The Oncosearch | Oncotarget

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

Hung-Ju Shih, Hsiao-Huei Chen, Yen-An Chen, Meng-Hsun Wu, Gan-Guang Liou, Wei-Wen Chang, Linyi Chen, Lu-Hai Wang, Hsin-Ling Hsu

Published Nov 9, 2012 · Vol. 3, No. 11 · pp. 1401-1415

Keywords: MCT-1, Shc, Ras, ERK, apoptosis, tumor

Down-regulation of Sox7 is associated with aberrant activation of Wnt/Î²-catenin signaling in endometrial cancer Research Paper

David W Chan, Celia SL Mak, Thomas HY Leung, Karen KL Chan, Hextan YS Ngan

Published Nov 7, 2012 · Vol. 3, No. 12 · pp. 1546-1556

Keywords: Sox7, Wnt/ï¢-catenin, endometrial cancer, TCF/LEF-1, CyclinD1, FGF9

Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma Research Paper

Takashi Kinoshita, Toyoyuki Hanazawa, Nijiro Nohata, Naoko Kikkawa, Hideki Enokida, Hirofumi Yoshino, Takeshi Yamasaki, Hideo Hidaka, Masayuki Nakagawa, Yoshitaka Okamoto, Naohiko Seki

Published Nov 7, 2012 · Vol. 3, No. 11 · pp. 1386-1400

Keywords: microRNA, miR-218, tumor suppressor, focal adhesion, laminin-332, head and neck squamous cell carcinoma

Inhibiting the molecular evolution of cancer through HSP90 Editorial

Ana Sofia Martins, Faith E. Davies, Paul Workman

Published Nov 5, 2012 · Vol. 3, No. 10 · pp. 1054-1056

Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis Research Paper

Katharina Bluemlein, Matthias Glueckmann, Nana-Maria GrÃ¼ning, RenÃ© Feichtinger, Antje KrÃ¼ger, Mirjam MC. Wamelink, Hans Lehrach, Stephen Tate, Daniel Neureiter, Kofler Barbara, Markus Ralser

Published Nov 1, 2012 · Vol. 3, No. 11 · pp. 1356-1369

Keywords: cancer metabolism, pyruvate kinase, proteomics, amino acid profile

Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN Research Paper

Andrew D Beggs, Enric Domingo, Megan McGregor, Mikael Presz, Elaine Johnstone, Rachel Midgley, David Kerr, Dahmane Oukrif, Marco Novelli, Muti Abulafi, Shirley V Hodgson, Wakkas Fadhil, Mohammed Ilyas, Ian P Tomlinson

Published Oct 28, 2012 · Vol. 3, No. 11 · pp. 1348-1355

Keywords: Double strand break repair, ATM, g-H2AX, colorectal cancer, prognosis

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma Research Paper

Nicola Amodio, Marzia Leotta, Dina Bellizzi, Maria Teresa Di Martino, Patrizia D'Aquila, Marta Lionetti, Fernanda Fabiani, Emanuela Leone, Anna Maria GullÃ, Giuseppe Passarino, Michele Caraglia, Massimo Negrini, Antonino Neri, Antonio Giordano, Pierosandro Tagliaferri, Pierfrancesco Tassone

Published Oct 21, 2012 · Vol. 3, No. 10 · pp. 1246-1258

Keywords: miRNA, miR-29b, multiple myeloma, DNMT

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance Review

James Andrew McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Saverio Candido, Grazia Malaponte, Maria C. Mazzarino, Paolo Fagone, Ferdinando Nicoletti, JÃ¶rg BÃ¤secke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Francesca Chiarini, Camilla Evangelisti, Lucio Cocco, Alberto M. Martelli

Published Oct 20, 2012 · Vol. 3, No. 10 · pp. 1068-1111

Keywords: Targeted Therapy, Therapy Resistance, Cancer Stem Cells, Raf, Akt, PI3K, mTOR

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

William H Chappell, Stephen L. Abrams, Richard A Franklin, Giuseppe Montalto, Melchiorre Cervello, Alberto M Martelli, Saverio Candido, Massimo Libra, Jerry Polesel, Renato Talamini, Ralph Arlinghaus, Linda S Steelman, James A McCubrey

Published Oct 20, 2012 · Vol. 3, No. 10 · pp. 1236-1245

Keywords: NGAL, Lcn2, Doxorubicin, lipocalins, siderocalins, iron transport, MMP-9, drug resistance

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Robert Callahan, Uma Mudunuri, Sharon Bargo, Ahmed Raafat, David McCurdy, Corinne Boulanger, William Lowther, Robert Stephens, Brian T. Luke, Claudia Stewart, Xiaolin Wu, David Munroe, Gilbert H. Smith

Published Oct 17, 2012 · Vol. 3, No. 11 · pp. 1320-1334

Keywords: mouse mammary tumor virus, premalignant lesions, mammary tumors, genes, human breast carcinomas, metastases

Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets. Research Paper

Pamela L. Strissel, Matthias Ruebner, Falk Thiel, David Wachter, Arif B. Ekici, Friedericke Wolf, Franziska Thieme, Klemens Ruprecht, Matthias W. Beckmann, Reiner Strick

Published Oct 13, 2012 · Vol. 3, No. 10 · pp. 1204-1219

Keywords: Endometrial carcinoma, hyperplasia, polyp, ERV, Syncytin.

