The Oncosearch | Oncotarget

CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

Andrey Astori, Hanne Kristin Fredly, Thomas Aquinas Aloysius, Lars Bullinger, VÃ©ronique Mansat-De Mas, Pierre de la Grange, Francois Delhommeau, Karen Marie Hagen, Christian RÃ©cher, Isabelle Dusanter-Fourt, Stian Knappskog, Johan Richard Lillehaug, Frederic Pendino, Ã˜ystein Bruserud

Published Aug 15, 2013 · Vol. 4, No. 9 · pp. 1438-1448

Keywords: CXXC5, mRNA, acute myeloid leukemia, chemotherapy, apoptosis

Small-molecule targeting of translation initiation for cancer therapy Research Paper

Bertal H. Aktas, Yuan Qiao, Esra Ozdelen, Roland Schubert, Sema Sevinc, Fred Harbinski, Luciano Grubissich, Samuel Singer, Jose A. Halperin

Published Aug 14, 2013 · Vol. 4, No. 10 · pp. 1606-1617

Keywords: CANCER, TERNARY COMPLEX, TRANSLATION, eIF2, UTR

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

Emma M. Smith, Lei Zhang, Brian A. Walker, Emma L. Davenport, Lauren I. Aronson, David Krige, Leon Hooftman, Alan H. Drummond, Gareth J. Morgan, Faith E. Davies

Published Aug 12, 2013 · Vol. 6, No. 19 · pp. 17314-17327

Keywords: Myeloma, HDAC inhibitor, aminopeptidase inhibitor, NFÎºB

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

Niraj M Shah, Stuart A Rushworth, Megan Y Murray, Kristian M Bowles, David J MacEwan

Published Aug 8, 2013 · Vol. 4, No. 8 · pp. 1130-1142

Keywords: NRF2, miRNA, transcription factor, oncogenesis, drug resistance

Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness Research Paper

Helge Siemens, Rene Jackstadt, Markus Kaller, Heiko Hermeking

Published Aug 6, 2013 · Vol. 4, No. 9 · pp. 1399-1415

Keywords: p53, miR-34, c-Kit, migration, chemoresistance, stemness

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

Xiaoli Wu, Mihir K. Bhayani, Cristina T. Dodge, Milena S. Nicoloso, Yunyun Chen, Xiaofeng Yan, Makoto Adachi, Ligy Thomas, Chad E. Galer, Tilahun Jiffar, Curtis R. Pickering, Michael E. Kupferman, Jeffrey N. Myers, George A. Calin, Stephen Y. Lai

Published Aug 6, 2013 · Vol. 4, No. 9 · pp. 1388-1398

Keywords: miRNA EGFR AKT1 mTOR miRNA-27a* miRNA-27a-5p

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity Research Paper

Matthew P Ablett, Ciara S O'Brien, Andrew H Sims, Gillian Farnie, Robert B Clarke

Published Jul 30, 2013 · Vol. 5, No. 3 · pp. 599-612

Keywords: CXCR4, stem cells, breast cancer, mammospheres, AMD3100, SDF-1

Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells. Research Paper

Raffaella Spina, Gessica Filocamo, Enrico Iaccino, Stefania Scicchitano, Michela Lupia, Emanuela Chiarella, Tiziana Mega, Francesca Bernaudo, Daniela Pelaggi, Maria Mesuraca, Simonetta Pazzaglia, Samantha Semenkow, Eli E Bar, Marcel Kool, Stefan Pfister, Heather M Bond, Charles G Eberhart, Christian SteinkÃ¼hler, Giovanni Morrone

Published Jul 27, 2013 · Vol. 4, No. 8 · pp. 1280-1292

Keywords: ZNF521, gene expression, medulloblastoma, cell growth, tumorigenicity, cancer stem cells

A Tumor initiating cell-enriched prognostic signature for HER2+:ERÎ±- breast cancer; rationale, new features, controversies and future directions Research Perspective

Jeff C. Liu, Sean E. Egan, Eldad Zacksenhaus

Published Jul 26, 2013 · Vol. 4, No. 8 · pp. 1317-1328

Keywords: Breast Cancer, HER2, prognostic signature, tumor-initiating cells

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

Alexandra Canonici, Merel Gijsen, Maeve Mullooly, Ruth Bennett, Noujoude Bouguern, Kasper Pedersen, Neil A Oâ€™Brien, Ioannis Roxanis, Ji-Liang Li, Esther Bridge, Richard Finn, Dennis Slamon, Patricia McGowan, Michael J. Duffy, Norma Oâ€™Donovan, John Crown, Anthony Kong

Published Jul 25, 2013 · Vol. 4, No. 10 · pp. 1592-1605

Keywords: breast cancer, HER2/ErbB2, trastuzumab (Herceptin), neratinib, panHER inhibitor

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients Research Paper

Marc Delord, Philippe Rousselot, Jean-Michel Cayuela, FranÃ§ois Sigaux, JoÃ«lle Guilhot, Claude Preudhomme, FranÃ§ois Guilhot, Pascale Loiseau, Emmanuel Raffoux, Daniela Geromin, Emmanuelle Genin, Fabien Calvo, Heriberto Bruzzoni-Giovanelli

Published Jul 18, 2013 · Vol. 4, No. 10 · pp. 1582-1591

Keywords: CML, Imatinib, SNPs, ABCG2, Pharmacogenetic, molecular response, BCR-ABL

Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis Research Paper

Noor A. Lokman, Alison SF. Elder, Miranda P Ween, Carmen E. Pyragius, Peter Hoffmann, Martin K. Oehler, Carmela Ricciardelli

Published Jul 14, 2013 · Vol. 4, No. 8 · pp. 1199-1211

Keywords: annexin A2, ovarian cancer, invasion, chick chorioallantoic membrane assay, xenograft model

Combining TRAIL with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling Research Paper

Grazia Saturno, Melanie Valenti, Alexis De Haven Brandon, George V. Thomas, Suzanne Eccles, Paul A. Clarke, Paul Workman

Published Jul 14, 2013 · Vol. 4, No. 8 · pp. 1185-1198

Keywords: TRAIL, PI3 Kinase/mTOR, HSP90, apoptosis, colorectal cancer

STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL) Research Paper

Olga Ritz, Karolin Rommel, Karola Dorsch, Elena Kelsch, Julia Melzner, Michaela Buck, Karen Leroy, Vasiliki Papadopoulou, Simon Wagner, Jochen K Lennerz, Peter MÃ¶ller

Published Jul 13, 2013 · Vol. 4, No. 7 · pp. 1093-1102

Keywords: intratumoral heterogenity, PMBL, BCL6, pSTAT6

Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target Research Paper

Jun Huang, Sho Tabata, Soji Kakiuchi, Trung The Van, Hisatsugu Goto, Masaki Hanibuchi, Yasuhiko Nishioka

Published Jul 8, 2013 · Vol. 4, No. 8 · pp. 1172-1184

Keywords: malignant pleural mesothelioma, pregnancy-associated plasma protein A, migration, orthotopic xenograft mouse model

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

Kristin Beebe, Mehdi Mollapour, Bradley Scroggins, Chrisostomos Prodromou, Wanping Xu, Mari Tokita, Tony Taldone, Lester Pullen, Bettina K Zierer, Min-Jung Lee, Jane Trepel, Johannes Buchner, Daniel Bolon, Gabriela Chiosis, Len Neckers

Published Jul 7, 2013 · Vol. 4, No. 7 · pp. 1065-1074

Keywords: Hsp90, posttranslational modification, phosphorylation, drug binding, Hsp90 inhibitor

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

Limin Wang, Kathleen A Gallo, Susan E Conrad

Published Jul 7, 2013 · Vol. 4, No. 8 · pp. 1158-1171

Keywords: breast cancer, kinase inhibitors, cell cycle, apoptosis

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

William J. Fredericks, Jorge Sepulveda, Priti Lal, John E. Tomaszewski, Ming-Fong Lin, Terry McGarvey, Frank J. Rauscher III, S. Bruce Malkowicz

Published Jul 7, 2013 · Vol. 4, No. 7 · pp. 1075-1092

Keywords: TERE1, UBIAD1, prostate cancer, castrate resistant prostate cancer, CRPC, LnCaP, cholesterol, SXR, androgen catabolism, Vitamin K-2

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

Silke KaulfuÃŸ, Henning Seemann, Rovena Kampe, Julia Meyer, Ralf Dressel, Britta KÃ¶nig, Jens-Gerd Scharf, Peter Burfeind

Published Jun 30, 2013 · Vol. 4, No. 7 · pp. 1037-1049

Keywords: colorectal cancer, PDGF receptor, c-KIT, SRC, cell proliferation, apoptosis, RNA interference, targeted therapy

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper

Tatiana N Moiseeva, Andrew Bottrill, Gerry Melino, Nickolai A Barlev

Published Jun 29, 2013 · Vol. 4, No. 9 · pp. 1338-1348

Keywords: proteasome, DNA damage, proteolytic activities, ubiquitylation

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CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

Small-molecule targeting of translation initiation for cancer therapy Research Paper

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness Research Paper

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity Research Paper

Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells. Research Paper

A Tumor initiating cell-enriched prognostic signature for HER2+:ERÎ±- breast cancer; rationale, new features, controversies and future directions Research Perspective

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients Research Paper

Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis Research Paper

Combining TRAIL with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling Research Paper

STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL) Research Paper

Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target Research Paper

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper

Publication Alerts

European Cancer and Oncology Congress

Oncoscience

Post-Publication Promotion

Search Oncotarget

CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia Research Paper

Small-molecule targeting of translation initiation for cancer therapy Research Paper

The combination of HDAC and aminopeptidase inhibitors is highly synergistic in myeloma and leads to disruption of the NFÎºB signalling pathway Research Paper

Understanding the role of NRF2-regulated miRNAs in human malignancies Review

Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness Research Paper

Coordinated Targeting of the EGFR Signaling Axis by MicroRNA-27a* Research Paper

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity Research Paper

Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells. Research Paper

A Tumor initiating cell-enriched prognostic signature for HER2+:ERÎ±- breast cancer; rationale, new features, controversies and future directions Research Perspective

Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer Research Paper

High imatinib dose overcomes insufficient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients Research Paper

Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis Research Paper

Combining TRAIL with PI3 kinase or HSP90 inhibitors enhances apoptosis in colorectal cancer cells via suppression of survival signaling Research Paper

STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL) Research Paper

Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target Research Paper

Posttranslational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors Research Paper

Targeting mixed lineage kinases in ER-positive breast cancer cells leads to G2/M cell cycle arrest and apoptosis. Research Paper

The tumor suppressor TERE1 (UBIAD1) prenyltransferase regulates the elevated cholesterol phenotype in castration resistant prostate cancer by controlling a program of ligand dependent SXR target genes. Research Paper

Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells Research Paper

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity Research Paper