The Oncosearch | Oncotarget

A dual mechanism of activation of the Sonic Hedgehog pathway in anaplastic thyroid cancer: crosstalk with RAS-BRAF-MEK pathway and ligand secretion by tumor stroma Research Paper

Alessia Parascandolo, Mikko O. Laukkanen, Nancy De Rosa, Clara Ugolini, Maria Carmela Cantisani, Anna Maria Cirafici, Fulvio Basolo, Massimo Santoro, Maria Domenica Castellone

Published Dec 17, 2017 · Vol. 9, No. 4 · pp. 4496-4510

EGFR expression in patients with stage III colorectal cancer after adjuvant chemotherapy and on cancer cell function Research Paper

Ching-Wen Huang, Yi-Ting Chen, Hsiang-Lin Tsai, Yung-Sung Yeh, Wei-Chih Su, Cheng-Jen Ma, Tsen-Ni Tsai, Jaw-Yuan Wang

Published Dec 9, 2017 · Vol. 8, No. 70 · pp. 114663-114676

Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression Research Paper

Linda S. Steelman, Steve L. Abrams, Peter Ruvolo, Vivian Ruvolo, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Luca M. Neri, Saverio Candido, Massimo Libra, James A. McCubrey

Published Dec 6, 2017 · Vol. 8, No. 68 · pp. 113013-113033

Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells Research Paper

Natalia I. DÃaz-Valdivia, Claudia C. CalderÃ³n, Jorge E. DÃaz, Lorena Lobos-GonzÃ¡lez, Hugo Sepulveda, Rina J. OrtÃz, Samuel Martinez, Veronica Silva, Horacio J. Maldonado, Patricio Silva, Sergio Wehinger, VerÃ³nica A. Burzio, Vicente A. Torres, MartÃn Montecino, Lisette Leyton, Andrew F.G. Quest

Published Dec 5, 2017 · Vol. 8, No. 67 · pp. 111943-111965

Integrative molecular network analysis identifies emergent enzalutamide resistance mechanisms in prostate cancer Research Paper

Carly J. King, Josha Woodward, Jacob Schwartzman, Daniel J. Coleman, Robert Lisac, Nicholas J. Wang, Kathryn Van Hook, Lina Gao, Joshua Urrutia, Mark A. Dane, Laura M. Heiser, Joshi J. Alumkal

Published Nov 20, 2017 · Vol. 8, No. 67 · pp. 111084-111095

Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin Research Paper

Chengying Xie, Xiangling Chen, Mingyue Zheng, Xiaohong Liu, Hongbin Wang, Liguang Lou

Published Nov 14, 2017 · Vol. 8, No. 64 · pp. 107977-107990

Antitumor effects of regorafenib and sorafenib in preclinical models of hepatocellular carcinoma Research Paper

Maria Kissel, Sandra Berndt, Lukas Fiebig, Simon Kling, Qunsheng Ji, Qingyang Gu, Tina Lang, Frank-Thorsten Hafner, Michael Teufel, Dieter Zopf

Published Nov 6, 2017 · Vol. 8, No. 63 · pp. 107096-107108

MEK/ERK addiction in CNL/aCML Editorial

Meenu Kesarwani, Zachary Kincaid, Mohammad Azam

Published Nov 3, 2017 · Vol. 8, No. 59 · pp. 99215-99216

Mek activity is required for ErbB2 expression in breast cancer cells detached from the extracellular matrix Research Paper

Iman A. Khan, Byong H. Yoo, Janusz Rak, Kirill V. Rosen

Published Oct 31, 2017 · Vol. 8, No. 62 · pp. 105383-105396

SPC24 promotes osteosarcoma progression by increasing EGFR/MAPK signaling Research Paper

Jun Sheng, Mengchen Yin, Zhengwang Sun, Xia Kang, Da Liu, Kai Jiang, Jia Xu, Feixing Zhao, Qunfeng Guo, Wei Zheng

Published Oct 27, 2017 · Vol. 8, No. 62 · pp. 105276-105283

MicroRNA-433 inhibits oral squamous cell carcinoma cells by targeting FAK Research Paper

