The Oncosearch | Oncotarget

MEK inhibition enhances efficacy of bacillus Calmette-Guérin on bladder cancer cells by reducing release of Toll-like receptor 2-activated antimicrobial peptides Research Paper

Young Mi Whang, Su Bin Jin, Serk In Park, In Ho Chang

Published May 26, 2017 · Vol. 8, No. 32 · pp. 53168-53179

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition Priority Research Paper

Gongda Xue, Reto Kohler, Fengyuan Tang, Debby Hynx, Yuhua Wang, Francesca Orso, Vincent PrÃªtre, Reto Ritschard, Petra Hirschmann, Peter Cron, Tim Roloff, Reinhard Dummer, Mario MandalÃ, Sandrine Bichet, Christel Genoud, Alexandra G. Meyer, Manuele G. Muraro, Giulio C. Spagnoli, Daniela Taverna, Curzio RÃ¼egg, Taha Merghoub, Daniela Massi, Huifang Tang, Mitchell P. Levesque, Stephan Dirnhofer, Alfred Zippelius, Brian A. Hemmings, Andreas Wicki

Published May 25, 2017 · Vol. 8, No. 41 · pp. 69204-69218

Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death Research Paper

Jeng-Yuan Shiau, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyur

Published May 25, 2017 · Vol. 8, No. 34 · pp. 56942-56958

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer Research Paper

Dominika E. Butler, Christopher Marlein, Hannah F. Walker, Fiona M. Frame, Vincent M. Mann, Matthew S. Simms, Barry R. Davies, Anne T. Collins, Norman J. Maitland

Published May 23, 2017 · Vol. 8, No. 34 · pp. 56698-56713

Correlation between MEK signature and Ras gene alteration in advanced gastric cancer Research Paper

Soomin Ahn, Roz Brant, Alan Sharpe, Jonathan R. Dry, Darren R. Hodgson, Elaine Kilgour, Kyung Kim, Seung Tae Kim, Se Hoon Park, Won Ki Kang, Kyoung-Mee Kim, Jeeyun Lee

Published May 23, 2017 · Vol. 8, No. 64 · pp. 107492-107499

Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer Research Paper

Changwen Ning, Min Liang, Shuang Liu, Guan Wang, Holly Edwards, Yang Xia, Lisa Polin, Gregory Dyson, Jeffrey W. Taub, Ramzi M. Mohammad, Asfar S. Azmi, Lijing Zhao, Yubin Ge

Published May 15, 2017 · Vol. 8, No. 27 · pp. 44295-44311

Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells Research Paper

Eun-Hye Hur, Bon-Kwan Goo, Juhyun Moon, Yunsuk Choi, Jung Jin Hwang, Choung-Soo Kim, Kyun Seop Bae, Jene Choi, Suk Young Cho, Sang-Hwa Yang, Jeongbeob Seo, Gilnam Lee, Je-Hwan Lee

Published May 15, 2017 · Vol. 8, No. 25 · pp. 41387-41400

BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma Research Paper

Fen Liu, Chen Chen Jiang, Xu Guang Yan, Hsin-Yi Tseng, Chun Yan Wang, Yuan Yuan Zhang, Hamed Yari, Ting La, Margaret Farrelly, Su Tang Guo, Rick F. Thorne, Lei Jin, Qi Wang, Xu Dong Zhang

Published May 9, 2017 · Vol. 8, No. 41 · pp. 69477-69492

Correction: LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/Î²-catenin signalling in neuroblastoma Correction

Gabriella Cunha Vieira, S. Chockalingam, Zsombor Melegh, Alexander Greenhough, Sally Malik, Marianna Szemes, Ji Hyun Park, Abderrahmane Kaidi, Li Zhou, Daniel Catchpoole, Rhys Morgan, David O. Bates, Peter J. Gabb, Karim Malik

