The Oncosearch | Oncotarget

In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma Research Paper

Maria Teresa Di Martino, Annamaria GullÃ, Maria Eugenia Gallo Cantafio, Marta Lionetti, Emanuela Leone, Nicola Amodio, Pietro Hiram Guzzi, Umberto Foresta, Francesco Conforti, Mario Cannataro, Antonino Neri, Antonio Giordano, Pierosandro Tagliaferri, Pierfrancesco Tassone

Published Feb 24, 2013 · Vol. 4, No. 2 · pp. 242-255

Keywords: miR-221, miR-222, microRNA, miRNA, multiple myeloma, plasma cell leukemia

Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on Î²-catenin Research Paper

Joshua E. Allen, Wafik S. El-Deiry

Published Feb 18, 2013 · Vol. 4, No. 2 · pp. 184-191

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells Research Paper

Dimitra Bourboulia, HuiYing Han, Sandra Jensen-Taubman, Noah Gavil, Biju Isaac, Beiyang Wei, Len Neckers, William Stetler-Stevenson

Published Jan 27, 2013 · Vol. 4, No. 1 · pp. 163-173

Keywords: TIMP-2, microarray analysis, E-cadherin, cell adhesion, tumor growth inhibition

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention Research Paper

Meiyun Fan, Susan R. Pfeffer, Henry T. Lynch, Pamela Cassidy, Sancy Leachman, Lawrence M. Pfeffer, Levy Kopelovich

Published Jan 19, 2013 · Vol. 4, No. 1 · pp. 128-141

Keywords: Familial Melanoma, gene expression, CDKN2A, p16, Mutations, Melanoma

Gene expression-based risk score in diffuse large B-cell lymphoma Research Paper

Caroline Bret, Bernard Klein, JÃ©rÃ´me Moreaux

Published Dec 31, 2012 · Vol. 3, No. 12 · pp. 1700-1710

Keywords: DLBCL, gene expression profile, risk score, prognosis

Advances in Targeting Signal Transduction Pathways. Review

James Andrew McCubrey, Linda S Steelman, William H Chappell, Lin Sun, Nicole M Davis, Stephen L Abrams, Richard A Franklin, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto M Martelli, Massimo Libra, Saverio Candido, Grazia Malaponte, Maria C Mazzarino, Paolo Fagone, Marco Donia, Ferdinando Nicoletti, Jerry Polesel, Renato Talamini, Jorg Basecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Joanna DuliÅ„ska-Litewka, Piotr Laidler, Antonio B D'Assoro, Lyudmyla Drobot, Kazuo Umezawa, Giuseppe Montalto, Melchiorre Cervello, Zoya N Demidenko

Published Dec 30, 2012 · Vol. 3, No. 12 · pp. 1505-1521

Keywords: Targeted Therapy, Therapy Resistance, Cancer Stem Cells, Raf, Akt, PI3K, mTOR, AMPK, Metformin

Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes Review

Albert E. Berman, Olga V. Leontieva, Venkatesh Natarajan, James A. McCubrey, Zoya N. Demidenko, Mikhail A. Nikiforov

Published Dec 30, 2012 · Vol. 3, No. 12 · pp. 1522-1532

Lin28b Promotes Head and Neck Cancer Progression via Modulation of the Insulin-Like Growth Factor Survival Pathway Research Paper

Nehad M Alajez, Wei Shi, Dennis Wong, Michelle Lenarduzzi, John Waldron, Ilan Weinreb, Fei-Fei Liu

Published Dec 29, 2012 · Vol. 3, No. 12 · pp. 1641-1652

Keywords: Lin28b, microRNA, Let-7, HNC, IGF

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

Suyoun Chung, Hanae Suzuki, Takashi Miyamoto, Naofumi Takamatsu, Ayako Tatsuguchi, Koji Ueda, Kyoko Kijima, Yusuke Nakamura, Yo Matsuo

