The Oncosearch | Oncotarget

Negative regulation of DAB2IP by Akt and SCF^Fbw7 pathways Research Paper

Xiangpeng Dai, Brian J. North, Hiroyuki Inuzuka

Published May 1, 2014 · Vol. 5, No. 10 · pp. 3307-3315

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups Research Paper

Michele Simbolo, Matteo Fassan, Andrea Ruzzenente, Andrea Mafficini, Laura D. Wood, Vincenzo Corbo, Davide Melisi, Giuseppe Malleo, Caterina Vicentini, Giorgio Malpeli, Davide Antonello, Nicola Sperandio, Paola Capelli, Anna Tomezzoli, Calogero Iacono, Rita T. Lawlor, Claudio Bassi, Ralph H. Hruban, Alfredo Guglielmi, Giampaolo Tortora, Filippo de Braud, Aldo Scarpa

Published May 1, 2014 · Vol. 5, No. 9 · pp. 2839-2852

Rad51 supports triple negative breast cancer metastasis. Research Paper

Adrian P. Wiegmans, Fares Al-Ejeh, Nicole Chee, Pei-Yi Yap, Julia J. Gorski, Leonard Da Silva, Emma Bolderson, Georgia Chenevix-Trench, Robin Anderson, Peter T. Simpson, Sunil R. Lakhani, Kum Kum Khanna

Published Apr 27, 2014 · Vol. 5, No. 10 · pp. 3261-3272

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy Research Paper

Rachel Abbotts, Rosalyn Jewell, JÃ©rÃ©mie Nsengimana, David J. Maloney, Anton Simeonov, Claire Seedhouse, Faye Elliott, Jon Laye, Christy Walker, Ajit Jadhav, Anna Grabowska, Graham Ball, Poulam M. Patel, Julia Newton-Bishop, David M. Wilson III, Srinivasan Madhusudan

Published Apr 27, 2014 · Vol. 5, No. 10 · pp. 3273-3286

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways Priority Research Paper

Anne Y. Saiki, Sean Caenepeel, Dongyin Yu, Julie A. Lofgren, Tao Osgood, Rebecca Robertson, Jude Canon, Cheng Su, Adrie Jones, Xiaoning Zhao, Chetan Deshpande, Marc Payton, Jebediah Ledell, Paul E. Hughes, Jonathan D. Oliner

Published Apr 23, 2014 · Vol. 5, No. 8 · pp. 2030-2043

Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression Research Paper

Eric A. Voll, Irene M. Ogden, Janet M. Pavese, XiaoKe Huang, Li Xu, Borko D. Jovanovic, Raymond C. Bergan

Published Apr 21, 2014 · Vol. 5, No. 9 · pp. 2648-2663

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model Research Paper

Kodappully Sivaraman Siveen, Kwang Seok Ahn, Tina H. Ong, Muthu K. Shanmugam, Feng Li, Wei Ney Yap, Alan Prem Kumar, Chee Wai Fong, Vinay Tergaonkar, Kam M. Hui, Gautam Sethi

Published Mar 31, 2014 · Vol. 5, No. 7 · pp. 1897-1911

Therapeutic Targeting of c-Myc in T-Cell Acute Lymphoblastic Leukemia (T-ALL) Research Paper

Marie Loosveld, RÃ©my Castellano, StÃ©phanie Gon, Armelle Goubard, Thomas Crouzet, Laurent Pouyet, Thomas Prebet, Norbert Vey, Bertrand Nadel, Yves Collette, Dominique Payet-Bornet

Published Mar 27, 2014 · Vol. 5, No. 10 · pp. 3168-3172

FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor Research Paper

Koichi Azuma, Akihiko Kawahara, Kahori Sonoda, Kazutaka Nakashima, Kousuke Tashiro, Kosuke Watari, Hiroto Izumi, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono, Tomoaki Hoshino

Published Mar 26, 2014 · Vol. 5, No. 15 · pp. 5908-5919

Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo Research Paper

Shou-Hung Tang, Hsu-Shan Huang, Hong-Ui Wu, Yi-Ta Tsai, Mei-Jen Chuang, Cheng-Ping Yu, Shih-Ming Huang, Guang-Huan Sun, Sun-Yran Chang, Pei-Wen Hsiao, Dah-Shyong Yu, Tai-Lung Cha

Published Mar 26, 2014 · Vol. 5, No. 21 · pp. 10342-10355

Artesunate overcomes drug resistance in multiple myeloma by inducing mitochondrial stress and non-caspase apoptosis Research Paper

Xenofon Papanikolaou, Sarah Johnson, Tarun Garg, Erming Tian, Ruslana Tytarenko, Qing Zhang, Caleb Stein, Bart Barlogie, Joshua Epstein, Christoph Heuck

Published Mar 24, 2014 · Vol. 5, No. 12 · pp. 4118-4128

Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation Research Paper

Hua Yang, Harshani Lawrence, Aslamuzzaman Kazi, Harsukh Gevariya, Ronil Patel, Yunting Luo, Uwe Rix, Ernst Schonbrunn, Nicholas J. Lawrence, Said M Sebti