Published May 8, 2017 · Vol. 8, No. 19 · pp. 32381-32381

NRAS mutations in cutaneous T cell lymphoma (CTCL) sensitize tumors towards treatment with the multikinase inhibitor Sorafenib Research Paper

Michael K. KieÃŸling, Jan P. Nicolay, Tabea SchlÃ¶r, Claus-Detlev Klemke, Dorothee SÃ¼ss, Peter H. Krammer, Karsten GÃ¼low

Published May 7, 2017 · Vol. 8, No. 28 · pp. 45687-45697

MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX) Research Paper

Kei Kawaguchi, Kentaro Igarashi, Takashi Murakami, Tasuku Kiyuna, Thinzar M. Lwin, Ho Kyoung Hwang, Jonathan C. Delong, Bryan M. Clary, Michael Bouvet, Michiaki Unno, Robert M. Hoffman

Published May 7, 2017 · Vol. 8, No. 29 · pp. 47490-47496

Activating MAPK1 (ERK2) mutation in an aggressive case of disseminated juvenile xanthogranuloma Research Paper

Rikhia Chakraborty, Oliver A. Hampton, Harshal Abhyankar, Daniel J. Zinn, Amanda Grimes, Brooks Skull, Olive Eckstein, Nadia Mahmood, David A. Wheeler, Dolores Lopez-Terrada, Tricia L. Peters, John M. Hicks, Tarek Elghetany, Robert Krance, Poulikos I. Poulikakos, Miriam Merad, Kenneth L. McClain, Carl E. Allen, Williams D. Parsons

Published Apr 29, 2017 · Vol. 8, No. 28 · pp. 46065-46070

Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy Research Paper

Stefan Kasper, Henning Reis, Sophie Ziegler, Silke Nothdurft, Andre Mueller, Moritz Goetz, Marcel Wiesweg, Jeannette Phasue, Saskia Ting, Sarah Wieczorek, Anna Even, Karl Worm, Michael Pogorzelski, Sandra Breitenbuecher, Johannes Meiler, Andreas Paul, Tanja Trarbach, Kurt Werner Schmid, Frank Breitenbuecher, Martin Schuler

Published Apr 26, 2017 · Vol. 8, No. 28 · pp. 45898-45917

Correction: Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway Correction

Jui-Chieh Chen, Yu-Ju Chen, Chih-Yang Lin, Yi-Chin Fong, Chin-Jung Hsu, Chun-Hao Tsai, Jen-Liang Su, Chih-Hsin Tang

Published Apr 10, 2017 · Vol. 8, No. 15 · pp. 25830-25830

ERK expression and its correlation with STAT1 in esophageal squamous cell carcinoma Research Paper

Hu Wang, Ying Zhang, Hailong Yun, Shubiao Chen, Yelong Chen, Zhaoyong Liu

Published Apr 6, 2017 · Vol. 8, No. 28 · pp. 45249-45258

Identification of MAP kinase pathways as therapeutic targets in gallbladder carcinoma using targeted parallel sequencing Research Paper

Mengdan Li, Lihong Chen, Yiping Qu, Fang Sui, Qi Yang, Meiju Ji, Bingyin Shi, Mingwei Chen, Peng Hou

Published Mar 31, 2017 · Vol. 8, No. 22 · pp. 36319-36330

Human melanoma cells resistant to MAPK inhibitors can be effectively targeted by inhibition of the p90 ribosomal S6 kinase Research Paper

Corinna Kosnopfel, Tobias Sinnberg, Birgit Sauer, Heike Niessner, Anja Schmitt, Elena Makino, Andrea Forschner, Stephan Hailfinger, Claus Garbe, Birgit Schittek

Published Mar 15, 2017 · Vol. 8, No. 22 · pp. 35761-35775

HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAF^V600E Research Paper

Lingxiao Cheng, Yuchen Jin, Min Liu, Maomei Ruan, Libo Chen

Published Feb 28, 2017 · Vol. 8, No. 12 · pp. 19843-19854

Efficacy and safety of BRAF inhibition alone versus combined BRAF and MEK inhibition in melanoma: a meta-analysis of randomized controlled trials Review

