The Oncosearch | Oncotarget

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death Review

Alexander Chota, Blassan P. George, Heidi Abrahamse

Published Jul 19, 2021 · Vol. 12, No. 16 · pp. 1615-1626

Keywords: apoptosis, caspases, cancer, Bcl-2 family proteins, p53

Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Yuki Okawa, Nobutaka Ebata, Nayoung K.D. Kim, Masashi Fujita, Kazuhiro Maejima, Shota Sasagawa, Toru Nakamura, Woong-Yang Park, Satoshi Hirano, Hidewaki Nakagawa

Published Jun 28, 2021 · Vol. 12, No. 15 · pp. 1540-1552

Keywords: biliary tract cancer, mutation, immunotherapic biomarker, knowledgebase, molecular targeted therapy

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Nikolai Petrov, Hee-Sheung Lee, Mikhail Liskovykh, Marie-Paule Teulade-Fichou, Hiroshi Masumoto, William C. Earnshaw, Yves Pommier, Vladimir Larionov, Natalay Kouprina

Published Jun 27, 2021 · Vol. 12, No. 15 · pp. 1444-1456

Keywords: chromosome instability, CIN, platinum-derived G4-quadruplexes, telomere dysfunction, human artificial chromosome

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Pareesa Kamgar-Dayhoff, Tinatin I. Brelidze

Published Jun 19, 2021 · Vol. 12, No. 14 · pp. 1406-1426

Keywords: chlorpromazine, repurposing

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Kassidy A. Hebert, Sergio Jaramillo, Wangjie Yu, Min Wang, Ratna Veeramachaneni, Vlad C. Sandulache, Andrew G. Sikora, Mark D. Bonnen, Ananth V. Annapragada, David Corry, Farrah Kheradmand, Raj K. Pandita, Michelle S. Ludwig, Tej K. Pandita, Shixia Huang, Cristian Coarfa, Sandra L. Grimm, Dimuthu Perera, George Miles, Yohannes T. Ghebre

Published Jun 19, 2021 · Vol. 12, No. 14 · pp. 1339-1353

Keywords: esomeprazole, proton pump inhibitors, ionizing radiation, radiosensitization, tumor control

Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent/metastatic head and neck squamous cell carcinoma Research Paper

Catherine T. Haring, Chandan Bhambhani, Collin Brummel, Brittany Jewell, Emily Bellile, Molly E. Heft Neal, Erin Sandford, Ryan M. Spengler, Apurva Bhangale, Matthew E. Spector, Jonathan McHugh, Mark E. Prince, Michelle Mierzwa, Francis P. Worden, Muneesh Tewari, Paul L. Swiecicki, J. Chad Brenner

Published Jun 11, 2021 · Vol. 12, No. 13 · pp. 1214-1229

Keywords: HPV, head and neck cancer, oropharyngeal cancer, ctDNA, circulating tumor DNA

Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors Review

Shilpa S. Dhar, Min Gyu Lee

Published Jun 9, 2021 · Vol. 12, No. 13 · pp. 1296-1308

Keywords: cancer, epigenetics, histone methyltransferase, KMT2D, MLL4

Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Sukhmani K. Padda, Yesim Gökmen-Polar, Jessica A. Hellyer, Sunil S. Badve, Neeraj K. Singh, Sumanth M. Vasista, Kabya Basu, Ansu Kumar, Heather A. Wakelee

Published May 21, 2021 · Vol. 12, No. 12 · pp. 1178-1186

Keywords: thymic epithelial tumor, thymoma, genomics, clustering, computational analysis

Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity Priority Research Paper

Viola Ellison, George K. Annor, Clara Freedman, Gu Xiao, Devon Lundine, Elzbieta Freulich, Carol Prives, Jill Bargonetti

Published May 20, 2021 · Vol. 12, No. 12 · pp. 1128-1146

Keywords: mutant p53, gain-of-function, oligomerization, DNA replication, frame-shift

Occurence of RAS reversion in metastatic colorectal cancer patients treated with bevacizumab Research Paper

Samantha Epistolio, Marco Cefalì, Paolo Spina, Francesca Molinari, Alessandra Movilia, Massimiliano Cergnul, Luca Mazzucchelli, Sara De Dosso, Milo Frattini, Piercarlo Saletti

Published May 7, 2021 · Vol. 12, No. 11 · pp. 1046-1056

Keywords: RAS mutations, bevacizumab, metastatic colorectal cancer, next-generation sequencing

Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma Research Paper

Rami Mäkelä, Ville Härmä, Nibal Badra Fajardo, Greg Wells, Zoi Lygerou, Olle Sangfelt, Juha Kononen, Juha K. Rantala

Published May 6, 2021 · Vol. 12, No. 11 · pp. 1100-1109

Keywords: cutaneous apocrine sweat gland carcinoma, ex vivo drug screening, DNA repair, PALB2, rare cancer

CEA as a blood-based biomarker in anal cancer Research Paper

Robert Hester, Shailesh Advani, Asif Rashid, Emma Holliday, Craig Messick, Prajnan Das, Yi-Qian N. You, Cullen Taniguchi, Eugene J. Koay, Brian Bednarski, Miguel Rodriguez-Bigas, John Skibber, Robert Wolff, George J. Chang, Bruce D. Minsky, Wai Chin Foo, Nicole Rothschild, Van K. Morris, Cathy Eng

Published May 5, 2021 · Vol. 12, No. 11 · pp. 1037-1045

Keywords: carcinoembryonic antigen, squamous cell carcinoma of anal canal, anal cancer, biomarkers, HPV

