The Oncosearch | Oncotarget

DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway Research Paper

Caroline Dafflon, Swann Gaulis, Louise Barys, Karen Kapur, Vanessa Cornacchione, Lina Schukur, Sebastian Bergling, Elisabetta Traggiai, Selina Jansky, Leon Hellmann, Barbara Schacher Engstler, Grainne Kerr, Antoine de Weck, David A. Ruddy, Ulrike Naumann, Frédéric Stauffer, Christoph Gaul, Ying Lin, Eric Billy, Andreas Weiss, Francesco Hofmann, Moriko Ito, Ralph Tiedt

Published Mar 17, 2020 · Vol. 11, No. 11 · pp. 956-968

Keywords: DOT1L, multiple myeloma, epigenetics, histone methylation, unfolded protein response

Correction: Enhanced tumorigenicity by mitochondrial DNA mild mutations Correction

Alberto Cruz-Bermúdez, Carmen G. Vallejo, Ramiro J. Vicente-Blanco, María Esther Gallardo, Miguel Ángel Fernández-Moreno, Miguel Quintanilla, Rafael Garesse

Published Mar 12, 2020 · Vol. 11, No. 11 · pp. 1006-1006

DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues Research Paper

Cristina Gallego-Fabrega, Natalia Cullell, Carolina Soriano-Tárraga, Caty Carrera, Nuria P. Torres-Aguila, Elena Muiño, Jara Cárcel-Márquez, Manuel Castro de Moura, Alba Fernández-Sanlés, Manel Esteller, Roberto Elosua, Jordi Jiménez-Conde, Jaume Roquer, Joan Montaner, Jerzy Krupinski, Israel Fernandez-Cadenas

Published Mar 10, 2020 · Vol. 11, No. 10 · pp. 905-912

Keywords: atherosclerotic plaque, epigenetics, DNA methylation, matrix metalloproteinases

Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis Research Paper

Stefanie Schlager, Carina Salomon, Sabine Olt, Christoph Albrecht, Anja Ebert, Oliver Bergner, Johannes Wachter, Francesca Trapani, Daniel Gerlach, Tilman Voss, Anna Traunbauer, Julian Jude, Matthias Hinterndorfer, Martina Minnich, Norbert Schweifer, Sophia M. Blake, Vittoria Zinzalla, Barbara Drobits, Darryl B. McConnell, Norbert Kraut, Mark Pearson, Johannes Zuber, Manfred Koegl

Published Mar 3, 2020 · Vol. 11, No. 9 · pp. 875-890

Keywords: BCL6, DLBCL, lymphoma, inducible CRISPR/Cas9, in vivo xenograft

Subcellular localization of FANCD2 is associated with survival in ovarian carcinoma Research Paper

Sonali Joshi, Shawn Campbell, Jeong Y. Lim, Shannon McWeeney, Adam Krieg, Yukie Bean, Nadja Pejovic, Paulette Mhawech-Fauceglia, Tanja Pejovic

Published Feb 25, 2020 · Vol. 11, No. 8 · pp. 775-783

Keywords: FANCD2, ovarian carcinoma, subcellular localization

Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment Research Paper

Shrilekha Misra, Xiaoli Zhang, Nissar Ahmad Wani, Steven Sizemore, Alo Ray

Published Feb 25, 2020 · Vol. 11, No. 8 · pp. 784-800

Keywords: triple-negative breast cancer, MLN4924, cisplatin, cell cycle, DNA damage

MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21^Cip1 Research Paper

Anna Huo-Chang Mei, Kaity Tung, Jessie Han, Deepak Perumal, Alessandro Laganà, Jonathan Keats, Daniel Auclair, Ajai Chari, Sundar Jagannath, Samir Parekh, Hearn Jay Cho

Published Feb 18, 2020 · Vol. 11, No. 7 · pp. 727-739

Keywords: MAGE-A3, multiple myeloma, apoptosis, cell cycle regulation, DNA repair

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR Research Paper

Sonia Zicari, Adhikarimayum Lakhikumar Sharma, Geetaram Sahu, Larisa Dubrovsky, Lin Sun, Han Yue, Tejaswi Jada, Alex Ochem, Gary Simon, Michael Bukrinsky, Mudit Tyagi

Published Feb 18, 2020 · Vol. 11, No. 7 · pp. 699-726

Keywords: HIV, DNA-PK, transcription, replication, DNA-PK inhibitors

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

Richard K. Yang, Yun Qing, Fatima Zahra Jelloul, Mark J. Routbort, Peng Wang, Kenna Shaw, Jiexin Zhang, Jack Lee, L. Jeffrey Medeiros, Scott Kopetz, Michael T. Tetzlaff, Russell R. Broaddus

Published Feb 11, 2020 · Vol. 11, No. 6 · pp. 600-618

Keywords: biomarkers, immunotherapy, mutations, TMB, histology

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response Research Paper

James Jabalee, Rebecca Towle, James Lawson, Christopher Dickman, Cathie Garnis

Published Feb 4, 2020 · Vol. 11, No. 5 · pp. 523-534

Keywords: oral squamous cell carcinoma, DNA methylation, SMPD3, erlotinib, cancer progression

Inherited DNA-repair gene mutations in African American men with prostate cancer Research Paper

Oliver Sartor, Shan Yang, Elisa Ledet, Marcus Moses, Piper Nicolosi

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 440-442

Keywords: prostate cancer, DNA repair, BRCA, African American, ethnicity

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Chie Nakashima, Kazuhiko Yamamoto, Shingo Kishi, Takamitsu Sasaki, Hitoshi Ohmori, Rina Fujiwara-Tani, Shiori Mori, Isao Kawahara, Yukiko Nishiguchi, Takuya Mori, Masuo Kondoh, Yi Luo, Tadaaki Kirita, Hiroki Kuniyasu

