The Oncosearch | Oncotarget

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Charles R. Schutt, Hua Sun, Jaya Sarin Pradhan, Yvonne Saenger, Jessica Ley, Douglas Adkins, Matthew Ingham, Li Ding, Brian A. Van Tine

Published Feb 21, 2021 · Vol. 12, No. 6 · pp. 534-548

Keywords: head and neck squamous cell carcinoma, neoantigens, mutational evolution, tumor relapse, immune cell infiltration

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Bryony J. Telford, Sanaz Yahyanejad, Thijs de Gunst, Harm C. den Boer, Rogier M. Vos, Marieke Stegink, Marion T.J. van den Bosch, Mir Farshid Alemdehy, Laurens A.H. van Pinxteren, Roel Q.J. Schaapveld, Michel Janicot

Published Feb 7, 2021 · Vol. 12, No. 5 · pp. 422-439

Keywords: miR-193a-3p, microRNA mimic, microRNA delivery in vivo, pleiotropic mechanism of microRNA,

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

Juan Pablo Cerapio, Agnès Marchio, Luis Cano, Ignacio López, Jean-Jacques Fournié, Béatrice Régnault, Sandro Casavilca-Zambrano, Eloy Ruiz, Anne Dejean, Stéphane Bertani, Pascal Pineau

Published Feb 3, 2021 · Vol. 12, No. 5 · pp. 475-492

Keywords: hepatitis B virus, indigenous people, integrative genomics, liver cancer

STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells Research Paper

Uri Rozovski, David M. Harris, Ping Li, Zhiming Liu, Preetesh Jain, Taghi Manshouri, Ivo Veletic, Alessandra Ferrajoli, Prithviraj Bose, Phillip Thompson, Nitin Jain, Srdan Verstovsek, William Wierda, Michael J. Keating, Zeev Estrov

Published Jan 30, 2021 · Vol. 12, No. 5 · pp. 401-411

Keywords: CLL, STAT3, GLI1, apoptosis, transcription

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper

Eric Russ, Krithika Bhuvaneshwar, Guisong Wang, Benjamin Jin, Michele M. Gage, Subha Madhavan, Yuriy Gusev, Geeta Upadhyay

Published Jan 26, 2021 · Vol. 12, No. 3 · pp. 145-159

Keywords: LY6 genes, pancreatic cancer, immune cells, survival outcome

Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells Research Paper

Andrew Henry Lewis, Cory Seth Bridges, Viraaj Singh Punia, Abraham Fausto Jornada Cooper, Monica Puppi, H. Daniel Lacorazza

Published Jan 25, 2021 · Vol. 12, No. 4 · pp. 255-267

Keywords: acute myeloid leukemia, KLF4, cancer, gene editing, cell growth

Folinic acid in colorectal cancer: esquire or fellow knight? Real-world results from a mono institutional, retrospective study Research Paper

Francesco Jacopo Romano, Carmela Barbato, Maria Biglietto, Vincenzo Di Lauro, Dario Arundine, Roberto Fiorentino, Francesca Ambrosio, Maresa Cammarota, Bruno Chiurazzi, Livio Puglia, Sarah Scagliarini, Raffaella Ruocco, Carmen Mocerino, Ivana Cerillo, Maria Fiorella Brangi, Ferdinando Riccardi

Published Jan 19, 2021 · Vol. 12, No. 3 · pp. 221-229

Keywords: colorectal cancer, folinic acid, sodium levofolinate, thymidylate synthase, non oncogene addiction

Clinical application of liquid biopsies to detect somatic BRCA1/2 mutations and guide potential therapeutic intervention for patients with metastatic breast cancer Research Perspective

Neelima Vidula, Leif W. Ellisen, Aditya Bardia

Published Dec 28, 2020 · Vol. 12, No. 2 · pp. 63-65

Keywords: cell-free DNA, BRCA1/2, PARP inhibitor, metastatic breast cancer, plasma based genotyping

Data driven precision medicine: who is the driver? Editorial

Sebastian Klein, Reinhard Büttner

Published Dec 26, 2020 · Vol. 12, No. 4 · pp. 253-254

Keywords: pleomorphic dermal sarcoma, sarcoma, computational biology, computational pathology, precision medicine

Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma Research Paper

Yuji Morine, Tohru Utsunomiya, Yu Saito, Shinichiro Yamada, Satoru Imura, Tetsuya Ikemoto, Akihiro Kitagawa, Yuta Kobayashi, Seiichiro Takao, Keisuke Kosai, Koshi Mimori, Yasuhito Tanaka, Mitsuo Shimada

Published Dec 16, 2020 · Vol. 11, No. 52 · pp. 4803-4812

Keywords: genome-wide analysis, methylation, tumor suppressor gene, prognostic biomarker, hepatocellular carcinoma

Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent in vivo and retards B16-F10 melanoma growth in a preclinical model Research Paper

Adilson Kleber Ferreira, Brunella Cristofaro, Milene Cristina Menezes, Ana Karina de Oliveira, Alexandre Keiji Tashima, Robson Lopes de Melo, Cristiane Castilho Fernandes Silva, Miryam Guillermina Palomino Rodriguez, Daniela Cajado de Oliveira Souza Carvalho, Ricardo Alexandre de Azevedo, Paulo Luiz de Sá Junior, Lisley Inata Mambelli, Fernanda Vieira Portaro, Luc Pardanaud, Anne Eichmann, Osvaldo Augusto Sant’Anna, Mxarcella Faria

Published Nov 30, 2020 · Vol. 11, No. 51 · pp. 4770-4787

Keywords: alphastatin-C, angiogenesis, peptides, melanoma, angiostatic

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas Research Perspective

Syed M. Faisal, Flor M. Mendez, Fernando Nunez, Maria G. Castro, Pedro R. Lowenstein

Published Nov 27, 2020 · Vol. 11, No. 50 · pp. 4607-4612

Keywords: immunotherapy, gene therapy, thymidine kinase, Flt3L, DIPG

Selective amplification of hypermethylated DNA from diverse tumor types via MSRE-PCR Research Paper

Karen B. Chapman, Brandon W. Higgs

Published Nov 18, 2020 · Vol. 11, No. 47 · pp. 4387-4400

Keywords: MSRE-PCR, cDMR, DNA methylation biomarkers, epigenetics, cancer

Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism Research Paper

Abram Calderon, Samantha S. Soldan, Alessandra De Leo, Zhong Deng, Drew M. Frase, Emma M. Anderson, Yue Zhang, Olga Vladimirova, Fang Lu, Jessica C. Leung, Maureen E. Murphy, Paul M. Lieberman

Published Nov 7, 2020 · Vol. 11, No. 46 · pp. 4224-4242

Keywords: KSHV, LANA, high-throughput screen (HTS), primary effusion lymphoma, Mubritinib

The impact of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor Research Paper

Yousef G. Amaar, Mark E. Reeves

Published Oct 26, 2020 · Vol. 11, No. 45 · pp. 4082-4092

Keywords: lung cancer, RASSF1C, PIWIL1, DNA metylation,

Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies Research Paper

Michael E. Clark, Helen Rizos, Michelle R. Pereira, Ashleigh C. McEvoy, Gabriela Marsavela, Leslie Calapre, Katie Meehan, Olivia Ruhen, Muhammad A. Khattak, Tarek M. Meniawy, Georgina V. Long, Matteo S. Carlino, Alexander M. Menzies, Michael Millward, Melanie Ziman, Elin S. Gray

Published Oct 22, 2020 · Vol. 11, No. 44 · pp. 4016-4027

Keywords: melanoma, targeted therapy, drug resistance, BRAF splicing, extracellular vesicles

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Marion Dubuissez, Sonia Paget, Souhila Abdelfettah, Nathalie Spruyt, Vanessa Dehennaut, Gaylor Boulay, Ingrid Loison, Clementine de Schutter, Brian R. Rood, Martine Duterque-Coquillaud, Xavier Leroy, Dominique Leprince

Published Oct 21, 2020 · Vol. 11, No. 45 · pp. 4138-4154

Keywords: HIC1, CXCL12, SDF1, α-SMA, Acta2

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Niraj Lodhi, Moe Tun, Poonam Nagpal, Arati A. Inamdar, Nehad M. Ayoub, Noor Siyam, Lucia Oton-Gonzalez, Angela Gerona, Dainelle Morris, Rana Sandhu, Kwangsun Stephen Suh

