Vol 5, No 22

Angiostatic vaccines, an underestimated approach of cancer therapy

ADAM10 and ADAM17: New Players in Trastuzumab Resistance

Double-punching PMBL

Reciprocity in breast cancer progression

A pathophysiological view of the long non-coding RNA world

Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat

Bioinformatics analysis of the serine and glycine pathway in cancer cells

Revealed: The spy who regulates neuroblastoma stem cells

Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition

Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer

Prognostic impact of alternative splicing-derived hMENA isoforms in resected, node-negative, non-small-cell lung cancer

NBN gain is predictive for adverse outcome following image-guided radiotherapy for localized prostate cancer

Development and prospective multicenter evaluation of the long noncoding RNA MALAT-1 as a diagnostic urinary biomarker for prostate cancer

Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma

Peritumoral Neuropilin-1 and VEGF receptor-2 expression increases time to recurrence in hepatocellular carcinoma patients undergoing curative hepatectomy

The role of systemic chemotherapy and multidisciplinary management in improving the overall survival of patients with metastatic squamous cell carcinoma of the anal canal

Intermediate neoadjuvant radiotherapy for T3 low/middle rectal cancer: postoperative outcomes of a non-controlled clinical trial

A phase 1b, open-label study of trebananib plus bevacizumab or motesanib in patients with solid tumours

Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase I clinical experience

The IGF-1 receptor inhibitor picropodophyllin potentiates the anti-myeloma activity of a BH3-mimetic

Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer

Maspin expression in prostate tumor elicits host anti-tumor immunity

Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells

Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

Apoptin enhances the oncolytic properties of vaccinia virus and modifies mechanisms of tumor regression

Multiple myeloma cells recruit tumor-supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype

DNA mismatch repair gene MLH1 induces apoptosis in prostate cancer cells

Therapeutic potential of ERK5 targeting in triple negative breast cancer

EZH2 promotes angiogenesis through inhibition of miR-1/Endothelin-1 axis in nasopharyngeal carcinoma

Overexpression of human β-defensin 2 promotes growth and invasion during esophageal carcinogenesis

Interactome analysis of myeloid-derived suppressor cells in murine models of colon and breast cancer

Identification and validation of p50 as the cellular target of eriocalyxin B

Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells

Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress

Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition

Chemopreventive apigenin controls UVB-induced cutaneous proliferation and angiogenesis through HuR and thrombospondin-1

Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance

Senescence of tumor cells induced by oxaliplatin increases the efficiency of a lipid A immunotherapy via the recruitment of neutrophils

Pharmacological induction of cell surface GRP78 contributes to apoptosis in triple negative breast cancer cells

Human recombinant truncated RNASET2, devoid of RNase activity; A potential cancer therapeutic agent

Mastl kinase, a promising therapeutic target, promotes cancer recurrence

CXCL12/CXCR4 signaling counteracts docetaxel-induced microtubule stabilization via p21-activated kinase 4-dependent activation of LIM domain kinase 1

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support

STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters

A novel DAG-dependent mechanism links PKCɑ and Cyclin B1 regulating cell cycle progression

Inhibition of glioblastoma malignancy by Lgl1

Methylation of miR-129-5p CpG island modulates multi-drug resistance in gastric cancer by targeting ABC transporters

High Id1 expression, a generally negative prognostic factor, paradoxically predicts a favorable prognosis for adjuvant paclitaxel plus cisplatin therapy in surgically treated lung cancer patients

Suppression of esophageal tumor growth and chemoresistance by directly targeting the PI3K/AKT pathway

AMACR amplification and overexpression in primary imatinib-naïve gastrointestinal stromal tumors: a driver of cell proliferation indicating adverse prognosis

RYBP expression is associated with better survival of patients with hepatocellular carcinoma (HCC) and responsiveness to chemotherapy of HCC cells in vitro and in vivo

Activation of miR-9 by human papillomavirus in cervical cancer

Down-regulation of miR-203 induced by Helicobacter pylori infection promotes the proliferation and invasion of gastric cancer by targeting CASK

Cisplatin in combination with Phenethyl Isothiocyanate (PEITC), a potential new therapeutic strategy for malignant pleural mesothelioma

Dysregulation of autophagy in human follicular lymphoma is independent of overexpression of BCL-2

MicroRNA-9 promotes tumor metastasis via repressing E-cadherin in esophageal squamous cell carcinoma

Suppressor of fused (Sufu) represses Gli1 transcription and nuclear accumulation, inhibits glioma cell proliferation, invasion and vasculogenic mimicry, improving glioma chemo-sensitivity and prognosis

Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer

Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma

MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors

Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP