The Oncosearch | Oncotarget

Combined MEK and Pi3â€™-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo Research Paper

Oussama ElMokh, DorothÃ©e Ruffieux-DaidiÃ©, Matthias A. Roelli, Amandine Stooss, Wayne A. Phillips, JÃ¼rg Gertsch, Matthias S. Dettmer, Roch-Philippe Charles

Published Feb 21, 2017 · Vol. 8, No. 15 · pp. 24604-24620

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer Research Paper

Riley A. Hampsch, Kevin Shee, Darcy Bates, Lionel D. Lewis, Laurent DÃ©sirÃ©, Bertrand Leblond, Eugene Demidenko, Kurtis Stefan, Yina H. Huang, Todd W. Miller

Published Feb 21, 2017 · Vol. 8, No. 13 · pp. 21806-21817

The cyclin-like protein, SPY1, regulates the ERÎ± and ERK1/2 pathways promoting tamoxifen resistance Research Paper

Rosa-Maria Ferraiuolo, Janice Tubman, Indrajit Sinha, Caroline Hamm, Lisa Ann Porter

Published Feb 21, 2017 · Vol. 8, No. 14 · pp. 23337-23352

HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells Research Paper

Lanlan Tang, Wenwen Chai, Fanghua Ye, Yan Yu, Lizhi Cao, Minghua Yang, Min Xie, Liangchun Yang

Published Feb 17, 2017 · Vol. 8, No. 16 · pp. 27314-27327

Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways Research Paper

Guanzhao Liang, Musang Liu, Qiong Wang, Yongnian Shen, Huan Mei, Dongmei Li, Weida Liu

Published Feb 14, 2017 · Vol. 8, No. 17 · pp. 28510-28525

An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells Research Paper

Asako Sasahara, Kana Tominaga, Tatsunori Nishimura, Masao Yano, Etsuko Kiyokawa, Miki Noguchi, Masakuni Noguchi, Hajime Kanauchi, Toshihisa Ogawa, Hiroshi Minato, Keiichiro Tada, Yasuyuki Seto, Arinobu Tojo, Noriko Gotoh

Published Feb 11, 2017 · Vol. 8, No. 15 · pp. 24869-24881

PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p Research Paper

Valentina Audrito, Sara Serra, Aureliano Stingi, Francesca Orso, Federica Gaudino, Cinzia Bologna, Francesco Neri, Giulia Garaffo, Romina Nassini, Gianna Baroni, Eliana Rulli, Daniela Massi, Salvatore Oliviero, Roberto Piva, Daniela Taverna, Mario MandalÃ, Silvia Deaglio

Published Feb 9, 2017 · Vol. 8, No. 9 · pp. 15894-15911

The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRAS^Q61K melanoma Priority Research Paper

Cynthia M. Simbulan-Rosenthal, Sivanesan Dakshanamurthy, Anirudh Gaur, You-Shin Chen, Hong-Bin Fang, Maryam Abdussamad, Hengbo Zhou, John Zapas, Valerie Calvert, Emanuel F. Petricoin, Michael B. Atkins, Stephen W. Byers, Dean S. Rosenthal

Published Feb 2, 2017 · Vol. 8, No. 8 · pp. 12576-12595

FM807, a curcumin analogue, shows potent antitumor effects in nasopharyngeal carcinoma cells by heat shock protein 90 inhibition Research Paper

Min Ye, Wei Huang, Wen-wei Wu, Yang Liu, Sheng-nan Ye, Jian-hua Xu

Published Feb 1, 2017 · Vol. 8, No. 9 · pp. 15364-15376

Claudin-3 expression increases the malignant potential of lung adenocarcinoma cells: role of epidermal growth factor receptor activation Research Paper

Lianmin Zhang, Yuan Wang, Bin Zhang, Hua Zhang, Meng Zhou, Mei Wei, Qiuping Dong, Yue Xu, Zhaosong Wang, Liuwei Gao, Yanjun Qu, Bowen Shi, Jinfang Zhu, Yuesong Yin, Yulong Chen, Lu Sun, Wei Zhang, Shilei Xu, Guoguang Ying, Changli Wang

Published Feb 1, 2017 · Vol. 8, No. 14 · pp. 23033-23047

MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor Research Paper

Sean Caenepeel, Keegan Cooke, Sarah Wadsworth, Guo Huang, Lidia Robert, Blanca Homet Moreno, Giulia Parisi, Elaina Cajulis, Richard Kendall, Pedro Beltran, Antoni Ribas, Angela Coxon, Paul E. Hughes

Published Jan 27, 2017 · Vol. 8, No. 11 · pp. 17795-17809

MicroRNAs in melanoma development and resistance to target therapy Review

Luigi Fattore, Susan Costantini, Debora Malpicci, Ciro Francesco Ruggiero, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini, Gennaro Ciliberto

Published Jan 19, 2017 · Vol. 8, No. 13 · pp. 22262-22278

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells Research Paper

Renate Wagner, Gerald StÃ¼biger, Daniel Veigel, Michael Wuczkowski, Peter Lanzerstorfer, Julian Weghuber, Emmanouil Karteris, Karin Nowikovsky, Nastasia Wilfinger-Lutz, Christian F. Singer, RamÃ³n Colomer, Bellinda BenhamÃº, MarÃa Luz LÃ³pez-RodrÃguez, Peter Valent, Thomas W. Grunt

Published Jan 10, 2017 · Vol. 8, No. 7 · pp. 11600-11613

Androgen suppresses protein kinase D1 expression through fibroblast growth factor receptor substrate 2 in prostate cancer cells Research Paper