Published Dec 21, 2012 · Vol. 3, No. 12 · pp. 1629-1640

Keywords: oncogene, drug discovery, kinase inhibitor, cancer stem cell

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

Francesca Chiarini, Annalisa Lonetti, Gabriella Teti, Ester Orsini, Daniela Bressanin, Alessandra Cappellini, Francesca Ricci, Pier Luigi Tazzari, Andrea Ognibene, Mirella Falconi, Pasqualepaolo Pagliaro, Ilaria Iacobucci, Giovanni Martinelli, Sergio Amadori, James A McCubrey, Alberto M Martelli

Published Dec 18, 2012 · Vol. 3, No. 12 · pp. 1615-1628

Keywords: AML, PI3K/Akt/mTOR signaling, apoptosis, autophagy combination therapy, leukemia initiating cells

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

Laura Lehtinen, Kirsi Ketola, Rami MÃ¤kelÃ¤, John-Patrick Mpindi, Miro Viitala, Olli Kallioniemi, Kristiina Iljin

Published Dec 17, 2012 · Vol. 4, No. 1 · pp. 48-63

Keywords: Breast cancer, vimentin, MTHFD2

SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Research Paper

Birgit Schif, Jochen K Lennerz, Christian W Kohler, Markus Kreuz, Stefan Bentink, Ingo Melzner, Olga Ritz, Lorenz TrÃ¼mper, Markus LÃ¶ffler, Rainer Spang, Peter MÃ¶ller

Published Dec 9, 2012 · Vol. 4, No. 1 · pp. 35-47

Keywords: biomarker, SOCS, JAK/STAT, GCB

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

Takayuki Yoshida, Junya Kakegawa, Takayuki Yamaguchi, Yoshiji Hantani, Nobuyuki Okajima, Toshiyuki Sakai, Yoshihiro Watanabe, Motonao Nakamura

Published Dec 1, 2012 · Vol. 3, No. 12 · pp. 1533-1545

Keywords: MEK inhibitor, JTP-74057/GSK1120212/trametinib, chemical probe-affinity chromatography, target identification, unphosphorylated MEK (u-MEK)

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Filip Janku, Jennifer J. Wheler, Aung Naing, Vanda M. T. Stepanek, Gerald S. Falchook, Siqing Fu, Ignacio Garrido-Laguna, Apostolia M. Tsimberidou, Sarina A. Piha-Paul, Stacy L. Moulder, J. Jack Lee, Rajyalakshmi Luthra, David S. Hong, Razelle Kurzrock

Published Nov 30, 2012 · Vol. 3, No. 12 · pp. 1566-1575

Keywords: PIK3CA mutation, phenotypic taxonomy, clinical outcome

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) Research Paper

Harald Herrmann, Katharina Blatt, Junwei Shi, Karoline V. Gleixner, Sabine Cerny-Reiterer, Leonhard MÃ¼llauer, Christopher R. Vakoc, Wolfgang R. Sperr, Hans-Peter Horny, James E. Bradner, Johannes Zuber, Peter Valent

Published Nov 27, 2012 · Vol. 3, No. 12 · pp. 1588-1599

Keywords: AML, leukemic stem cells, BRD4, JQ1, targeted therapy

Identification of miR-30d as a novel prognostic maker of prostate cancer. Research Paper

Naohito Kobayashi, Hiroji Uemura, Kiyotaka Nagahama, Koji Okudela, Mitsuko Furuya, Yoko Ino, Yusuke Ito, Hisashi Hirano, Yoshiaki Inayama, Ichiro Aoki, Yoji Nagashima, Yoshinobu Kubota, Hitoshi Ishiguro

Published Nov 17, 2012 · Vol. 3, No. 11 · pp. 1455-1471

Keywords: miRNA-30d, prostate cancer, biochemical recurrence, SOCS1

KDM1 is a novel therapeutic target for the treatment of gliomas Research Paper

Gangadhara R Sareddy, Binoj C. Nair, Samaya K Krishnan, Vijay K Gonugunta, Quan-guang Zhang, Naoki Miyata, Takayoshi Suzuki, Andrew Brenner, Darrell W Brann, Ratna K Vadlamudi