Published Oct 20, 2020 · Vol. 11, No. 44 · pp. 4045-4073

Keywords: DLBCL, diagnosis, R-CHOP, precision medicine, prognosis

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Geraldine O'Sullivan Coyne, Shivaani Kummar, Robert S. Meehan, Khanh Do, Jerry M. Collins, Larry Anderson, Kazusa Ishii, Naoko Takebe, Jennifer Zlott, Lamin Juwara, Richard Piekarz, Howard Streicher, Elad Sharon, Larry Rubinstein, Andrea Regier Voth, Jay Lozier, Angie B. Dull, Deborah Wilsker, Toshinori Hinoue, Peter W. Laird, Katherine V. Ferry-Galow, Robert J. Kinders, Ralph E. Parchment, James H. Doroshow, Alice P. Chen

Published Oct 12, 2020 · Vol. 11, No. 44 · pp. 3959-3971

Keywords: DNA damage repair, base excision repair, MGMT, rational combination therapy, molecular pharmacodynamics

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper

Noymi Yam, Jason Levin, Zhengzheng Bao, Wubin Qian, Victor A. Levin

Published Oct 9, 2020 · Vol. 11, No. 44 · pp. 3933-3942

Keywords: glioma, eflornithine, temozolomide, chemotherapy, secondary mutations

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Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells Research Paper

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper

Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells Research Paper

Folinic acid in colorectal cancer: esquire or fellow knight? Real-world results from a mono institutional, retrospective study Research Paper

Clinical application of liquid biopsies to detect somatic BRCA1/2 mutations and guide potential therapeutic intervention for patients with metastatic breast cancer Research Perspective

Data driven precision medicine: who is the driver? Editorial

Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma Research Paper

Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent in vivo and retards B16-F10 melanoma growth in a preclinical model Research Paper

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas Research Perspective

Selective amplification of hypermethylated DNA from diverse tumor types via MSRE-PCR Research Paper

Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism Research Paper

The impact of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor Research Paper

Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies Research Paper

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Genomic and neoantigen evolution from primary tumor to first metastases in head and neck squamous cell carcinoma Research Paper

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology Research Paper

Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry Research Paper

STAT3 induces the expression of GLI1 in chronic lymphocytic leukemia cells Research Paper

High mRNA expression of LY6 gene family is associated with overall survival outcome in pancreatic ductal adenocarcinoma Research Paper

Krüppel-like factor 4 promotes survival and expansion in acute myeloid leukemia cells Research Paper

Folinic acid in colorectal cancer: esquire or fellow knight? Real-world results from a mono institutional, retrospective study Research Paper

Clinical application of liquid biopsies to detect somatic BRCA1/2 mutations and guide potential therapeutic intervention for patients with metastatic breast cancer Research Perspective

Data driven precision medicine: who is the driver? Editorial

Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma Research Paper

Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent in vivo and retards B16-F10 melanoma growth in a preclinical model Research Paper

Immune-stimulatory (TK/Flt3L) gene therapy opens the door to a promising new treatment strategy against brainstem gliomas Research Perspective

Selective amplification of hypermethylated DNA from diverse tumor types via MSRE-PCR Research Paper

Identification of Mubritinib (TAK 165) as an inhibitor of KSHV driven primary effusion lymphoma via disruption of mitochondrial OXPHOS metabolism Research Paper

The impact of the RASSF1C and PIWIL1 on DNA methylation: the identification of GMIP as a tumor suppressor Research Paper

Detection of BRAF splicing variants in plasma-derived cell-free nucleic acids and extracellular vesicles of melanoma patients failing targeted therapy therapies Research Paper

HIC1 (Hypermethylated in Cancer 1) modulates the contractile activity of prostate stromal fibroblasts and directly regulates CXCL12 expression Research Paper

Biomarkers and novel therapeutic approaches for diffuse large B-cell lymphoma in the era of precision medicine Review

Phase I trial of TRC102 (methoxyamine HCl) in combination with temozolomide in patients with relapsed solid tumors and lymphomas Research Paper

Effect of eflornithine on mutation frequency in temozolomide-treated U87MG cells Research Paper