The Oncosearch | Oncotarget

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Limin Wang, Kathleen A Gallo, Susan E Conrad

Published Jul 7, 2013 · Vol. 4, No. 8 · pp. 1158-1171

Keywords: breast cancer, kinase inhibitors, cell cycle, apoptosis

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

William J. Fredericks, Jorge Sepulveda, Priti Lal, John E. Tomaszewski, Ming-Fong Lin, Terry McGarvey, Frank J. Rauscher III, S. Bruce Malkowicz

Published Jul 7, 2013 · Vol. 4, No. 7 · pp. 1075-1092

Keywords: TERE1, UBIAD1, prostate cancer, castrate resistant prostate cancer, CRPC, LnCaP, cholesterol, SXR, androgen catabolism, Vitamin K-2

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper

Tatiana N Moiseeva, Andrew Bottrill, Gerry Melino, Nickolai A Barlev

Published Jun 29, 2013 · Vol. 4, No. 9 · pp. 1338-1348

Keywords: proteasome, DNA damage, proteolytic activities, ubiquitylation

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma Research Paper

Pritha Paul, Natasha S. Volny, Sora Lee, Jingbo Qiao, Dai H. Chung

Published Jun 29, 2013 · Vol. 4, No. 8 · pp. 1149-1157

Keywords: Gli1, AKT2, Neuroblastoma, SUFU

Plasma Membrane Proteomics Identifies Biomarkers Associated with MMSET Overexpression in T(4;14) Multiple Myeloma Research Paper

Zhigang Xie, Jayantha Gunaratne, Lip Lee Cheong, Shaw Cheng Liu, Tze Loong Koh, Gaofeng Huang, Walter P Blackstock, Wee Joo Chng

Published Jun 26, 2013 · Vol. 4, No. 7 · pp. 1008-1018

Keywords: SILAC, quantitative proteomics, oncotargets, multiple myeloma

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Yunyun Jiang, Filip Janku, Vivek Subbiah, Laura S. Angelo, Aung Naing, Peter M. Anderson, Cynthia E. Herzog, Siqing Fu, Robert S. Benjamin, Razelle Kurzrock

Published Jun 5, 2013 · Vol. 4, No. 6 · pp. 884-889

Keywords: Ewing sarcoma, PTPRD, mutation, germline

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper

Ryan T Pitman, Luke Wojdyla, Neelu Puri

Published Jun 3, 2013 · Vol. 4, No. 5 · pp. 761-771

Keywords: T-oligo, Tankyrase, TRF1, telomere, p53, melanoma

pRb controls Estrogen Receptor alpha protein stability and activity Research Paper

Isabella Caligiuri, Giuseppe Toffoli, Antonio Giordano, Flavio Rizzolio

Published Jun 3, 2013 · Vol. 4, No. 6 · pp. 875-883

Keywords: pRb, Estrogen receptor alpha, proteasome, chaperone proteins, breast cancer

Cross-species genomic and epigenomic landscape of retinoblastoma Research Paper

Claudia A. Benavente, Justina D. McEvoy, David Finkelstein, Lei Wei, Guolian Kang, Yong-Dong Wang, Geoffrey Neale, Susan Ragsdale, Virginia Valentine, Armita Bahrami, Jamshid Temirov, Stanley Pounds, Jinghui Zhang, Michael A. Dyer

Published Jun 1, 2013 · Vol. 4, No. 6 · pp. 844-859

Keywords: retinoblastoma, RB1, epigenetics

To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells Review

Ilia A. Droujinine, Mark A Eckert, Weian Zhao

Published May 31, 2013 · Vol. 4, No. 5 · pp. 651-664

Keywords: mesenchymal stem cells, cell therapy, stroma, microenvironment, tumor associated fibroblasts

STAT5b in LGL leukemia â€“ a novel therapeutic target? Editorial

Hanna L. M. Rajala, Satu Mustjoki

Published May 16, 2013 · Vol. 4, No. 6 · pp. 808-809

FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Research Paper

Rocky Cipriano, Kristy L.S. Miskimen, Benjamin L. Bryson, Chase R. Foy, Courtney A. Bartel, Mark W Jackson

Published May 11, 2013 · Vol. 4, No. 5 · pp. 729-738

Keywords: FAM83B, transformation, drug resistance, CRAF, PI3K

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations Research Paper

Jonathan M. Gerber, Jessica L. Gucwa, David Esopi, Meltem Gurel, Michael C. Haffner, Milada Vala, William G. Nelson, Richard J. Jones, Srinivasan Yegnasubramanian

Published May 6, 2013 · Vol. 4, No. 5 · pp. 715-728

Keywords: chronic myeloid leukemia, CML, leukemic stem cell, LSC, normal hematopoietic stem cell, HSC, myeloid progenitor cells, CD34, CD38, ALDH, IL2RA, CD25, DPP4, CD26, GAS2

Prostate derived Ets transcription factor and Carcinoembryonic antigen related cell adhesion molecule 6 constitute a highly active oncogenic axis in breast cancer Research Paper

