The Oncosearch | Oncotarget

Targeting Autophagy Addiction in Cancer Research Perspective

Joseph D. Mancias, Alec C. Kimmelman

Published Dec 19, 2011 · Vol. 2, No. 12 · pp. 1302-1306

Keywords: Autophagy, Ras, Metabolism, Cancer, tumor, therapy

Geminin overexpression induces mammary tumors via suppressing cytokinesis. Research Paper

Zannel Blanchard, Rohit Malik, Nicole Mullins, Christine Maric, Hugh Luk, David Horio, Brenda Hernandez, Jeffrey Killeen, Wael M. ElShamy

Published Dec 17, 2011 · Vol. 2, No. 12 · pp. 1011-1027

Keywords: Geminin, breast cancer, aneuploidy, Aurora B kinase, xenograft and orthotopic mouse tumors.

Pilot study of a pediatric metronomic 4-drug regimen Brief Reports

Nicolas AndrÃ©, Sylvie Abed, Daniel Orbach, Corinne Armari Alla, Laetitia Padovani, Eddy Pasquier, Jean Claude Gentet, Arnauld Verschuur

Published Dec 5, 2011 · Vol. 2, No. 12 · pp. 960-965

Keywords: cancer, children, paediatric, metronomic, angiogenesis, immunity

Systemic use of tumor necrosis factor alpha as an anticancer agent Review

Nicholas J. Roberts, Shibin Zhou, Luis A. Diaz, Matthias Holdhoff

Published Oct 27, 2011 · Vol. 2, No. 10 · pp. 739-751

Keywords: TNF-Î±, systemic, therapy

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 Research Paper

Sally-Anne Heasman, Lyubov Zaitseva, Kristian M. Bowles, Stuart A. Rushworth, David J. MacEwan

Published Sep 9, 2011 · Vol. 2, No. 9 · pp. 658-668

Keywords: drug-resistance, antioxidant, transcription factor, apoptosis, chemotherapy

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

Jackson R. Taylor, Brian D. Lehmann, William H. Chappell, Stephen L. Abrams, Linda S. Steelman, James A. McCubrey

Published Aug 30, 2011 · Vol. 2, No. 8 · pp. 610-626

Keywords: Akt, ERK, mTOR, Senescence, Drug Resistance, Tamoxifen

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

Melissa L. Sokolosky, Kristin M. Stadelman, William H. Chappell, Stephen L. Abrams, Alberto M. Martelli, Franca Stivala, Massimo Libra, Ferdinando Nicoletti, Lyudmyla B. Drobot, Richard A. Franklin, Linda S. Steelman, James A. McCubrey

Published Jul 1, 2011 · Vol. 2, No. 7 · pp. 538-550

Keywords: Akt, mTOR, Targeted Therapy, Drug Resistance

A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables Research Paper

David Endesfelder, Nicholas McGranahan, Nicolai Juul Birkbak, Zoltan Szallasi, Maik Kschischo, Trevor Graham, Charles Swanton

Published Jun 25, 2011 · Vol. 2, No. 7 · pp. 529-537

Keywords: breast cancer, age, chromosomal instability, histopathological parameters

A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation Research Perspective

Erik A. Nelson, Sreenath V. Sharma, Jeffrey Settleman, David A. Frank

Published Jun 15, 2011 · Vol. 2, No. 6 · pp. 518-524

Keywords: STAT transcription factors, signal transduction, cancer therapy

Class III Î²-Tubulin Counteracts the Ability of Paclitaxel to Inhibit Cell Migration Research Paper

Anutosh Ganguly, Hailing Yang, Fernando Cabral

Published May 16, 2011 · Vol. 2, No. 5 · pp. 368-377

Keywords: tubulin isotypes, microtubules, dynamic instability, motility, drug resistance

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors Research Paper

Asfar S. Azmi, Sanjeev Banerjee, Shadan Ali, Zhiwei Wang, Bin Bao, Frances WJ Beck, Anthony F. Shields, Philip Philip, Fazlul H. Sarkar, Ramzi M. Mohammad

Published May 16, 2011 · Vol. 2, No. 5 · pp. 378-392

Keywords: p53, MDM2, MDM2 inhibitor, oxaliplatin, Systems biology, Network Modeling, Combination Synergy, Pancreatic ductal adenocarcinoma

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity Research Perspective

Mehdi Mollapour, Shinji Tsutsumi, Yeong Sang Kim, Jane Trepel, Len Neckers

Published May 14, 2011 · Vol. 2, No. 5 · pp. 407-417

Keywords: heat shock protein 90, phosphorylation, casein kinase 2, Hsp90 inhibitors, heat shock response, oncotargets, cancer

Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting Research Paper

Aman P. Mann, Rohan C. Bhavane, Anoma Somasunderam, Brenda Liz Montalvo-Ortiz, Ketan B. Ghaghada, David Volk, RenÃ© Nieves-Alicea, K. Stephen Suh, Mauro Ferrari, Ananth Annapragada, David G. Gorenstein, Takemi Tanaka

