The Oncosearch | Oncotarget

Toward the use of precision medicine for the treatment of head and neck squamous cell carcinoma Research Paper

Wang Gong, Yandi Xiao, Zihao Wei, Yao Yuan, Min Qiu, Chongkui Sun, Xin Zeng, Xinhua Liang, Mingye Feng, Qianming Chen Chen

Published Dec 4, 2016 · Vol. 8, No. 2 · pp. 2141-2152

FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway Research Paper

Kun Li, Qunfeng Guo, Jun Yang, Hui Chen, Kewen Hu, Juan Zhao, Xiufeng Pang, Sufang Zhou, Yongyan Dang, Lei Li

Published Dec 3, 2016 · Vol. 8, No. 3 · pp. 5048-5056

Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-κB pathway in human hepatocellular carcinoma-bearing mouse model Research Paper

John Chun-Hao Chen, Hui-Yen Chuang, Fei-Ting Hsu, Yi-Chen Chen, Yi-Chun Chien, Jeng-Jong Hwang

Published Nov 16, 2016 · Vol. 7, No. 51 · pp. 85450-85463

Epigenetically upregulated WIPF1 plays a major role in BRAF V600E-promoted papillary thyroid cancer aggressiveness Research Paper

Tao Zhang, Xiaopei Shen, Rengyun Liu, Guangwu Zhu, Justin Bishop, Mingzhao Xing

Published Nov 16, 2016 · Vol. 8, No. 1 · pp. 900-914

Thyroid transcription factor FOXE1 interacts with ETS factor ELK1 to co-regulate TERT Research Paper

Martyn Bullock, Grace Lim, Cheng Li, In Ho Choi, Shivansh Kochhar, Chris Liddle, Lei Zhang, Roderick J. Clifton-Bligh

Published Nov 11, 2016 · Vol. 7, No. 52 · pp. 85948-85962

Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinase-mediated signaling pathway in hepatocellular carcinoma Research Paper

Xuejing Lin, Zhangxiao Peng, Xiaohui Fu, Chunying Liu, Yang Xu, Weidan Ji, Jianhui Fan, Lei Chen, Lin Fang, Yao Huang, Changqing Su

Published Oct 28, 2016 · Vol. 7, No. 48 · pp. 79761-79773

PRIMA-1^Met suppresses colorectal cancer independent of p53 by targeting MEK Research Paper

Tao Lu, Yanmei Zou, Guogang Xu, Jane A. Potter, Garry L. Taylor, Qiuhong Duan, Qin Yang, Huihua Xiong, Hong Qiu, Dawei Ye, Peng Zhang, Shiying Yu, Xianglin Yuan, Feng Zhu, Yihua Wang, Hua Xiong

Published Oct 27, 2016 · Vol. 7, No. 50 · pp. 83017-83030

Co-existence of BRAF and NRAS driver mutations in the same melanoma cells results in heterogeneity of targeted therapy resistance Research Paper

Marieke I.G. Raaijmakers, Daniel S. Widmer, Apurva Narechania, Ossia Eichhoff, Sandra N. Freiberger, Judith Wenzina, Phil F. Cheng, Daniela Mihic-Probst, Rob Desalle, Reinhard Dummer, Mitchell P. Levesque

Published Oct 24, 2016 · Vol. 7, No. 47 · pp. 77163-77174

In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC Research Paper

Susan Heavey, Sinead Cuffe, Stephen Finn, Vincent Young, Ronan Ryan, Siobhan Nicholson, Niamh Leonard, Niall McVeigh, Martin Barr, Kenneth Oâ€™Byrne, Kathy Gately

Published Oct 19, 2016 · Vol. 7, No. 48 · pp. 79526-79543

Phosphorylation of PPARÎ³ at Ser84 promotes glycolysis and cell proliferation in hepatocellular carcinoma by targeting PFKFB4 Research Paper

Yuxin Shu, Yan Lu, Xiaojuan Pang, Wei Zheng, Yahong Huang, Jiahong Li, Jianguo Ji, Can Zhang, Pingping Shen

Published Oct 19, 2016 · Vol. 7, No. 47 · pp. 76984-76994

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation Research Paper

Francesca Megiorni, Simona Camero, Simona Ceccarelli, Heather P. McDowell, Olga Mannarino, Francesco Marampon, Barry Pizer, Rajeev Shukla, Antonio Pizzuti, Cinzia Marchese, Anna Clerico, Carlo Dominici

Published Oct 15, 2016 · Vol. 7, No. 48 · pp. 79342-79356

MEK1 is required for the development of NRAS-driven leukemia Priority Research Paper

Joanna D. Nowacka, Christian Baumgartner, Cristiana Pelorosso, Mareike Roth, Johannes Zuber, Manuela Baccarini

Published Oct 10, 2016 · Vol. 7, No. 49 · pp. 80113-80130

Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAF^V600E targeted inhibition in a novel syngeneic murine glioma model Research Paper

Stefan Grossauer, Katharina Koeck, Nicole E. Murphy, Ian D. Meyers, Mathieu Daynac, Nathalene Truffaux, Albert Y. Truong, Theodore P. Nicolaides, Martin McMahon, Mitchel S. Berger, Joanna J. Phillips, David C. James, Claudia K. Petritsch

Published Oct 3, 2016 · Vol. 7, No. 46 · pp. 75839-75853

Targeting the ERK pathway for the treatment of Cushingâ€™s disease Priority Research Paper

Dongyun Zhang, Marvin Bergsneider, Marilene B. Wang, Anthony P. Heaney

Published Sep 30, 2016 · Vol. 7, No. 43 · pp. 69149-69158

Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model Research Paper

Kei Kawaguchi, Takashi Murakami, Bartosz Chmielowski, Kentaro Igarashi, Tasuku Kiyuna, Michiaki Unno, Scott D. Nelson, Tara A. Russell, Sarah M. Dry, Yunfeng Li, Fritz C. Eilber, Robert M. Hoffman