Published Mar 22, 2014 · Vol. 5, No. 10 · pp. 2947-2961

Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling Research Paper

Jun Zhang, Ji Cao, Shenglin Ma, Rong Dong, Wen Meng, Meidan Ying, Qinjie Weng, Zibo Chen, Jian Ma, Qingxia Fang, Qiaojun He, Bo Yang

Published Mar 22, 2014 · Vol. 5, No. 20 · pp. 9664-9677

Eradication of metastatic melanoma through cooperative expression of RNA-based HDAC1 inhibitor and p73 by oncolytic adenovirus Research Paper

Holger Schipper, Vijay Alla, Claudia Meier, Dirk M. Nettelbeck, Ottmar HerchenrÃ¶der, Brigitte M. PÃ¼tzer

Published Mar 21, 2014 · Vol. 5, No. 15 · pp. 5893-5907

Latest progress in tyrosine kinase inhibitors Research Perspective

Tatiana V. Pospelova, Valery A. Pospelov

Published Mar 20, 2014 · Vol. 5, No. 5 · pp. 1157-1161

Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress Research Paper

Yanira Gonzalez, Baikuntha Aryal, Leena Chehab, V Ashutosh Rao

Published Mar 12, 2014 · Vol. 5, No. 6 · pp. 1526-1537

Keywords: autophagy, reactive oxygen species, mitoquinone, breast cancer

Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors Research Paper

Albert A. AntolÃn, Jordi Mestres

Published Mar 10, 2014 · Vol. 5, No. 10 · pp. 3023-3028

A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy Research Paper

Alboukadel Kassambara, Claire Gourzones-Dmitriev, Surinder Sahota, Thierry RÃ¨me, JÃ©rÃ´me Moreaux, Hartmut Goldschmidt, Angelos Constantinou, Phillipe Pasero, Dirk Hose, Bernard Klein

Published Feb 24, 2014 · Vol. 5, No. 9 · pp. 2487-2498

Keywords: DNA repair, Multiple Myeloma, prognosis

Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice Research Paper

Bojidar M. Kojouharov, Craig M. Brackett, Jean M. Veith, Christopher P. Johnson, Ilya I. Gitlin, Ilia A. Toshkov, Anatoli S. Gleiberman, Andrei V. Gudkov, Lyudmila G. Burdelya

Published Feb 23, 2014 · Vol. 5, No. 3 · pp. 802-814

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

Shigeru Kawabata, Chun-Te Chiang, Junji Tsurutani, Hideaki Shiga, Matthew L. Arwood, Takefumi Komiya, Joell J. Gills, Regan M. Memmott, Phillip A. Dennis

Published Feb 16, 2014 · Vol. 5, No. 4 · pp. 1062-1070

Keywords: Rapamycin, Pemetrexed, Drug synergy, mTOR, Thymidylate Synthase, Lung Cancer

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Negative regulation of DAB2IP by Akt and SCF^Fbw7 pathways Research Paper

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups Research Paper

Rad51 supports triple negative breast cancer metastasis. Research Paper

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy Research Paper

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways Priority Research Paper

Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression Research Paper

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model Research Paper

Therapeutic Targeting of c-Myc in T-Cell Acute Lymphoblastic Leukemia (T-ALL) Research Paper

FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor Research Paper

Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo Research Paper

Artesunate overcomes drug resistance in multiple myeloma by inducing mitochondrial stress and non-caspase apoptosis Research Paper

Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation Research Paper

Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling Research Paper

Eradication of metastatic melanoma through cooperative expression of RNA-based HDAC1 inhibitor and p73 by oncolytic adenovirus Research Paper

Latest progress in tyrosine kinase inhibitors Research Perspective

Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress Research Paper

Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors Research Paper

A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy Research Paper

Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice Research Paper

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Negative regulation of DAB2IP by Akt and SCFFbw7 pathways Research Paper

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups Research Paper

Rad51 supports triple negative breast cancer metastasis. Research Paper

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy Research Paper

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways Priority Research Paper

Heat shock protein 27 regulates human prostate cancer cell motility and metastatic progression Research Paper

γ-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model Research Paper

Therapeutic Targeting of c-Myc in T-Cell Acute Lymphoblastic Leukemia (T-ALL) Research Paper

FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor Research Paper

Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo Research Paper

Artesunate overcomes drug resistance in multiple myeloma by inducing mitochondrial stress and non-caspase apoptosis Research Paper

Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation Research Paper

Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling Research Paper

Eradication of metastatic melanoma through cooperative expression of RNA-based HDAC1 inhibitor and p73 by oncolytic adenovirus Research Paper

Latest progress in tyrosine kinase inhibitors Research Perspective

Atg7- and Keap1-dependent autophagy protects breast cancer cell lines against mitoquinone-induced oxidative stress Research Paper

Linking off-target kinase pharmacology to the differential cellular effects observed among PARP inhibitors Research Paper

A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy Research Paper

Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice Research Paper

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer Research Paper

Negative regulation of DAB2IP by Akt and SCF^Fbw7 pathways Research Paper