The Oncosearch | Oncotarget

Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations Research Paper

Shaohua Peng, Banibrata Sen, Tuhina Mazumdar, Lauren A. Byers, Lixia Diao, Jing Wang, Pan Tong, Uma Giri, John V. Heymach, Humam N. Kadara, Faye M. Johnson

Published Nov 23, 2015 · Vol. 7, No. 1 · pp. 565-579

Concomitant BET and MAPK blockade for effective treatment of ovarian cancer Research Paper

Ying Jing, Zhenfeng Zhang, Pengfei Ma, Shimin An, Ying Shen, Liang Zhu, Guanglei Zhuang

Published Nov 12, 2015 · Vol. 7, No. 3 · pp. 2545-2554

Mutant HRAS as novel target for MEK and mTOR inhibitors Research Paper

Michael K. Kiessling, Alessandra Curioni-Fontecedro, Panagiotis Samaras, Kirstin Atrott, Jesus Cosin-Roger, Silvia Lang, Michael Scharl, Gerhard Rogler

Published Nov 3, 2015 · Vol. 6, No. 39 · pp. 42183-42196

Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways Research Paper

Lu Qian Wang, Kwan Yeung Wong, Anders RosÃ¨n, Chor Sang Chim

Published Oct 27, 2015 · Vol. 6, No. 42 · pp. 44422-44436

Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma Research Paper

Harish C. Pal, Ariana C. Diamond, Leah R. Strickland, John C. Kappes, Santosh K. Katiyar, Craig A. Elmets, Mohammad Athar, Farrukh Afaq

Published Oct 26, 2015 · Vol. 7, No. 2 · pp. 1227-1241

LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/Î²-catenin signalling in neuroblastoma Research Paper

Gabriella Cunha Vieira, S. Chockalingam, Zsombor Melegh, Alexander Greenhough, Sally Malik, Marianna Szemes, Ji Hyun Park, Abderrahmane Kaidi, Li Zhou, Daniel Catchpoole, Rhys Morgan, David O. Bates, Peter J. Gabb, Karim Malik

Published Oct 23, 2015 · Vol. 6, No. 37 · pp. 40053-40067

mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer Research Paper

Harrison Cash, Sujay Shah, Ellen Moore, Andria Caruso, Ravindra Uppaluri, Carter Van Waes, Clint Allen

Published Oct 22, 2015 · Vol. 6, No. 34 · pp. 36400-36417

E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling Research Paper

Sharon McGonigle, Zhihong Chen, Jiayi Wu, Paul Chang, Donna Kolber-Simonds, Karen Ackermann, Natalie C. Twine, Jue-lon Shie, Jingzang Tao Miu, Kuan-Chun Huang, George A. Moniz, Kenichi Nomoto

Published Oct 20, 2015 · Vol. 6, No. 38 · pp. 41307-41323

Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes Research Paper

Sally M. Hunter, Michael S. Anglesio, Georgina L. Ryland, Raghwa Sharma, Yoke-Eng Chiew, Simone M. Rowley, Maria A. Doyle, Jason Li, C. Blake Gilks, Phillip Moss, Prue E. Allan, Andrew N. Stephens, David G. Huntsman, Anna deFazio, David D. Bowtell, Australian Ovarian Cancer Study Group, Kylie L. Gorringe, Ian G. Campbell

Published Oct 19, 2015 · Vol. 6, No. 35 · pp. 37663-37677

Deletion of cyclooxygenase-2 inhibits K-rasâ€“induced lung carcinogenesis Research Paper

Yong Pan, Yan Jiang, Lin Tan, Murali K. Ravoori, Mihai Gagea, Vikus Kundra, Susan M. Fischer, Peiying Yang

Published Oct 3, 2015 · Vol. 6, No. 36 · pp. 38816-38826

Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts Research Paper

Christopher H. Lieu, Peter J. Klauck, Patrick K. Henthorn, John J. Tentler, Aik-Choon Tan, Anna Spreafico, Heather M. Selby, Blair C. Britt, Stacey M. Bagby, John J. Arcaroli, Wells A. Messersmith, Todd M. Pitts, S. Gail Eckhardt

Published Oct 1, 2015 · Vol. 6, No. 33 · pp. 34561-34572

Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy Research Paper

Sara Alves, Lisandra Castro, Maria Sofia Fernandes, Rita Francisco, Paula Castro, Muriel Priault, Susana Rodrigues Chaves, Mary Pat Moyer, Carla Oliveira, Raquel Seruca, Manuela CÃ´rte-Real, Maria JoÃ£o Sousa, Ana Preto

Published Sep 25, 2015 · Vol. 6, No. 31 · pp. 30787-30802

sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1Î± signaling pathways Research Paper

Boh-Ram Kim, Seung Hee Seo, Mi Sun Park, Seung-Hoon Lee, Youngjoo Kwon, Seung Bae Rho

Published Sep 10, 2015 · Vol. 6, No. 31 · pp. 31830-31843

DNA-mediated adjuvant immunotherapy extends survival in two different mouse models of myeloid malignancies Research Paper