Published Nov 17, 2012 · Vol. 4, No. 1 · pp. 18-28

Keywords: Oncogene, epigenetic modifications, gliomas, p53

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

SÃlvia CufÃ, Alejandro Vazquez-Martin, Ceistina Oliveras-Ferraros, Bruna Corominas-Faja, Ander Urruticoechea, BegoÃ±a Martin-Castillo, Javier A Menendez

Published Nov 17, 2012 · Vol. 3, No. 12 · pp. 1600-1614

Keywords: Autophagy, ATG genes, HER2, trastuzumab, lapatinib

FAK is a critical regulator of neuroblastoma liver metastasis Research Paper

Sora Lee, Jingbo Qiao, Pritha Paul, Kathleen L. Oâ€™Connor, Mark Evers, Dai H. Chung

Published Nov 16, 2012 · Vol. 3, No. 12 · pp. 1576-1587

Keywords: GRP-R, FAK, malignant transformation, metastasis, neuroblastoma

Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans Research Paper

Kyle M. Walsh, Christopher I. Amos, Angela S. Wenzlaff, Ivan P. Gorlov, Jennette D. Sison, Xifeng Wu, Margaret R. Spitz, Helen M. Hansen, Emily Y. Lu, Chongjuan Wei, Huifeng Zhang, Wei Chen, Stacy M. Lloyd, Marsha L. Frazier, Paige M. Bracci, Michael F. Seldin, Margaret R. Wrensch, Ann G. Schwartz, John K. Wiencke

Published Nov 16, 2012 · Vol. 3, No. 11 · pp. 1428-1438

Keywords: Lung cancer, nicotine dependence, African-Americans, genetic association

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In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma Research Paper

Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on Î²-catenin Research Paper

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells Research Paper

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention Research Paper

Gene expression-based risk score in diffuse large B-cell lymphoma Research Paper

Advances in Targeting Signal Transduction Pathways. Review

Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes Review

Lin28b Promotes Head and Neck Cancer Progression via Modulation of the Insulin-Like Growth Factor Survival Pathway Research Paper

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Research Paper

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) Research Paper

Identification of miR-30d as a novel prognostic maker of prostate cancer. Research Paper

KDM1 is a novel therapeutic target for the treatment of gliomas Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

FAK is a critical regulator of neuroblastoma liver metastasis Research Paper

Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

In Vitro and in Vivo Anti-tumor Activity of miR-221/222 Inhibitors in Multiple Myeloma Research Paper

Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on Î²-catenin Research Paper

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells Research Paper

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention Research Paper

Gene expression-based risk score in diffuse large B-cell lymphoma Research Paper

Advances in Targeting Signal Transduction Pathways. Review

Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes Review

Lin28b Promotes Head and Neck Cancer Progression via Modulation of the Insulin-Like Growth Factor Survival Pathway Research Paper

Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer Research Paper

A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia Research Paper

High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion Research Paper

SOCS1 Mutation Subtypes Predict Divergent Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) Patients Research Paper

Identification and Characterization of a Novel Chemotype MEK Inhibitor Able to Alter the Phosphorylation State of MEK1/2 Research Paper

PIK3CA Mutations in Advanced Cancers: Characteristics and Outcomes Research Paper

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) Research Paper

Identification of miR-30d as a novel prognostic maker of prostate cancer. Research Paper

KDM1 is a novel therapeutic target for the treatment of gliomas Research Paper

Autophagy-related gene 12 (ATG12) is a novel determinant of primary resistance to HER2-targeted therapies: Utility of transcriptome analysis of the autophagy interactome to guide breast cancer treatment Research Paper

FAK is a critical regulator of neuroblastoma liver metastasis Research Paper

Association study of nicotinic acetylcholine receptor genes identifies a novel lung cancer susceptibility locus near CHRNA1 in African-Americans Research Paper