Alka Mukhopadhyay, Thaer Khoury, Leighton Stein, Protul Shrikant, Ashwani K. Sood

Published Apr 10, 2013 · Vol. 4, No. 4 · pp. 610-621

Keywords: PDEF, SPDEF, CEACAM6, Elevated co-expression, Tumor cell survival, PDEF-CEACAM6 oncogenic axis, Novel targets in breast cancer

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

Mark J Axelrod, Vicki Gordon, Mark Conaway, Adel Tarcsafalvi, Daniel J Neitzke, Daniel Gioeli, Michael J Weber

Published Apr 10, 2013 · Vol. 4, No. 4 · pp. 622-635

Keywords: Targeted therapies, Compensatory signaling, Pathway interactions, Crosstalk, Feedback inhibition

MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1 Research Paper

Ariel Bier, Niss Giladi, Noam Kronfeld, Hae Kyung Lee, Simona Cazacu, Susan Finniss, Cunli Xiang, Laila Poisson, Ana C deCarvalho, Shimon Slavin, Elad Jacoby, Michal Yalon, Amos Toren, Tom Mikkelsen, Chaya Brodie

Published Apr 9, 2013 · Vol. 4, No. 5 · pp. 665-676

Keywords: glioblastoma, glioma stem cells, miR-137, RTVP-1, stemness, CXCR4

The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism Research Paper

Khoi Chu, Kimberkey M. Boley, Ricardo Moraes, Sanford H. Barsky, Fredika M. Robertson

Published Mar 21, 2013 · Vol. 4, No. 3 · pp. 446-462

Keywords: E-Cadherin, Inflammatory Breast Cander, Mesenchymal-Epithelial transition (MET), HIF-1Î±, Metabolism, Glycolysis

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Kristen M. Reipas, Jennifer H. Law, Nicole Couto, Sumaiya Islam, Yvonne Li, Huifang Li, Artem Cherkasov, Karen Jung, Amarpal S. Cheema, Steven J.M. Jones, John A. Hassell, Sandra E. Dunn

Published Feb 27, 2013 · Vol. 4, No. 2 · pp. 329-345

Keywords: Triple-negative breast cancer, p90 ribosomal S6 kinase, Y-box binding protein-1, tumor-initiating cells, drug repositioning

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

Raya Faigenbaum, Roni Haklai, Gilad Ben-Baruch, Yoel Kloog

Published Feb 27, 2013 · Vol. 4, No. 2 · pp. 316-328

Keywords: Endometrial cancer, medroxyprogesterone acetate, FTS, Ras, ERÎ±, ERÎ²

DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells Research Paper

M. Zulfiquer Hossain, Megan A. Healey, Calvin Lee, Weijie Poh, Sashidhar R. Yerram, Kalpesh Patel, Nilofer S. Azad, James G. Herman, Scott E. Kern

Published Feb 26, 2013 · Vol. 4, No. 2 · pp. 298-309

Keywords: cancer, gene methylation, demethylation, DNA-intercalator, quinacrine, DNMT inhibitor, epigenetics, silencing and re-activation of gene expression, small molecule-DNA interactions

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Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma Research Paper

Plasma Membrane Proteomics Identifies Biomarkers Associated with MMSET Overexpression in T(4;14) Multiple Myeloma Research Paper

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper

pRb controls Estrogen Receptor alpha protein stability and activity Research Paper

Cross-species genomic and epigenomic landscape of retinoblastoma Research Paper

To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells Review

STAT5b in LGL leukemia â€“ a novel therapeutic target? Editorial

FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Research Paper

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations Research Paper

Prostate derived Ets transcription factor and Carcinoembryonic antigen related cell adhesion molecule 6 constitute a highly active oncogenic axis in breast cancer Research Paper

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1 Research Paper

The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism Research Paper

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper

Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma Research Paper

Plasma Membrane Proteomics Identifies Biomarkers Associated with MMSET Overexpression in T(4;14) Multiple Myeloma Research Paper

Germline PTPRD Mutations in Ewing Sarcoma: Biologic and Clinical Implications Research Paper

Mechanism of DNA damage responses induced by exposure to an oligonucleotide homologous to the telomere overhang in melanoma Research Paper

pRb controls Estrogen Receptor alpha protein stability and activity Research Paper

Cross-species genomic and epigenomic landscape of retinoblastoma Research Paper

To grab the stroma by the horns: From biology to cancer therapy with mesenchymal stem cells Review

STAT5b in LGL leukemia â€“ a novel therapeutic target? Editorial

FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies. Research Paper

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations Research Paper

Prostate derived Ets transcription factor and Carcinoembryonic antigen related cell adhesion molecule 6 constitute a highly active oncogenic axis in breast cancer Research Paper

Combinatorial drug screening identifies compensatory pathway interactions and adaptive resistance mechanisms Research Paper

MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1 Research Paper

The Paradox of E-Cadherin: Role in response to hypoxia in the tumor microenvironment and regulation of energy metabolism Research Paper

Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) Research Paper

Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib Research Paper

DNA-intercalators Causing Rapid Re-expression of Methylated and Silenced Genes in Cancer Cells Research Paper