome Proliferator-Activated Receptorγ Enhances the Chemopreventive Effect of Anti-Estrogen Research Paper

Over-expression of Thioredoxin-1 mediates growth, survival, and chemoresistance and is a druggable target in diffuse large B-cell lymphoma Research Paper

Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice Brief Reports

Targeting Mnks for Cancer Therapy Review

Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes Research Paper

Curtailing side effects in chemotherapy: a tale of PKCÎ´ in cisplatin treatment Research Perspective

Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in cancer Research Perspective

A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer Research Paper

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target Review

Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1 Research Paper

AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disorders Review

Pooled shRNA screen for sensitizers to inhibition of the mitotic regulator polo-like kinase (PLK1) Research Paper

Metformin: Multi-faceted protection against cancer Review

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation Research Paper

Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins Research Paper

TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death Research Paper

Finding cancerâ€™s weakest link Research Perspective