The Oncosearch | Oncotarget

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia Research Paper

Annalisa Astolfi, Francesca Vendemini, Milena Urbini, Fraia Melchionda, Riccardo Masetti, Monica Franzoni, Virginia Libri, Salvatore Serravalle, Marco Togni, Giuseppina Paone, Luca Montemurro, Daniela Bressanin, Francesca Chiarini, Alberto M Martelli, Roberto Tonelli, Andrea Pession

Published Sep 29, 2013 · Vol. 5, No. 1 · pp. 120-130

Keywords: pediatric T-ALL, MYCN, peptide nucleic acid, TAL1

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

Leigh Ellis, ShengYu Ku, Swathi Ramakrishnan, Elena Lasorsa, Gizzou Azabdaftari, Alejandro Godoy, Roberto Pili

Published Sep 27, 2013 · Vol. 4, No. 12 · pp. 2225-2236

Keywords: prostate cancer, BEZ235, panobinostat, DNA damage, ATM, therapy

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells Research Paper

Eiko Kawamura, Andrew B. Fielding, Nagarajan Kannan, Aruna Balgi, Connie J. Eaves, Michel Roberge, Shoukat Dedhar

Published Sep 25, 2013 · Vol. 4, No. 10 · pp. 1763-1776

Keywords: centrosome clustering, multipolar mitosis, small molecule, cancer specific, spindle

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations Research Paper

Roxana S Redis, Anieta M Siewerts, Maxime P Look, Oana Tudoran, Cristina Ivan, Riccardo Spizzo, Xinna Zhang, Vanja de Weerd, Masayoshi Shimizu, Hui Ling, Rares Buiga, Victor Pop, Alexandru Irimie, Riccardo Fodde, Isabella Bedrosian, John WM Martens, John A Foekens, Ioana Berindan-Neagoe, George A Calin

Published Sep 18, 2013 · Vol. 4, No. 10 · pp. 1748-1762

Keywords: non coding RNA, CCAT2, breast cancer, prognosis, real-time PCR

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas Research Paper

Julia M. Fraile, Gonzalo R. OrdoÃ±ez, Pedro M. Quiros, Aurora Astudillo, Jose A. Galvan, Dolors Colomer, Carlos Lopez-Otin, Jose M.P. Freije, Xose S. Puente

Published Sep 15, 2013 · Vol. 4, No. 11 · pp. 1919-1932

Keywords: proteolysis, metastasis, invasion, cancer

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival Research Paper

Aurelie Poli, Jian Wang, Olivia Domingues, JesÃºs PlanagumÃ, Tao Yan, Kai Ove Skaftnesmo, Cecilie Brekke Rygh, Frits Thorsen, Emmet McCormack, FranÃ§ois Hentges, Paal Henning Pedersen, Jacques Zimmer, Per Ã˜yvind Enger, Martha Chekenya

Published Sep 9, 2013 · Vol. 4, No. 9 · pp. 1527-1546

Keywords: Microglia, NK cells, glioblastoma, immunotherapy, NG2/CSPG4

DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia Research Paper

Riccardo Masetti, Marco Togni, Annalisa Astolfi, Martina Pigazzi, Elena Manara, Valentina Indio, Carmelo Rizzari, Sergio Rutella, Giuseppe Basso, Andrea Pession, Franco Locatelli

Published Sep 7, 2013 · Vol. 4, No. 10 · pp. 1712-1720

Keywords: pediatric acute myeloid leukemia, citogenetically normal acute myeloid leuekemia, whole-transcriptome massively parallel sequencing, CBFA2T3-GLIS2 fusion transcript, DHH-RHEBL1 fusion transcript.

Altered glycosylation of MUC1 influences its association with CIN85: the role of this novel complex in cancer cell invasion and migration Research Paper

Sandra Cascio, Adam M Farkas, Rebecca P Hughey, Olivera J Finn

Published Sep 7, 2013 · Vol. 4, No. 10 · pp. 1686-1697

Keywords: MUC1, CIN85, protein-protein interaction, cell migration, metastasis, novel targets, glycosylation

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

Sylvain Couty, Isaac M. Westwood, Andrew Kalusa, Celine Cano, Jon Travers, Kathy Boxall, Chiau Ling Chow, Sam Burns, Jessica Schmitt, Lisa Pickard, Caterina Barillari, P. Craig McAndrew, Paul A. Clarke, Spiros Linardopoulos, Roger J. Griffin, G. Wynne Aherne, Florence I. Raynaud, Paul Workman, Keith Jones, Rob L.M. van Montfort

Published Aug 25, 2013 · Vol. 4, No. 10 · pp. 1647-1661

Keywords: S6 kinase, P70S6K, cancer, inhibitor, structure-based drug design

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

Emma M. Smith, Lei Zhang, Brian A. Walker, Emma L. Davenport, Lauren I. Aronson, David Krige, Leon Hooftman, Alan H. Drummond, Gareth J. Morgan, Faith E. Davies

Published Aug 12, 2013 · Vol. 6, No. 19 · pp. 17314-17327

Keywords: Myeloma, HDAC inhibitor, aminopeptidase inhibitor, NFÎºB

A Hidden Role of the Inactivated FANCD2: Upregulating Î”Np63 Research Paper

Jayabal Panneerselvam, Anna Pickering, Jun Zhang, Hong Wang, Hui Tian, Junnian Zheng, Peiwen Fei

Published Aug 11, 2013 · Vol. 4, No. 9 · pp. 1416-1426

Keywords: P63, Fanconi Anemia tumor supressor pathway, oncogene delta N p63, FANCD2, tumorigenicity, transactivation

Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice Research Paper

Marianna L Ianzano, Stefania Croci, Giordano Nicoletti, Arianna Palladini, Lorena Landuzzi, Valentina Grosso, Dario Ranieri, Massimiliano Dall'Ora, Ilaria Santeramo, Milena Urbini, Carla De Giovanni, Pier Luigi Lollini, Patrizia Nanni

Published Aug 6, 2013 · Vol. 5, No. 1 · pp. 108-119

Keywords: rhabdomyosarcoma, p53, HER-2, p19Arf, p21Cip1

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Xiaoli Wu, Mihir K. Bhayani, Cristina T. Dodge, Milena S. Nicoloso, Yunyun Chen, Xiaofeng Yan, Makoto Adachi, Ligy Thomas, Chad E. Galer, Tilahun Jiffar, Curtis R. Pickering, Michael E. Kupferman, Jeffrey N. Myers, George A. Calin, Stephen Y. Lai

Published Aug 6, 2013 · Vol. 4, No. 9 · pp. 1388-1398

Keywords: miRNA EGFR AKT1 mTOR miRNA-27a* miRNA-27a-5p

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation Research Paper

Urszula Liwak, Lindsay E Jordan, Sally Davidson Von-Holt, Poonam Singh, Jennifer E. L. Hanson, Ian A Lorimer, Federico Roncaroli, Martin Holcik

Published Jul 28, 2013 · Vol. 4, No. 9 · pp. 1365-1372

Keywords: Glioblastoma multiforme, Bcl-xL, PDCD4, ABT-737, translation initiation

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

Xu Di, Guofeng Zhang, Yaqin Zhang, Kazuyo Takeda, Leslie A. Rivera Rosado, Baolin Zhang

Published Jul 27, 2013 · Vol. 4, No. 9 · pp. 1349-1364

Keywords: TRAIL resistance, basal autophagosomes, death receptors, cell surface expression

Cancer Metabolism: New Validated Targets for Drug Discovery Research Perspective

Federica Sotgia, Ubaldo E. Martinez-Outschoorn, Michael P Lisanti

Published Jul 22, 2013 · Vol. 4, No. 8 · pp. 1309-1316

Keywords: cancer metabolism, therapeutic targets, drug discovery

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

Judith Hagenbuchner, Ursula Kiechl-Kohlendorfer, Petra Obexer, Michael J. Ausserlechner

Published Jul 15, 2013 · Vol. 4, No. 8 · pp. 1241-1252

Keywords: BCL2 proteins, TRAIL, Fas-induced apoptosis, Noxa

Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis Research Paper

Noor A. Lokman, Alison SF. Elder, Miranda P Ween, Carmen E. Pyragius, Peter Hoffmann, Martin K. Oehler, Carmela Ricciardelli

Published Jul 14, 2013 · Vol. 4, No. 8 · pp. 1199-1211

Keywords: annexin A2, ovarian cancer, invasion, chick chorioallantoic membrane assay, xenograft model

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

Elizabeth Rico-Bautista, Wenhong Zhu, Shinichi Kitada, Suthakar Ganapathy, Eric Lau, Stan Krajewski, Joel Ramirez, Jason A. Bush, Zhimin Yuan, Dieter A. Wolf

Published Jul 14, 2013 · Vol. 4, No. 8 · pp. 1212-1229

Keywords: Prostate cancer, cell cycle arrest, apoptosis, oxidative stress, small molecule inhibitor, mitochondrial function

Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target Research Paper

Jun Huang, Sho Tabata, Soji Kakiuchi, Trung The Van, Hisatsugu Goto, Masaki Hanibuchi, Yasuhiko Nishioka

Published Jul 8, 2013 · Vol. 4, No. 8 · pp. 1172-1184

Keywords: malignant pleural mesothelioma, pregnancy-associated plasma protein A, migration, orthotopic xenograft mouse model

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MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia Research Paper

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells Research Paper

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations Research Paper

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas Research Paper

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival Research Paper

DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia Research Paper

Altered glycosylation of MUC1 influences its association with CIN85: the role of this novel complex in cancer cell invasion and migration Research Paper

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

A Hidden Role of the Inactivated FANCD2: Upregulating Î”Np63 Research Paper

Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice Research Paper

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation Research Paper

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

Cancer Metabolism: New Validated Targets for Drug Discovery Research Perspective

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis Research Paper

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia Research Paper

Combinatorial antitumor effect of HDACs and the PI3K-Akt-mTOR pathway inhibition in a Pten deficient model of prostate cancer Research Paper

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells Research Paper

CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations Research Paper

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas Research Paper

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival Research Paper

DHH-RHEBL1 fusion transcript: a novel recurrent feature in the new landscape of pediatric CBFA2T3-GLIS2-positive acute myeloid leukemia Research Paper

Altered glycosylation of MUC1 influences its association with CIN85: the role of this novel complex in cancer cell invasion and migration Research Paper

The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design Research Paper

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

A Hidden Role of the Inactivated FANCD2: Upregulating Î”Np63 Research Paper

Tumor suppressor genes promote rhabdomyosarcoma progression in p53 heterozygous, HER-2/neu transgenic mice Research Paper

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Loss of PDCD4 contributes to enhanced chemoresistance in Glioblastoma Multiforme through de-repression of Bcl-xL translation Research Paper

Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5 Research Paper

Cancer Metabolism: New Validated Targets for Drug Discovery Research Perspective

A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration Research Paper

Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis Research Paper

Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling Research Paper

Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target Research Paper