The Oncosearch | Oncotarget

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

Kristin Beebe, Mehdi Mollapour, Bradley Scroggins, Chrisostomos Prodromou, Wanping Xu, Mari Tokita, Tony Taldone, Lester Pullen, Bettina K Zierer, Min-Jung Lee, Jane Trepel, Johannes Buchner, Daniel Bolon, Gabriela Chiosis, Len Neckers

Published Jul 7, 2013 · Vol. 4, No. 7 · pp. 1065-1074

Keywords: Hsp90, posttranslational modification, phosphorylation, drug binding, Hsp90 inhibitor

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells Research Paper

Yong Weon Yi, Hyo Jin Kang, Hee Jeong Kim, Yali Kong, Milton M. Brown, Insoo Bae

Published Jul 5, 2013 · Vol. 4, No. 7 · pp. 984-994

Keywords: mutant p53 (mtp53), deacetylation, SIRT1, activator, triple-negative breast cancer (TNBC)

Radiation therapy induces the DNA damage response in peripheral blood Research Paper

Christopher J Bakkenist, R Kenneth Czambel, David A Clump, Joel S Greenberger, Jan H Beumer, John C Schmitz

Published Jun 26, 2013 · Vol. 4, No. 8 · pp. 1143-1148

Keywords: DNA damage response, ATM

Plasma Membrane Proteomics Identifies Biomarkers Associated with MMSET Overexpression in T(4;14) Multiple Myeloma Research Paper

Zhigang Xie, Jayantha Gunaratne, Lip Lee Cheong, Shaw Cheng Liu, Tze Loong Koh, Gaofeng Huang, Walter P Blackstock, Wee Joo Chng

Published Jun 26, 2013 · Vol. 4, No. 7 · pp. 1008-1018

Keywords: SILAC, quantitative proteomics, oncotargets, multiple myeloma

Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5 Research Paper

Huabo Wang, Jay Chauhan, Angela Hu, Kelsey Pendleton, Jeremy L. Yap, Philip E. Sabato, Jace W. Jones, Mariarita Perri, Jianshi Yu, Erika Cione, Maureen A. Kane, Steven Fletcher, Edward V. Prochownik

Published Jun 22, 2013 · Vol. 4, No. 6 · pp. 936-949

Keywords: 10058-F4, 10074-G5, intrinsically disordered proteins, JQ-1, BRD4

FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Research Paper

Rocky Cipriano, Kristy L.S. Miskimen, Benjamin L. Bryson, Chase R. Foy, Courtney A. Bartel, Mark W Jackson

Published May 11, 2013 · Vol. 4, No. 5 · pp. 729-738

Keywords: FAM83B, transformation, drug resistance, CRAF, PI3K

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

Yaoyu Chen, Jinyun Chen, Alice Loo, Savina Jaeger, Linda Bagdasarian, Jianjun Yu, Franklin Chung, Joshua Korn, David Ruddy, Ribo Guo, Margaret Mclaughlin, Fei Feng, Ping Zhu, Frank Stegmeier, Raymond Pagliarini, Dale Porter, Wenlai Zhou

Published Apr 23, 2013 · Vol. 4, No. 6 · pp. 816-829

Keywords: HSF1, cancer cells, HSP90 inhibitor, Melanoma, HCC, DEDD2

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Review

Richard E. Kast, John A. Boockvar, Ansgar BrÃ¼ning, Francesco Cappello, Wen-Wei Chang, Boris Cvek, Q Ping Dou, Alfonso Duenas-Gonzalez, Thomas Efferth, Daniele Focosi, Seyed H. Ghaffari, Georg Karpel-Massler, Kirsi Ketola, Alireza Khoshnevisan, Daniel Keizman, Nicolas MagnÃ©, Christine Marosi, Kerrie McDonald, Miguel MuÃ±oz, Nathan David Sassoon, Mohammad H. Pourgholami, Iacopo Sardi, Avishay Sella, Kalkunte S. Srivenugopal, Marco Tuccori, Weiguang Wang, Christian R. Wirtz, Marc-Eric Halatsch