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 309-321

Keywords: clostridium perfringens enterotoxin, claudin-4, YAP, Hippo signal, oral squamous cell carcinoma, Pathology

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin Research Paper

Gleb Baida, Shivani Agarwal, Ben Readhead, Joel T. Dudley, Irina Budunova

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 409-418

Keywords: glucocorticoid, skin atrophy, REDD1, mTOR, sexual dimorphism

Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

Evan A. Clayton, Shareef Khalid, Dongjo Ban, Lu Wang, I. King Jordan, John F. McDonald

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 462-479

Keywords: allele-specific expression, alternative splicing, antisense RNA, cancer, tumor-suppressor genes

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary Research Paper

Francois Kraus, Julie Dremaux, Wajd Altakfi, Magalie Goux, Léa Pontois, Henri Sevestre, Stéphanie Trudel

Published Jan 28, 2020 · Vol. 11, No. 4 · pp. 419-428

Keywords: granulosa cell tumor, recurrence, FOXL2, array comparative genomic hybridization, chromosome instability

Correction: JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells Correction

Bo Tang, Guangying Qi, Fang Tang, Shengguang Yuan, Zhenran Wang, Xingsi Liang, Bo Li, Shuiping Yu, Jie Liu, Qi Huang, Yangchao Wei, Run Zhai, Biao Lei, Hongping Yu, Xingyuan Jiao, Songqing He

Published Jan 26, 2020 · Vol. 11, No. 19 · pp. 1797-1798

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Wayne D. Blosser, Jack A. Dempsey, Ann M. McNulty, Xi Rao, Philip J. Ebert, Caitlin D. Lowery, Philip W. Iversen, Yue Wang Webster, Gregory P. Donoho, Xueqian Gong, Farhana F. Merzoug, Sean Buchanan, Karsten Boehnke, Chunping Yu, Xin Tian You, Richard P. Beckmann, Wenjuan Wu, Samuel C. McNeely, Aimee Bence Lin, Ricardo Martinez

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 216-236

Keywords: CHK1, prexasertib, replication stress, replication fork, innate immunity

Prevalence and clinical significance of VHL mutations and 3p25 deletions in renal tumor subtypes Research Paper

Franziska Büscheck, Christoph Fraune, Ronald Simon, Martina Kluth, Claudia Hube-Magg, Christina Möller-Koop, Imren Sarper, Kathrin Ketterer, Tjark Henke, Christian Eichelberg, Roland Dahlem, Waldemar Wilczak, Guido Sauter, Margit Fisch, Till Eichenauer, Michael Rink

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 237-249

Keywords: renal cell tumors, von Hippel-Lindau gene, VHL mutation, 3p copy number, fluorescence in-situ hybridization

The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis Research Paper

Ryan M. Carey, Karthik Rajasekaran, Tyler Seckar, Xiang Lin, Zhi Wei, Charles C.L. Tong, Viran J. Ranasinghe, Jason G. Newman, Bert W. O'Malley Jr., Gregory S. Weinstein, Michael D. Feldman, Erle S. Robertson

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 282-293

Keywords: HPV, cancer, virus, virome, oropharyngeal squamous cell carcinoma

TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC Research Paper

Julia Roeper, Markus Falk, Athena Chalaris-Rißmann, Anne C. Lueers, Hayat Ramdani, Katrin Wedeken, Ursula Stropiep, Linda Diehl, Markus Tiemann, Lukas C. Heukamp, Fabian Otto-Sobotka, Frank Griesinger

Published Jan 21, 2020 · Vol. 11, No. 3 · pp. 250-264

Keywords: NSCLC, EGFR, TP53 mutation, TKI

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DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway Research Paper

Correction: Enhanced tumorigenicity by mitochondrial DNA mild mutations Correction

DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues Research Paper

Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis Research Paper

Subcellular localization of FANCD2 is associated with survival in ovarian carcinoma Research Paper

Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment Research Paper

MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21^Cip1 Research Paper

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR Research Paper

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response Research Paper

Inherited DNA-repair gene mutations in African American men with prostate cancer Research Paper

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin Research Paper

Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary Research Paper

Correction: JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells Correction

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Prevalence and clinical significance of VHL mutations and 3p25 deletions in renal tumor subtypes Research Paper

The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis Research Paper

TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway Research Paper

Correction: Enhanced tumorigenicity by mitochondrial DNA mild mutations Correction

DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues Research Paper

Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis Research Paper

Subcellular localization of FANCD2 is associated with survival in ovarian carcinoma Research Paper

Both BRCA1-wild type and -mutant triple-negative breast cancers show sensitivity to the NAE inhibitor MLN4924 which is enhanced upon MLN4924 and cisplatin combination treatment Research Paper

MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21Cip1 Research Paper

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR Research Paper

Identification of biomarkers of immune checkpoint blockade efficacy in recurrent or refractory solid tumor malignancies Research Paper

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response Research Paper

Inherited DNA-repair gene mutations in African American men with prostate cancer Research Paper

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell carcinomas Research Paper

Sexual dimorphism in atrophic effects of topical glucocorticoids is driven by differential regulation of atrophogene REDD1 in male and female skin Research Paper

Tumor suppressor genes and allele-specific expression: mechanisms and significance Research Paper

FOXL2 homozygous genotype and chromosome instability are associated with recurrence in adult granulosa cell tumors of the ovary Research Paper

Correction: JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells Correction

A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib Research Paper

Prevalence and clinical significance of VHL mutations and 3p25 deletions in renal tumor subtypes Research Paper

The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis Research Paper

TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC Research Paper

MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21^Cip1 Research Paper