The Oncosearch | Oncotarget

NF-ÎºB1 inhibits c-Myc protein degradation through suppression of FBW7 expression Research Paper

Haishan Huang, Li Ma, Jingxia Li, Yonghui Yu, Dongyun Zhang, Jinlong Wei, Honglei Jin, Derek Xu, Jinmin Gao, Chuanshu Huang

Published Jan 15, 2014 · Vol. 5, No. 2 · pp. 493-505

Keywords: NF-ÎºB p50, arsenite, c-Myc, protein degradation, FBW7

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

John T. Heap, Jan Theys, Muhammad Ehsaan, Aleksandra M Kubiak, Ludwig Dubois, Kim Paesmans, Lieve Van Mellaert, Richard Knox, Sarah A. Kuehne, Phillipe Lambin, Nigel P. Minton

Published Jan 12, 2014 · Vol. 5, No. 7 · pp. 1761-1769

RB1 gene inactivation by chromothripsis in human retinoblastoma Research Paper

Justina McEvoy, Panduka Nagahawatte, David Finkelstein, Jennifer Richards-Yutz, Marcus Valentine, Jing Ma, Charles Mullighan, Guangchun Song, Xiang Chen, Matthew Wilson, Rachel Brennan, Stanely Pounds, Jared Becksfort, Robert Huether, Charles Lu, Robert S. Fulton, Lucinda L. Fulton, Xin Hong, David J. Dooling, Kerri Ochoa, Elaine R. Mardis, Richard K. Wilson, John Easton, Jinghui Zhang, James R. Downing, Arupa Ganguly, Michael A. Dyer

Published Jan 11, 2014 · Vol. 5, No. 2 · pp. 438-450

Keywords: chromothripsis, retinoblastoma, RB1, MYCN

Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites Research Paper

Catherine A. Vaughan, Swati P. Deb, Sumitra Deb, Brad Windle

Published Jan 2, 2014 · Vol. 5, No. 2 · pp. 417-427

Keywords: mutant p53, ChIP-Seq, ETS1, bi-directional promoter

Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production Research Paper

Yosuke Togashi, Tokuzo Arao, Hiroki Kato, Kazuko Matsumoto, Masato Terashima, Hidetoshi Hayashi, Marco A. de Velasco, Yoshihiko Fujita, Hideharu Kimura, Takushi Yasuda, Hitoshi Shiozaki, Kazuto Nishio

Published Dec 30, 2013 · Vol. 5, No. 10 · pp. 2962-2973

Keywords: oral cancer overexpressed 1, esophageal squamous cell cancer, pyrroline-5-carboxylate reductase, proline metabolism, reactive oxygen species

Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer Research Paper

Da Li, Fang-Fang Bi, Ji-Min Cao, Chen Cao, Chun-Yan Li, Bo Liu, Qing Yang

Published Dec 29, 2013 · Vol. 5, No. 1 · pp. 291-297

Keywords: PARP1, H3K9ac, ETS1, BRCA1, Ovarian cancer

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis Priority Research Paper

Regina M. Graham, John W. Thompson, Keith A. Webster

Published Dec 29, 2013 · Vol. 5, No. 5 · pp. 1162-1173

Keywords: hypoxia, cancer, xenograft, programmed cell death, bafilomycin A1

SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I Research Paper

Francesco Ciscato, Marco Sciacovelli, Gianmarco Villano, Cristian Turato, Paolo Bernardi, Andrea Rasola, Patrizia Pontisso

Published Dec 24, 2013 · Vol. 5, No. 9 · pp. 2418-2427

Keywords: SERPINB3, chemotherapeutics, mitochondria, respiratory complexes, reactive oxygen species, cell death

Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway Research Paper

Bahityar Rahmutulla, Kazuyuki Matsushita, Mamoru Satoh, Masanori Seimiya, Sachio Tsuchida, Shuji Kubo, Hideaki Shimada, Masayuki Ohtsuka, Masaru Miyazaki, Fumio Nomura

Published Dec 21, 2013 · Vol. 5, No. 9 · pp. 2404-2417

Keywords: FBP interacting repressor (FIR), bleomycin, DNA damage, Ku86, c-Myc, P27Kip1

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine Research Paper

Elisabeth Walsby, Guy Pratt, Hao Shao, Abdullah Y. Abbas, Peter M. Fischer, Tracey D. Bradshaw, Paul Brennan, Chris Fegan, Shudong Wang, Chris Pepper

Published Dec 18, 2013 · Vol. 5, No. 2 · pp. 375-385

Keywords: CLL, cdk9, synergy, MCL1

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Cindy Neuzillet, Armand de Gramont, AnnemilaÃ¯ Tijeras-Raballand, Louis de Mestier, JÃ©rÃ´me Cros, Sandrine Faivre, Eric Raymond

Published Dec 18, 2013 · Vol. 5, No. 1 · pp. 78-94

Keywords: SMAD, stellate cells, extracellular matrix, EMT, TGF-Î² inhibitors

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

Kodappully Sivaraman Siveen, Nurulhuda Mustafa, Feng Li, Radhamani Kannaiyan, Kwang Seok Ahn, Alan Prem Kumar, Wee-Joo Chng, Gautam Sethi

Published Dec 18, 2013 · Vol. 5, No. 3 · pp. 634-648

Keywords: Thymoquinone, MM, bortezomib, apoptosis, NF-ÎºB

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

Zhongwu li, Yanling Wang, Jing Qiu, Qiang Li, Chunping Yuan, Wei Zhang, Dongmiao Wang, Jinhai Ye, Hongbin Jiang, Jianrong Yang, Jie Cheng

Published Dec 7, 2013 · Vol. 4, No. 12 · pp. 2532-2549

Keywords: tongue squamous cell carcinoma, polycomb complex, EZH2, DZNep

Glycogen synthase kinase-3Î² inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth Research Paper

Jan Kroon, Lars S. in 't Veld, Jeroen T. Buijs, Henry Cheung, Geertje van der Horst, Gabri van der Pluijm

Published Dec 5, 2013 · Vol. 5, No. 19 · pp. 8986-8994

Keywords: Cancer Stem Cells, GSK-3Î², Metastasis, Prostate Cancer, Wnt signaling

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

Liliana H. Mochmann, Martin Neumann, Eva K. von Der Heide, Verena Nowak, Anja A. KÃ¼hl, Jutta Ortiz-Tanchez, Juliane Bock, Wolf K Hofmann, Claudia D Baldus

Published Dec 4, 2013 · Vol. 5, No. 2 · pp. 351-362

Keywords: ERG, ERK, EMT, Chemoresistance

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects Research Paper

Jason U. Tilan, Congyi Lu, Susana Galli, Ewa Izycka-Swieszewska, Joshua P. Earnest, Asim Shabbir, Lindsay M. Everhart, Shuo Wang, Samantha Martin, Meredith Horton, Akanksha Mahajan, David Christian, Alison O'Neill, Hongkun Wang, Tingting Zhuang, Magdalena Czarnecka, Michael D. Johnson, Jeffrey A. Toretsky, Joanna B. Kitlinska

Published Nov 26, 2013 · Vol. 4, No. 12 · pp. 2487-2501

Keywords: Neuropeptide Y, Ewing sarcoma, hypoxia, cancer stem cells, angiogenesis

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine Research Paper

Chiou-Tsun Tsai, Pei-Ming Yang, Ting-Rong Chern, Shu-Hui Chuang, Jung-Hsin Lin, Lars Klemm, Markus MÃ¼schen, Ching-Chow Chen

Published Nov 25, 2013 · Vol. 5, No. 1 · pp. 211-223

Keywords: AID, 5-aza-CdR, Zebularine, DNMT1

High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer Research Paper

Shuyan Liu, Pengsheng Zheng

Published Nov 25, 2013 · Vol. 4, No. 12 · pp. 2462-2475

Keywords: aldehyde dehydrogenase, cancer stem cells, cervical cancer, self-renewal, chemoresistance

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7 Research Paper

Zeran Wang, Yueyong Liu, Pengju Zhang, Weiguo Zhang, Weijing Wang, Kenneth Curr, Guangwei Wei, Jian-Hua Mao

Published Nov 25, 2013 · Vol. 4, No. 12 · pp. 2476-2486

Keywords: FAM83D, FBXW7, breast cancer, epithelial-mesenchymal transition, invasion

Targeting nucleocytoplasmic transport in cancer therapy Review

Richard Hill, Bastien Cautain, Nuria de Pedro, Wolfgang Link

Published Nov 24, 2013 · Vol. 5, No. 1 · pp. 11-28

Keywords: Tumor suppressors, Cancer, Anti-cancer therapy, Nuclear export, nuclear import

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NF-ÎºB1 inhibits c-Myc protein degradation through suppression of FBW7 expression Research Paper

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

RB1 gene inactivation by chromothripsis in human retinoblastoma Research Paper

Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites Research Paper

Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production Research Paper

Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer Research Paper

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis Priority Research Paper

SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I Research Paper

Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway Research Paper

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine Research Paper

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

Glycogen synthase kinase-3Î² inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth Research Paper

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects Research Paper

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine Research Paper

High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer Research Paper

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7 Research Paper

Targeting nucleocytoplasmic transport in cancer therapy Review

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

NF-ÎºB1 inhibits c-Myc protein degradation through suppression of FBW7 expression Research Paper

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo Research Paper

RB1 gene inactivation by chromothripsis in human retinoblastoma Research Paper

Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites Research Paper

Frequent amplification of ORAOV1 gene in esophageal squamous cell cancer promotes an aggressive phenotype via proline metabolism and ROS production Research Paper

Poly (ADP-ribose) polymerase 1 transcriptional regulation: A novel crosstalk between histone modification H3K9ac and ETS1 motif hypomethylation in BRCA1-mutated ovarian cancer Research Paper

Inhibition of the vacuolar ATPase induces Bnip3-dependent death of cancer cells and a reduction in tumor burden and metastasis Priority Research Paper

SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I Research Paper

Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway Research Paper

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine Research Paper

Perspectives of TGF-Î² inhibition in pancreatic and hepatocellular carcinomas Review

Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-ÎºB regulated gene products in multiple myeloma xenograft mouse model Research Paper

The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer Research Paper

Glycogen synthase kinase-3Î² inhibition depletes the population of prostate cancer stem/progenitor-like cells and attenuates metastatic growth Research Paper

ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cells Research Paper

Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects Research Paper

AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine Research Paper

High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer Research Paper

FAM83D promotes cell proliferation and motility by downregulating tumor suppressor gene FBXW7 Research Paper

Targeting nucleocytoplasmic transport in cancer therapy Review