Published May 7, 2011 · Vol. 2, No. 4 · pp. 298-304

Keywords: drug delivery, aptamer, E-selectin

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper

Anastasios D. Papanastasiou, Georgios Pampalakis, Dionyssios Katsaros, Georgia Sotiropoulou

Published May 2, 2011 · Vol. 2, No. 5 · pp. 363-367

Keywords: Netrin-1 (NTN1), ovarian cancer, biomarker

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective

John M. Koomen, Keiran S. M. Smalley

Published Apr 15, 2011 · Vol. 2, No. 4 · pp. 329-335

Keywords: Oncogene, cancer, kinase, BRAF V600E, drug resistance, proteomics

Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture Research Paper

Pasha Apontes, Olga V. Leontieva, Zoya N. Demidenko, Fengzhi Li, Mikhail V. Blagosklonny

Published Mar 28, 2011 · Vol. 2, No. 3 · pp. 222-233

Keywords: cancer, chemotherapy, chemoprotection, normal cells, cyclotherapy, rapamycin, metformin, p53

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health Review

William H. Chappell, Linda S. Steelman, Jacquelyn M. Long, Ruth C. Kempf, Stephen L. Abrams, Richard A. Franklin, JÃ¶rg BÃ¤secke, Franca Stivala, Marco Donia, Paolo Fagone, Graziella Malaponte, Maria C. Mazzarino, Ferdinando Nicoletti, Massimo Libra, Danijela Maksimovic-Ivanic, Sanja Mijatovic, Giuseppe Montalto, Melchiorre Cervello, Piotr Laidler, Michele Milella, Agostino Tafuri, Antonio Bonati, Camilla Evangelisti, Lucio Cocco, Alberto M. Martelli, James A. McCubrey

Published Mar 11, 2011 · Vol. 2, No. 3 · pp. 135-164

Keywords: Targeted Therapy, Combination Therapy, Drug Resistance, Cancer Stem Cells, Aging, Senescence, Raf, Akt, PI3K, mTOR

A Robust Approach to Enhance Tumor-selective Accumulation of Nanoparticles Research Paper

Yuan Qiao, Xin Huang, Sridhar Nimmagadda, Renyuan Bai, Verena Staedtke, Catherine A. Foss, Ian Cheong, Matthias Holdhoff, Yoshinori Kato, Martin G. Pomper, Gregory J. Riggins, Kenneth W. Kinzler, Luis A. Diaz, Bert Vogelstein, Shibin Zhou

Published Mar 1, 2011 · Vol. 2, No. 1-2 · pp. 59-68

Keywords: Tumor, Vasculature, Nanoparticle, Inflammation, TNF-Î±

Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells Review

Joshua C. Curtin, Matthew V. Lorenzi

Published Oct 30, 2010 · Vol. 1, No. 7 · pp. 563-577

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy Research Paper

Bhavya Rao, Ingeborg M.M. van Leeuwen, Maureen Higgins, Johanna Campbell, Alastair M. Thompson, David P. Lane, Sonia Lain

Published Oct 30, 2010 · Vol. 1, No. 7 · pp. 639-650

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Targeting Autophagy Addiction in Cancer Research Perspective

Geminin overexpression induces mammary tumors via suppressing cytokinesis. Research Paper

Pilot study of a pediatric metronomic 4-drug regimen Brief Reports

Systemic use of tumor necrosis factor alpha as an anticancer agent Review

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 Research Paper

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables Research Paper

A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation Research Perspective

Class III Î²-Tubulin Counteracts the Ability of Paclitaxel to Inhibit Cell Migration Research Paper

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors Research Paper

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity Research Perspective

Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting Research Paper

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective

Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture Research Paper

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health Review

A Robust Approach to Enhance Tumor-selective Accumulation of Nanoparticles Research Paper

Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells Review

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Targeting Autophagy Addiction in Cancer Research Perspective

Geminin overexpression induces mammary tumors via suppressing cytokinesis. Research Paper

Pilot study of a pediatric metronomic 4-drug regimen Brief Reports

Systemic use of tumor necrosis factor alpha as an anticancer agent Review

Protection of acute myeloid leukaemia cells from apoptosis induced by front-line chemotherapeutics is mediated by haem oxygenase-1 Research Paper

Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells Research Paper

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy Research Paper

A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables Research Paper

A Chemical Biology Approach to Developing STAT Inhibitors: Molecular Strategies for Accelerating Clinical Translation Research Perspective

Class III Î²-Tubulin Counteracts the Ability of Paclitaxel to Inhibit Cell Migration Research Paper

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors Research Paper

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity Research Perspective

Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting Research Paper

Netrin-1 overexpression is predictive of ovarian malignancies Research Paper

Using quantitative proteomic analysis to understand genotype specific intrinsic drug resistance in melanoma Research Perspective

Exploring long-term protection of normal human fibroblasts and epithelial cells from chemotherapy in cell culture Research Paper

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health Review

A Robust Approach to Enhance Tumor-selective Accumulation of Nanoparticles Research Paper

Drug Discovery Approaches to Target Wnt Signaling in Cancer Stem Cells Review

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy Research Paper