The Oncosearch | Oncotarget

Mitochondrial oxidative phosphorylation controls cancer cellâ€™s life and death decisions upon exposure to MAPK inhibitors Research Paper

Paola Corazao-Rozas, Pierre Guerreschi, Fanny AndrÃ©, Pierre-Elliott Gabert, Steve Lancel, Salim Dekiouk, Delphine Fontaine, Meryem Tardivel, Ariel Savina, Bruno Quesnel, Laurent Mortier, Philippe Marchetti, JÃ©rome Kluza

Published Feb 29, 2016 · Vol. 7, No. 26 · pp. 39473-39485

PLA2G16 promotes osteosarcoma metastasis and drug resistance via the MAPK pathway Research Paper

Lin Li, Shoulei Liang, Amanda R. Wasylishen, Yanqin Zhang, Xueli Yang, Bingzheng Zhou, Luling Shan, Xiuxin Han, Tianyang Mu, Guowen Wang, Shunbin Xiong

Published Feb 25, 2016 · Vol. 7, No. 14 · pp. 18021-18035

AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin Research Paper

Mei Gao, Qingbin Kong, Hui Hua, Yancun Yin, Jiao Wang, Ting Luo, Yangfu Jiang

Published Feb 23, 2016 · Vol. 7, No. 13 · pp. 16349-16361

Areca nut components stimulate ADAM17, IL-1α, PGE2 and 8-isoprostane production in oral keratinocyte: role of reactive oxygen species, EGF and JAK signaling Research Paper

Mei-Chi Chang, Chiu-Po Chan, Yi-Jane Chen, Hsiang-Chi Hsien, Ya-Ching Chang, Sin-Yuet Yeung, Po-Yuan Jeng, Ru-Hsiu Cheng, Liang-Jiunn Hahn, Jiiang-Huei Jeng

Published Feb 23, 2016 · Vol. 7, No. 13 · pp. 16879-16894

Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies Research Paper

Valentina Salizzato, Christian Borgo, Luca Cesaro, Lorenzo A. Pinna, Arianna Donella-Deana

Published Feb 22, 2016 · Vol. 7, No. 14 · pp. 18204-18218

Keywords: chronic myeloid leukaemia, imatinib-resistance, protein kinase CK2, rpS6, CX-5011

Hepatocyte growth factor reduces sensitivity to the epidermal growth factor receptor-tyrosine kinase inhibitor, gefitinib, in lung adenocarcinoma cells harboring wild-type EGFR Research Paper

Hua Yang, Rong Wang, Shunli Peng, Longhua Chen, Qi Li, Wei Wang

Published Feb 22, 2016 · Vol. 7, No. 13 · pp. 16273-16281

Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase Research Paper

Jong-Eun Kim, Jae Hwan Kim, Younghyun Lee, Hee Yang, Yong-Seok Heo, Ann M. Bode, Ki Won Lee, Zigang Dong

Published Feb 20, 2016 · Vol. 7, No. 12 · pp. 14616-14627

Validation of a preclinical model for assessment of drug efficacy in melanoma Research Paper

Julie Delyon, Mariana Varna, Jean-Paul Feugeas, AurÃ©lie Sadoux, Saliha Yahiaoui, Marie-Pierre Podgorniak, Geoffroy Leclert, Sarra Mazouz Dorval, Nicolas Dumaz, Anne Janin, Samia Mourah, CÃ©leste LebbÃ©

Published Feb 20, 2016 · Vol. 7, No. 11 · pp. 13069-13081

Dual mTORC1/2 inhibition induces anti-proliferative effect in NF1-associated plexiform neurofibroma and malignant peripheral nerve sheath tumor cells Research Paper

Jennifer Varin, Laury Poulain, Mikael Hivelin, Patrick Nusbaum, Arnaud Hubas, Ingrid Laurendeau, Laurent Lantieri, Pierre Wolkenstein, Michel Vidaud, Eric Pasmant, Nicolas Chapuis, BÃ©atrice Parfait

Published Jan 31, 2016 · Vol. 7, No. 24 · pp. 35753-35767

Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M^high melanoma cell populations Research Paper

Mariusz L. Hartman, Beata Talar, Malgorzata Sztiller-Sikorska, Dariusz Nejc, Malgorzata Czyz

Published Jan 27, 2016 · Vol. 7, No. 8 · pp. 9026-9040

MIIP accelerates epidermal growth factor receptor protein turnover and attenuates proliferation in non-small cell lung cancer Research Paper

Jing Wen, Jianhua Fu, Yihong Ling, Wei Zhang

Published Jan 26, 2016 · Vol. 7, No. 8 · pp. 9118-9134

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis Research Paper

Raphaela Fritsche-Guenther, Franziska Witzel, Stefan Kempa, Tilman Brummer, Christine Sers, Nils BlÃ¼thgen

Published Jan 20, 2016 · Vol. 7, No. 7 · pp. 7960-7969

BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells Research Paper

Maria Goulielmaki, Evangelos Koustas, Eirini Moysidou, Margarita Vlassi, Takehiko Sasazuki, Senji Shirasawa, George Zografos, Eftychia Oikonomou, Alexander Pintzas

Published Jan 18, 2016 · Vol. 7, No. 8 · pp. 9188-9221

DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer Research Paper

TaeWoo Kwon, HyeSook Youn, Beomseok Son, Daehoon Kim, Ki Moon Seong, Sungkyun Park, Wanyeon Kim, BuHyun Youn

Published Jan 12, 2016 · Vol. 7, No. 6 · pp. 7193-7206

Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors Research Paper

Daniel H. Ahn, Hatice Gulcin Ozer, Baris Hancioglu, Gregory B. Lesinski, Cynthia Timmers, Tanios Bekaii-Saab