Yong-Jian Wang, Zi-Feng Zhang, Shao-Hua Fan, Juan Zhuang, Qun Shan, Xin-Rui Han, Xin Wen, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Bin Qiao, Qian Tao, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng

Published Oct 27, 2017 · Vol. 8, No. 59 · pp. 100227-100241

Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells Research Paper

Yujuan Chen, Xiaoyun Wang, Chuan Cao, Xiaodong Wang, Shufang Liang, Cheng Peng, Leilei Fu, Gu He

Published Oct 26, 2017 · Vol. 8, No. 61 · pp. 104193-104205

Low concentration of formononetin promotes proliferation of estrogen receptor-positive cells through an ERα-miR-375-PTEN-ERK1/2-bcl-2 pathway Research Paper

Yan-Hong Guo, Feng-Yan Tang, Yong Wang, Wen-Jun Huang, Jing Tian, Hui-Ling Lu, Min Xin, Jian Chen

Published Oct 19, 2017 · Vol. 8, No. 59 · pp. 100045-100055

Trichostatin A inhibits radiation-induced epithelial-to-mesenchymal transition in the alveolar epithelial cells Research Paper

Devipriya Nagarajan, Lei Wang, Weiling Zhao, Xiaochen Han

Published Oct 9, 2017 · Vol. 8, No. 60 · pp. 101745-101759

Extracellular ATP, as an energy and phosphorylating molecule, induces different types of drug resistances in cancer cells through ATP internalization and intracellular ATP level increase Research Paper

Xuan Wang, Yunsheng Li, Yanrong Qian, Yanyang Cao, Pratik Shriwas, Haiyun Zhang, Xiaozhuo Chen

Published Sep 23, 2017 · Vol. 8, No. 50 · pp. 87860-87877

Incidence and relative risk of cutaneous squamous cell carcinoma with single-agent BRAF inhibitor and dual BRAF/MEK inhibitors in cancer patients: a meta-analysis Meta-Analysis

Ling Peng, Yina Wang, Yun Hong, Xianghua Ye, Peng Shi, Junyan Zhang, Qiong Zhao

Published Sep 19, 2017 · Vol. 8, No. 47 · pp. 83280-83291

Inhibition of Miro1 disturbs mitophagy and pancreatic Î²-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes Research Paper

Lingling Chen, Chunyan Liu, Jianfeng Gao, Zhiwen Xie, Lawrence W.C. Chan, Damien J. Keating, Yibin Yang, Jiazhong Sun, Fuling Zhou, Yongchang Wei, Xiuli Men, Sijun Yang

Published Sep 16, 2017 · Vol. 8, No. 53 · pp. 90693-90705

Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells Research Paper

Peng-Yuan Zhuang, Ke-Wei Zhang, Jian-Dong Wang, Xue-Ping Zhou, Ying-Bin Liu, Zhi-Wei Quan, Jun Shen

Published Sep 15, 2017 · Vol. 8, No. 44 · pp. 77915-77927

Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways Priority Research Paper

Payal Jain, Amanda Silva, Harry J. Han, Shih-Shan Lang, Yuankun Zhu, Katie Boucher, Tiffany E. Smith, Aesha Vakil, Patrick Diviney, Namrata Choudhari, Pichai Raman, Christine M. Busch, Tim Delaney, Xiaodong Yang, Aleksandra K. Olow, Sabine Mueller, Daphne Haas-Kogan, Elizabeth Fox, Phillip B. Storm, Adam C. Resnick, Angela J. Waanders

Published Sep 15, 2017 · Vol. 8, No. 49 · pp. 84697-84713

chr19_34670, a newly identified miRNA, represses rapid tumor growth of cystic vestibular schwannomas by targeting transforming growth factor α and inhibiting MAPK pathway Research Paper

Zirong Huo, Shuang Yan, Tao Yang, Zhentao Wang, Qi Huang, Zhaoyan Wang, Hongsai Chen, Penghui Chen, Huan Jia, Zhihua Zhang, Hao Wu

