The Oncosearch | Oncotarget

Large scale integration of drug-target information reveals poly-pharmacological drug action mechanisms in tumor cell line growth inhibition assays Research Paper

Richard Knight, Mikhail Gostev, Sergei Ilisavskii, Anne E Willis, Gerry Melino, Alexey V Antonov

Published Jan 21, 2014 · Vol. 5, No. 3 · pp. 659-666

Keywords: oncotargets, drug action mechanisms, polypharmacology

microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers Priority Research Paper

Pierluigi Gasparini, Luciano Cascione, Matteo Fassan, Francesca Lovat, Gulnur Guler, Serdar Balci, Cigdem Irkkan, Carl Morrison, Carlo M. Croce, Charles L. Shapiro, Kay Huebner

Published Jan 21, 2014 · Vol. 5, No. 5 · pp. 1174-1184

Keywords: Triple Negative breast cancer, microRNA, five markers, prognosis, treatments, outcome

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

Paul MÃ©sange, Virginie Poindessous, MichÃ¨le Sabbah, Alexandre E. Escargueil, Aimery de Gramont, Annette K. Larsen

Published Jan 20, 2014 · Vol. 5, No. 13 · pp. 4709-4721

Keywords: resistance, angiogenesis inhibition, vascular endothelial growth factor (VEGF)-signaling, hypoxia, bevacizumab, nintedanib

MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression Research Paper

Lekun Fang, Haoran Li, Lei Wang, Jun Hu, Tianru Jin, Jianping Wang, Burton B. Yang

Published Jan 19, 2014 · Vol. 5, No. 10 · pp. 2974-2987

Keywords: microRNA, stem cell, miR-17, colon cancer, drug resistance

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Ho Kyung Seo, Kyung-Ohk Ahn, Nae-Rae Jung, Ji-Sun Shin, Weon Seo Park, Kang-Hyun Lee, Sang-Jin Lee, Kyung-Chae Jeong

Published Jan 16, 2014 · Vol. 5, No. 2 · pp. 326-337

Keywords: Bladder cancer, c-Myc, inhibitor, gemcitabine, gemcitabine resistance

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

John T. Heap, Jan Theys, Muhammad Ehsaan, Aleksandra M Kubiak, Ludwig Dubois, Kim Paesmans, Lieve Van Mellaert, Richard Knox, Sarah A. Kuehne, Phillipe Lambin, Nigel P. Minton

Published Jan 12, 2014 · Vol. 5, No. 7 · pp. 1761-1769

Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN Research Paper

Tian-Huei Chu, Hoi-Hung Chan, Hsiao-Mei Kuo, Li-Fen Liu, Tsung-Hui Hu, Cheuk-Kwan Sun, Mei-Lang Kung, Shih-Wei Lin, E-Ming Wang, Yi-Ling Ma, Kwan-Hung Cheng, Kwok-Hung Lai, Zhi-Hong Wen, Ping-I Hsu, Ming-Hong Tai

Published Dec 28, 2013 · Vol. 5, No. 6 · pp. 1475-1490

Keywords: hepatocellular carcinoma, hepatic cancer stem cells, celecoxib, prostaglandin E2, phosphatase and tensin homolog

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

Barak Rotblat, Thomas G. P. Grunewald, Gabriel Leprivier, Gerry Melino, Richard A. Knight

Published Dec 15, 2013 · Vol. 4, No. 12 · pp. 2577-2590

Keywords: anti-oxidant genes, glutathione, thioredoxin, breast cancer, lung cancer, NRF2, G6PD

mTOR pathway in colorectal cancer: an update Review

Maria Giovanna Francipane, Eric Lagasse

Published Dec 5, 2013 · Vol. 5, No. 1 · pp. 49-66

Keywords: mTOR, colorectal cancer, cancer stem-like cells, personalized medicine

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

Liliana H. Mochmann, Martin Neumann, Eva K. von Der Heide, Verena Nowak, Anja A. KÃ¼hl, Jutta Ortiz-Tanchez, Juliane Bock, Wolf K Hofmann, Claudia D Baldus

Published Dec 4, 2013 · Vol. 5, No. 2 · pp. 351-362

Keywords: ERG, ERK, EMT, Chemoresistance

Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system Research Paper

Sun-Hye Lee, Tae-Gyun Woo, Su-Jin Lee, Nam-Chul Ha, Bum-Joon Park

Published Dec 2, 2013 · Vol. 4, No. 12 · pp. 2523-2531

Keywords: p53 core domain, Oncogenic K-Ras, Caveolin-1, Drug delivery

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine Research Paper

Chiou-Tsun Tsai, Pei-Ming Yang, Ting-Rong Chern, Shu-Hui Chuang, Jung-Hsin Lin, Lars Klemm, Markus MÃ¼schen, Ching-Chow Chen