Liyong Zhang, Zhenlong Zhao, Shuping Xu, Manuj Tandon, Courtney R. LaValle, Fan Deng, Q. Jane Wang

Published Jan 6, 2017 · Vol. 8, No. 8 · pp. 12800-12811

Yes-associated protein 1 promotes papillary thyroid cancer cell proliferation by activating the ERK/MAPK signaling pathway Research Paper

Tian Liao, Duo Wen, Ben Ma, Jia-Qian Hu, Ning Qu, Rong-Liang Shi, Liang Liu, Qing Guan, Duan-Shu Li, Qing-Hai Ji

Published Dec 28, 2016 · Vol. 8, No. 7 · pp. 11719-11728

Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells Research Paper

Qiaoling Song, Xiaoxiao Sun, Hui Guo, Qiang Yu

Published Dec 17, 2016 · Vol. 8, No. 3 · pp. 5003-5015

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing Research Paper

Florian Selt, Juliane Hohloch, Thomas Hielscher, Felix Sahm, David Capper, Andrey Korshunov, Diren Usta, Sebastian Brabetz, Johannes Ridinger, Jonas Ecker, Ina Oehme, Jan Gronych, Viktoria Marquardt, David Pauck, Heidi BÃ¤chli, Charles D. Stiles, Andreas von Deimling, Marc Remke, Martin U. Schuhmann, Stefan M. Pfister, Tilman Brummer, David T.W. Jones, Olaf Witt, Till Milde

Published Dec 17, 2016 · Vol. 8, No. 7 · pp. 11460-11479

Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications Research Paper

Benjamin Fourneaux, Vanessa Chaire, Carlo Lucchesi, Marie Karanian, Raphael Pineau, Audrey Laroche-Clary, Antoine Italiano

Published Dec 16, 2016 · Vol. 8, No. 5 · pp. 7878-7890

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells Review

James A. McCubrey, Timothy L. Fitzgerald, Li V. Yang, Kvin Lertpiriyapong, Linda S. Steelman, Stephen L. Abrams, Giuseppe Montalto, Melchiorre Cervello, Luca M. Neri, Lucio Cocco, Alberto M. Martelli, Piotr Laidler, Joanna DuliÅ„ska-Litewka, Dariusz Rakus, Agnieszka Gizak, Ferdinando Nicoletti, Luca Falzone, Saverio Candido, Massimo Libra

Published Dec 16, 2016 · Vol. 8, No. 8 · pp. 14221-14250

Synthetic lethal interaction of cetuximab with MEK1/2 inhibition in NRAS-mutant metastatic colorectal cancer Research Paper

Bernardo Queralt, Elisabet CuyÃ s, Joaquim Bosch-Barrera, Anna Massaguer, Rafael de Llorens, BegoÃ±a Martin-Castillo, Joan Brunet, Ramon Salazar, Javier A. Menendez

Published Dec 13, 2016 · Vol. 7, No. 50 · pp. 82185-82199

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Combined MEK and Pi3â€™-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo Research Paper

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer Research Paper

The cyclin-like protein, SPY1, regulates the ERÎ± and ERK1/2 pathways promoting tamoxifen resistance Research Paper

HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells Research Paper

Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways Research Paper

An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells Research Paper

PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p Research Paper

The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRAS^Q61K melanoma Priority Research Paper

FM807, a curcumin analogue, shows potent antitumor effects in nasopharyngeal carcinoma cells by heat shock protein 90 inhibition Research Paper

Claudin-3 expression increases the malignant potential of lung adenocarcinoma cells: role of epidermal growth factor receptor activation Research Paper

MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor Research Paper

MicroRNAs in melanoma development and resistance to target therapy Review

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells Research Paper

Androgen suppresses protein kinase D1 expression through fibroblast growth factor receptor substrate 2 in prostate cancer cells Research Paper

Yes-associated protein 1 promotes papillary thyroid cancer cell proliferation by activating the ERK/MAPK signaling pathway Research Paper

Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells Research Paper

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing Research Paper

Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications Research Paper

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells Review

Synthetic lethal interaction of cetuximab with MEK1/2 inhibition in NRAS-mutant metastatic colorectal cancer Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Combined MEK and Pi3â€™-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo Research Paper

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer Research Paper

The cyclin-like protein, SPY1, regulates the ERÎ± and ERK1/2 pathways promoting tamoxifen resistance Research Paper

HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells Research Paper

Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathways Research Paper

An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells Research Paper

PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p Research Paper

The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma Priority Research Paper

FM807, a curcumin analogue, shows potent antitumor effects in nasopharyngeal carcinoma cells by heat shock protein 90 inhibition Research Paper

Claudin-3 expression increases the malignant potential of lung adenocarcinoma cells: role of epidermal growth factor receptor activation Research Paper

MAPK pathway inhibition induces MET and GAB1 levels, priming BRAF mutant melanoma for rescue by hepatocyte growth factor Research Paper

MicroRNAs in melanoma development and resistance to target therapy Review

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells Research Paper

Androgen suppresses protein kinase D1 expression through fibroblast growth factor receptor substrate 2 in prostate cancer cells Research Paper

Yes-associated protein 1 promotes papillary thyroid cancer cell proliferation by activating the ERK/MAPK signaling pathway Research Paper

Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells Research Paper

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing Research Paper

Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications Research Paper

Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells Review

Synthetic lethal interaction of cetuximab with MEK1/2 inhibition in NRAS-mutant metastatic colorectal cancer Research Paper

The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRAS^Q61K melanoma Priority Research Paper