The Oncosearch | Oncotarget

Functional consequence of the p53 codon 72 polymorphism in colorectal cancer Research Paper

Venkat R. Katkoori, Upender Manne, Lakshmi S. Chaturvedi, Marc D. Basson, Pam Haan, Daniel Coffey, Harvey L. Bumpers

Published Aug 29, 2017 · Vol. 8, No. 44 · pp. 76574-76586

Combined targeting of Raf and Mek synergistically inhibits tumorigenesis in triple negative breast cancer model systems Research Paper

Teddy S. Nagaria, Changnian Shi, Charles Leduc, Victoria Hoskin, Soma Sikdar, Waheed Sangrar, Peter A. Greer

Published Aug 24, 2017 · Vol. 8, No. 46 · pp. 80804-80819

Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer Research Paper

Katie M. Mishall, Thomas C. Beadnell, Brent M. Kuenzi, Dorothy M. Klimczak, Giulio Superti-Furga, Uwe Rix, Rebecca E. Schweppe

Published Aug 24, 2017 · Vol. 8, No. 61 · pp. 103014-103031

Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells Research Paper

Stephen L. Abrams, Peter P. Ruvolo, Vivian R. Ruvolo, Giovanni Ligresti, Alberto M. Martelli, Lucio Cocco, Stefano Ratti, Agostino Tafuri, Linda S. Steelman, Saverio Candido, Massimo Libra, James A. McCubrey

Published Aug 24, 2017 · Vol. 8, No. 44 · pp. 76525-76557

Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells Research Paper

Jia-Sin Yang, Chiao-Wen Lin, Yi-Hsien Hsieh, Ming-Hsien Chien, Chun-Yi Chuang, Shun-Fa Yang

Published Aug 12, 2017 · Vol. 8, No. 47 · pp. 83088-83099

Lack of adiponectin and adiponectin receptor 1 contributes to benign prostatic hyperplasia Research Paper

Shi Fu, Huan Xu, Meng Gu, Chong Liu, Xiang Wan, Yanbo Chen, Qi Chen, Juan Zhou, Zhong Wang

Published Aug 3, 2017 · Vol. 8, No. 51 · pp. 88537-88551

Activated spleen tyrosine kinase promotes malignant progression of oral squamous cell carcinoma via mTOR/S6 signaling pathway in an ERK1/2-independent manner Research Paper

Pan Gao, Xianghe Qiao, Haibin Sun, Yi Huang, Jie Lin, Longjiang Li, Xiaoyi Wang, Chunjie Li

Published Aug 3, 2017 · Vol. 8, No. 48 · pp. 83900-83912

Phenformin enhances the therapeutic effect of selumetinib in KRAS-mutant non-small cell lung cancer irrespective of LKB1 status Research Paper

Jun Zhang, Sreenivas Nannapaneni, Dongsheng Wang, Fakeng Liu, Xu Wang, Rui Jin, Xiuju Liu, Mohammad Aminur Rahman, Xianghong Peng, Guoqing Qian, Zhuo G. Chen, Kwok-Kin Wong, Fadlo R. Khuri, Wei Zhou, Dong M. Shin

Published Aug 1, 2017 · Vol. 8, No. 35 · pp. 59008-59022

A preclinical evaluation of the MEK inhibitor refametinib in HER2-positive breast cancer cell lines including those with acquired resistance to trastuzumab or lapatinib Research Paper

John Oâ€™Shea, Mattia Cremona, Clare Morgan, Malgorzata Milewska, Frankie Holmes, Virginia Espina, Lance Liotta, Joyce Oâ€™Shaughnessy, Sinead Toomey, Stephen F. Madden, Aoife Carr, Naomi Elster, Bryan T. Hennessy, Alex J. Eustace

Published Jul 22, 2017 · Vol. 8, No. 49 · pp. 85120-85135

A phase I clinical trial of binimetinib in combination with FOLFOX in patients with advanced metastatic colorectal cancer who failed prior standard therapy Clinical Research Papers

May Cho, Jun Gong, Paul Frankel, Timothy W. Synold, Dean Lim, Vincent Chung, Joseph Chao, Daneng Li, Yuan Chen, Stephen Sentovich, Kurt Melstrom, Gagandeep Singh, Eloise Luevanos, Marwan Fakih

Published Jul 18, 2017 · Vol. 8, No. 45 · pp. 79750-79760

Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation Research Paper

Naida Suleymanova, Caitrin Crudden, Claire Worrall, Anica Dricu, Ada Girnita, Leonard Girnita

Published Jul 17, 2017 · Vol. 8, No. 47 · pp. 82256-82267

EGFR or HER2 inhibition modulates the tumor microenvironment by suppression of PD-L1 and cytokines release Research Paper

Koung Jin Suh, Ji Hea Sung, Jin Won Kim, Song-Hee Han, Hye Seung Lee, Ahrum Min, Mi Hyun Kang, Ji Eun Kim, Ji-Won Kim, Se Hyun Kim, Jeong-Ok Lee, Yu Jung Kim, Keun-Wook Lee, Soo-Mee Bang, Seock-Ah Im, Jong Seok Lee

Published Jul 12, 2017 · Vol. 8, No. 38 · pp. 63901-63910

Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway Research Paper

Ming Jing Shen, Li Jun Xu, Li Yang, Ying Tsai, Peter C. Keng, Yongbing Chen, Soo Ok Lee, Yuhchyau Chen

Published Jul 12, 2017 · Vol. 8, No. 46 · pp. 80506-80520

Propoxur enhances MMP-2 expression and the corresponding invasion of human breast cancer cells via the ERK/Nrf2 signaling pathway Research Paper

