Vol 5, No 18

‘Sex’ in the cancer cell

Oncogene addiction: resetting the safety switch?

The IGF signalling pathway in Wilms tumours - A report from the ENCCA Renal Tumours Biology-driven drug development workshop

Correlation of long non-coding RNA expression with metastasis, drug resistance and clinical outcome in cancer

Regulatory roles of LINE-1-encoded reverse transcriptase in cancer onset and progression

Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment

TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity

A first in man phase I trial of the oral immunomodulator, indoximod, combined with docetaxel in patients with metastatic solid tumors

Co-expression of MET and CD47 is a novel prognosticator for survival of luminal-type breast cancer patients

A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors

Wogonin induces cell cycle arrest and erythroid differentiation in  imatinib-resistant K562 cells and primary CML cells

Tissue-specific isoform switch and DNA hypomethylation of the pyruvate kinase PKM gene in human cancers

Targeting CD13 (aminopeptidase-N) in turn downregulates ADAM17 by internalization in acute myeloid leukaemia cells

Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)

Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib

Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved

Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease

Chemical inhibition of acetyl-CoA carboxylase suppresses self-renewal growth of cancer stem cells

Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression

Peroxisome proliferator activated receptor alpha inhibits hepatocarcinogenesis through mediating NF-κB signaling pathway

HMGA1 pseudogenes as candidate proto-oncogenic competitive endogenous RNAs

ARID3B increases ovarian tumor burden and is associated with a cancer stem cell gene signature

Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer

Picropodophyllin causes mitotic arrest and catastrophe by depolymerizing microtubules via Insulin-like growth factor-1 receptor-independent mechanism

TALEN-mediated Nanog disruption results in less invasiveness, more chemosensitivity and reversal of EMT in Hela cells

Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model

Inhibition of STAT3 signaling targets both tumor-initiating and differentiated cell populations in prostate cancer

Interferon-stimulated gene 15 (ISG15) is a trigger for tumorigenesis and metastasis of hepatocellular carcinoma

Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells

Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins

PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation

The iron chelator Dp44mT inhibits hepatocellular carcinoma metastasis via N-Myc downstream-regulated gene 2 (NDRG2)/gp130/STAT3 pathway

Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer

The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets

Efficient lytic induction of kaposi’s sarcoma-associated herpesvirus (KSHV) by the anthracyclines

Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives

Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors

Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells

ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma

Epstein-Barr virus BALF3 mediates genomic instability and progressive malignancy in nasopharyngeal carcinoma

Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma

Selective targeting of liver cancer with the endothelial marker CD146

Integrated analysis of long noncoding RNAs and mRNAs reveals their potential roles in the pathogenesis of uterine leiomyomas

Selective JAK2/ABL dual inhibition therapy effectively eliminates TKI-insensitive CML stem/progenitor cells

Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease

Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell

Splice variant transcripts of the anterior gradient 2 gene as a marker of prostate cancer

Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility

Multiple blocks in the engagement of oxidative phosphorylation in putative ovarian cancer stem cells: implication for maintenance therapy with glycolysis inhibitors

IL-6-stimulated CD11b⁺ CD14⁺ HLA-DR⁻ myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus

Selective methioninase-induced trap of cancer cells in S/G₂ phase visualized by FUCCI imaging confers chemosensitivity

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

Using heterogeneity of the patient-derived xenograft model to identify the chemoresistant population in ovarian cancer

Interleukin-32α downregulates the activity of the B-cell CLL/lymphoma 6 protein by inhibiting protein kinase Cε-dependent SUMO-2 modification

p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway

IsomiR expression profiles in human lymphoblastoid cell lines exhibit population and gender dependencies

POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in Head and Neck cancer