The Oncosearch | Oncotarget

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

Ling Yu, Shiqing Liu, Chun Zhang, Bo Zhang, Bruno M. Simoes, Rachel Eyre, Yi Liang, Huichao Yan, Zheng Wu, Weichun Guo, Robert B. Clarke

Published Nov 5, 2013 · Vol. 4, No. 12 · pp. 2326-2338

Keywords: osteosarcoma, stem cells, sarcospheres, telomerase

A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors Research Paper

Emilia Mira, Lorena Carmona-RodrÃguez, Manuel TardÃ¡guila, IÃ±igo Azcoitia, Alicia GonzÃ¡lez-MartÃn, Luis Almonacid, Josefina Casas, Gemma FabriÃ¡s, Santos MaÃ±es

Published Oct 26, 2013 · Vol. 4, No. 12 · pp. 2288-2301

Keywords: Placental growth factor, statins, immunity, macrophage polarization, inflammation

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway Research Paper

Qiong Wu, Rui Wang, Qingling Yang, Xin Hou, Sulian Chen, Yueyue Hou, Changjie Chen, Yan Yang, Lucio Miele, Fazlul Sarkar, Yuqing Chen, Zhiwei Wang

Published Oct 7, 2013 · Vol. 4, No. 11 · pp. 1999-2009

Keywords: Hepatocellular carcinoma, chemoresistance, PDGF-D, EMT, gemcitabine

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

Paola Corazao-Rozas, Pierre Guerreschi, Manel Jendoubi, Fanny AndrÃ©, AurÃ©lie Jonneaux, Camille Scalbert, Guillaume GarÃ§on, Myriam Mallet-Martino, StÃ©phane Balayssac, Stephane Rocchi, Ariel Savina, Pierre Formstecher, Laurent Mortier, Jerome Kluza, Philippe Marchetti

Published Oct 6, 2013 · Vol. 4, No. 11 · pp. 1986-1998

Keywords: metabolism, oxidative phosphorylation, elesclomol, ROS

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Elena Kurenova, Jianqun Liao, Di-Hua He, Darrell Hunt, Michael Yemma, Wiam Bshara, Mukund Seshadri, William G Cance

Published Sep 30, 2013 · Vol. 4, No. 10 · pp. 1632-1646

Keywords: FAK Scaffold Inhibitor, pancreatic cancer, FAK-VEGFR-3 interaction, protein-protein interaction

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

Maria Giovanna Francipane, Eric Lagasse

Published Sep 19, 2013 · Vol. 4, No. 11 · pp. 1948-1962

Keywords: colorectal cancer, cancer stem cells, mTOR, apoptosis

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft Research Paper

Alexandra Borodovsky, Vafi Salmasi, Sevin Turcan, Armida W. M. Fabius, Gilson Baia, Charles G Eberhart, Jon D. Weingart, Gary L Gallia, Stephen B Baylin, Timothy A Chan, Gregory J Riggins

Published Sep 16, 2013 · Vol. 4, No. 10 · pp. 1737-1747

Keywords: IDH, 5-azacytidine, progressive glioma, xenograft, astrocytoma, methylation

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Daniela Loetsch, Elisabeth Steiner, Klaus Holzmann, Sabine Spiegl-Kreinecker, Christine Pirker, Juraj Hlavaty, Helga Petznek, Balazs Hegedus, Tamas Garay, Thomas Mohr, Wolfgang Sommergruber, Walter Berger, Michael Grusch

Published Sep 1, 2013 · Vol. 4, No. 11 · pp. 1904-1918

Keywords: major vault protein, vault particles, glioblastoma multiforme, EGFR, PI3K, migration, invasion

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper

Jing Liu, Zhijie Xiao, Sunny Kit-Man Wong, Vicky Pui-Chi Tin, Ka-Yan Ho, Junwen Wang, Mai-Har Sham, Maria Pik Wong

Published Aug 30, 2013 · Vol. 4, No. 10 · pp. 1698-1711

Keywords: lung cancer, tumor initiating cell, aldehyde dehydrogenase, CD44, drug resistance

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Sylvain Couty, Isaac M. Westwood, Andrew Kalusa, Celine Cano, Jon Travers, Kathy Boxall, Chiau Ling Chow, Sam Burns, Jessica Schmitt, Lisa Pickard, Caterina Barillari, P. Craig McAndrew, Paul A. Clarke, Spiros Linardopoulos, Roger J. Griffin, G. Wynne Aherne, Florence I. Raynaud, Paul Workman, Keith Jones, Rob L.M. van Montfort

Published Aug 25, 2013 · Vol. 4, No. 10 · pp. 1647-1661

Keywords: S6 kinase, P70S6K, cancer, inhibitor, structure-based drug design

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

Catia Giovannini, Michele Baglioni, Marco Baron Toaldo, Cristiano Ventrucci, Stefania D'Adamo, Mario Cipone, Pasquale Chieco, Laura Gramantieri, Luigi Bolondi

Published Aug 24, 2013 · Vol. 4, No. 10 · pp. 1618-1631

Keywords: ERK, drug resistance, angiogenesis, cell proliferation, Notch3

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Carolina Simioni, Alberto M. Martelli, Alice Cani, Rengul Cetin-Atalay, James A. McCubrey, Silvano Capitani, Luca M. Neri

Published Aug 24, 2013 · Vol. 4, No. 9 · pp. 1496-1506

Keywords: Hepatocellular carcinoma, MK-2206, Akt-1, targeted therapy, apoptosis, autophagy

