The Oncosearch | Oncotarget

Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras Research Paper

Julian C. Bahr, Robert W. Robey, Victoria Luchenko, Agnes Basseville, Arup R. Chakraborty, Hanna Kozlowski, Gary T. Pauly, Paresma Patel, Joel P. Schneider, Michael M. Gottesman, Susan E. Bates

Published Sep 13, 2016 · Vol. 7, No. 43 · pp. 69804-69815

MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations Research Paper

Mark Kerstjens, Emma M.C. Driessen, Merel Willekes, Sandra S. PinhanÃ§os, Pauline Schneider, Rob Pieters, Ronald W. Stam

Published Aug 31, 2016 · Vol. 8, No. 9 · pp. 14835-14846

Modeling of signaling crosstalk-mediated drug resistance and its implications on drug combination Research Paper

Xiaoqiang Sun, Jiguang Bao, Zhuhong You, Xing Chen, Jun Cui

Published Aug 31, 2016 · Vol. 7, No. 39 · pp. 63995-64006

Interleukin-32α induces migration of human melanoma cells through downregulation of E-cadherin Research Paper

Joohyun Lee, Kyung Eun Kim, Soyoung Cheon, Ju Han Song, Younkyung Houh, Tae Sung Kim, Minchan Gil, Kyung Jin Lee, Seonghan Kim, Daejin Kim, Dae Young Hur, Yoolhee Yang, Sa Ik Bang, Hyun Jeong Park, Daeho Cho

Published Aug 29, 2016 · Vol. 7, No. 40 · pp. 65825-65836

Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells Research Paper

Hui Ren, Hua Guo, Asmitananda Thakur, Shuo Zhang, Ting Wang, Yiqian Liang, Puyu Shi, Lei Gao, Feng Liu, Jing Feng, Tianjun Chen, Tian Yang, Dong Shang, Johnson J. Liu, Feng Xu, Mingwei Chen

Published Aug 27, 2016 · Vol. 7, No. 41 · pp. 67277-67287

Non-V600 BRAF mutations recurrently found in lung cancer predict sensitivity to the combination of Trametinib and Dabrafenib Research Paper

Amir Noeparast, Erik Teugels, Philippe Giron, Gil Verschelden, Sylvia De Brakeleer, Lore Decoster, Jacques De GrÃ¨ve

Published Aug 26, 2016 · Vol. 8, No. 36 · pp. 60094-60108

Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2 Research Paper

Bong Hee Park, Joung Eun Lim, Hwang Gyun Jeon, Seong Il Seo, Hyun Moo Lee, Han Yong Choi, Seong Soo Jeon, Byong Chang Jeong

Published Aug 24, 2016 · Vol. 7, No. 39 · pp. 63870-63886

Role of EGF/ERBB1 in the transcriptional regulation of the prolactin receptor independent of estrogen and prolactin in breast cancer cells Research Paper

Raghuveer Kavarthapu, Maria L. Dufau

Published Aug 24, 2016 · Vol. 7, No. 40 · pp. 65602-65613

Integrin Î²1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer Research Paper

Cheolwon Choi, Junyeob Kwon, Sunyoung Lim, David M. Helfman

Published Aug 23, 2016 · Vol. 7, No. 39 · pp. 63466-63487

Cytokines can counteract the inhibitory effect of MEK-i on NK-cell function Research Paper

Claudia Manzini, Roberta VenÃ¨, Irene Cossu, Marina Gualco, Simonetta Zupo, Mariella Dono, Francesco Spagnolo, Paola Queirolo, Lorenzo Moretta, Maria Cristina Mingari, Gabriella Pietra

Published Aug 22, 2016 · Vol. 7, No. 38 · pp. 60858-60871

Adrenomedullin blockade suppresses sunitinib-resistant renal cell carcinoma growth by targeting the ERK/MAPK pathway Research Paper

Yongqian Gao, Jinyi Li, Na Qiao, Qingsong Meng, Ming Zhang, Xin Wang, Jianghua Jia, Shuwen Yang, Changbao Qu, Wei Li, Dongbin Wang

Published Aug 22, 2016 · Vol. 7, No. 39 · pp. 63374-63387

Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells Research Paper

Fuling Zhou, Ming Li, Yongchang Wei, Kevin Lin, Yue Lu, Jianjun Shen, Gary L. Johanning, Feng Wang-Johanning

Published Aug 20, 2016 · Vol. 7, No. 51 · pp. 84093-84117

The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation Research Paper

Nianzhu Zhang, Lu Liu, Ning Fan, Qian Zhang, Weijie Wang, Mingnan Zheng, Lingfei Ma, Yan Li, Lei Shi

Published Aug 19, 2016 · Vol. 7, No. 38 · pp. 61587-61600

Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers Research Paper

Giulia Bon, Rossella Loria, Carla Azzurra Amoreo, Alessandra Verdina, Isabella Sperduti, Arianna Mastrofrancesco, Silvia Soddu, Maria Grazia Diodoro, Marcella Mottolese, Matilde Todaro, Giorgio Stassi, Michele Milella, Ruggero De Maria, Rita Falcioni

Published Aug 19, 2016 · Vol. 8, No. 65 · pp. 108463-108479

Induction of exportin-5 expression during melanoma development supports the cellular behavior of human malignant melanoma cells Research Paper

Corinna Anna Ott, Lisa Linck, Elisabeth Kremmer, Gunter Meister, Anja Katrin Bosserhoff

Published Aug 19, 2016 · Vol. 7, No. 38 · pp. 62292-62304

Distinct role of interleukin-6 and tumor necrosis factor receptor-1 in oval cell- mediated liver regeneration and inflammation-associated hepatocarcinogenesis Research Paper