Genome wide DNA methylation landscape reveals glioblastoma’s influence on epigenetic changes in tumor infiltrating CD4+ T cells Research Paper

Marpe Bam, Sreenivasulu Chintala, Kaleigh Fetcko, Brooke Carmen Williamsen, Seema Siraj, Sheng Liu, Jun Wan, Xiaoling Xuei, Yunlong Liu, Adam T. Leibold, Mahua Dey

Published Apr 25, 2021 · Vol. 12, No. 10 · pp. 967-981

Keywords: glioblastoma, malignant glioma, CD4+ T cell, DNA methylation, brain cancer

Piperlongumine promotes death of retinoblastoma cancer cells Research Paper

Nathalie Allaman-Pillet, Daniel F. Schorderet

Published Apr 8, 2021 · Vol. 12, No. 9 · pp. 907-916

Keywords: cancer, retinoblastoma, piperlongumine, programmed cell death

Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra^® Research Paper

Tracey White, Szabolcs Szelinger, Janine LoBello, Amy King, Jessica Aldrich, Nathan Garinger, Matthew Halbert, Ryan F. Richholt, Stephen D. Mastrian, Cody Babb, Audrey A. Ozols, Laurie J. Goodman, Gargi D. Basu, Thomas Royce

Published Apr 7, 2021 · Vol. 12, No. 8 · pp. 726-739

Keywords: comprehensive genomic profiling, whole exome sequencing, RNA sequencing, precision medicine, pan-cancer

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore Research Paper

Sateja Paradkar, James Herrington, Adam Hendricson, Piyasena Hewawasam, Mark Plummer, Denton Hoyer, Ranjini K. Sundaram, Yulia V. Surovtseva, Ranjit S. Bindra

Published Mar 27, 2021 · Vol. 12, No. 9 · pp. 891-906

Keywords: glioblastoma, radiosensitizers, mibefradil, DNA repair, alternative non-homologous end joining

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Christelle Morris, Sébastien Durand, Pierre Jalinot

Published Mar 13, 2021 · Vol. 12, No. 7 · pp. 649-664

Keywords: breast cancer, senescence-associated secretory phenotype, eIF3, PARP1, mTORC1

Polo-like kinase inhibition as a therapeutic target in acute myeloid leukemia Research Perspective

Jan Philipp Bewersdorf, Amer M. Zeidan

Published Mar 11, 2021 · Vol. 12, No. 13 · pp. 1314-1317

Keywords: acute myeloid leukemia, AML, PLK-1 inhibitor, onvansertib, volasertib

Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells Research Paper

Bhaskar Bhattacharya, Daniel Q. Huang, Sarah Hong Hui Low, Gim Hwa Tan, Min Ji Han, Sanamerjit Singh, Benny Tang, Sheng Chun Chang, Joey Sze Yun Lim, Mohd Feroz Mohd Omar, Yock Young Dan, Richie Soong

Published Mar 3, 2021 · Vol. 12, No. 7 · pp. 674-685

Keywords: drug development, microenvironment, glycolysis

Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients Research Paper

Duna H. Barakeh, Rasha Aljelaify, Yara Bashawri, Amal Almutairi, Fatimah Alqubaishi, Mohammed Alnamnakani, Latifa Almubarak, Abdulrahman Al Naeem, Fatema Almushawah, May Alrashed, Malak Abedalthagafi

Published Feb 27, 2021 · Vol. 12, No. 7 · pp. 686-697

Keywords: breast cancer, PIK3CA, BCa, Saudi Arabia, BRCA

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Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death Review

Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent/metastatic head and neck squamous cell carcinoma Research Paper

Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors Review

Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity Priority Research Paper

Occurence of RAS reversion in metastatic colorectal cancer patients treated with bevacizumab Research Paper

Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma Research Paper

CEA as a blood-based biomarker in anal cancer Research Paper

Genome wide DNA methylation landscape reveals glioblastoma’s influence on epigenetic changes in tumor infiltrating CD4+ T cells Research Paper

Piperlongumine promotes death of retinoblastoma cancer cells Research Paper

Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra^® Research Paper

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore Research Paper

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Polo-like kinase inhibition as a therapeutic target in acute myeloid leukemia Research Perspective

Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells Research Paper

Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death Review

Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase Research Paper

Terpyridine platinum compounds induce telomere dysfunction and chromosome instability in cancer cells Priority Research Paper

Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment Review

Esomeprazole enhances the effect of ionizing radiation to improve tumor control Research Paper

Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent/metastatic head and neck squamous cell carcinoma Research Paper

Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors Review

Genomic clustering analysis identifies molecular subtypes of thymic epithelial tumors independent of World Health Organization histologic type Research Paper

Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity Priority Research Paper

Occurence of RAS reversion in metastatic colorectal cancer patients treated with bevacizumab Research Paper

Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma Research Paper

CEA as a blood-based biomarker in anal cancer Research Paper

Genome wide DNA methylation landscape reveals glioblastoma’s influence on epigenetic changes in tumor infiltrating CD4+ T cells Research Paper

Piperlongumine promotes death of retinoblastoma cancer cells Research Paper

Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra® Research Paper

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore Research Paper

Decreased expression of the translation factor eIF3e induces senescence in breast cancer cells via suppression of PARP1 and activation of mTORC1 Research Paper

Polo-like kinase inhibition as a therapeutic target in acute myeloid leukemia Research Perspective

Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells Research Paper

Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients Research Paper

Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra^® Research Paper