Recurrent targets of aberrant somatic hypermutation in lymphoma Research Paper

Alireza Hadj Khodabakhshi, Ryan D Morin, Anthony P Fejes, Andrew J Mungall, Karen L Mungall, Madison Bolger-Munro, Nathalie A Johnson, Joseph M Connors, Randy D Gascoyne, Marco A Marra, Inanc Birol, Steven JM Jones

Published Oct 12, 2012 · Vol. 3, No. 11 · pp. 1308-1319

Keywords: Aberrant somatic hypermutation, Genome wide study, Diffuse large B-cell lymphoma, Genomic rearrangements.

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Kasthuri Kannan, Akiko Inagaki, Joachim Silber, Daniel Gorovets, Jianan Zhang, Edward R. Kastenhuber, Adriana Heguy, John H. Petrini, Timothy A. Chan, Jason T. Huse

Published Oct 11, 2012 · Vol. 3, No. 10 · pp. 1194-1203

Keywords: glioma, astrocytoma, IDH, ATRX, whole-exome sequencing

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

Lydia Kriegl, Michael Vieth, Thomas Kirchner, Antje Menssen

Published Oct 3, 2012 · Vol. 3, No. 10 · pp. 1182-1193

Keywords: Serrated route, colorectal cancer, SIRT1, c-MYC, BRAF and KRAS mutation, wnt signalling

FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration Research Paper

VÃ©ronique Frattini, Federica Pisati, Maria Carmela Speranza, Pietro Luigi Poliani, Gianmaria FrigÃ©, Gabriele Cantini, Dimos Kapetis, Manuela Cominelli, Alessandra Rossi, Gaetano Finocchiaro, Serena Pellegatta

Published Sep 22, 2012 · Vol. 3, No. 10 · pp. 1146-1157

Keywords: FOXP3, glioblastoma, neurospheres, proliferation, migration

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

James Andrew McCubrey, Linda Steeman, William Chappell, Stephen Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria Mazzarino, Saverio Candido, Massimo Libra, Jorg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto Martelli

Published Sep 20, 2012 · Vol. 3, No. 9 · pp. 954-987

Keywords: targeted therapy, therapy resistance, mutations, Raf, Akt, PI3K, mTOR

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

Zhiwei Wang, Hiroyuki Inuzuka, Jiateng Zhong, Hidefumi Fukushima, Lixin Wan, Pengda Liu, Wenyi Wei

Published Sep 11, 2012 · Vol. 3, No. 9 · pp. 1026-1035

Keywords: Mdm2, ATM, CKI, phosphorylation, beta-TRCP, ubiquitination, DNA damage

Glyceraldehyde-3-Phosphate Dehydrogenase: A Promising Target for Molecular Therapy in Hepatocellular Carcinoma Review

Shanmugasundaram Ganapathy-Kanniappan, Rani Kunjithapatham, Jean-Francois Geschwind

Published Sep 7, 2012 · Vol. 3, No. 9 · pp. 940-953

Keywords: GAPDH, HCC, 3-bromopyruvate

Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target Research Paper

Fang Zhang, Kristi Rothermund, Sajithal B. Gangadharan, Yves Pommier, Edward V. Prochownik, John S. Lazo

Published Aug 31, 2012 · Vol. 3, No. 9 · pp. 998-1010

Keywords: : cancer stem cell, Topoisomerase I, small molecule inhibitor, compound library screening

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper

Valentina Bevelacqua, Ylenia Bevelacqua, Saverio Candido, Evangelica Skarmoutsou, Alfredo Amoroso, Claudio Guarneri, Angela Strazzanti, Pietro Gangemi, Maria Clorinda Mazzarino, Fabio D'Amico, James A McCubrey, Massimo Libra, Grazia Malaponte

Published Aug 26, 2012 · Vol. 3, No. 8 · pp. 882-892

Keywords: NECL-5, melanoma, nevus, skin

Publication Alerts

European Cancer and Oncology Congress

Post-Publication Promotion

Search Oncotarget

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

Down-regulation of Sox7 is associated with aberrant activation of Wnt/Î²-catenin signaling in endometrial cancer Research Paper

Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma Research Paper

Inhibiting the molecular evolution of cancer through HSP90 Editorial

Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis Research Paper

Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN Research Paper

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma Research Paper

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance Review

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets. Research Paper

Recurrent targets of aberrant somatic hypermutation in lymphoma Research Paper

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

Glyceraldehyde-3-Phosphate Dehydrogenase: A Promising Target for Molecular Therapy in Hepatocellular Carcinoma Review

Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target Research Paper

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

Targeting MCT-1 oncogene inhibits Shc pathway and xenograft tumorigenicity Research Paper

Down-regulation of Sox7 is associated with aberrant activation of Wnt/Î²-catenin signaling in endometrial cancer Research Paper

Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion through targeting laminin-332 in head and neck squamous cell carcinoma Research Paper

Inhibiting the molecular evolution of cancer through HSP90 Editorial

Pyruvate kinase is a dosage-dependent regulator of cellular amino acid homeostasis Research Paper

Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN Research Paper

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma Research Paper

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance Review

Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity. Research Paper

Genes affected by mouse mammary tumor virus (MMTV) proviral insertions in mouse mammary tumors are deregulated or mutated in primary human mammary tumors. Research Paper

Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets. Research Paper

Recurrent targets of aberrant somatic hypermutation in lymphoma Research Paper

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma Research Paper

Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer Research Paper

FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration Research Paper

Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response. Review

DNA damage-induced activation of ATM promotes Î²-TRCP-mediated Mdm2 ubiquitination and destruction Research Paper

Glyceraldehyde-3-Phosphate Dehydrogenase: A Promising Target for Molecular Therapy in Hepatocellular Carcinoma Review

Phenotypic Screening Reveals Topoisomerase I as a Breast Cancer Stem Cell Therapeutic Target Research Paper

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma Research Paper