Published Sep 28, 2016 · Vol. 7, No. 44 · pp. 71737-71743

Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway Research Paper

Zhou Xing, Minling Zeng, Huixian Hu, Hui Zhang, Zhuofang Hao, Yuesheng Long, Shengqiang Chen, Hang Su, Zhongmin Yuan, Meng Xu, Jingqi Chen

Published Sep 23, 2016 · Vol. 7, No. 46 · pp. 75394-75406

RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis Research Paper

Catherine E. Bond, Diane M. McKeone, Murugan Kalimutho, Mark L. Bettington, Sally-Ann Pearson, Troy D. Dumenil, Leesa F. Wockner, Matthew Burge, Barbara A. Leggett, Vicki L.J. Whitehall

Published Sep 20, 2016 · Vol. 7, No. 43 · pp. 70589-70600

STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways Research Paper

Bing Chen, Xiao Zeng, Yu He, Xixi Wang, Ziwei Liang, Jingjing Liu, Peng Zhang, Hongxia Zhu, Ningzhi Xu, Shufang Liang

Published Sep 20, 2016 · Vol. 7, No. 44 · pp. 71400-71416

CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network Research Paper

Elana J. Fertig, Hiroyuki Ozawa, Manjusha Thakar, Jason D. Howard, Luciane T. Kagohara, Gabriel Krigsfeld, Ruchira S. Ranaweera, Robert M. Hughes, Jimena Perez, SiÃ¢n Jones, Alexander V. Favorov, Jacob Carey, Genevieve Stein-Oâ€™Brien, Daria A. Gaykalova, Daria A. Gaykalova, Michael F. Ochs, Christine H. Chung

Published Sep 16, 2016 · Vol. 7, No. 45 · pp. 73845-73864

Adenosine A₃ receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells Research Paper

Angelo Torres, Yosselyn Vargas, Daniel Uribe, Catherine Jaramillo, Alejandra Gleisner, Flavio Salazar-Onfray, Mercedes N. LÃ³pez, RÃ³mulo Melo, Carlos OyarzÃºn, Rody San MartÃn, Claudia Quezada

Published Sep 15, 2016 · Vol. 7, No. 41 · pp. 67373-67386

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Toward the use of precision medicine for the treatment of head and neck squamous cell carcinoma Research Paper

FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway Research Paper

Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-κB pathway in human hepatocellular carcinoma-bearing mouse model Research Paper

Epigenetically upregulated WIPF1 plays a major role in BRAF V600E-promoted papillary thyroid cancer aggressiveness Research Paper

Thyroid transcription factor FOXE1 interacts with ETS factor ELK1 to co-regulate TERT Research Paper

Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinase-mediated signaling pathway in hepatocellular carcinoma Research Paper

PRIMA-1^Met suppresses colorectal cancer independent of p53 by targeting MEK Research Paper

Co-existence of BRAF and NRAS driver mutations in the same melanoma cells results in heterogeneity of targeted therapy resistance Research Paper

In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC Research Paper

Phosphorylation of PPARÎ³ at Ser84 promotes glycolysis and cell proliferation in hepatocellular carcinoma by targeting PFKFB4 Research Paper

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation Research Paper

MEK1 is required for the development of NRAS-driven leukemia Priority Research Paper

Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAF^V600E targeted inhibition in a novel syngeneic murine glioma model Research Paper

Targeting the ERK pathway for the treatment of Cushingâ€™s disease Priority Research Paper

Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model Research Paper

Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway Research Paper

RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis Research Paper

STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways Research Paper

CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network Research Paper

Adenosine A₃ receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Toward the use of precision medicine for the treatment of head and neck squamous cell carcinoma Research Paper

FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway Research Paper

Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-κB pathway in human hepatocellular carcinoma-bearing mouse model Research Paper

Epigenetically upregulated WIPF1 plays a major role in BRAF V600E-promoted papillary thyroid cancer aggressiveness Research Paper

Thyroid transcription factor FOXE1 interacts with ETS factor ELK1 to co-regulate TERT Research Paper

Volatile oil from Saussurea lappa exerts antitumor efficacy by inhibiting epithelial growth factor receptor tyrosine kinase-mediated signaling pathway in hepatocellular carcinoma Research Paper

PRIMA-1Met suppresses colorectal cancer independent of p53 by targeting MEK Research Paper

Co-existence of BRAF and NRAS driver mutations in the same melanoma cells results in heterogeneity of targeted therapy resistance Research Paper

In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC Research Paper

Phosphorylation of PPARÎ³ at Ser84 promotes glycolysis and cell proliferation in hepatocellular carcinoma by targeting PFKFB4 Research Paper

DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation Research Paper

MEK1 is required for the development of NRAS-driven leukemia Priority Research Paper

Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAFV600E targeted inhibition in a novel syngeneic murine glioma model Research Paper

Targeting the ERK pathway for the treatment of Cushingâ€™s disease Priority Research Paper

Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model Research Paper

Fragile X mental retardation protein promotes astrocytoma proliferation via the MEK/ERK signaling pathway Research Paper

RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis Research Paper

STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways Research Paper

CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network Research Paper

Adenosine A3 receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells Research Paper

PRIMA-1^Met suppresses colorectal cancer independent of p53 by targeting MEK Research Paper

Concurrent MEK targeted therapy prevents MAPK pathway reactivation during BRAF^V600E targeted inhibition in a novel syngeneic murine glioma model Research Paper

Adenosine A₃ receptor elicits chemoresistance mediated by multiple resistance-associated protein-1 in human glioblastoma stem-like cells Research Paper