Yunxiang Shi, Daizhi An, Yiping Liu, Qiong Feng, Xu Fang, Guilan Pan, Qiang Wang

Published Jul 7, 2017 · Vol. 8, No. 50 · pp. 87107-87123

Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib Research Paper

Nataliya Rohr-Udilova, Florian KlinglmÃ¼ller, Martha Seif, Hubert Hayden, Martin Bilban, Matthias Pinter, Klaus Stolze, Wolfgang Sieghart, Markus Peck-Radosavljevic, Michael Trauner

Published Jul 6, 2017 · Vol. 8, No. 34 · pp. 57109-57120

Tumor-specific hepatic stellate cells (tHSCs) induces DIgR2 expression in dendritic cells to inhibit T cells Research Paper

Yun-Hong Xia, Zhen Lu, Min Zhao, Wen-Ting Dai, Lu Ding, Li-Xia Hu, Guo-Lin Jiang

Published Jul 5, 2017 · Vol. 8, No. 33 · pp. 55084-55093

Impact of phosphoinositide-3-kinase and vitamin D3 nuclear receptor single-nucleotide polymorphisms on the outcome of malignant melanoma patients Research Paper

Francesca Morgese, Davide Soldato, Silvia Pagliaretta, Riccardo Giampieri, Donatella Brancorsini, Mariangela Torniai, Silvia Rinaldi, Agnese Savini, Azzurra Onofri, Marina Scarpelli, Rossana Berardi

Published May 30, 2017 · Vol. 8, No. 44 · pp. 75914-75923

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Functional consequence of the p53 codon 72 polymorphism in colorectal cancer Research Paper

Combined targeting of Raf and Mek synergistically inhibits tumorigenesis in triple negative breast cancer model systems Research Paper

Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer Research Paper

Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells Research Paper

Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells Research Paper

Lack of adiponectin and adiponectin receptor 1 contributes to benign prostatic hyperplasia Research Paper

Activated spleen tyrosine kinase promotes malignant progression of oral squamous cell carcinoma via mTOR/S6 signaling pathway in an ERK1/2-independent manner Research Paper

Phenformin enhances the therapeutic effect of selumetinib in KRAS-mutant non-small cell lung cancer irrespective of LKB1 status Research Paper

A preclinical evaluation of the MEK inhibitor refametinib in HER2-positive breast cancer cell lines including those with acquired resistance to trastuzumab or lapatinib Research Paper

A phase I clinical trial of binimetinib in combination with FOLFOX in patients with advanced metastatic colorectal cancer who failed prior standard therapy Clinical Research Papers

Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation Research Paper

EGFR or HER2 inhibition modulates the tumor microenvironment by suppression of PD-L1 and cytokines release Research Paper

Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway Research Paper

Propoxur enhances MMP-2 expression and the corresponding invasion of human breast cancer cells via the ERK/Nrf2 signaling pathway Research Paper

Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib Research Paper

Tumor-specific hepatic stellate cells (tHSCs) induces DIgR2 expression in dendritic cells to inhibit T cells Research Paper

AM1241 alleviates MPTP-induced Parkinson's disease and promotes the regeneration of DA neurons in PD mice Research Paper

SHP2 negatively regulates HLA-ABC and PD-L1 expression via STAT1 phosphorylation in prostate cancer cells Research Paper

Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma Review

Impact of phosphoinositide-3-kinase and vitamin D3 nuclear receptor single-nucleotide polymorphisms on the outcome of malignant melanoma patients Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Functional consequence of the p53 codon 72 polymorphism in colorectal cancer Research Paper

Combined targeting of Raf and Mek synergistically inhibits tumorigenesis in triple negative breast cancer model systems Research Paper

Sustained activation of the AKT/mTOR and MAP kinase pathways mediate resistance to the Src inhibitor, dasatinib, in thyroid cancer Research Paper

Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells Research Paper

Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells Research Paper

Lack of adiponectin and adiponectin receptor 1 contributes to benign prostatic hyperplasia Research Paper

Activated spleen tyrosine kinase promotes malignant progression of oral squamous cell carcinoma via mTOR/S6 signaling pathway in an ERK1/2-independent manner Research Paper

Phenformin enhances the therapeutic effect of selumetinib in KRAS-mutant non-small cell lung cancer irrespective of LKB1 status Research Paper

A preclinical evaluation of the MEK inhibitor refametinib in HER2-positive breast cancer cell lines including those with acquired resistance to trastuzumab or lapatinib Research Paper

A phase I clinical trial of binimetinib in combination with FOLFOX in patients with advanced metastatic colorectal cancer who failed prior standard therapy Clinical Research Papers

Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation Research Paper

EGFR or HER2 inhibition modulates the tumor microenvironment by suppression of PD-L1 and cytokines release Research Paper

Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway Research Paper

Propoxur enhances MMP-2 expression and the corresponding invasion of human breast cancer cells via the ERK/Nrf2 signaling pathway Research Paper

Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib Research Paper

Tumor-specific hepatic stellate cells (tHSCs) induces DIgR2 expression in dendritic cells to inhibit T cells Research Paper

AM1241 alleviates MPTP-induced Parkinson's disease and promotes the regeneration of DA neurons in PD mice Research Paper

SHP2 negatively regulates HLA-ABC and PD-L1 expression via STAT1 phosphorylation in prostate cancer cells Research Paper

Overcoming resistance to targeted therapy with immunotherapy and combination therapy for metastatic melanoma Review

Impact of phosphoinositide-3-kinase and vitamin D3 nuclear receptor single-nucleotide polymorphisms on the outcome of malignant melanoma patients Research Paper