Tong Ji, Gaofeng Li, Jiang Chen, Jie Zhao, Xi Li, Hui Lin, Xiujun Cai, Yong Cang

Published Aug 18, 2016 · Vol. 7, No. 41 · pp. 66635-66646

TGF-Î²1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways Research Paper

Siyuan Xiong, Jung-Chien Cheng, Christian Klausen, Jianfang Zhao, Peter C.K. Leung

Published Aug 16, 2016 · Vol. 7, No. 38 · pp. 61262-61272

Combinatorial therapeutic targeting of BMP2 and MEK-ERK pathways in NF1-associated malignant peripheral nerve sheath tumors Research Paper

Sidra Ahsan, Yubin Ge, Michael A. Tainsky

Published Aug 3, 2016 · Vol. 7, No. 35 · pp. 57171-57185

Agonistic analogs of growth hormone releasing hormone (GHRH) promote wound healing by stimulating the proliferation and survival of human dermal fibroblasts through ERK and AKT pathways Priority Research Paper

Tengjiao Cui, Joaquin J. Jimenez, Norman L. Block, Evangelos V. Badiavas, Luis Rodriguez-Menocal, Ailin Vila Granda, Renzhi Cai, Wei Sha, Marta Zarandi, Roberto Perez, Andrew V. Schally

Published Aug 2, 2016 · Vol. 7, No. 33 · pp. 52661-52672

Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway Research Paper

Laura Lagares-Tena, Silvia GarcÃa-MonclÃºs, Roser LÃ³pez-Alemany, Olga Almacellas-Rabaiget, Juan Huertas-MartÃnez, Miguel SÃ¡inz-Jaspeado, Silvia Mateo-Lozano, Carlos RodrÃguez-Galindo, Santiago Rello-Varona, David Herrero-MartÃn, Oscar M. Tirado

Published Jul 28, 2016 · Vol. 7, No. 35 · pp. 56889-56903

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Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras Research Paper

MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations Research Paper

Modeling of signaling crosstalk-mediated drug resistance and its implications on drug combination Research Paper

Interleukin-32α induces migration of human melanoma cells through downregulation of E-cadherin Research Paper

Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells Research Paper

Non-V600 BRAF mutations recurrently found in lung cancer predict sensitivity to the combination of Trametinib and Dabrafenib Research Paper

Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2 Research Paper

Role of EGF/ERBB1 in the transcriptional regulation of the prolactin receptor independent of estrogen and prolactin in breast cancer cells Research Paper

Integrin Î²1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer Research Paper

Cytokines can counteract the inhibitory effect of MEK-i on NK-cell function Research Paper

Adrenomedullin blockade suppresses sunitinib-resistant renal cell carcinoma growth by targeting the ERK/MAPK pathway Research Paper

Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells Research Paper

The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation Research Paper

Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers Research Paper

Induction of exportin-5 expression during melanoma development supports the cellular behavior of human malignant melanoma cells Research Paper

Distinct role of interleukin-6 and tumor necrosis factor receptor-1 in oval cell- mediated liver regeneration and inflammation-associated hepatocarcinogenesis Research Paper

TGF-Î²1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways Research Paper

Combinatorial therapeutic targeting of BMP2 and MEK-ERK pathways in NF1-associated malignant peripheral nerve sheath tumors Research Paper

Agonistic analogs of growth hormone releasing hormone (GHRH) promote wound healing by stimulating the proliferation and survival of human dermal fibroblasts through ERK and AKT pathways Priority Research Paper

Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras Research Paper

MEK inhibition is a promising therapeutic strategy for MLL-rearranged infant acute lymphoblastic leukemia patients carrying RAS mutations Research Paper

Modeling of signaling crosstalk-mediated drug resistance and its implications on drug combination Research Paper

Interleukin-32α induces migration of human melanoma cells through downregulation of E-cadherin Research Paper

Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells Research Paper

Non-V600 BRAF mutations recurrently found in lung cancer predict sensitivity to the combination of Trametinib and Dabrafenib Research Paper

Curcumin potentiates antitumor activity of cisplatin in bladder cancer cell lines via ROS-mediated activation of ERK1/2 Research Paper

Role of EGF/ERBB1 in the transcriptional regulation of the prolactin receptor independent of estrogen and prolactin in breast cancer cells Research Paper

Integrin Î²1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer Research Paper

Cytokines can counteract the inhibitory effect of MEK-i on NK-cell function Research Paper

Adrenomedullin blockade suppresses sunitinib-resistant renal cell carcinoma growth by targeting the ERK/MAPK pathway Research Paper

Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells Research Paper

The requirement of SEPT2 and SEPT7 for migration and invasion in human breast cancer via MEK/ERK activation Research Paper

Dual targeting of HER3 and MEK may overcome HER3-dependent drug-resistance of colon cancers Research Paper

Induction of exportin-5 expression during melanoma development supports the cellular behavior of human malignant melanoma cells Research Paper

Distinct role of interleukin-6 and tumor necrosis factor receptor-1 in oval cell- mediated liver regeneration and inflammation-associated hepatocarcinogenesis Research Paper

TGF-Î²1 stimulates migration of type II endometrial cancer cells by down-regulating PTEN via activation of SMAD and ERK1/2 signaling pathways Research Paper

Combinatorial therapeutic targeting of BMP2 and MEK-ERK pathways in NF1-associated malignant peripheral nerve sheath tumors Research Paper

Agonistic analogs of growth hormone releasing hormone (GHRH) promote wound healing by stimulating the proliferation and survival of human dermal fibroblasts through ERK and AKT pathways Priority Research Paper

Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway Research Paper