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin Research Paper

Silvia Cufi, Bruna Corominas-Faja, Eugeni Lopez-Bonet, Rosa Bonavia, Sonia Pernas, Isabel Alvarez Lopez, Joan Dorca, Susana Martinez, Norberto Batista Lopez, Severina Dominguez Martinez, Elisabet Cuyas, Joana Visa, Esther Rodriguez-Gallego, Rosa Quirantes-Pine, Antonio Segura-Carretero, Jorge Joven, Begona Martin-Castillo, Javier A Menendez

Published Aug 21, 2013 · Vol. 4, No. 9 · pp. 1484-1495

Keywords: Metformin, cancer, PI3K, PIK3CA mutations, dietary restriction, calorie restriction, rapamycin

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

Niraj M Shah, Stuart A Rushworth, Megan Y Murray, Kristian M Bowles, David J MacEwan

Published Aug 8, 2013 · Vol. 4, No. 8 · pp. 1130-1142

Keywords: NRF2, miRNA, transcription factor, oncogenesis, drug resistance

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation Research Paper

Urszula Liwak, Lindsay E Jordan, Sally Davidson Von-Holt, Poonam Singh, Jennifer E. L. Hanson, Ian A Lorimer, Federico Roncaroli, Martin Holcik

Published Jul 28, 2013 · Vol. 4, No. 9 · pp. 1365-1372

Keywords: Glioblastoma multiforme, Bcl-xL, PDCD4, ABT-737, translation initiation

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

Xu Di, Guofeng Zhang, Yaqin Zhang, Kazuyo Takeda, Leslie A. Rivera Rosado, Baolin Zhang

Published Jul 27, 2013 · Vol. 4, No. 9 · pp. 1349-1364

Keywords: TRAIL resistance, basal autophagosomes, death receptors, cell surface expression

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

Alexandra Canonici, Merel Gijsen, Maeve Mullooly, Ruth Bennett, Noujoude Bouguern, Kasper Pedersen, Neil A Oâ€™Brien, Ioannis Roxanis, Ji-Liang Li, Esther Bridge, Richard Finn, Dennis Slamon, Patricia McGowan, Michael J. Duffy, Norma Oâ€™Donovan, John Crown, Anthony Kong

Published Jul 25, 2013 · Vol. 4, No. 10 · pp. 1592-1605

Keywords: breast cancer, HER2/ErbB2, trastuzumab (Herceptin), neratinib, panHER inhibitor

Cancer Metabolism: New Validated Targets for Drug Discovery Research Perspective

Federica Sotgia, Ubaldo E. Martinez-Outschoorn, Michael P Lisanti

Published Jul 22, 2013 · Vol. 4, No. 8 · pp. 1309-1316

Keywords: cancer metabolism, therapeutic targets, drug discovery

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer Research Paper

Alessia Noto, Claudia De Vitis, Giuseppe Roscilli, Luigi Fattore, Debora Malpicci, Emanuele Marra, Laura Luberto, Antonio D'Andrilli, Pierpaolo Coluccia, Maria Rosaria Giovagnoli, Nicola Normanno, Luigi Ruco, Luigi Aurisicchio, Rita Mancini, Gennaro Ciliberto

Published Jul 21, 2013 · Vol. 4, No. 8 · pp. 1253-1265

Keywords: Lung cancer, primary cultures, TKIs, ErbB3, monoclonal antibodies

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients Research Paper

Marc Delord, Philippe Rousselot, Jean-Michel Cayuela, FranÃ§ois Sigaux, JoÃ«lle Guilhot, Claude Preudhomme, FranÃ§ois Guilhot, Pascale Loiseau, Emmanuel Raffoux, Daniela Geromin, Emmanuelle Genin, Fabien Calvo, Heriberto Bruzzoni-Giovanelli

Published Jul 18, 2013 · Vol. 4, No. 10 · pp. 1582-1591

Keywords: CML, Imatinib, SNPs, ABCG2, Pharmacogenetic, molecular response, BCR-ABL

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Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors Research Paper

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway Research Paper

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft Research Paper

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin Research Paper

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation Research Paper

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

Cancer Metabolism: New Validated Targets for Drug Discovery Research Perspective

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer Research Paper

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity Research Paper

A lovastatin-elicited genetic program inhibits M2 macrophage polarization and enhances T cell infiltration into spontaneous mouse mammary tumors Research Paper

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway Research Paper

Mitochondrial oxidative stress is the achilleâ€™s heel of melanoma cells resistant to Braf-mutant inhibitor Research Paper

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth Research Paper

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1 Research Paper

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft Research Paper

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDHhi CD44hi tumor initiating cells Research Paper

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Notch3 inhibition enhances sorafenib cytotoxic efficacy by promoting GSK3Î² phosphorylation and p21 down-regulation in hepatocellular carcinoma Research Paper

The AKT Inhibitor MK-2206 is Cytotoxic in Hepatocarcinoma Cells Displaying Hyperphosphorylated AKT-1 and Synergizes with Conventional Chemotherapy Research Paper

Dietary restriction-resistant human tumors harboring the PIK3CA-activating mutation H1047R are sensitive to metformin Research Paper

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation Research Paper

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

Cancer Metabolism: New Validated Targets for Drug Discovery Research Perspective

Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits Non-small Cell Lung Cancer Research Paper

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients Research Paper

Lung cancer tumorigenicity and drug resistance are maintained through ALDH^hi CD44^hi tumor initiating cells Research Paper