Carole Le Pogam, Satyananda Patel, Petra Gorombei, Laura Guerenne, Patricia Krief, Nader Omidvar, Nilgun Tekin, Elena Bernasconi, Flore Sicre, Marie-Helene Schlageter, Martine Chopin, Maria-Elena Noguera, Robert West, Ansu Abu, Vikram Mathews, Marika Pla, Pierre Fenaux, Christine Chomienne, Rose Ann Padua

Published Sep 10, 2015 · Vol. 6, No. 32 · pp. 32494-32508

Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin Research Paper

Aparna Lakshmanan, Daniel Scarberry, Jill A. Green, Xiaoli Zhang, Samia Selmi-Ruby, Sissy M. Jhiang

Published Sep 9, 2015 · Vol. 6, No. 31 · pp. 31792-31804

Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling Research Paper

Saluja Kaduwal, Woo-Jeong Jeong, Jong-Chan Park, Kug Hwa Lee, Young-Mi Lee, Soung Hoo Jeon, Yong-Beom Lim, Do Sik Min, Kang-Yell Choi

Published Sep 5, 2015 · Vol. 6, No. 32 · pp. 33091-33105

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells Research Paper

Hong Wu, Aoli Wang, Wei Zhang, Beilei Wang, Cheng Chen, Wenchao Wang, Chen Hu, Zi Ye, Zheng Zhao, Li Wang, Xixiang Li, Kailin Yu, Juan Liu, Jiaxin Wu, Xiao-E Yan, Peng Zhao, Jinhua Wang, Chu Wang, Ellen L. Weisberg, Nathanael S. Gray, Cai-Hong Yun, Jing Liu, Liang Chen, Qingsong Liu

Published Sep 5, 2015 · Vol. 6, No. 31 · pp. 31313-31322

Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma Research Paper

Kian Ngiap Chua, Li Ren Kong, Wen Jing Sim, Hsien Chun Ng, Weijie Richard Ong, Jean Paul Thiery, Hung Huynh, Boon Cher Goh

Published Aug 17, 2015 · Vol. 6, No. 30 · pp. 29991-30005

Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H₂O₂ generation: antagonism by tetrathiomolybdate Research Paper

Ali Calderon-Aparicio, Mary Strasberg-Rieber, Manuel Rieber

Published Aug 7, 2015 · Vol. 6, No. 30 · pp. 29771-29781

Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status Research Paper

Luigi Formisano, Valentina Dâ€™Amato, Alberto Servetto, Simona Brillante, Lucia Raimondo, Concetta Di Mauro, Roberta Marciano, Roberta Clara Orsini, Sandro Cosconati, Antonio Randazzo, Sarah J. Parsons, Nunzia Montuori, Bianca Maria Veneziani, Sabino De Placido, Roberta Rosa, Roberto Bianco

Published Aug 3, 2015 · Vol. 6, No. 28 · pp. 26090-26103

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Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations Research Paper

Concomitant BET and MAPK blockade for effective treatment of ovarian cancer Research Paper

Mutant HRAS as novel target for MEK and mTOR inhibitors Research Paper

Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways Research Paper

Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma Research Paper

LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/Î²-catenin signalling in neuroblastoma Research Paper

mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer Research Paper

E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling Research Paper

Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes Research Paper

Deletion of cyclooxygenase-2 inhibits K-rasâ€“induced lung carcinogenesis Research Paper

Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts Research Paper

Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy Research Paper

sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1Î± signaling pathways Research Paper

DNA-mediated adjuvant immunotherapy extends survival in two different mouse models of myeloid malignancies Research Paper

Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin Research Paper

Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling Research Paper

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells Research Paper

Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma Research Paper

Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H₂O₂ generation: antagonism by tetrathiomolybdate Research Paper

Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations Research Paper

Concomitant BET and MAPK blockade for effective treatment of ovarian cancer Research Paper

Mutant HRAS as novel target for MEK and mTOR inhibitors Research Paper

Epigenetic silencing of tumor suppressor miR-3151 contributes to Chinese chronic lymphocytic leukemia by constitutive activation of MADD/ERK and PIK3R2/AKT signaling pathways Research Paper

Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma Research Paper

LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/Î²-catenin signalling in neuroblastoma Research Paper

mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer Research Paper

E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling Research Paper

Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes Research Paper

Deletion of cyclooxygenase-2 inhibits K-rasâ€“induced lung carcinogenesis Research Paper

Antitumor activity of a potent MEK inhibitor, TAK-733, against colorectal cancer cell lines and patient derived xenografts Research Paper

Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy Research Paper

sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1Î± signaling pathways Research Paper

DNA-mediated adjuvant immunotherapy extends survival in two different mouse models of myeloid malignancies Research Paper

Modulation of thyroidal radioiodide uptake by oncological pipeline inhibitors and Apigenin Research Paper

Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling Research Paper

Ibrutinib selectively and irreversibly targets EGFR (L858R, Del19) mutant but is moderately resistant to EGFR (T790M) mutant NSCLC Cells Research Paper

Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma Research Paper

Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H2O2 generation: antagonism by tetrathiomolybdate Research Paper

Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status Research Paper

Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H₂O₂ generation: antagonism by tetrathiomolybdate Research Paper