Mengdong Liu, Xuekang Yang, Jiaqi Liu, Bin Zhao, Weixia Cai, Yan Li, Dahai Hu

Published Feb 23, 2017 · Vol. 8, No. 19 · pp. 32258-32269

The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agent Research Paper

Zuquan Xiong, Yiwen Zang, Shan Zhong, Lujia Zou, Yishuo Wu, Shenghua Liu, Zujun Fang, Zhoujun Shen, Qiang Ding, Shanwen Chen

Published Feb 22, 2017 · Vol. 8, No. 18 · pp. 30151-30161

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MEK inhibition enhances efficacy of bacillus Calmette-Guérin on bladder cancer cells by reducing release of Toll-like receptor 2-activated antimicrobial peptides Research Paper

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition Priority Research Paper

Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death Research Paper

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer Research Paper

Correlation between MEK signature and Ras gene alteration in advanced gastric cancer Research Paper

Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer Research Paper

Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells Research Paper

BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma Research Paper

Correction: LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/Î²-catenin signalling in neuroblastoma Correction

NRAS mutations in cutaneous T cell lymphoma (CTCL) sensitize tumors towards treatment with the multikinase inhibitor Sorafenib Research Paper

MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX) Research Paper

Activating MAPK1 (ERK2) mutation in an aggressive case of disseminated juvenile xanthogranuloma Research Paper

Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy Research Paper

Correction: Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway Correction

ERK expression and its correlation with STAT1 in esophageal squamous cell carcinoma Research Paper

Identification of MAP kinase pathways as therapeutic targets in gallbladder carcinoma using targeted parallel sequencing Research Paper

Human melanoma cells resistant to MAPK inhibitors can be effectively targeted by inhibition of the p90 ribosomal S6 kinase Research Paper

HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAF^V600E Research Paper

Efficacy and safety of BRAF inhibition alone versus combined BRAF and MEK inhibition in melanoma: a meta-analysis of randomized controlled trials Review

The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agent Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

MEK inhibition enhances efficacy of bacillus Calmette-Guérin on bladder cancer cells by reducing release of Toll-like receptor 2-activated antimicrobial peptides Research Paper

mTORC1/autophagy-regulated MerTK in mutant BRAFV600 melanoma with acquired resistance to BRAF inhibition Priority Research Paper

Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death Research Paper

Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer Research Paper

Correlation between MEK signature and Ras gene alteration in advanced gastric cancer Research Paper

Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer Research Paper

Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells Research Paper

BRAF/MEK inhibitors promote CD47 expression that is reversible by ERK inhibition in melanoma Research Paper

Correction: LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/Î²-catenin signalling in neuroblastoma Correction

NRAS mutations in cutaneous T cell lymphoma (CTCL) sensitize tumors towards treatment with the multikinase inhibitor Sorafenib Research Paper

MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX) Research Paper

Activating MAPK1 (ERK2) mutation in an aggressive case of disseminated juvenile xanthogranuloma Research Paper

Molecular dissection of effector mechanisms of RAS-mediated resistance to anti-EGFR antibody therapy Research Paper

Correction: Amphiregulin enhances alpha6beta1 integrin expression and cell motility in human chondrosarcoma cells through Ras/Raf/MEK/ERK/AP-1 pathway Correction

ERK expression and its correlation with STAT1 in esophageal squamous cell carcinoma Research Paper

Identification of MAP kinase pathways as therapeutic targets in gallbladder carcinoma using targeted parallel sequencing Research Paper

Human melanoma cells resistant to MAPK inhibitors can be effectively targeted by inhibition of the p90 ribosomal S6 kinase Research Paper

HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAFV600E Research Paper

Efficacy and safety of BRAF inhibition alone versus combined BRAF and MEK inhibition in melanoma: a meta-analysis of randomized controlled trials Review

The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agent Research Paper

HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAF^V600E Research Paper