Published Sep 8, 2017 · Vol. 5 · pp. 216-228

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A dual mechanism of activation of the Sonic Hedgehog pathway in anaplastic thyroid cancer: crosstalk with RAS-BRAF-MEK pathway and ligand secretion by tumor stroma Research Paper

EGFR expression in patients with stage III colorectal cancer after adjuvant chemotherapy and on cancer cell function Research Paper

Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression Research Paper

Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells Research Paper

Integrative molecular network analysis identifies emergent enzalutamide resistance mechanisms in prostate cancer Research Paper

Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin Research Paper

Antitumor effects of regorafenib and sorafenib in preclinical models of hepatocellular carcinoma Research Paper

MEK/ERK addiction in CNL/aCML Editorial

Mek activity is required for ErbB2 expression in breast cancer cells detached from the extracellular matrix Research Paper

SPC24 promotes osteosarcoma progression by increasing EGFR/MAPK signaling Research Paper

MicroRNA-433 inhibits oral squamous cell carcinoma cells by targeting FAK Research Paper

Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells Research Paper

Low concentration of formononetin promotes proliferation of estrogen receptor-positive cells through an ERα-miR-375-PTEN-ERK1/2-bcl-2 pathway Research Paper

Trichostatin A inhibits radiation-induced epithelial-to-mesenchymal transition in the alveolar epithelial cells Research Paper

Extracellular ATP, as an energy and phosphorylating molecule, induces different types of drug resistances in cancer cells through ATP internalization and intracellular ATP level increase Research Paper

Incidence and relative risk of cutaneous squamous cell carcinoma with single-agent BRAF inhibitor and dual BRAF/MEK inhibitors in cancer patients: a meta-analysis Meta-Analysis

Inhibition of Miro1 disturbs mitophagy and pancreatic Î²-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes Research Paper

Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells Research Paper

Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways Priority Research Paper

chr19_34670, a newly identified miRNA, represses rapid tumor growth of cystic vestibular schwannomas by targeting transforming growth factor α and inhibiting MAPK pathway Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

A dual mechanism of activation of the Sonic Hedgehog pathway in anaplastic thyroid cancer: crosstalk with RAS-BRAF-MEK pathway and ligand secretion by tumor stroma Research Paper

EGFR expression in patients with stage III colorectal cancer after adjuvant chemotherapy and on cancer cell function Research Paper

Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression Research Paper

Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells Research Paper

Integrative molecular network analysis identifies emergent enzalutamide resistance mechanisms in prostate cancer Research Paper

Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin Research Paper

Antitumor effects of regorafenib and sorafenib in preclinical models of hepatocellular carcinoma Research Paper

MEK/ERK addiction in CNL/aCML Editorial

Mek activity is required for ErbB2 expression in breast cancer cells detached from the extracellular matrix Research Paper

SPC24 promotes osteosarcoma progression by increasing EGFR/MAPK signaling Research Paper

MicroRNA-433 inhibits oral squamous cell carcinoma cells by targeting FAK Research Paper

Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells Research Paper

Low concentration of formononetin promotes proliferation of estrogen receptor-positive cells through an ERα-miR-375-PTEN-ERK1/2-bcl-2 pathway Research Paper

Trichostatin A inhibits radiation-induced epithelial-to-mesenchymal transition in the alveolar epithelial cells Research Paper

Extracellular ATP, as an energy and phosphorylating molecule, induces different types of drug resistances in cancer cells through ATP internalization and intracellular ATP level increase Research Paper

Incidence and relative risk of cutaneous squamous cell carcinoma with single-agent BRAF inhibitor and dual BRAF/MEK inhibitors in cancer patients: a meta-analysis Meta-Analysis

Inhibition of Miro1 disturbs mitophagy and pancreatic Î²-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes Research Paper

Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells Research Paper

Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways Priority Research Paper

chr19_34670, a newly identified miRNA, represses rapid tumor growth of cystic vestibular schwannomas by targeting transforming growth factor α and inhibiting MAPK pathway Research Paper