Published Nov 25, 2013 · Vol. 5, No. 1 · pp. 211-223

Keywords: AID, 5-aza-CdR, Zebularine, DNMT1

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms Review

Jahangir Abdi, Guoan Chen, Hong Chang

Published Nov 24, 2013 · Vol. 4, No. 12 · pp. 2186-2207

Keywords: multiple myeloma, drug resistance, signaling pathways, oncogenes

Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells Research Paper

Kai Wu, Qingshan Chang, Yongju Lu, Ping Qiu, Bailing Chen, Chitra Thakur, Jiaying Sun, Lingzhi Li, Anjaneyulu Kowluru, Fei Chen

Published Nov 24, 2013 · Vol. 4, No. 12 · pp. 2430-2438

Keywords: Gefitinib, EGFR, STAT3, Akt recovery

Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death Research Paper

Eran Schmukler, Eya Wolfson, Roni Haklai, Galit Elad-Sfadia, Yoel Kloog, Ronit Pinkas-Kramarski

Published Nov 20, 2013 · Vol. 5, No. 1 · pp. 173-184

Keywords: Autophagy, Ras, Transformation, signal transduction.

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Vivek Subbiah, Robert E. Brown, Mary F. McGuire, Jamie Buryanek, Filip Janku, Anas Younes, David Hong

Published Nov 19, 2013 · Vol. 5, No. 1 · pp. 95-102

Keywords: Hodgkin's lymphoma, mTOR, HDAC, Sirolimus, Vorinostat, Targeted therapy

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. Research Paper

Shahin Assefnia, Sivanesan Dakshanamurthy, Jaime M. Guidry Auvil, Constanze Hampel, Panos Z. Anastasiadis, Bhaskar Kallakury, Aykut Uren, David W. Foley, Milton L. Brown, Lawrence Shapiro, Michael Brenner, David Haigh, Stephen W. Byers

Published Nov 15, 2013 · Vol. 5, No. 6 · pp. 1458-1474

Keywords: cadherin-11, breast cancer, glioblastoma, small molecule inhibitor, rheumatoid arthritis, celecoxib

Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis Research Paper

Alejandra M. Petrilli, Marga Bott, Cristina FernÃ¡ndez-Valle

Published Nov 15, 2013 · Vol. 4, No. 12 · pp. 2354-2365

Keywords: Neurofibromatosis Type 2, SIRT2, tumor suppressor

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Sung-Hyeok Hong, Sarah E. Youbi, S. Peter Hong, Bhaskar Kallakury, Phillip Monroe, Hayriye V. Erkizan, Julie S. Barber-Rotenberg, Peter Houghton, Aykut Ãœren, Jeffrey A. Toretsky

Published Nov 11, 2013 · Vol. 5, No. 2 · pp. 338-350

Keywords: YK-4-279, EWS-FLI1, Ewing Sarcoma, rat xenograft, pharmacokinetic modeling

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper

Veronica Martinez-Marignac, Nader Toban, Miguel Bazile, Raquel Aloyz

Published Nov 7, 2013 · Vol. 4, No. 12 · pp. 2550-2566

Keywords: CLL, AMPK, Dasatinib, kinase inhibitor, metabolism, glycolysis, OXPHOS

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Large scale integration of drug-target information reveals poly-pharmacological drug action mechanisms in tumor cell line growth inhibition assays Research Paper

microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers Priority Research Paper

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression Research Paper

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN Research Paper

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

mTOR pathway in colorectal cancer: an update Review

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system Research Paper

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine Research Paper

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms Review

Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells Research Paper

Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death Research Paper

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. Research Paper

Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis Research Paper

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Large scale integration of drug-target information reveals poly-pharmacological drug action mechanisms in tumor cell line growth inhibition assays Research Paper

microRNA expression profiling identifies a four microRNA signature as a novel diagnostic and prognostic biomarker in triple negative breast cancers Priority Research Paper

Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor. Research Paper

MicroRNA-17-5p promotes chemotherapeutic drug resistance and tumour metastasis of colorectal cancer by repressing PTEN expression Research Paper

Antitumor activity of the c-Myc inhibitor KSI-3716 in gemcitabine-resistant bladder cancer Research Paper

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

Celecoxib suppresses hepatoma stemness and progression by up-regulating PTEN Research Paper

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers Research Perspective

mTOR pathway in colorectal cancer: an update Review

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system Research Paper

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine Research Paper

Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms Review

Gefitinib resistance resulted from STAT3-mediated Akt activation in lung cancer cells Research Paper

Chloroquine synergizes with FTS to enhance cell growth inhibition and cell death Research Paper

A novel immunomodulatory and molecularly targeted strategy for refractory Hodgkinâ€™s lymphoma Brief Reports

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies. Research Paper

Inhibition of SIRT2 in merlin/NF2-mutant Schwann cells triggers necrosis Research Paper

Pharmacokinetic modeling optimizes inhibition of the â€˜undruggableâ€™ EWS-FLI1 transcription factor in Ewing Sarcoma Research Paper

Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic re-programming Research Paper