Published Apr 13, 2013 · Vol. 4, No. 4 · pp. 502-530

Keywords: angiotensin, aprepitant, artesunate, auranofin, captopril, cytokines, disulfiram, glioblastoma, ketoconazole, nelfinavir, neurokinin, sertraline, temozolomide

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

Mark J Axelrod, Vicki Gordon, Mark Conaway, Adel Tarcsafalvi, Daniel J Neitzke, Daniel Gioeli, Michael J Weber

Published Apr 10, 2013 · Vol. 4, No. 4 · pp. 622-635

Keywords: Targeted therapies, Compensatory signaling, Pathway interactions, Crosstalk, Feedback inhibition

Drug-Loaded Nanoparticle Systems And Adult Stem Cells: A Potential Marriage For The Treatment Of Malignant Glioma? Review

Brenda Auffinger, Ramin Morshed, Alex Tobias, Yu Cheng, Atique U Ahmed, Maciej S Lesniak

Published Mar 26, 2013 · Vol. 4, No. 3 · pp. 378-396

Keywords: Nanoparticle, drug delivery systems, stem cell carriers, malignant glioma, brain cancer, targeted delivery

Linked-In: Design and Efficacy of Antibody Drug Conjugates in Oncology Review

Jonathan Feld, Stefan K. Barta, Carolina Schinke, Ira Braunschweig, Yiyu Zhou, Amit K. Verma

Published Mar 26, 2013 · Vol. 4, No. 3 · pp. 397-412

Keywords: antibody drug conjugates, oncotargets, immunotoxins

Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating/Aging, Rapidly Growing/Immortal, and Senescent Cells Research Paper

Jin Ho Oh, Arkadiusz Gertych, Jian Tajbakhsh

Published Mar 26, 2013 · Vol. 4, No. 3 · pp. 474-493

Keywords: DNA methylation, chromatin condensation, cell proliferation, aging, senescence, cancer, 3D imaging, cell-by-cell analysis

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Kristen M. Reipas, Jennifer H. Law, Nicole Couto, Sumaiya Islam, Yvonne Li, Huifang Li, Artem Cherkasov, Karen Jung, Amarpal S. Cheema, Steven J.M. Jones, John A. Hassell, Sandra E. Dunn

Published Feb 27, 2013 · Vol. 4, No. 2 · pp. 329-345

Keywords: Triple-negative breast cancer, p90 ribosomal S6 kinase, Y-box binding protein-1, tumor-initiating cells, drug repositioning

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

Raya Faigenbaum, Roni Haklai, Gilad Ben-Baruch, Yoel Kloog

Published Feb 27, 2013 · Vol. 4, No. 2 · pp. 316-328

Keywords: Endometrial cancer, medroxyprogesterone acetate, FTS, Ras, ERÎ±, ERÎ²

TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5 Research Paper

Jun-jie Chen, Constantinos M. Mikelis, Yaqin Zhang, J. Silvio Gutkind, Baolin Zhang

Published Feb 23, 2013 · Vol. 4, No. 2 · pp. 206-217

Keywords: oral cancer, TRAIL, death receptors, apoptosis, Ras, oncotarget

Targeted Therapy of Advanced Gallbladder Cancer and Cholangiocarcinoma with Aggressive Biology: Eliciting Early Response Signals from Phase 1 trials Research Paper

Ishwaria Subbiah, Vivek Subbiah, Apostolia M Tsimberidou, Aung Naing, Ahmed Kaseb, Javle Milind, Siqing Fu, David S Hong, Sarina Piha-Paul, Jenifer Wheler, Kenneth Hess, Filip Janku, Gerald Falchook, Robert A Wolff, Razelle Kurzrock

Published Jan 27, 2013 · Vol. 4, No. 1 · pp. 153-162

Keywords: Gallbladder Cancer, Cholangiocarcinoma, Phase 1 trials

Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer Research Paper

W. Nathaniel Brennen, Shuangling Chen, Samuel R. Denmeade, John T. Isaacs

Published Jan 13, 2013 · Vol. 4, No. 1 · pp. 106-117

Keywords: Mesenchymal Stem Cells, MSC, Inflammation, Prostate Cancer, Drug Delivery, CAF

Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2 Research Paper

Haoran Li, Burton B Yang

Published Dec 31, 2012 · Vol. 3, No. 12 · pp. 1653-1668

Keywords: microRNA, stem cell, miR-17, stress response, drug resistance

Enhancing the Efficacy of Drug-loaded Nanocarriers against Brain Tumors by Targeted Radiation Therapy Research Paper

Brian C. Baumann, Gary D. Kao, Abdullah Mahmud, Takamasa Harada, Joe Swift, Christina Chapman, Xiangsheng Xu, Dennis E. Discher, Jay F. Dorsey

Published Dec 23, 2012 · Vol. 4, No. 1 · pp. 64-79

Keywords: glioblastoma multiforme, nanocarrier, radiation therapy, brain tumors, chemotherapy

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

Suyoun Chung, Hanae Suzuki, Takashi Miyamoto, Naofumi Takamatsu, Ayako Tatsuguchi, Koji Ueda, Kyoko Kijima, Yusuke Nakamura, Yo Matsuo

Published Dec 21, 2012 · Vol. 3, No. 12 · pp. 1629-1640

Keywords: oncogene, drug discovery, kinase inhibitor, cancer stem cell

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Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells Research Paper

Radiation therapy induces the DNA damage response in peripheral blood Research Paper

Plasma Membrane Proteomics Identifies Biomarkers Associated with MMSET Overexpression in T(4;14) Multiple Myeloma Research Paper

Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5 Research Paper

FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Research Paper

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Review

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

Drug-Loaded Nanoparticle Systems And Adult Stem Cells: A Potential Marriage For The Treatment Of Malignant Glioma? Review

Linked-In: Design and Efficacy of Antibody Drug Conjugates in Oncology Review

Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating/Aging, Rapidly Growing/Immortal, and Senescent Cells Research Paper

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5 Research Paper

Targeted Therapy of Advanced Gallbladder Cancer and Cholangiocarcinoma with Aggressive Biology: Eliciting Early Response Signals from Phase 1 trials Research Paper

Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer Research Paper

Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2 Research Paper

Enhancing the Efficacy of Drug-loaded Nanocarriers against Brain Tumors by Targeted Radiation Therapy Research Paper

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

Targeting Mutant p53 by a SIRT1 Activator YK-3-237 Inhibits the Proliferation of Triple-Negative Breast Cancer Cells Research Paper

Radiation therapy induces the DNA damage response in peripheral blood Research Paper

Plasma Membrane Proteomics Identifies Biomarkers Associated with MMSET Overexpression in T(4;14) Multiple Myeloma Research Paper

Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5 Research Paper

FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Research Paper

Targeting HSF1 sensitizes cancer cells to HSP90 inhibition Research Paper

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Review

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

Drug-Loaded Nanoparticle Systems And Adult Stem Cells: A Potential Marriage For The Treatment Of Malignant Glioma? Review

Linked-In: Design and Efficacy of Antibody Drug Conjugates in Oncology Review

Nuclear DNA Methylation and Chromatin Condensation Phenotypes Are Distinct Between Normally Proliferating/Aging, Rapidly Growing/Immortal, and Senescent Cells Research Paper

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5 Research Paper

Targeted Therapy of Advanced Gallbladder Cancer and Cholangiocarcinoma with Aggressive Biology: Eliciting Early Response Signals from Phase 1 trials Research Paper

Quantification of Mesenchymal Stem Cells (MSCs) at Sites of Human Prostate Cancer Research Paper

Stress Response of Glioblastoma Cells Mediated by miR-17-5p Targeting PTEN and the Passenger Strand miR-17-3p Targeting MDM2 Research Paper

Enhancing the Efficacy of Drug-loaded Nanocarriers against Brain Tumors by Targeted Radiation Therapy Research Paper

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper