The Oncosearch | Oncotarget

Ishwaria Subbiah, Vivek Subbiah, Apostolia M Tsimberidou, Aung Naing, Ahmed Kaseb, Javle Milind, Siqing Fu, David S Hong, Sarina Piha-Paul, Jenifer Wheler, Kenneth Hess, Filip Janku, Gerald Falchook, Robert A Wolff, Razelle Kurzrock

Published Jan 27, 2013 · Vol. 4, No. 1 · pp. 153-162

Keywords: Gallbladder Cancer, Cholangiocarcinoma, Phase 1 trials

Lin28b Promotes Head and Neck Cancer Progression via Modulation of the Insulin-Like Growth Factor Survival Pathway Research Paper

Nehad M Alajez, Wei Shi, Dennis Wong, Michelle Lenarduzzi, John Waldron, Ilan Weinreb, Fei-Fei Liu

Published Dec 29, 2012 · Vol. 3, No. 12 · pp. 1641-1652

Keywords: Lin28b, microRNA, Let-7, HNC, IGF

Enhancing the Efficacy of Drug-loaded Nanocarriers against Brain Tumors by Targeted Radiation Therapy Research Paper

Brian C. Baumann, Gary D. Kao, Abdullah Mahmud, Takamasa Harada, Joe Swift, Christina Chapman, Xiangsheng Xu, Dennis E. Discher, Jay F. Dorsey

Published Dec 23, 2012 · Vol. 4, No. 1 · pp. 64-79

Keywords: glioblastoma multiforme, nanocarrier, radiation therapy, brain tumors, chemotherapy

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

Suyoun Chung, Hanae Suzuki, Takashi Miyamoto, Naofumi Takamatsu, Ayako Tatsuguchi, Koji Ueda, Kyoko Kijima, Yusuke Nakamura, Yo Matsuo

Published Dec 21, 2012 · Vol. 3, No. 12 · pp. 1629-1640

Keywords: oncogene, drug discovery, kinase inhibitor, cancer stem cell

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Francesca Chiarini, Annalisa Lonetti, Gabriella Teti, Ester Orsini, Daniela Bressanin, Alessandra Cappellini, Francesca Ricci, Pier Luigi Tazzari, Andrea Ognibene, Mirella Falconi, Pasqualepaolo Pagliaro, Ilaria Iacobucci, Giovanni Martinelli, Sergio Amadori, James A McCubrey, Alberto M Martelli

Published Dec 18, 2012 · Vol. 3, No. 12 · pp. 1615-1628

Keywords: AML, PI3K/Akt/mTOR signaling, apoptosis, autophagy combination therapy, leukemia initiating cells

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Laura Lehtinen, Kirsi Ketola, Rami MÃ¤kelÃ¤, John-Patrick Mpindi, Miro Viitala, Olli Kallioniemi, Kristiina Iljin

Published Dec 17, 2012 · Vol. 4, No. 1 · pp. 48-63

Keywords: Breast cancer, vimentin, MTHFD2

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

Takayuki Yoshida, Junya Kakegawa, Takayuki Yamaguchi, Yoshiji Hantani, Nobuyuki Okajima, Toshiyuki Sakai, Yoshihiro Watanabe, Motonao Nakamura

Published Dec 1, 2012 · Vol. 3, No. 12 · pp. 1533-1545

Keywords: MEK inhibitor, JTP-74057/GSK1120212/trametinib, chemical probe-affinity chromatography, target identification, unphosphorylated MEK (u-MEK)

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

Kyung H Yi, Jossette Axtmayer, John P Gustin, Anandita Rajpurohit, Josh Lauring

Published Nov 29, 2012 · Vol. 4, No. 1 · pp. 29-34

Keywords: AKT1, mutation, personalized, cancer, therapy

KDM1 is a novel therapeutic target for the treatment of gliomas Research Paper

Gangadhara R Sareddy, Binoj C. Nair, Samaya K Krishnan, Vijay K Gonugunta, Quan-guang Zhang, Naoki Miyata, Takayoshi Suzuki, Andrew Brenner, Darrell W Brann, Ratna K Vadlamudi

Published Nov 17, 2012 · Vol. 4, No. 1 · pp. 18-28

Keywords: Oncogene, epigenetic modifications, gliomas, p53

Identification of miR-30d as a novel prognostic maker of prostate cancer. Research Paper

Naohito Kobayashi, Hiroji Uemura, Kiyotaka Nagahama, Koji Okudela, Mitsuko Furuya, Yoko Ino, Yusuke Ito, Hisashi Hirano, Yoshiaki Inayama, Ichiro Aoki, Yoji Nagashima, Yoshinobu Kubota, Hitoshi Ishiguro

Published Nov 17, 2012 · Vol. 3, No. 11 · pp. 1455-1471

Keywords: miRNA-30d, prostate cancer, biochemical recurrence, SOCS1

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

SÃlvia CufÃ, Alejandro Vazquez-Martin, Ceistina Oliveras-Ferraros, Bruna Corominas-Faja, Ander Urruticoechea, BegoÃ±a Martin-Castillo, Javier A Menendez

Published Nov 17, 2012 · Vol. 3, No. 12 · pp. 1600-1614

Keywords: Autophagy, ATG genes, HER2, trastuzumab, lapatinib

Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans Research Paper

Kyle M. Walsh, Christopher I. Amos, Angela S. Wenzlaff, Ivan P. Gorlov, Jennette D. Sison, Xifeng Wu, Margaret R. Spitz, Helen M. Hansen, Emily Y. Lu, Chongjuan Wei, Huifeng Zhang, Wei Chen, Stacy M. Lloyd, Marsha L. Frazier, Paige M. Bracci, Michael F. Seldin, Margaret R. Wrensch, Ann G. Schwartz, John K. Wiencke

Published Nov 16, 2012 · Vol. 3, No. 11 · pp. 1428-1438

Keywords: Lung cancer, nicotine dependence, African-Americans, genetic association

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

Zhiwei Wang, Hiroyuki Inuzuka, Jiateng Zhong, Pengda Liu, Fakul H Sarkar, Yi Sun, Wenyi Wei

Published Nov 16, 2012 · Vol. 3, No. 11 · pp. 1294-1300

Keywords: acetylation, cancer, deacetylation, SIRT3, oncoprotein, ubiquitination, phosphorylation, F-box protein, Skp2, therapy

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

Hung-Ju Shih, Hsiao-Huei Chen, Yen-An Chen, Meng-Hsun Wu, Gan-Guang Liou, Wei-Wen Chang, Linyi Chen, Lu-Hai Wang, Hsin-Ling Hsu

Published Nov 9, 2012 · Vol. 3, No. 11 · pp. 1401-1415

Keywords: MCT-1, Shc, Ras, ERK, apoptosis, tumor

Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma Research Paper

Takashi Kinoshita, Toyoyuki Hanazawa, Nijiro Nohata, Naoko Kikkawa, Hideki Enokida, Hirofumi Yoshino, Takeshi Yamasaki, Hideo Hidaka, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki

Published Nov 7, 2012 · Vol. 3, No. 11 · pp. 1386-1400

Keywords: microRNA, miR-218, tumor suppressor, focal adhesion, laminin-332, head and neck squamous cell carcinoma

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Targeted alpha-therapy using [Bi-213]anti-CD20 as novel treatment option for radio- and chemoresistant non-Hodgkin lymphoma cells Research Paper

Comedo-DCIS is a precursor lesion for basal-like breast carcinoma: identification of a novel p63/Her2/neu expressing subgroup Research Paper

Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis Research Paper

Protease nexin 1: a novel regulator of prostate cancer cell growth and neo-angiogenesis Editorial

Targeting glycogen metabolism: a novel strategy to inhibit cancer cell growth? Editorial

Targeted Therapy of Advanced Gallbladder Cancer and Cholangiocarcinoma with Aggressive Biology: Eliciting Early Response Signals from Phase 1 trials Research Paper

Lin28b Promotes Head and Neck Cancer Progression via Modulation of the Insulin-Like Growth Factor Survival Pathway Research Paper

Enhancing the Efficacy of Drug-loaded Nanocarriers against Brain Tumors by Targeted Radiation Therapy Research Paper

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

KDM1 is a novel therapeutic target for the treatment of gliomas Research Paper

Identification of miR-30d as a novel prognostic maker of prostate cancer. Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans Research Paper

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Targeted alpha-therapy using [Bi-213]anti-CD20 as novel treatment option for radio- and chemoresistant non-Hodgkin lymphoma cells Research Paper

Comedo-DCIS is a precursor lesion for basal-like breast carcinoma: identification of a novel p63/Her2/neu expressing subgroup Research Paper

Ras inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosis Research Paper

Protease nexin 1: a novel regulator of prostate cancer cell growth and neo-angiogenesis Editorial

Targeting glycogen metabolism: a novel strategy to inhibit cancer cell growth? Editorial

Targeted Therapy of Advanced Gallbladder Cancer and Cholangiocarcinoma with Aggressive Biology: Eliciting Early Response Signals from Phase 1 trials Research Paper

Lin28b Promotes Head and Neck Cancer Progression via Modulation of the Insulin-Like Growth Factor Survival Pathway Research Paper

Enhancing the Efficacy of Drug-loaded Nanocarriers against Brain Tumors by Targeted Radiation Therapy Research Paper

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine Research Paper

KDM1 is a novel therapeutic target for the treatment of gliomas Research Paper

Identification of miR-30d as a novel prognostic maker of prostate cancer. Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans Research Paper

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2 Research Perspective

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma Research Paper