Published Dec 16, 2015 · Vol. 7, No. 5 · pp. 5306-5312

Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade Research Paper

Ilaria Penna, Alessandra Molla, Giulia Grazia, Loredana Cleris, Gabriella Nicolini, Federica Perrone, Benedetta Picciani, Michele Del Vecchio, Filippo de Braud, Roberta Mortarini, Andrea Anichini

Published Dec 14, 2015 · Vol. 7, No. 4 · pp. 3947-3965

Metformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cells Research Paper

Carminia Maria Della Corte, Vincenza Ciaramella, Concetta Di Mauro, Maria Domenica Castellone, Federica Papaccio, Morena Fasano, Ferdinando Carlo Sasso, Erika Martinelli, Teresa Troiani, Ferdinando De Vita, Michele Orditura, Roberto Bianco, Fortunato Ciardiello, Floriana Morgillo

Published Dec 11, 2015 · Vol. 7, No. 4 · pp. 4265-4278

Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer Research Paper

Zhijie Ding, Yuanzhi Lao, Hong Zhang, Wenwei Fu, Lunlun Zhu, Hongsheng Tan, Hongxi Xu

Published Dec 7, 2015 · Vol. 7, No. 2 · pp. 1826-1837

Zerumbone suppresses the motility and tumorigenecity of triple negative breast cancer cells via the inhibition of TGF-Î²1 signaling pathway Research Paper

Sangmin Kim, Jeongmin Lee, Myeongjin Jeon, Jeong Eon Lee, Seok Jin Nam

Published Nov 30, 2015 · Vol. 7, No. 2 · pp. 1544-1558

Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells Research Paper

Kelly Airiau, ValÃ©rie Prouzet-MaulÃ©on, Benoit Rousseau, Arnaud Pigneux, Marie Jeanneteau, Manon Giraudon, Kaoutar Allou, Pierre Dubus, Francis Belloc, FranÃ§ois-Xavier Mahon

Published Nov 27, 2015 · Vol. 7, No. 1 · pp. 845-859

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Mitochondrial oxidative phosphorylation controls cancer cellâ€™s life and death decisions upon exposure to MAPK inhibitors Research Paper

PLA2G16 promotes osteosarcoma metastasis and drug resistance via the MAPK pathway Research Paper

AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin Research Paper

Areca nut components stimulate ADAM17, IL-1α, PGE2 and 8-isoprostane production in oral keratinocyte: role of reactive oxygen species, EGF and JAK signaling Research Paper

Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies Research Paper

Hepatocyte growth factor reduces sensitivity to the epidermal growth factor receptor-tyrosine kinase inhibitor, gefitinib, in lung adenocarcinoma cells harboring wild-type EGFR Research Paper

Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase Research Paper

Validation of a preclinical model for assessment of drug efficacy in melanoma Research Paper

Dual mTORC1/2 inhibition induces anti-proliferative effect in NF1-associated plexiform neurofibroma and malignant peripheral nerve sheath tumor cells Research Paper

Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M^high melanoma cell populations Research Paper

MIIP accelerates epidermal growth factor receptor protein turnover and attenuates proliferation in non-small cell lung cancer Research Paper

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis Research Paper

BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells Research Paper

DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer Research Paper

Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors Research Paper

Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade Research Paper

Metformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cells Research Paper

Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer Research Paper

Zerumbone suppresses the motility and tumorigenecity of triple negative breast cancer cells via the inhibition of TGF-Î²1 signaling pathway Research Paper

Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Mitochondrial oxidative phosphorylation controls cancer cellâ€™s life and death decisions upon exposure to MAPK inhibitors Research Paper

PLA2G16 promotes osteosarcoma metastasis and drug resistance via the MAPK pathway Research Paper

AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin Research Paper

Areca nut components stimulate ADAM17, IL-1α, PGE2 and 8-isoprostane production in oral keratinocyte: role of reactive oxygen species, EGF and JAK signaling Research Paper

Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies Research Paper

Hepatocyte growth factor reduces sensitivity to the epidermal growth factor receptor-tyrosine kinase inhibitor, gefitinib, in lung adenocarcinoma cells harboring wild-type EGFR Research Paper

Bakuchiol suppresses proliferation of skin cancer cells by directly targeting Hck, Blk, and p38 MAP kinase Research Paper

Validation of a preclinical model for assessment of drug efficacy in melanoma Research Paper

Dual mTORC1/2 inhibition induces anti-proliferative effect in NF1-associated plexiform neurofibroma and malignant peripheral nerve sheath tumor cells Research Paper

Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-Mhigh melanoma cell populations Research Paper

MIIP accelerates epidermal growth factor receptor protein turnover and attenuates proliferation in non-small cell lung cancer Research Paper

Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis Research Paper

BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells Research Paper

DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer Research Paper

Whole-exome tumor sequencing study in biliary cancer patients with a response to MEK inhibitors Research Paper

Primary cross-resistance to BRAFV600E-, MEK1/2- and PI3K/mTOR-specific inhibitors in BRAF-mutant melanoma cells counteracted by dual pathway blockade Research Paper

Metformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cells Research Paper

Griffipavixanthone, a dimeric xanthone extracted from edible plants, inhibits tumor metastasis and proliferation via downregulation of the RAF pathway in esophageal cancer Research Paper

Zerumbone suppresses the motility and tumorigenecity of triple negative breast cancer cells via the inhibition of TGF-Î²1 signaling pathway Research Paper

Synergistic cooperation between ABT-263 and MEK1/2 inhibitor: effect on apoptosis and proliferation of acute myeloid leukemia cells Research Paper

Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M^high melanoma cell populations Research Paper